{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:37:37Z","timestamp":1791293857882,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.neuroscience.2008.11.007","type":"journal-article","created":{"date-parts":[[2008,11,9]],"date-time":"2008-11-09T09:32:24Z","timestamp":1226223144000},"page":"1326-1337","source":"Crossref","is-referenced-by-count":48,"title":["Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-d-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits"],"prefix":"10.1016","volume":"158","author":[{"given":"C.S.","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.L.","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.F.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.T.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.F.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2008.11.007_bib1","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1523\/JNEUROSCI.3639-07.2008","article-title":"NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory","volume":"28","author":"Bannerman","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1046\/j.1460-9568.2001.01432.x","article-title":"Enhanced phosphorylation in immature dentate gyrus cells precedes neurotrophin expression and indicates a specific role of CREB in granule cells differentiation","volume":"13","author":"Bender","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0306-3623(94)00147-F","article-title":"Down-regulation of N-methyl-D-aspartate (NMDA) receptors of brain regions and spinal cord of rats treated chronically with morphine","volume":"26","author":"Bhargava","year":"1995","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1528-1167.2006.00420.x","article-title":"Alterations in long-term seizure susceptibility and the complex of PSD-95 with NMDA receptor from animals previously exposed to perinatal hypoxia","volume":"47","author":"Chen","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.expneurol.2006.12.002","article-title":"Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia","volume":"204","author":"Chen","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00001756-200302100-00016","article-title":"Prenatal morphine exposure decreases analgesia but not K+ channel activation","volume":"14","author":"Chiou","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib7","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1073\/pnas.95.5.2313","article-title":"Presence and phosphorylation of transcription factors in developing dendrites","volume":"95","author":"Crino","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0896-6273(00)80026-4","article-title":"Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity","volume":"16","author":"Deisseroth","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1113\/jphysiol.2004.080028","article-title":"Subunit-specific gating controls rat NR1\/NR2A and NR1\/NR2B NMDA channel kinetics and synaptic signaling profiles","volume":"563","author":"Erreger","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0079-6123(08)61135-8","article-title":"Expression of c-Jun and Jun-D transcription factors represent specific changes in neuronal gene expression following axotomy","volume":"103","author":"Herdegen","year":"1994","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0091-3057(96)00274-2","article-title":"Prenatal exposure to morphine affects juvenile play behavior and adult social behavior in rats","volume":"55","author":"Hol","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1523\/JNEUROSCI.18-02-00625.1998","article-title":"Assembly of proteins to the postsynaptic density after transient cerebral ischemia","volume":"18","author":"Hu","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib14","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1523\/JNEUROSCI.21-17-06459.2001","article-title":"Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons","volume":"21","author":"Iida","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib15","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0896-6273(00)80602-9","article-title":"Cross talk between ERK and PKA required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation","volume":"21","author":"Impey","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0896-6273(00)80747-3","article-title":"Making new connections: role of ERK\/MAP kinase signalling in neuronal plasticity","volume":"23","author":"Impey","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuron.2004.09.016","article-title":"Memory and addiction: shared neural circuitry and molecular mechanisms","volume":"44","author":"Kelley","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.290.5492.750","article-title":"Signal-processing machines at the postsynaptic density","volume":"290","author":"Kennedy","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.neuron.2005.04.031","article-title":"Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking","volume":"40","author":"Kim","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib20","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0091-3057(82)90113-7","article-title":"Enhanced analgesic response to morphine in adult rats exposed to morphine prenatally","volume":"17","author":"Kirby","year":"1982","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1469-7793.1999.00099.x","article-title":"Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells","volume":"52","author":"Kirson","year":"1999","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00441-006-0273-6","article-title":"NMDA receptor function: subunit composition versus spatial distribution","volume":"326","author":"Kohr","year":"2006","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib23","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1126\/science.7569905","article-title":"Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95","volume":"269","author":"Kornau","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(03)00645-7","article-title":"The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1","volume":"40","author":"Krapivinsky","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/358036a0","article-title":"Molecular diversity of the NMDA receptors","volume":"358","author":"Kutsuwada","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib26","doi-asserted-by":"crossref","first-page":"20036","DOI":"10.1074\/jbc.270.34.20036","article-title":"Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits","volume":"270","author":"Lau","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(97)01400-3","article-title":"Acute effects of morphine on the expression of mRNAs for NMDA receptor subunits in the rat hippocampus, hypothalamus and spinal cord","volume":"341","author":"Le Greves","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib28","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1523\/JNEUROSCI.3990-05.2006","article-title":"Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression","volume":"26","author":"Li","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0165-0173(99)00020-X","article-title":"NMDA and opioid receptor: their interactions in antinociception, tolerance and neuroplasticity","volume":"30","author":"Mao","year":"1999","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib30","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1523\/JNEUROSCI.19-06-01988.1999","article-title":"Modification of postsynaptic densities after transient cerebral ischemia: a quantitative and three-dimensional ultrastructural study","volume":"19","author":"Martone","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/24790","article-title":"Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein","volume":"396","author":"Migaud","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib32","doi-asserted-by":"crossref","first-page":"7116","DOI":"10.1523\/JNEUROSCI.20-18-07116.2000","article-title":"Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats","volume":"20","author":"Mizuno","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib33","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1126\/science.256.5060.1217","article-title":"Heteromeric NMDA receptors: molecular and functional distinction of subtypes","volume":"256","author":"Monyer","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib35","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/0028-3908(95)00109-J","article-title":"Structure and function of the NMDA receptor channel","volume":"34","author":"Mori","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/354031a0","article-title":"Molecular cloning and characterization of the rat NMDA receptor","volume":"354","author":"Moriyoshi","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib37","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/319774a0","article-title":"Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist AP5","volume":"319","author":"Morris","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib38","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib39","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0028-3908(99)00050-7","article-title":"Social behavior of juvenile rats after in utero exposure to morphine: dose-time-effect relationship","volume":"38","author":"Niesink","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib40","first-page":"905","article-title":"Social play in juvenile rats after in utero exposure to morphine","volume":"17","author":"Niesink","year":"1996","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib41","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1523\/JNEUROSCI.16-07-02157.1996","article-title":"Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases","volume":"16","author":"Niethammer","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib42","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0022-3565(25)30537-9","article-title":"Prenatal administration of morphine to the rat: tolerance to the analgesic effect of morphine in the offspring","volume":"197","author":"O'Callaghan","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/(SICI)1098-1063(1998)8:4<402::AID-HIPO8>3.0.CO;2-I","article-title":"Age-related deficits on the radial maze and in fear conditioning: hippocampal processing and consolidation","volume":"8","author":"Oler","year":"1998","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib44","first-page":"97","article-title":"Remembrances of places passed: spatial memory in rats","volume":"2","author":"Olton","year":"1976","journal-title":"J Exp Psychol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib45","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.mcn.2005.03.013","article-title":"Ontogeny of postsynaptic density proteins at glutamatergic synapses","volume":"29","author":"Petralia","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib46","first-page":"187","article-title":"Single dose of morphine influences plasma corticosterone and gene expression of main NMDA receptor subunit in the adrenal gland but not in the hippocampus","volume":"35","author":"Pirnik","year":"2001","journal-title":"Endocr Regul"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib47","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1523\/JNEUROSCI.19-11-04337.1999","article-title":"The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus","volume":"19","author":"Roberson","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.psych.54.101601.145237","article-title":"Addiction","volume":"54","author":"Robinson","year":"2003","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","article-title":"Structural plasticity associated with exposure to drugs of abuse","volume":"47","author":"Robinson","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib50","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1126\/science.284.5421.1845","article-title":"Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein","volume":"284","author":"Sattler","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/368144a0","article-title":"Changing subunit composition of heteromeric NMDA receptors during development of rat cortex","volume":"368","author":"Sheng","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib52","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.neuro.21.1.127","article-title":"CREB and memory","volume":"21","author":"Silva","year":"1998","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0092-8674(00)80921-6","article-title":"Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo","volume":"92","author":"Sprengel","year":"1998","journal-title":"Cell"},{"issue":"Pt 1","key":"10.1016\/j.neuroscience.2008.11.007_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1469-7793.1998.013bu.x","article-title":"Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons","volume":"507","author":"Stocca","year":"1998","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0166-4328(83)90188-2","article-title":"A behavioral analysis of spatial localization following electrolytic, kinate-, or colchicine-induced damage to the hippocampal formation in the rat","volume":"7","author":"Sutherland","year":"1983","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1471-4159.2000.0740169.x","article-title":"Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia","volume":"74","author":"Takagi","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib57","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/S0024-3205(01)01316-9","article-title":"Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring","volume":"69","author":"Tao","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib58","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1073\/pnas.96.2.435","article-title":"PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A","volume":"96","author":"Tezuka","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib59","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1152\/jn.00771.2005","article-title":"Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons","volume":"95","author":"Thomas","year":"2006","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib60","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1523\/JNEUROSCI.19-10-04180.1999","article-title":"The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro","volume":"19","author":"Tovar","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib61","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0092-8674(00)81827-9","article-title":"The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory","volume":"87","author":"Tsien","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib62","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1440-1681.2003.03835.x","article-title":"Molecular basis of opioid dependence: role of signal regulation by G-proteins","volume":"30","author":"Tso","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib63","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0376-8716(03)00193-5","article-title":"The effect of drugs of abuse on NMDAR1 receptor expression in the rat limbic system","volume":"72","author":"Turchan","year":"2003","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib64","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1651-2227.1994.tb13383.x","article-title":"Development after prenatal exposure to cocaine, heroin and methadone","volume":"404","author":"Van Baar","year":"1994","journal-title":"Acta Paediatr Suppl"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib65","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0306-4530(01)00049-X","article-title":"Prenatal opiate exposure: long CNS consequences in the stress system of offspring","volume":"27","author":"Vathy","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib66","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-3806(99)00068-1","article-title":"Prenatal morphine exposure differentially alters seizure susceptibility in developing female rats","volume":"116","author":"Veliskova","year":"1999","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib67","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1074\/jbc.R000025200","article-title":"CREB-binding protein and p300 in transcriptional regulation","volume":"276","author":"Vo","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib68","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0306-4522(00)00469-3","article-title":"Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities","volume":"102","author":"Wyneken","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1528-1157.2003.17602.x","article-title":"Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities","volume":"44","author":"Wyneken","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib70","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1111\/j.1460-9568.2006.05188.x","article-title":"Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons","volume":"24","author":"Xing","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib71","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1074\/jbc.274.10.6647","article-title":"Modulation of the channel activity of the \u03b52\/\u03b61-subtype N-methyl-D-aspartate receptor by PSD-95","volume":"274","author":"Yamada","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib72","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hipo.10137","article-title":"Prenatal administration of morphine decreases CREBSerine-133 phosphorylation and synaptic plasticity range-mediated by glutamatergic transmission in the hippocampal CA1 area of cognitive deficient rat offspring","volume":"13","author":"Yang","year":"2003","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib73","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/hipo.20179","article-title":"Alterations of postsynaptic density proteins in the hippocampus of cognitive deficient rat offspring from the morphine-addicted mother: beneficial effect of dextromethorphan","volume":"16","author":"Yang","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib74","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/1098-1063(2000)10:6<654::AID-HIPO1003>3.0.CO;2-T","article-title":"Prenatal exposure to morphine alters kinetic properties of NMDA receptor-mediated synaptic currents in the hippocampus of rat offspring","volume":"10","author":"Yang","year":"2000","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib75","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0896-6273(04)00048-0","article-title":"Identification of PSD-95 as regulator of dopamine-mediated synaptic and behavioral plasticity","volume":"41","author":"Yao","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib76","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1523\/JNEUROSCI.4299-05.2006","article-title":"Development changes in NMDA neurotoxicity reflect development changes in subunit composition of NMDA receptors","volume":"26","author":"Zhou","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib77","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-2999(98)00861-9","article-title":"Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment","volume":"365","author":"Zhu","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib78","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev.ne.16.030193.002555","article-title":"Neuroanatomy of memory","volume":"16","author":"Zola-Morgan","year":"1993","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2008.11.007_bib79","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0031-3955(16)38226-8","article-title":"Developmental and behavioral consequences of prenatal drug and alcohol exposure","volume":"38","author":"Zuckerman","year":"1991","journal-title":"Pediatr Clin North Am"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208016631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208016631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T16:01:48Z","timestamp":1738512108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452208016631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0306452208016631"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2008.11.007","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}