{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:12:19Z","timestamp":1767093139186},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.neuroscience.2008.12.005","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T10:28:05Z","timestamp":1229423285000},"page":"1390-1396","source":"Crossref","is-referenced-by-count":7,"title":["Whole-body periodic acceleration reduces brain damage in a focal ischemia model"],"prefix":"10.1016","volume":"158","author":[{"given":"R.","family":"Mart\u00ednez-Murillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2008.12.005_bib1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/japplphysiol.00662.2004","article-title":"Periodic acceleration: effects on vasoactive, fibrinolytic, and coagulation factors","volume":"98","author":"Adams","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib2","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00003246-200110000-00022","article-title":"Regional blood flow during periodic acceleration","volume":"29","author":"Adams","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib3","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1114\/1.1623486","article-title":"Effects of periodic body acceleration on the in vivo vasoactive response to N-omega-nitro-L-arginine and the in vitro nitric oxide production","volume":"31","author":"Adams","year":"2003","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2174\/156720207781387169","article-title":"Neurohormonal activation in ischemic stroke: effects of acute phase disturbances on long-term mortality","volume":"4","author":"Anne","year":"2007","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib5","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/sim.1749","article-title":"Tree and spline based association analysis of gene-gene interaction models for ischemic stroke","volume":"23","author":"Cook","year":"2004","journal-title":"Stat Med"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib6","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1161\/hs1001.097222","article-title":"Cost of stroke in Australia from a societal perspective: results from the North East Melbourne Stroke Incidence Study (NEMESIS)","volume":"32","author":"Dewey","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib7","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","article-title":"Stroke","volume":"371","author":"Donnan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1747-4949.2006.00059.x","article-title":"Glyceryl trinitrate vs. control, and continuing vs. stopping temporarily prior antihypertensive therapy, in acute stroke: rationale and design of the Efficacy of Nitric Oxide in Stroke (ENOS) trial (ISRCTN99414122)","volume":"1","year":"2006","journal-title":"Int J Stroke"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/auto.2156","article-title":"Neurodegeneration induces upregulation of Beclin 1","volume":"2","author":"Erlich","year":"2006","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0165-3806(03)00068-3","article-title":"Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery","volume":"142","author":"Fernandez","year":"2003","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuropharm.2007.12.007","article-title":"Neuroprotection for ischemic stroke: past, present and future","volume":"55","author":"Ginsberg","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/14737175.7.2.143","article-title":"Endovascular management of acute ischemic stroke: advances in patient and treatment selection","volume":"7","author":"Gupta","year":"2007","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1203\/PDR.0b013e31816c825c","article-title":"Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin","volume":"63","author":"Haynes","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1161\/STROKEAHA.107.494955","article-title":"Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke","volume":"39","author":"Hermann","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1248\/bpb.31.633","article-title":"Refined Qing Kai Ling, traditional Chinese medicinal preparation, reduces ischemic stroke-induced infarct size and neurological deficits and increases expression of endothelial nitric oxide synthase","volume":"31","author":"Hua","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib16","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/00004647-199609000-00023","article-title":"Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine","volume":"16","author":"Huang","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib17","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.7522345","article-title":"Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase","volume":"265","author":"Huang","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/HJH.0b013e3282f2dac9","article-title":"Candesartan but not ramipril pretreatment improves outcome after stroke and stimulates neurotrophin BNDF\/TrkB system in rats","volume":"26","author":"Krikov","year":"2008","journal-title":"J Hypertens"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2796.2007.01867.x","article-title":"Travel and venous thrombosis: a systematic review","volume":"262","author":"Kuipers","year":"2007","journal-title":"J Intern Med"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib20","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/jnr.21553","article-title":"Versican and brevican are expressed with distinct pathology in neonatal hypoxic-ischemic injury","volume":"86","author":"Leonardo","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12031-007-0058-8","article-title":"Function of COX-2 and prostaglandins in neurological disease","volume":"33","author":"Liang","year":"2007","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0006-8993(99)01388-8","article-title":"Expression of nitric oxide synthase (NOS)-2 following permanent focal ischemia and the role of nitric oxide in infarct generation in male, female and NOS-2 gene-deficient mice","volume":"830","author":"Loihl","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib23","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1161\/STROKEAHA.108.527531","article-title":"Treadmill exercise activates subcortical neural networks and improves walking after stroke","volume":"39","author":"Luft","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.peptides.2007.10.021","article-title":"Adrenomedullin is increased by pulsatile shear stress on the vascular endothelium via periodic acceleration (pGz)","volume":"29","author":"Martinez","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib25","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.2174\/138161207781368774","article-title":"Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks","volume":"13","author":"Martinez-Gonzalez","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neulet.2007.01.011","article-title":"The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model","volume":"415","author":"Martinez-Murillo","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1253\/circj.72.139","article-title":"Whole-body periodic acceleration enhances brachial endothelial function","volume":"72","author":"Matsumoto","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib28","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/sj.jcbfm.9600059","article-title":"Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection","volume":"25","author":"McCullough","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib29","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1210\/en.2005-1038","article-title":"The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential","volume":"147","author":"Miyashita","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib30","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(96)07493-4","article-title":"Mortality by cause for eight regions of the world: Global Burden of Disease Study","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib31","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1556-4029.2006.00174.x","article-title":"Cerebral hypoxia and ischemia: the forensic point of view: a review","volume":"51","author":"Oechmichen","year":"2006","journal-title":"J Forensic Sci"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-0404.1997.tb00102.x","article-title":"Regional measurements of NO formed in vivo during brain ischemia","volume":"95","author":"Olesen","year":"1997","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jnnp.67.1.1","article-title":"Nitric oxide in acute ischaemic stroke: a target for neuroprotection","volume":"67","author":"O'Mahony","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib34","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1158\/0008-5472.CAN-05-4412","article-title":"Bcl-2 inhibition of autophagy: a new route to cancer?","volume":"66","author":"Pattingre","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib35","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4161\/auto.5778","article-title":"Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?","volume":"4","author":"Rami","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nbd.2007.08.005","article-title":"Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death","volume":"29","author":"Rami","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0006-8993(01)02613-0","article-title":"Neuronal and inducible nitric oxide synthase expression and protein nitration in rat cerebellum after oxygen and glucose deprivation","volume":"909","author":"Rodrigo","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2005.02.010","article-title":"The role of free radicals in cerebral hypoxia and ischemia","volume":"39","author":"Rodrigo","year":"2005","journal-title":"Free Radic Biol Med"},{"issue":"Suppl 5","key":"10.1016\/j.neuroscience.2008.12.005_bib39","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1185\/030079907X260737","article-title":"Risk reduction by preventing stroke: need for blockade of angiotensin II and catecholamines?","volume":"23","author":"Rupp","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib40","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1378\/chest.128.4.2794","article-title":"Effect of moderate-intensity exercise, whole-body periodic acceleration, and passive cycling on nitric oxide release into circulation","volume":"128","author":"Sackner","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mehy.2004.01.025","article-title":"Say NO to fibromyalgia and chronic fatigue syndrome: an alternative and complementary therapy to aerobic exercise","volume":"63","author":"Sackner","year":"2004","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/157016107782023424","article-title":"Saving the ischemic penumbra: potential role for statins and phosphodiesterase inhibitors","volume":"5","author":"Sallustio","year":"2007","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib43","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1161\/CIRCULATIONAHA.105.557892","article-title":"Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium","volume":"112","author":"Saraiva","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neuroscience.2006.07.046","article-title":"Effects of acute hypobaric hypoxia on the nitric oxide system of the rat cerebral cortex: Protective role of nitric oxide inhibitors","volume":"142","author":"Serrano","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.amjmed.2007.06.030","article-title":"Biomarkers to predict recurrent cardiovascular disease: the Heart and Soul Study","volume":"121","author":"Shlipak","year":"2008","journal-title":"Am J Med"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2165\/00129784-200606040-00007","article-title":"Reteplase: a review of its use in the management of thrombotic occlusive disorders","volume":"6","author":"Simpson","year":"2006","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib47","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1365-2362.2007.01884.x","article-title":"Leisure time but not occupational physical activity significantly affects cardiovascular risk factors in an adult population","volume":"37","author":"Sofi","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(97)00918-X","article-title":"Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis","volume":"240","author":"Togashi","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1258\/jrsm.2008.070366","article-title":"A case-control study of seated immobility at work as a risk factor for venous thromboembolism","volume":"101","author":"West","year":"2008","journal-title":"J R Soc Med"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.resuscitation.2005.12.016","article-title":"Post-resuscitation reperfusion injury: comparison of periodic Gz acceleration versus thumper CPR","volume":"70","author":"Wu","year":"2006","journal-title":"Resuscitation"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib51","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/sj.jcbfm.9600553","article-title":"DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats","volume":"28","author":"Yanagisawa","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib52","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0304-3940(95)11752-I","article-title":"Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion","volume":"194","author":"Yoshida","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2008.12.005_bib53","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1161\/STROKEAHA.106.479725","article-title":"Blood pressure in relation to the incidence of cerebral infarction and intracerebral hemorrhage","volume":"38","author":"Zia","year":"2007","journal-title":"Stroke"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208017600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208017600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T10:57:19Z","timestamp":1545562639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452208017600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0306452208017600"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2008.12.005","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}