{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:09:27Z","timestamp":1761174567937},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.neuroscience.2008.12.034","type":"journal-article","created":{"date-parts":[[2009,1,3]],"date-time":"2009-01-03T04:12:56Z","timestamp":1230955976000},"page":"136-142","source":"Crossref","is-referenced-by-count":20,"title":["Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis"],"prefix":"10.1016","volume":"159","author":[{"given":"Z.-Y.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Schluesener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2008.12.034_bib1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1189\/jlb.1207844","article-title":"Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis","volume":"84","author":"Andersson","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib2","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.peptides.2008.01.019","article-title":"VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4","volume":"29","author":"Arranz","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib3","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1074\/jbc.M200497200","article-title":"Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4","volume":"277","author":"Asea","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib4","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1084\/jem.20050914","article-title":"Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus","volume":"202","author":"Barrat","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib5","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2741\/1304","article-title":"NF-\u03baB action in sepsis: the innate immune system and the heart","volume":"9","author":"Brown","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.it.2006.12.006","article-title":"Opposing effects of toll-like receptor stimulation induce autoimmunity or tolerance","volume":"28","author":"Ehlers","year":"2007","journal-title":"Trends Immunol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1357-4310(99)01639-1","article-title":"Animal models for autoimmune demyelinating disorders of the nervous system","volume":"6","author":"Gold","year":"2000","journal-title":"Mol Med Today"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1189\/jlb.1004564","article-title":"Time-course expression of toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP","volume":"78","author":"Gomariz","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib9","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.4049\/jimmunol.178.11.6715","article-title":"Cutting edge: TLR2 directly triggers Th1 effector functions","volume":"178","author":"Imanishi","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib10","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib11","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jaci.2006.02.023","article-title":"Toll-like receptor function and signaling","volume":"117","author":"Kaisho","year":"2006","journal-title":"J Allerg Clin Immunol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/ibd.20017","article-title":"Extracorporeal elimination of TNF-alpha-producing CD14(dull) CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis","volume":"13","author":"Kanai","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2006.01.004","article-title":"Immunolocalization and activation of nuclear factor-kappaB in the sciatic nerves of rats with experimental autoimmune neuritis","volume":"174","author":"Laur\u00e0","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib14","first-page":"S7","article-title":"Cellular immunity in inflammatory autoimmune neuropathies","volume":"158","author":"M\u00e4urer","year":"2002","journal-title":"Rev Neurol Paris"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib15","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2174\/092986708784221458","article-title":"Role of the innate immune system in autoimmune inflammatory demyelination","volume":"15","author":"O'Brien","year":"2008","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jaut.2007.09.001","article-title":"Toll like receptors and autoimmunity: a critical appraisal","volume":"29","author":"Papadimitraki","year":"2007","journal-title":"J Autoimmun"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib17","doi-asserted-by":"crossref","first-page":"15107","DOI":"10.1074\/jbc.M111204200","article-title":"HSP70 as endogenous stimulus of the toll\/interleukin-1 receptor signal pathway","volume":"277","author":"Vabulas","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.imbio.2006.05.004","article-title":"Toll-like receptor 9 contributes to recognition of Mycobacterium bovis bacillus Calmette-Gu\u00e9rin by Flt3-ligand generated dendritic cells","volume":"211","author":"von Meyenn","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1750-3639.2002.tb00445.x","article-title":"The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS","volume":"12","author":"Zekki","year":"2002","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1582-4934.2007.00004.x","article-title":"Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis","volume":"11","author":"Zhang","year":"2007","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib21","article-title":"Expression of interleukin-16 in sciatic nerves, spinal roots and spinal cords of experimental autoimmune neuritis rats","author":"Zhang","year":"2008","journal-title":"Brain Pathol [Epub ahead of print]"},{"key":"10.1016\/j.neuroscience.2008.12.034_bib22","first-page":"30","article-title":"The effects of monoamine reuptake inhibiting antidepressants in experimental allergic neuritis","volume":"2","author":"Zhu","year":"1997","journal-title":"J Peripher Nerv Syst"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208018502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452208018502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T01:23:42Z","timestamp":1545528222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452208018502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0306452208018502"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2008.12.034","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}