{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:40:13Z","timestamp":1769550013257,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.neuroscience.2009.02.035","type":"journal-article","created":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T09:28:15Z","timestamp":1235899695000},"page":"661-675","source":"Crossref","is-referenced-by-count":68,"title":["Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation"],"prefix":"10.1016","volume":"160","author":[{"given":"P.","family":"Capetian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Knoth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Maciaczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pantazis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ditter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bokla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.B.","family":"Landwehrmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Volk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Nikkhah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2009.02.035_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1474-4422(06)70381-7","article-title":"Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study","volume":"5","author":"Bachoud-Levi","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib2","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(00)03310-9","article-title":"Motor and cognitive improvements in patients with Huntington's disease after neural transplantation","volume":"356","author":"Bachoud-Levi","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0963-6897(97)00165-6","article-title":"Immunological responses to injury and grafting in the central nervous system of nonhuman primates","volume":"7","author":"Bakay","year":"1998","journal-title":"Cell Transplant"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/exnr.1996.0177","article-title":"Contributions of donor and host blood vessels in CNS allografts","volume":"142","author":"Baker-Cairns","year":"1996","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib5","first-page":"375","article-title":"Theory and practice of histological techniques","author":"Bancroft","year":"2002"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib6","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1602\/neurorx.1.4.472","article-title":"Immune problems in central nervous system cell therapy","volume":"1","author":"Barker","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib7","series-title":"Huntington's disease","author":"Bates","year":"2002"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib8","doi-asserted-by":"crossref","first-page":"10452","DOI":"10.1523\/JNEUROSCI.2850-06.2006","article-title":"A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6\/2 mouse","volume":"26","author":"Batista","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00221-005-0233-5","article-title":"Chemical characterization of newly generated neurons in the striatum of adult primates","volume":"170","author":"Bedard","year":"2006","journal-title":"Exp Brain Res Exp Hirnforschung"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00920568","article-title":"Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research","volume":"242","author":"Boer","year":"1994","journal-title":"J Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/jemt.1070270603","article-title":"Allografts of CNS tissue possess a blood\u2013brain barrier: III","volume":"27","author":"Broadwell","year":"1994","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2004.08.007","article-title":"Morphology and distribution of dopaminergic neurons intrinsic to the human striatum","volume":"29","author":"Cossette","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"Couillard-Despres","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.neuroscience.2004.12.051","article-title":"The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain","volume":"132","author":"Curtis","year":"2005","journal-title":"Neuroscience"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2009.02.035_bib15","doi-asserted-by":"crossref","first-page":"11866","DOI":"10.1073\/pnas.1834200100","article-title":"Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells","volume":"100","author":"D'Amour","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0079-6123(00)27017-9","article-title":"The integration and function of striatal grafts","volume":"127","author":"Dunnett","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1602\/neurorx.1.4.394","article-title":"Cell therapy in Huntington's disease","volume":"1","author":"Dunnett","year":"2004","journal-title":"NeuroRx"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000082134","article-title":"SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult","volume":"26","author":"Ellis","year":"2004","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib19","doi-asserted-by":"crossref","first-page":"13877","DOI":"10.1073\/pnas.97.25.13877","article-title":"Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology","volume":"97","author":"Freeman","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1460-9568.2004.03149.x","article-title":"Striatal neurons in striatal grafts are derived from both post-mitotic cells and dividing progenitors","volume":"19","author":"Fricker-Gates","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib21","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0896-6273(00)80778-3","article-title":"Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons","volume":"23","author":"Gleeson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0166-2236(90)90044-B","article-title":"Riding the glial monorail: a common mechanism for glial-guided neuronal migration in different regions of the developing mammalian brain","volume":"13","author":"Hatten","year":"1990","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ana.410190610","article-title":"Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions","volume":"19","author":"Hauser","year":"1986","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/brain\/awl332","article-title":"The fate of striatal dopaminergic neurons in Parkinson's disease and Huntington's chorea","volume":"130","author":"Huot","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib26","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1046\/j.1460-9568.2002.01959.x","article-title":"Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS","volume":"15","author":"Hurelbrink","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib27","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1111\/j.1460-9568.2005.03963.x","article-title":"Migration of cells from primary transplants of allo- and xenografted foetal striatal tissue in the adult rat brain","volume":"21","author":"Hurelbrink","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/dbio.2002.0586","article-title":"Tangential migration in neocortical development","volume":"244","author":"Jimenez","year":"2002","journal-title":"Dev Biol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib29","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0166-2236(95)98374-8","article-title":"Striatal interneurones: chemical, physiological and morphological characterization","volume":"18","author":"Kawaguchi","year":"1995","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib30","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1212\/01.wnl.0000264504.14301.f5","article-title":"Neural transplantation in Huntington disease: long-term grafts in two patients","volume":"68","author":"Keene","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm0698-727","article-title":"Functional integration of striatal allografts in a primate model of Huntington's disease","volume":"4","author":"Kendall","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/mds.870130303","article-title":"Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease","volume":"13","author":"Kordower","year":"1998","journal-title":"Mov Disord"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<203::AID-CNE6>3.0.CO;2-6","article-title":"Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies","volume":"370","author":"Kordower","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib34","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1371\/journal.pone.0000166","article-title":"Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in Patients with Huntington's disease","volume":"2","author":"Krystkowiak","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/dvdy.21024","article-title":"Prox1 expression patterns in the developing and adult murine brain","volume":"236","author":"Lavado","year":"2007","journal-title":"Dev Dyn"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/cm.970170207","article-title":"The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis","volume":"17","author":"Lee","year":"1990","journal-title":"Cell Motil Cytoskeleton"},{"issue":"5","key":"10.1016\/j.neuroscience.2009.02.035_bib37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nm1746","article-title":"Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation","volume":"14","author":"Li","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0306-4522(84)90070-8","article-title":"An autoradiographic study of neuronal development, vascularization and glial cell migration from hippocampal transplants labelled in intermediate explant culture","volume":"12","author":"Lindsay","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib39","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1523\/JNEUROSCI.12-02-00674.1992","article-title":"Transient calbindin-D28k-positive systems in the telencephalon: ganglionic eminence, developing striatum and cerebral cortex","volume":"12","author":"Liu","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib40","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1523\/JNEUROSCI.20-16-06063.2000","article-title":"Origin and molecular specification of striatal interneurons","volume":"20","author":"Marin","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib41","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/brain\/awh510","article-title":"Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease","volume":"128","author":"Mendez","year":"2005","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.neuroscience.2009.02.035_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nm1752","article-title":"Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years","volume":"14","author":"Mendez","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib43","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0306-4522(96)00238-2","article-title":"DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease","volume":"74","author":"Nakao","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib44","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0306-4522(97)00532-0","article-title":"Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence","volume":"84","author":"Olsson","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib45","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm0898-963","article-title":"Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease","volume":"4","author":"Palfi","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nbd.2007.08.008","article-title":"Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease","volume":"29","author":"Redmond","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib47","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1136\/jnnp.73.6.678","article-title":"Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475","volume":"73","author":"Rosser","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1096-9861(19990308)405:2<185::AID-CNE4>3.0.CO;2-B","article-title":"Postnatal development of calretinin- and parvalbumin-positive interneurons in the rat neostriatum: an immunohistochemical study","volume":"405","author":"Schlosser","year":"1999","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib49","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s004150170154","article-title":"Vasculitis of the nervous system","volume":"248","author":"Siva","year":"2001","journal-title":"J Neurol"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib50","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1089\/15258160360732731","article-title":"Embryonic neural progenitor cells: the effects of species, region, and culture conditions on long-term proliferation and neuronal differentiation","volume":"12","author":"Smith","year":"2003","journal-title":"J Hematother Stem Cell Res"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib51","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/hmg\/ddl252","article-title":"Cholinergic neuronal defect without cell loss in Huntington's disease","volume":"15","author":"Smith","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib52","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2004.04.061","article-title":"Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease","volume":"127","author":"Tattersfield","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib53","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0736-5748(93)90049-J","article-title":"Transplantation of oligodendrocyte precursors in the adult demyelinated spinal cord: migration and remyelination","volume":"11","author":"Vignais","year":"1993","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib54","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1523\/JNEUROSCI.5060-06.2007","article-title":"The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells","volume":"27","author":"Walker","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/096368970000900310","article-title":"The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces","volume":"9","author":"Watts","year":"2000","journal-title":"Cell Transplant"},{"key":"10.1016\/j.neuroscience.2009.02.035_bib56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/096368970000900109","article-title":"Volume and differentiation of striatal grafts in rats: relationship to the number of cells implanted","volume":"9","author":"Watts","year":"2000","journal-title":"Cell Transplant"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209001997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209001997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T10:12:16Z","timestamp":1558174336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452209001997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0306452209001997"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.02.035","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}