{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:50:12Z","timestamp":1788717012391,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.neuroscience.2009.06.016","type":"journal-article","created":{"date-parts":[[2009,6,12]],"date-time":"2009-06-12T12:49:19Z","timestamp":1244810959000},"page":"23-33","source":"Crossref","is-referenced-by-count":43,"title":["Nalfurafine prevents 5\u2032-guanidinonaltrindole- and compound 48\/80-induced spinal c-fos expression and attenuates 5\u2032-guanidinonaltrindole-elicited scratching behavior in mice"],"prefix":"10.1016","volume":"163","author":[{"given":"S.","family":"Inan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Dun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2009.06.016_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/82924","article-title":"Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch","volume":"4","author":"Andrew","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cld.2007.11.009","article-title":"Update on the treatment of the pruritus of cholestasis","volume":"12","author":"Bergasa","year":"2008","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib3","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/jm0309203","article-title":"Guanidino N-substituted and N,N-disubstituted derivatives of the \u03ba-opioid antagonist GNTI","volume":"46","author":"Black","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/cne.20350","article-title":"Kiss-1 expression and metastatin-like immunoreactivity in the rat brain","volume":"481","author":"Brailoiu","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-8993(00)03254-6","article-title":"Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-fos protein study","volume":"891","author":"Buritova","year":"2001","journal-title":"Brain Res"},{"issue":"Suppl","key":"10.1016\/j.neuroscience.2009.06.016_bib6","first-page":"169P","article-title":"Antagonism by opioids of compound 48\/80-induced scratching in mice","volume":"122","author":"Cowan","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2009.06.016_bib7","first-page":"A51","article-title":"GNTI, a kappa receptor antagonist, causes scratching in mice","volume":"44","author":"Cowan","year":"2002","journal-title":"Pharmacologist"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib8","series-title":"Opioid receptors and antagonists: from bench to clinic (volume in the contemporary neuroscience series)","first-page":"533","article-title":"Kappa-opioid antagonists as pruritogenic agents","author":"Cowan","year":"2009"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib9","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0024-3205(99)00417-8","article-title":"Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist","volume":"65","author":"Endoh","year":"1999","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-2999(99)00815-8","article-title":"Characterization of the antinociceptive effects of TRK-820 in the rat","volume":"387","author":"Endoh","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1254\/jjp.85.282","article-title":"TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys","volume":"85","author":"Endoh","year":"2001","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/apm.1966.66.3.313","article-title":"Mast cells in gastrointestinal mucosa","volume":"66","author":"Enerb\u00e4ck","year":"1966","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1749-6632.1988.tb38614.x","article-title":"Role of opioid receptors in bombesin-induced grooming","volume":"525","author":"Gmerek","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2006.06.058","article-title":"Neuronal conditions of spinal cord in dermatitis are improved by olopatadine","volume":"547","author":"Hamada","year":"2006","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-2999(02)01933-7","article-title":"Involvement of unique mechanisms in the induction of scratching behavior in BALB\/c mice by compound 48\/80","volume":"448","author":"Inagaki","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2004.09.010","article-title":"Kappa opioid agonists suppress chloroquine-induced scratching in mice","volume":"502","author":"Inan","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib18","first-page":"38","article-title":"Agmatine-induced stereotyped scratching in mice is antagonized by nalfurafine, a kappa opioid agonist","volume":"48","author":"Inan","year":"2006","journal-title":"Pharmacologist"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbb.2006.07.004","article-title":"Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats","volume":"85","author":"Inan","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00210-008-0358-8","article-title":"Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A","volume":"379","author":"Inan","year":"2009","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(00)00208-9","article-title":"5\u2032-Guanidinonaltrindole, a highly selective and potent \u03ba-opioid receptor antagonist","volume":"396","author":"Jones","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(01)00941-4","article-title":"Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice","volume":"418","author":"Kamei","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib23","first-page":"A801","article-title":"Stereoselective antipruritic effects of enadoline and GR 94839 in mice","volume":"13","author":"Kehner","year":"1999","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.01.091","article-title":"Pattrens of fos expression in the rostral medulla and caudal pons evoked by noxious craniovascular stimulation and periaqueductal gray stimulation in the cat","volume":"1045","author":"Knight","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/jpet.102.044909","article-title":"Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys","volume":"305","author":"Ko","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/jpet.108.143925","article-title":"Effects of atypical \u03ba-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates","volume":"328","author":"Ko","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0014-2999(85)90687-9","article-title":"Histamine release induced from mast cells by active components of compound 48\/80","volume":"115","author":"Koibuchi","year":"1985","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroscience.2004.04.047","article-title":"Cocaine-induced fos expression in rat striatum is blocked by chloral hydrate or urethane","volume":"127","author":"Kreuter","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-2999(94)00780-B","article-title":"Scratching behavior induced by pruritogenic but not algesiogenic agents in mice","volume":"275","author":"Kuraishi","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1248\/cpb.46.366","article-title":"Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan","volume":"46","author":"Nagase","year":"1998","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/WNR.0b013e3282fdf6c5","article-title":"Different dorsal horn neurons responding to histamine and allergic itch stimuli","volume":"19","author":"Nakano","year":"2008","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib32","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1152\/jn.90482.2008","article-title":"Separate peripheral pathways for pruritus in man","volume":"100","author":"Namer","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(03)00609-8","article-title":"C-fos expression in superficial dorsal horn of cervical spinal cord associated with spontaneous scratching in rats with dry skin","volume":"347","author":"Nojima","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib34","doi-asserted-by":"crossref","first-page":"10784","DOI":"10.1523\/JNEUROSCI.23-34-10784.2003","article-title":"Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin","volume":"23","author":"Nojima","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.ajkd.2007.03.010","article-title":"An update on pruritus associated with CKD","volume":"50","author":"Patel","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib36","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib37","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1523\/JNEUROSCI.17-20-08003.1997","article-title":"Specific C-receptors for itch in human skin","volume":"17","author":"Schmelz","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib38","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.pain.2008.08.002","article-title":"Behavioral differentiation between itch and pain in mice","volume":"139","author":"Shimada","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00288-X","article-title":"Effects of histamine H1 receptor antagonists on compound 48\/80-induced scratching behavior in mice","volume":"351","author":"Sugimoto","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2003.09.057","article-title":"Effect of repeated administration TRK-820, a kappa-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions","volume":"995","author":"Suzuki","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0014-2999(01)01588-6","article-title":"Antipruritic activity of the \u03ba-opioid receptor agonist, TRK-820","volume":"435","author":"Togashi","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib42","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1016\/j.lfs.2004.05.033","article-title":"Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys","volume":"75","author":"Wakasa","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1124\/jpet.104.073668","article-title":"Comparison of pharmacological activities of three distinct \u03ba ligands (salvinorin A, TRK-820 and 3FLB) on \u03ba opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo","volume":"312","author":"Wang","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib44","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1681\/ASN.2005020152","article-title":"\u03ba-Opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies","volume":"16","author":"Wikstr\u00f6m","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuroscience.2009.06.016_bib45","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1097\/00001756-199707070-00049","article-title":"C-fos expression in the trigeminal sensory complex and pontine parabrachial areas following experimental tooth movement","volume":"8","author":"Yamashiro","year":"1997","journal-title":"Neuroreport"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209010045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209010045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T21:46:28Z","timestamp":1558388788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452209010045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0306452209010045"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.06.016","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}