{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:36Z","timestamp":1791252876188,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.neuroscience.2009.07.015","type":"journal-article","created":{"date-parts":[[2009,7,12]],"date-time":"2009-07-12T08:11:31Z","timestamp":1247386291000},"page":"933-941","source":"Crossref","is-referenced-by-count":24,"title":["Non-competitive metabotropic glutamate 1 receptor antagonists block activity of slowly adapting type I mechanoreceptor units in the rat sinus hair follicle"],"prefix":"10.1016","volume":"163","author":[{"given":"P.M.B.","family":"Cahusac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Mavulati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2009.07.015_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pain.2005.07.017","article-title":"Role of peripheral group I and II metabotropic glutamate receptors in IL-1 beta-induced mechanical allodynia in the orofacial area of conscious rats","volume":"118","author":"Ahn","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0960-894X(96)00104-7","article-title":"A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates","volume":"6","author":"Annoura","year":"1996","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0028-3908(97)00014-2","article-title":"Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices","volume":"36","author":"Batchelor","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0024-3205(69)90283-5","article-title":"Synthetic interstitial fluid for isolated mammalian tissue","volume":"8","author":"Bretag","year":"1969","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib5","series-title":"Amino acid receptor research","first-page":"125","article-title":"Glutamate signalling in the skin","author":"Cahusac","year":"2008"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuroscience.2007.06.018","article-title":"A pharmacological study of slowly adapting mechanoreceptors responsive to cold thermal stimulation","volume":"148","author":"Cahusac","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/syn.20236","article-title":"Metabotropic glutamate receptor antagonists selectively enhance responses of slowly adapting type I mechanoreceptors","volume":"59","author":"Cahusac","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.neuroscience.2005.03.018","article-title":"Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses?","volume":"133","author":"Cahusac","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1113\/expphysiol.1972.sp002177","article-title":"The structure and function of the slowly adapting type II mechanoreceptor in hairy skin","volume":"57","author":"Chambers","year":"1972","journal-title":"Q J Exp Physiol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cne.10277","article-title":"Similarities and differences in the innervation of mystacial vibrissal follicle-sinus complexes in the rat and cat: a confocal microscopic study","volume":"449","author":"Ebara","year":"2002","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00001756-200102120-00032","article-title":"Evidence for glutamate receptor mediated transmission at mechanoreceptors in the skin","volume":"12","author":"Fagan","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.bjp.0707286","article-title":"Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices","volume":"151","author":"Fukunaga","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.neuropharm.2006.08.014","article-title":"The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors","volume":"52","author":"Fukunaga","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1113\/jphysiol.1973.sp010388","article-title":"Functional characteristics of mechanoreceptors in sinus hair follicles of the cat","volume":"235","author":"Gottschaldt","year":"1973","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib15","first-page":"1399","article-title":"The non-competitive metabotropic glutamate receptor-1 antagonist CPCCOEt inhibits the in vitro growth of human melanoma","volume":"17","author":"Haas","year":"2007","journal-title":"Oncol Rep"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib16","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1073\/pnas.0406308101","article-title":"Molecular profiling reveals synaptic release machinery in Merkel cells","volume":"101","author":"Haeberle","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ar.a.10029","article-title":"Friedrich Sigmund Merkel and his \u201cMerkel cell\u201d, morphology, development, and physiology: review and new results","volume":"271A","author":"Halata","year":"2003","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0165-6147(92)90115-M","article-title":"Amiloride: a molecular probe for mechanosensitive channels","volume":"13","author":"Hamill","year":"1992","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0031-6997(25)06942-X","article-title":"The pharmacology of mechanogated membrane ion channels","volume":"48","author":"Hamill","year":"1996","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-2999(96)00253-1","article-title":"The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase","volume":"307","author":"Hawkinson","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neulet.2004.02.071","article-title":"Essential components for a glutamatergic synapse between Merkel cell and nerve terminal in rats","volume":"3","author":"Hitchcock","year":"2004","journal-title":"Neurosci Lett 362\/"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib22","series-title":"Sensory receptor mechanisms","first-page":"117","article-title":"A review of Merkel cell mechanisms","author":"Iggo","year":"1984"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib23","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1113\/jphysiol.1969.sp008721","article-title":"The structure and function of a slowly adapting touch corpuscle in hairy skin","volume":"200","author":"Iggo","year":"1969","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1124\/jpet.105.087171","volume":"315","author":"Kohara","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature03896","article-title":"A possible unifying principle for mechanosensation","volume":"436","author":"Kung","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1476-5381.1992.tb14329.x","article-title":"Structure-activity relations of amiloride and its analogues in blocking the mechanosensitive channel in Xenopus oocytes","volume":"106","author":"Lane","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pain.2007.09.008","article-title":"Involvement of metabotropic glutamate 5 receptor in visceral pain","volume":"137","author":"Lindstrom","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0026-895X(24)12169-4","article-title":"CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding","volume":"55","author":"Litschig","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib29","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nature05662","article-title":"Mechanisms of sensory transduction in the skin","volume":"445","author":"Lumpkin","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib30","series-title":"The Merkel cell: structure-development-function-cancerogenesis","first-page":"179","article-title":"Merkel cell carcinoma\u2014a short review","author":"Mol","year":"2003"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/B:NEUR.0000044196.45602.92","article-title":"Merkel cells, corpuscular nerve endings and free nerve endings in the mouse palatine mucosa express three subtypes of vesicular glutamate transporters","volume":"33","author":"Nunzi","year":"2004","journal-title":"J Neurocytol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1113\/jphysiol.1994.sp020004","article-title":"Block by amiloride and its derivatives of mechanoelectrical transduction in outer hair-cells of mouse cochlear cultures","volume":"474","author":"R\u00fcsch","year":"1994","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.ph.57.030195.002001","article-title":"Mechanosensitive channels","volume":"57","author":"Sackin","year":"1995","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0922-4106(95)90120-5","article-title":"L-2-amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1a and 5 in Xenopus oocytes","volume":"289","author":"Saugstad","year":"1995","journal-title":"Eur J Pharmacol: Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1113\/jphysiol.1997.sp021996","article-title":"Functional evidence for calcium-induced calcium release in isolated rat vibrissal Merkel cell mechanoreceptors","volume":"500","author":"Senok","year":"1997","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib36","first-page":"862","article-title":"Potassium channels modulate the mechanical sensitivity of cutaneous type I slowly adapting mechanoreceptors","volume":"33","author":"Senok","year":"2007","journal-title":"Soc Neurosci Abstr"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib37","first-page":"130","article-title":"Spontaneous firing in vibrissal type II slowly adapting mechanoreceptors depends on potassium channel activity","volume":"27","author":"Senok","year":"2001","journal-title":"Soc Neurosci Abstr"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00418-003-0540-5","article-title":"Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-beta 1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles","volume":"120","author":"Tachibana","year":"2003","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib39","series-title":"The Merkel cell: structure-development-function-cancerogenesis","first-page":"147","article-title":"Localization of signal transduction proteins in the Merkel cell axon complex","author":"Tachibana","year":"2003"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/cne.21517","article-title":"Central and peripheral anatomy of slowly adapting type I low-threshold mechanoreceptors innervating trunk skin of neonatal mice","volume":"505","author":"Woodbury","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.07.015_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/08990229109144732","article-title":"Slowly adapting cutaneous mechanoreceptor afferent units associated with Merkel cells in frogs and effects of direct currents","volume":"8","author":"Yamashita","year":"1991","journal-title":"Somatosens Mot Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209011348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209011348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T22:33:10Z","timestamp":1739226790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452209011348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0306452209011348"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.07.015","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}