{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:34Z","timestamp":1791274594514,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.neuroscience.2009.08.037","type":"journal-article","created":{"date-parts":[[2009,8,23]],"date-time":"2009-08-23T04:34:48Z","timestamp":1251002088000},"page":"573-577","source":"Crossref","is-referenced-by-count":133,"title":["Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia"],"prefix":"10.1016","volume":"164","author":[{"given":"S.R.D.T.","family":"Siqueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.G.","family":"Malpartida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.T.T.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2009.08.037_bib1","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/hmg\/ddm160","article-title":"A stop codon mutation in SCN9A causes lack of pain sensation","volume":"16","author":"Ahmad","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3959(00)00417-6","article-title":"Neuropeptide Y in trigeminal ganglion following chronic constriction injury of the rat infraorbital nerve: is there correlation to somatosensory parameters?","volume":"91","author":"Benoliel","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.archoralbio.2006.11.011","article-title":"Na(v)1.7 sodium channel expression in human lingual nerve neuromas","volume":"52","author":"Bird","year":"2007","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/ana.21527","article-title":"Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas","volume":"64","author":"Black","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib5","first-page":"441","article-title":"Molecular properties of brain sodium channels: an important target for anticonvulsant drugs","volume":"79","author":"Catterall","year":"1999","journal-title":"Adv Neurol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib6","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/01.wnl.0000231514.33603.1e","article-title":"Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy","volume":"67","author":"Choi","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2007.07.026","article-title":"The roles of sodium channels in nociception: implications for mechanisms of pain","volume":"131","author":"Cummins","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.tins.2007.08.004","article-title":"From genes to pain: Na v 1.7 and human pain disorders","volume":"30","author":"Dib-Hajj","year":"2007","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1399-302X.2005.00211.x","article-title":"Differential gene expression of human \u03b2-defensins (hBD-1, -2, -3) in inflammatory gingival diseases","volume":"20","author":"Dommisch","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pain.2005.09.019","article-title":"Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model","volume":"119","author":"Eriksson","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib12","doi-asserted-by":"crossref","first-page":"11079","DOI":"10.1523\/JNEUROSCI.3443-08.2008","article-title":"NaV17 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders","volume":"28","author":"Estacion","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.earlhumdev.2006.09.013","article-title":"Molecular genetics of infantile nervous system channelopathies","volume":"82","author":"Gardiner","year":"2006","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1399-0004.2007.00790.x","article-title":"Loss-of-function mutations in the Nav17 gene underlie congenital indifference to pain in multiple human populations","volume":"71","author":"Goldberg","year":"2007","journal-title":"Clin Genet"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1744-8069-3-3","article-title":"Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav17","volume":"3","author":"Han","year":"2007","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ana.20776","article-title":"Sporadic onset of erythermalgia: a gain-of-function mutation in Nav17","volume":"59","author":"Han","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib17","doi-asserted-by":"crossref","first-page":"12566","DOI":"10.1523\/JNEUROSCI.3424-06.2006","article-title":"Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons","volume":"26","author":"Harty","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.pain.2006.05.028","article-title":"Increased sodium channel immunofluorescence at myelinated and demyelinated sites following an inflammatory and partial axotomy lesion of the rat infraorbital nerve","volume":"124","author":"Henry","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib19","first-page":"334","article-title":"Management of the failed patient with trigeminal neuralgia","volume":"32","author":"Jannetta","year":"1985","journal-title":"Clin Neurosurg"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib20","doi-asserted-by":"crossref","first-page":"36029","DOI":"10.1074\/jbc.M607637200","article-title":"Size matters: erythromelalgia mutation S241T in Nav17 alters channel gating","volume":"281","author":"Lampert","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1744-8069-4-16","article-title":"Nav17 expression is increased in painful human dental pulp","volume":"4","author":"Luo","year":"2008","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib22","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1172\/JCI25466","article-title":"Sodium channel mutations in epilepsy and other neurological disorders","volume":"8","author":"Meisler","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib23","series-title":"Classification of chronic pain","author":"Merskey","year":"1994"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib24","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1001\/archneur.62.10.1587","article-title":"Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav17","volume":"62","author":"Michiels","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6831-5-5","article-title":"Sodium channel Nav18 immunoreactivity in painful human dental pulp","volume":"5","author":"Renton","year":"2005","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.semcdb.2006.10.009","article-title":"The role of sodium channels in neuropathic pain","volume":"17","author":"Rogers","year":"2006","journal-title":"Cell Dev Biol"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0021-9681(73)90075-1","article-title":"Epidemiology of trigeminal neuralgia","volume":"26","author":"Rothman","year":"1973","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib28","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1073\/pnas.0602813103","article-title":"A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons","volume":"103","author":"Rush","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1744-8069-3-9","article-title":"Understanding LTP in pain pathways","volume":"3","author":"Sandk\u00fchler","year":"2007","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tripleo.2004.05.005","article-title":"Idiopathic trigeminal neuralgia: clinical aspects and dental procedures","volume":"98","author":"Siqueira","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.neuroscience.2009.08.037_bib31","series-title":"Molecular biology in malignant transformation: clinical manual","author":"Sogayar","year":"2007"},{"issue":"Suppl 2","key":"10.1016\/j.neuroscience.2009.08.037_bib32","first-page":"ii27","article-title":"Facial pain: neurological and non-neurological","volume":"72","author":"Zakrzewska","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209013931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209013931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T12:53:05Z","timestamp":1545051185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452209013931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0306452209013931"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.08.037","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}