{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:54:03Z","timestamp":1779288843073,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG-02754"],"award-info":[{"award-number":["AG-02754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS 30109"],"award-info":[{"award-number":["NS 30109"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IRG 06-25497"],"award-info":[{"award-number":["IRG 06-25497"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.neuroscience.2009.09.024","type":"journal-article","created":{"date-parts":[[2009,9,21]],"date-time":"2009-09-21T04:09:32Z","timestamp":1253506172000},"page":"1334-1346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Amyloid-\u03b2 expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum"],"prefix":"10.1016","volume":"164","author":[{"given":"R.T.","family":"Robertson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Baratta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"LaFerla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2009.09.024_bib1","doi-asserted-by":"crossref","first-page":"17268","DOI":"10.1074\/jbc.270.29.17268","article-title":"Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve","volume":"270","author":"Amaratunga","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2004.11.047","article-title":"Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease","volume":"132","author":"Aucoin","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0301-0082(02)00079-5","article-title":"Alzheimer's disease and the basal forebrain cholinergic system: relations to b-amyloid peptides, cognition, and treatment strategies","volume":"68","author":"Auld","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib7","doi-asserted-by":"crossref","first-page":"8164","DOI":"10.1523\/JNEUROSCI.21-20-08164.2001","article-title":"Selective immunolesions of cholinergic neurons in mice: effects on neuroanatomy, neurochemistry, and behavior","volume":"21","author":"Berger-Sweeney","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0361-9230(82)90101-0","article-title":"Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital and cingulate cortices: a combined fluorescent tracer and acetylcholinesterase analysis","volume":"8","author":"Bigl","year":"1982","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal Ab causes the onset of early Alzheimer's disease related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nrn2150","article-title":"Dendritic mRNA: transport, translation and function","volume":"8","author":"Bramham","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib11","series-title":"The rat nervous system","first-page":"1257","article-title":"Cholinergic neurons and networks revisited","author":"Butcher","year":"2004"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib12","doi-asserted-by":"crossref","first-page":"9629","DOI":"10.1523\/JNEUROSCI.18-23-09629.1998","article-title":"Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path","volume":"18","author":"Buxbaum","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib14","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1126\/science.6338589","article-title":"Alzheimer's disease: a disorder of cortical cholinergic innervation","volume":"219","author":"Coyle","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib15","first-page":"1943","article-title":"Selective loss of central cholinergic neurons in Alzheimer's disease","volume":"2","author":"Davies","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0197-4580(95)00013-5","article-title":"Correlations of synaptic and pathological markers with cognition of the elderly","volume":"16","author":"Dickson","year":"1995","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib17","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1523\/JNEUROSCI.13-07-03112.1993","article-title":"Intraneuronal compartments of the amyloid precursor protein","volume":"13","author":"Ferreira","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cne.10737","article-title":"Cholinergic neuropathology in a mouse model of Alzheimer's disease","volume":"462","author":"German","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ana.410420613","article-title":"Butyrylcholinesterase in the life cycle of amyloid plaques","volume":"42","author":"Guillozet","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/156720506775697098","article-title":"Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal","volume":"3","author":"Hardy","year":"2006","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/33.2.2578498","article-title":"A modified histochemical technique to visualize acetylcholinesterase-containing axons","volume":"33","author":"Hedreen","year":"1985","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0197-4580(92)90111-A","article-title":"Regional synaptic pathology in Alzheimer's disease","volume":"13","author":"Honer","year":"1992","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0306-4522(03)00394-4","article-title":"The impact of A\u03b2-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in Alzheimer\u2019s disease-like transgenic mice","volume":"121","author":"Hu","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib27","doi-asserted-by":"crossref","first-page":"31783","DOI":"10.1074\/jbc.271.50.31783","article-title":"Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway","volume":"271","author":"Ikin","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/exnr.2001.7710","article-title":"Neuropathology of mice carrying mutant APPswe and\/or PS1M146L transgenes: alterations in the p75NTR cholinergic basal forebrain septohippocampal pathway","volume":"170","author":"Jaffar","year":"2001","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1091\/mbc.11.4.1213","article-title":"Axonal membrane proteins are transported in distinct carriers: a two color video microscopy study in cultured hippocampal neurons","volume":"11","author":"Kaether","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0301-0082(97)00028-2","article-title":"The cholinergic system in Alzheimer's disease","volume":"52","author":"Kasa","year":"1997","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1750-1326-2-18","article-title":"Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers","volume":"2","author":"Kayed","year":"2007","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib33","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.87.4.1561","article-title":"Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport","volume":"87","author":"Koo","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/cne.900840302","article-title":"Connections of the cerebral cortex. I","volume":"84","author":"Krieg","year":"1943","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molmed.2005.02.009","article-title":"Alzheimer's disease: abeta, tau and synaptic dysfunction","volume":"11","author":"LaFerla","year":"2005","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib37","doi-asserted-by":"crossref","first-page":"9785","DOI":"10.1523\/JNEUROSCI.22-22-09785.2002","article-title":"Evidence that synaptically released b-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice","volume":"22","author":"Lazarov","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib38","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/0024-3205(79)90596-4","article-title":"Acetylcholinesterase and the cholinergic neuron","volume":"25","author":"Lehmann","year":"1979","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","article-title":"A specific amyloid-beta protein assembly in the brain impairs memory","volume":"16","author":"Lesne","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0306-4522(83)90042-8","article-title":"Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum","volume":"9","author":"Levey","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/90.3.521","article-title":"The cholinergic limbic system: projections to hippocampal formation, medial cortex, nuclei of the ascending cholinergic reticular system, and the subfornical organ and supra-optic crest","volume":"90","author":"Lewis","year":"1967","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0006-8993(03)02658-1","article-title":"Degeneration of beta-amyloid-associated cholinergic structures in transgenic APPsw mice","volume":"977","author":"L\u00fcth","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(02)00057-X","article-title":"Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta analysis","volume":"24","author":"Lyness","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib44","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0306-4522(89)90180-2","article-title":"An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex","volume":"28","author":"Lysakowski","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib45","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1002\/j.1460-2075.1985.tb04000.x","article-title":"Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels","volume":"4","author":"Masters","year":"1985","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib46","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of A\u03b2 amyloid as a determinant of severity of neurodegeneration in Alzheimer\u2019s disease","volume":"46","author":"McLean","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1101\/lm.69204","article-title":"The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?","volume":"11","author":"Mesulam","year":"2004","journal-title":"Learn Mem"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib48","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0306-4522(83)90108-2","article-title":"Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch 1-Ch 6)","volume":"10","author":"Mesulam","year":"1983","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib49","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","article-title":"Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline","volume":"283","author":"Naslund","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib50","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neurobiolaging.2003.08.012","article-title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease","volume":"24","author":"Oddo","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Ab and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib52","doi-asserted-by":"crossref","first-page":"39413","DOI":"10.1074\/jbc.M608485200","article-title":"Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles","volume":"281","author":"Oddo","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib53","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuint.2008.06.005","article-title":"Interactions between the amyloid and cholinergic mechanisms of Alzheimer's disease","volume":"53","author":"Pakaski","year":"2008","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib54","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2007.06.015","article-title":"Cholinergic forebrain degeneration in the APPswe\/PS1DE9 transgenic mouse","volume":"28","author":"Perez","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.neuro.21.1.479","article-title":"Mutant genes in familial Alzheimer's disease and transgenic models","volume":"21","author":"Price","year":"1998","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib57","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0197-4580(02)00230-0","article-title":"Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex","volume":"24","author":"Rees","year":"2003","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/cercor\/8.2.142","article-title":"Neonatal treatment with 192 IgG-saporin produces long term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons","volume":"8","author":"Robertson","year":"1998","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib60","first-page":"266","article-title":"Expression of acetylcholinesterase activity in neural development: new tricks for an old dog?","volume":"8","author":"Robertson","year":"1993","journal-title":"News Physiol Sci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib61","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib62","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0896-6273(91)90052-2","article-title":"The molecular pathology of Alzheimer's disease","volume":"6","author":"Selkoe","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib63","doi-asserted-by":"crossref","first-page":"18295","DOI":"10.1074\/jbc.271.31.18295","article-title":"Amyloid beta-protein and the genetics of Alzheimer's disease","volume":"271","author":"Selkoe","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib64","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib65","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimmers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib66","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1523\/JNEUROSCI.13-07-03136.1993","article-title":"Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system","volume":"13","author":"Sisodia","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib67","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00005072-199708000-00011","article-title":"Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease","volume":"56","author":"Sze","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib68","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","article-title":"Intraneuronal Alzheimer A-beta 42 accumulates in multivesicular bodies and is associated with synaptic pathology","volume":"161","author":"Takahashi","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib69","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1098\/rstb.2001.0887","article-title":"Protein synthesis in the dendrite","volume":"29","author":"Tang","year":"2002","journal-title":"Philos Trans R Soc Lond B"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0006-8993(92)91024-9","article-title":"Basal forebrain and anterior thalamic contributions to acetylcholinesterase activity in granular retrosplenial cortex of rats","volume":"594","author":"Tengelsen","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib71","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib71a","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1582-4934.2008.00411.x","article-title":"Parenchymal and vascular Abeta deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease","volume":"12","author":"Thal","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib73","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/cne.901950406","article-title":"Form and distribution of neurons in rat cingulate cortex: areas 32, 24 and 29","volume":"195","author":"Vogt","year":"1981","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib73a","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2004.09.010","article-title":"Deciphering the molecular basis of memory failure in Alzheimer's disease","volume":"44","author":"Walsh","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib74","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging","volume":"158","author":"Wang","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib75","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0092-8674(89)90177-3","article-title":"Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein","volume":"57","author":"Weidemann","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib76","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0165-0173(80)90011-9","article-title":"Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats","volume":"2","author":"Wenk","year":"1980","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib77","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3233\/JAD-2008-15404","article-title":"Anti-A\u03b2 immunothereapy in Alzheimer\u2019s disease; relevance of transgenic mouse studies to clinical trials","volume":"15","author":"Wilcock","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib78","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.410340312","article-title":"Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability","volume":"34","author":"Wright","year":"1993","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib79","first-page":"593","article-title":"Electron micrograph of diffuse plaques","volume":"135","author":"Yamaguchi","year":"1989","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2009.09.024_bib80","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1096\/fj.01-0251com","article-title":"Beta amyloid peptide (Abeta42) is internalized via the G-protein coupled receptor FPRL1 and forms fibrillar aggregates in macrophages","volume":"15","author":"Yazawa","year":"2001","journal-title":"FASEB J"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209014997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209014997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:04:45Z","timestamp":1773680685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452209014997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0306452209014997"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.09.024","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amyloid-\u03b2 expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.09.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 IBRO. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}