{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:25:05Z","timestamp":1784561105472,"version":"3.55.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.neuroscience.2009.11.013","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T05:59:02Z","timestamp":1258091942000},"page":"850-862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats"],"prefix":"10.1016","volume":"165","author":[{"given":"B.","family":"Meyers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D'Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Kritzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2009.11.013_bib1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0306-4522(98)00341-8","article-title":"Gonadectomy in adult life increases tyrosine hydroxylase immunoreactivity in the prefrontal cortex and decreases open field activity in male rats","volume":"89","author":"Adler","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/hbeh.1998.1439","article-title":"Androgen-behavior correlations in hypogonadal men and eugonadal men. II","volume":"33","author":"Alexander","year":"1998","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/archgenpsychiatry.2007.33","article-title":"Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men","volume":"65","author":"Almeida","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03324891","article-title":"Partial androgen deficiency, depression and testosterone treatment in aging men","volume":"21","author":"Amore","year":"2009","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.yhbeh.2008.04.001","article-title":"Effects of gonadectomy and hormone replacement on a spontaneous novel object recognition task in adult male rats","volume":"54","author":"Aubele","year":"2008","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib5a","series-title":"Gonadectomy in adult male rats increases extracellular dopamine levels in the prefrontal cortex: Possible causative role for effects on the norepinephrine transporter, but not the dopamine transporter or the enzyme catechol-O-methyltransferase","author":"Aubele","year":"2008"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1176\/ajp.2007.164.1.142","article-title":"Gender-specific effects of the catechol-O-methyltransferase Val108\/158Met polymorphism on cognitive function in children","volume":"164","author":"Barnett","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/frne.2001.0225","article-title":"Diverse actions of ovarian steroids in the serotonin neural system","volume":"23","author":"Bethea","year":"2002","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib8","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2004.12.013","article-title":"Dopamine transporter function differences between male and female CD-1 mice","volume":"1035","author":"Bhatt","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib9","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/ajmg.b.30874","article-title":"Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study","volume":"147B","author":"Biederman","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2008.05.014","article-title":"Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration","volume":"1219","author":"Birgner","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/clpt.1990.166","article-title":"Human liver catechol-O-methyltransferase pharmacogenetics","volume":"48","author":"Boudikova","year":"1990","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.8211186","article-title":"Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A","volume":"262","author":"Brunner","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib13","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.7792602","article-title":"Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA","volume":"268","author":"Cases","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1072290","article-title":"Role of genotype in the cycle of violence in maltreated children","volume":"297","author":"Caspi","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/425589","article-title":"Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain","volume":"75","author":"Chen","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1074\/jbc.M609830200","article-title":"Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice","volume":"282","author":"Chen","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/j.1939-4640.2003.tb02708.x","article-title":"Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report","volume":"24","author":"Cherrier","year":"2003","journal-title":"J Androl"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1212\/01.WNL.0000149639.25136.CA","article-title":"The role of aromatization in testosterone supplementation: effects on cognition in older men","volume":"64","author":"Cherrier","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib19","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1097\/01.ju.0000091640.59812.83","article-title":"The effects of combined androgen blockade on cognitive function during the first cycle of intermittent androgen suppression in patients with prostate cancer","volume":"170","author":"Cherrier","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0006-8993(81)90955-0","article-title":"Estradiol treatment decreases type A and increases type B monoamine oxidase in specific brain stem areas and cerebellum of ovariectomized rats","volume":"222","author":"Chevillard","year":"1981","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib21","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0024-3205(71)90335-3","article-title":"The effect of estradiol on catechol-O-methyltransferase activity in rat liver","volume":"10","author":"Cohn","year":"1971","journal-title":"Life Sci I"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib22","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.biopsych.2007.03.001","article-title":"Evolving knowledge of sex differences in brain structure, function, and chemistry","volume":"62","author":"Cosgrove","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2004.09.006","article-title":"Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates","volume":"28","author":"Dalley","year":"2004","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib24","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1176\/ajp.148.11.1474","article-title":"Dopamine in schizophrenia: a review and reconceptualization","volume":"148","author":"Davis","year":"1991","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.euroneuro.2005.12.001","article-title":"Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males","volume":"16","author":"Denys","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib26","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.neuroscience.2008.04.051","article-title":"Differences in reserpine-induced striatal dopamine output and content between female and male mice: implications for sex differences in vesicular monoamine transporter 2 function","volume":"154","author":"Dluzen","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1196\/annals.1432.010","article-title":"Sex differences in dopamine- and vesicular monoamine-transporter functions","volume":"1139","author":"Dluzen","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S146114570400416X","article-title":"Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in women","volume":"7","author":"Domschke","year":"2004","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib29","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/sj.mp.4001856","article-title":"A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index","volume":"11","author":"Ducci","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib30","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1073\/pnas.111134598","article-title":"Effect of COMT Val108\/158 Met genotype on frontal lobe function and risk for schizophrenia","volume":"98","author":"Egan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1080\/14640748008401840","article-title":"Spatial memory and response strategies in rats: age, sex and rearing differences in performance","volume":"32","author":"Einon","year":"1980","journal-title":"Q J Exp Psychol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib32","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ajmg.b.20046","article-title":"Association analysis of MAOA and COMT with neuroticism assessed by peers","volume":"120B","author":"Eley","year":"2003","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib33","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1600-0447.1980.tb00881.x","article-title":"Erythrocyte COMT-activity in patients with affective disorders","volume":"61","author":"Fahndrich","year":"1980","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-4328(99)00082-0","article-title":"Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory","volume":"105","author":"Fink","year":"1999","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF02088099","article-title":"Estrogen control of central neurotransmission: effect on mood, mental state, and memory","volume":"16","author":"Fink","year":"1996","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1399-0004.1981.tb00732.x","article-title":"The inheritance of human erythrocyte catechol-O-methyltransferase activity","volume":"19","author":"Floderus","year":"1981","journal-title":"Clin Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib37","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.95.17.9991","article-title":"Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior","volume":"95","author":"Gogos","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib38","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archpsyc.60.9.889","article-title":"Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia","volume":"60","author":"Goldberg","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tics.2004.05.011","article-title":"Genes and the parsing of cognitive processes","volume":"8","author":"Goldberg","year":"2004","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib40","first-page":"325","article-title":"Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates","volume":"85","author":"Goldman-Rakic","year":"1990","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib41","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1101\/SQB.1990.055.01.097","article-title":"Neocortical memory circuits","volume":"55","author":"Goldman-Rakic","year":"1990","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib42","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1469-7610.1989.tb00781.x","article-title":"A twin study of hyperactivity\u2014I","volume":"30","author":"Goodman","year":"1989","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib43","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1007\/s11064-008-9665-1","article-title":"Sex steroids effects on the content of GAD, TH, GABA(A), and glutamate receptors in the olfactory bulb of the male rat","volume":"33","author":"Guerra-Araiza","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00213-001-0959-0","article-title":"Ovarian steroid regulation of monoamine oxidase-A and -B mRNAs in the macaque dorsal raphe and hypothalamic nuclei","volume":"160","author":"Gundlah","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib44a","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0447.1987.tb02890.x","article-title":"Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome","volume":"76","author":"Hallman","year":"1987","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib45","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1038\/sj.npp.1301543","article-title":"Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders","volume":"33","author":"Harrison","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0024-3205(98)00255-0","article-title":"Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat","volume":"63","author":"Holschneider","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib47","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1124\/jpet.102.043042","article-title":"Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice","volume":"303","author":"Huotari","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib48","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuroscience.2005.09.007","article-title":"The role of androgens in cognition and brain aging in men","volume":"138","author":"Janowsky","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib49","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1162\/089892900562228","article-title":"Sex steroids modify working memory","volume":"12","author":"Janowsky","year":"2000","journal-title":"J Cogn Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib50","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1471-4159.2006.03866.x","article-title":"Regulation of tyrosine hydroxylase gene expression by retinoic acid receptor","volume":"98","author":"Jeong","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib51","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2826.2007.01581.x","article-title":"Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice","volume":"19","author":"Ji","year":"2007","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib52","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0028-3908(03)00286-7","article-title":"Human catechol-O-methyltransferase down-regulation by estradiol","volume":"45","author":"Jiang","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0166-4328(89)80079-8","article-title":"Ontogeny of open field activity in rats after neonatal lesioning of the mesocortical dopaminergic projection","volume":"32","author":"Kalsbeek","year":"1989","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib54","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1073\/pnas.94.9.4572","article-title":"Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder","volume":"94","author":"Karayiorgou","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib55","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0006-3223(98)00319-9","article-title":"Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder","volume":"45","author":"Karayiorgou","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib56","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1046\/j.1471-4159.1994.63030972.x","volume":"63","author":"Karoum","year":"1994","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib57","doi-asserted-by":"crossref","first-page":"M321","DOI":"10.1093\/gerona\/57.5.M321","article-title":"Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels","volume":"57","author":"Kenny","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib58","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0166-4328(81)90033-4","article-title":"Delayed-alternation performance after kainic acid lesions of the thalamic mediodorsal nucleus and the ventral tegmental area in the rat","volume":"3","author":"Kessler","year":"1981","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib59","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1073\/pnas.94.11.5929","article-title":"Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice","volume":"94","author":"Kim","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib60","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<628::AID-AJMG10>3.0.CO;2-E","article-title":"Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol O-methyltransferase (COMT) activity","volume":"88","author":"Kotler","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib61","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/1096-9861(20001127)427:4<617::AID-CNE9>3.0.CO;2-#","volume":"427","author":"Kritzer","year":"2000","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib62","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/cercor\/9.5.507","article-title":"Regionally selective effects of gonadectomy on cortical catecholamine innervation in adult male rats are most disruptive to afferents in prefrontal cortex","volume":"9","author":"Kritzer","year":"1999","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib63","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.yhbeh.2006.07.005","article-title":"Effects of gonadectomy on performance in operant tasks measuring prefrontal cortical function in adult male rats","volume":"51","author":"Kritzer","year":"2007","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/hbeh.2001.1645","article-title":"Gonadectomy impairs T-maze acquisition in adult male rats","volume":"39","author":"Kritzer","year":"2001","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib65","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1176\/ajp.155.6.835","article-title":"Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder","volume":"155","author":"Lachman","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib66","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuroscience.2005.09.006","article-title":"Effects of ovarian hormones on cognitive function in nonhuman primates","volume":"138","author":"Lacreuse","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0169-328X(03)00049-4","article-title":"Effect of chronic estradiol, tamoxifen or raloxifene treatment on serotonin 5-HT1A receptor","volume":"112","author":"Landry","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1139\/jpn.0517","article-title":"Changes in 5-HT1A receptor binding and G-protein activation in the rat brain after estrogen treatment: comparison with tamoxifen and raloxifene","volume":"30","author":"Le Saux","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2826.2005.01380.x","article-title":"Influence of oestrogenic compounds on monoamine transporters in rat striatum","volume":"18","author":"Le Saux","year":"2006","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib70","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1021\/bi00013a008","article-title":"Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme","volume":"34","author":"Lotta","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib71","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archneur.63.2.nct50002","article-title":"Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men","volume":"63","author":"Lu","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib72","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1365-2826.2008.01710.x","article-title":"Sex steroids and cognitive function","volume":"20","author":"Luine","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib73","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0006-8993(75)90704-0","article-title":"Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain","volume":"86","author":"Luine","year":"1975","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib74","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000123461","article-title":"Gonadal hormone regulation of MAO and other enzymes in hypothalamic areas","volume":"36","author":"Luine","year":"1983","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4838(95)00071-2","article-title":"Cloning, expression and structure of catechol-O-methyltransferase","volume":"1251","author":"Lundstrom","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib76","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2826.2009.01844.x","article-title":"Steroid hormone action in the brain: cross-talk between signalling pathways","volume":"21","author":"Mani","year":"2009","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib77","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/sj.npp.1300218","article-title":"Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia","volume":"28","author":"Matsumoto","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuroscience.2008.12.010","article-title":"In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex","volume":"159","author":"Meyers","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib79","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0361-9230(00)00290-2","article-title":"TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat","volume":"52","author":"Morrow","year":"2000","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib80","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1073\/pnas.93.3.1325","article-title":"Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys","volume":"93","author":"Murphy","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib81","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biopsych.2005.06.024","article-title":"Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity","volume":"59","author":"Nilsson","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib82","first-page":"337","article-title":"Hypothalamic monoamine oxidase activity in ovariectomized rats after sexual behavior restoration","volume":"25","author":"Ortega-Corona","year":"1994","journal-title":"Arch Med Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib83","doi-asserted-by":"crossref","first-page":"21512","DOI":"10.1074\/jbc.M600250200","article-title":"Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1","volume":"281","author":"Ou","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib84","series-title":"The rat brain in sterotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib85","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1523\/JNEUROSCI.16-21-07021.1996","article-title":"Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques","volume":"16","author":"Pecins-Thompson","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib86","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-1781(81)90017-2","article-title":"Catechol-O-methyltransferase of erythrocytes in patients with endogenous psychoses","volume":"4","author":"Philippu","year":"1981","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib87","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/sj.mp.4001951","article-title":"The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis","volume":"12","author":"Pooley","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib88","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2005.06.064","article-title":"COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study","volume":"389","author":"Poyurovsky","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib89","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00006842-197609000-00004","article-title":"The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey","volume":"38","author":"Redmond","year":"1976","journal-title":"Psychosom Med"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib90","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1038\/sj.npp.1301048","article-title":"Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder","volume":"31","author":"Rothe","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0165-1781(02)00013-6","article-title":"Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics","volume":"109","author":"Saito","year":"2002","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib92","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.fertnstert.2007.04.020","article-title":"Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome","volume":"89","author":"Salih","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib93","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/sj.bjc.6601235","article-title":"Androgen deprivation and cognition in prostate cancer","volume":"89","author":"Salminen","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib94","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/cncr.20962","article-title":"Estradiol and cognition during androgen deprivation in men with prostate carcinoma","volume":"103","author":"Salminen","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib95","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/schbul\/16.2.185","article-title":"The role of estrogens in schizophrenia gender differences","volume":"16","author":"Seeman","year":"1990","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.04.002","article-title":"Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration","volume":"1015","author":"Serova","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib97","first-page":"1","article-title":"Molecular basis of human MAO A and B","volume":"4","author":"Shih","year":"1991","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib98","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.neuro.22.1.197","article-title":"Monoamine oxidase: from genes to behavior","volume":"22","author":"Shih","year":"1999","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib99","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4088\/JCP.v66n0102","article-title":"Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity","volume":"66","author":"Shores","year":"2005","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib100","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1001\/archpsyc.61.2.162","article-title":"Increased incidence of diagnosed depressive illness in hypogonadal older men","volume":"61","author":"Shores","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib101","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0169-328X(89)90075-2","article-title":"Hormonal control of the development and regulation of tyrosine hydroxylase expression within a sexually dimorphic population of dopaminergic cells in the hypothalamus","volume":"6","author":"Simerly","year":"1989","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib102","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.npp.1301417","article-title":"A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior","volume":"33","author":"Sjoberg","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib103","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ajmg.b.30360","article-title":"Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors","volume":"144B","author":"Sjoberg","year":"2007","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib104","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/sj.npp.1300787","article-title":"COMT polymorphisms and anxiety-related personality traits","volume":"30","author":"Stein","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0006-3223(96)00474-X","article-title":"Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia","volume":"41","author":"Strous","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib106","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajmg.b.20021","article-title":"Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study","volume":"120B","author":"Strous","year":"2003","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib107","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(78)90197-X","article-title":"Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the fronto-cortical dopaminergic innervation in the rat","volume":"141","author":"Tassin","year":"1978","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib108","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/dev.420140505","article-title":"The effect of early visual experience on spatial maze learning in rats","volume":"14","author":"Tees","year":"1981","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/dna.1993.12.253","article-title":"Structure of the rat catechol-O-methyltransferase gene: separate promoters are used to produce mRNAs for soluble and membrane-bound forms of the enzyme","volume":"12","author":"Tenhunen","year":"1993","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib110","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0169-328X(02)00383-2","article-title":"Sex differences in the regulation of tyrosine hydroxylase gene transcription by estrogen in the locus coeruleus of TH9-LacZ transgenic mice","volume":"104","author":"Thanky","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib111","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.physbeh.2006.10.010","article-title":"On again, off again effects of gonadectomy on the acoustic startle reflex in adult male rats","volume":"90","author":"Turvin","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib112","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0149-7634(05)80157-5","article-title":"Behavioral differences between male and female rats: effects of gonadal hormones on learning and memory","volume":"14","author":"van Haaren","year":"1990","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib113","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1523\/JNEUROSCI.16-01-00373.1996","article-title":"NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine","volume":"16","author":"Verma","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib114","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1196\/annals.1330.023","article-title":"Catecholamines and aggression: the role of COMT and MAO polymorphisms","volume":"1036","author":"Volavka","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0006-8993(82)90391-2","article-title":"Simultaneous determination of the formation rate of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in various rat brain areas","volume":"252","author":"Westerink","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib116","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.biopsych.2006.03.039","article-title":"MAOA and the \u201ccycle of violence\u201d: childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior","volume":"60","author":"Widom","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib117","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jpsychires.2004.01.001","article-title":"The association between panic disorder and the L\/L genotype of catechol-O-methyltransferase","volume":"38","author":"Woo","year":"2004","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib118","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1124\/mol.56.1.31","article-title":"Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription","volume":"56","author":"Xie","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib119","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1523\/JNEUROSCI.0665-07.2007","article-title":"Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum","volume":"27","author":"Yavich","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.canlet.2004.04.032","article-title":"Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females","volume":"212","author":"Yin","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib121","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1523\/JNEUROSCI.17-21-08528.1997","article-title":"Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance","volume":"17","author":"Zahrt","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2009.11.013_bib122","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1471-4159.1982.tb10871.x","article-title":"Rapid and sensitive single-step radiochemical assay for catechol-O-methyltransferase","volume":"38","author":"Zurcher","year":"1982","journal-title":"J Neurochem"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209018302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452209018302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:33:44Z","timestamp":1759678424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452209018302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0306452209018302"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.11.013","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2009.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}