{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:24:00Z","timestamp":1792045440952,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["HL-085108"],"award-info":[{"award-number":["HL-085108"]}]},{"name":"NIH","award":["HL-55306"],"award-info":[{"award-number":["HL-55306"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.neuroscience.2010.02.012","type":"journal-article","created":{"date-parts":[[2010,2,13]],"date-time":"2010-02-13T09:32:40Z","timestamp":1266053560000},"page":"510-527","source":"Crossref","is-referenced-by-count":69,"title":["Sensory afferent and hypoxia-mediated activation of nucleus tractus solitarius neurons that project to the rostral ventrolateral medulla"],"prefix":"10.1016","volume":"167","author":[{"given":"D.D.","family":"Kline","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Austgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Heesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Hasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2010.02.012_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<62::AID-CNE6>3.0.CO;2-B","article-title":"Monosynaptic projections from the nucleus tractus solitarii to C1 adrenergic neurons in the rostral ventrolateral medulla: comparison with input from the caudal ventrolateral medulla","volume":"373","author":"Aicher","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.ph.56.030194.000521","article-title":"Nucleus tractus solitarius\u2014gateway to neural circulatory control","volume":"56","author":"Andresen","year":"1994","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.neuroscience.2008.09.060","article-title":"Expression of group I metabotropic glutamate receptors on phenotypically different cells within the nucleus of the solitary tract in the rat","volume":"159","author":"Austgen","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib4","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1152\/jn.1997.77.5.2539","article-title":"NMDA receptors contribute to primary visceral afferent transmission in the nucleus of the solitary tract","volume":"77","author":"Aylwin","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib5","doi-asserted-by":"crossref","first-page":"11893","DOI":"10.1523\/JNEUROSCI.2044-06.2006","article-title":"Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns","volume":"26","author":"Bailey","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0006-8993(99)02304-5","article-title":"Brainstem and hypothalamic areas involved in respiratory chemoreflexes: a Fos study in adult rats","volume":"857","author":"Berquin","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib7","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0006-8993(87)90604-4","article-title":"Neurons in the area postrema are the only catecholamine-synthesizing cells in the medulla or pons with projections to the rostral ventrolateral medulla (C1-area) in the rabbit","volume":"419","author":"Blessing","year":"1987","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1046\/j.1440-1681.2002.03662.x","article-title":"Glutamatergic neural transmission in the nucleus tractus solitarius: N-methyl-d-aspartate receptors","volume":"29","author":"Bonham","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1523\/JNEUROSCI.18-01-00371.1998","article-title":"Organization and transmitter specificity of medullary neurons activated by sustained hypertension: implications for understanding baroreceptor reflex circuitry","volume":"18","author":"Chan","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib10","first-page":"H1350","article-title":"A presynaptic mechanism contributes to depression of autonomic signal transmission in NTS","volume":"277","author":"Chen","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/physrev.1994.74.2.323","article-title":"Functional organization of central pathways regulating the cardiovascular system","volume":"74","author":"Dampney","year":"1994","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0301-0082(94)90064-7","article-title":"The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation","volume":"42","author":"Dampney","year":"1994","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/jn.1987.58.1.215","article-title":"In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius","volume":"58","author":"Dekin","year":"1987","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1152\/jn.1987.58.1.195","article-title":"In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius","volume":"58","author":"Dekin","year":"1987","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib15","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1152\/jn.2001.85.5.2213","article-title":"Reliability of monosynaptic sensory transmission in brain stem neurons in vitro","volume":"85","author":"Doyle","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jneumeth.2004.02.007","article-title":"Strategies for cellular identification in nucleus tractus solitarius slices","volume":"137","author":"Doyle","year":"2004","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0165-0270(89)90150-7","article-title":"The use of c-fos as a metabolic marker in neuronal pathway tracing","volume":"29","author":"Dragunow","year":"1989","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cne.903480202","article-title":"Hypoxia and electrical stimulation of the carotid sinus nerve induce Fos-like immunoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem","volume":"348","author":"Erickson","year":"1994","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(99)00065-8","article-title":"Hypoxia induces c-Fos protein expression in NMDA but not AMPA glutamate receptor labeled neurons within the nucleus tractus solitarii of the conscious rat","volume":"262","author":"Gozal","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/cne.902760310","article-title":"Evidence for direct projections from the nucleus of the solitary tract onto medullary adrenaline cells","volume":"276","author":"Hancock","year":"1988","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.expneurol.2005.12.028","article-title":"Most neurons in the nucleus tractus solitarii do not send collateral projections to multiple autonoic targets in the rat brain","volume":"198","author":"Hermes","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib23","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0306-4522(97)00111-5","article-title":"Hypoxia-induced Fos expression in neurons projecting to the pressor region in the rostral ventrolateral medulla","volume":"80","author":"Hirooka","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib24","doi-asserted-by":"crossref","first-page":"R1626","DOI":"10.1152\/ajpregu.00532.2005","article-title":"Activation of NADPH-diaphorase-positive projections to the rostral ventrolateral medulla following cardiac mechanoreceptor stimulation in the conscious rat","volume":"290","author":"Kantzides","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.neuroscience.2005.02.038","article-title":"Right atrial stretch activates neurons in autonomic brain regions that project to the rostral ventrolateral medulla in the rat","volume":"133","author":"Kantzides","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/310498a0","article-title":"Fluorescent latex microspheres as a retrograde neuronal marker for in vivo and in vitro studies of visual cortex","volume":"310","author":"Katz","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0165-1838(93)90329-S","article-title":"Non-NMDA receptors in the rostral ventrolateral medulla mediate somatosympathetic pressor responses","volume":"43","author":"Kiely","year":"1993","journal-title":"J Auton Nerv Syst"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.resp.2008.04.013","article-title":"Plasticity in glutamatergic NTS neurotransmission","volume":"164","author":"Kline","year":"2008","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib29","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1152\/jn.00224.2002","article-title":"Dopamine modulates synaptic transmission in the nucleus of the solitary tract","volume":"88","author":"Kline","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib30","first-page":"R1273","article-title":"NTS neurons with carotid chemoreceptor inputs arborize in the rostral ventrolateral medulla","volume":"270","author":"Koshiya","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib31","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0006-8993(93)90871-J","article-title":"Ventrolateral medulla and sympathetic chemoreflex in the rat","volume":"609","author":"Koshiya","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib32","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.neuroscience.2007.01.053","article-title":"Prostaglandin E2 depresses solitary tract-mediated synaptic transmission in the nucleus tractus solitarius","volume":"146","author":"Laaris","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.autneu.2007.04.006","article-title":"Membrane and synaptic properties of nucleus tractus solitarius neurons projecting to the caudal ventrolateral medulla","volume":"136","author":"Li","year":"2007","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02284796","article-title":"Carotid sinus nerve terminals which are tyrosine hydroxylase immunoreactive are found in the commissural nucleus of the tractus solitarius","volume":"25","author":"Massari","year":"1996","journal-title":"J Neurocytol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib35","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/cne.21371","article-title":"Ultrastructure of primary afferent terminals and synapses in the rat nucleus of the solitary tract: comparison among the greater superficial petrosal, chorda tympani, and glossopharyngeal nerves","volume":"502","author":"May","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib36","doi-asserted-by":"crossref","first-page":"R604","DOI":"10.1152\/ajpregu.00341.2001","article-title":"Increased GABAA inhibition of the RVLM following hindlimb unloading in rats","volume":"283","author":"Moffitt","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1113\/jphysiol.2002.038141","article-title":"Defining ventral medullary respiratory compartments with a glutamate receptor agonist in the rat","volume":"548","author":"Monnier","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cne.903240307","article-title":"Projections from the commissural subnucleus of the nucleus of the solitary tract: an anterograde tracing study in the cat","volume":"324","author":"Otake","year":"1992","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib39","series-title":"The Rat Brain in stereotaxic coordinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib40","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/cne.902420405","article-title":"Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla","volume":"242","author":"Ross","year":"1985","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1994.sp019997","article-title":"Central nervous mechanisms contributing to cardiovascular control","volume":"474","author":"Spyer","year":"1994","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib42","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1152\/jn.91182.2008","article-title":"Characteristics of rostral solitary tract nucleus neurons with identified afferent connections that project to the parabrachial nucleus in rats","volume":"102","author":"Suwabe","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1113\/jphysiol.2005.103788","article-title":"Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats","volume":"572","author":"Takakura","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib44","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jn.1994.71.2.479","article-title":"Whole-cell analysis of ionic currents underlying the firing pattern of neurons in the gustatory zone of the nucleus tractus solitarii","volume":"71","author":"Tell","year":"1994","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1096-9861(19971117)388:2<169::AID-CNE1>3.0.CO;2-#","article-title":"Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia","volume":"388","author":"Teppema","year":"1997","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib46","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cne.902900410","article-title":"Diverse afferents converge on the nucleus paragigantocellularis in the rat ventrolateral medulla: retrograde and anterograde tracing studies","volume":"290","author":"Van Bockstaele","year":"1989","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib47","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/j.1460-9568.1997.tb01519.x","article-title":"Postnatal changes in electrophysiological properties of rat nucleus tractus solitarii neurons","volume":"9","author":"Vincent","year":"1997","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.012_bib48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cne.10663","article-title":"Fos expression by glutamatergic neurons of the solitary tract nucleus after phenylephrine-induced hypertension in rats","volume":"460","author":"Weston","year":"2003","journal-title":"J Comp Neurol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210002034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210002034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T23:30:36Z","timestamp":1558827036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452210002034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0306452210002034"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.02.012","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}