{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:13:42Z","timestamp":1790831622944,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.neuroscience.2010.02.047","type":"journal-article","created":{"date-parts":[[2010,2,27]],"date-time":"2010-02-27T09:40:40Z","timestamp":1267263640000},"page":"929-945","source":"Crossref","is-referenced-by-count":63,"title":["Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies"],"prefix":"10.1016","volume":"167","author":[{"given":"A.M.","family":"Iyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Zurolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Baayen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Giangaspero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.C.","family":"Di Gennaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.G.M.","family":"Spliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.","family":"van Rijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Troost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Gorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Aronica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2010.02.047_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1160\/TH04-09-0592","article-title":"The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis","volume":"93","author":"Alfano","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/brain\/awh331","article-title":"Microanatomy of the dysplastic neocortex from epileptic patients","volume":"128","author":"Alonso-Nanclares","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuroscience.2007.10.036","article-title":"Gene expression profile analysis of epilepsy-associated gangliogliomas","volume":"151","author":"Aronica","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.nbd.2007.01.015","article-title":"Complement activation in experimental and human temporal lobe epilepsy","volume":"26","author":"Aronica","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0306-4522(01)00181-6","article-title":"Immunohistochemical localization of Group I and II metabotropic glutamate receptors in control and ALS human spinal cord: upregulation in reactive astrocytes","volume":"105","author":"Aronica","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.0013-9580.2004.57703.x","article-title":"Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy","volume":"45","author":"Aronica","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2990.2004.00636.x","article-title":"Distribution, characterization and clinical significance of microglia in glioneuronal tumours from patients with chronic intractable epilepsy","volume":"31","author":"Aronica","year":"2005","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s004010000296","article-title":"Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor","volume":"101","author":"Aronica","year":"2001","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s004010000296","article-title":"Expression of BDNF and tyrosine kinase B (TrkB) receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with NMDA receptor","volume":"101","author":"Aronica","year":"2001","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib10","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1212\/01.wnl.0000183747.05269.2d","article-title":"A developmental and genetic classification for malformations of cortical development","volume":"65","author":"Barkovich","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1212\/01.wnl.0000269668.08747.78","article-title":"Tissue plasminogen activator: beyond thrombolysis","volume":"69","author":"Benarroch","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib12","first-page":"251","article-title":"Quantitative RT-PCR assays for the determination of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 mRNA in primary tumor tissue of breast cancer patients: comparison to antigen quantification by ELISA","volume":"21","author":"Biermann","year":"2008","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-006-0187-0","article-title":"A new clinico-pathological classification system for mesial temporal sclerosis","volume":"113","author":"Blumcke","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1750-3639.2002.tb00436.x","article-title":"Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy","volume":"12","author":"Blumcke","year":"2002","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/j.1750-3639.2009.00341.x","article-title":"Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors","author":"Boer","year":"2009","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.eplepsyres.2007.10.002","article-title":"Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex","volume":"78","author":"Boer","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jneuroim.2006.01.002","article-title":"Evidence of activated microglia in focal cortical dysplasia","volume":"173","author":"Boer","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib18","doi-asserted-by":"crossref","first-page":"H1784","DOI":"10.1152\/ajpheart.2001.281.4.H1784","article-title":"Plasmin-dependent and \u2212independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis","volume":"281","author":"Brodsky","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-0038-1642716","article-title":"Gene targeting and gene transfer studies of the biological role of the plasminogen\/plasmin system","volume":"74","author":"Carmeliet","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1528-1167.2005.01013.x","article-title":"Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?","volume":"46","author":"Cepeda","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jnr.10604","article-title":"Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia","volume":"72","author":"Cepeda","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1055\/s-0037-1615841","article-title":"The plasminogen (fibrinolytic) system","volume":"82","author":"Collen","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib23","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.2741\/3032","article-title":"The plasminogen activation system in inflammation","volume":"13","author":"Del Rosso","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib24","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1460-9568.1993.tb00529.x","article-title":"Urokinase-type plasminogen activator expression by neurons and oligodendrocytes during process outgrowth in developing rat brain","volume":"5","author":"Dent","year":"1993","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S1740925X09000118","article-title":"Extracellular matrix in plasticity and epileptogenesis","volume":"4","author":"Dityatev","year":"2008","journal-title":"Neuron Glia Biol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/cne.20647","article-title":"Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-\/-) mouse","volume":"489","author":"Eagleson","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1471-4159.2009.05894.x","article-title":"Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain","volume":"109","author":"Fabbro","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib28","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/nm.1878","article-title":"A role for leukocyte-endothelial adhesion mechanisms in epilepsy","volume":"14","author":"Fabene","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib29","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1046\/j.1471-4159.1995.65041524.x","article-title":"Components of the plasminogen activator system in astrocytes are modulated by tumor necrosis factor-alpha and interleukin-1beta through similar signal transduction pathways","volume":"65","author":"Faber-Elman","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/jcp.1041640214","article-title":"THP-1 macrophage membrane-bound plasmin activity is up-regulated by transforming growth factor-beta 1 via increased expression of urokinase and the urokinase receptor","volume":"164","author":"Falcone","year":"1995","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib31","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.mcn.2003.11.002","article-title":"Is tissue-type plasminogen activator a neuromodulator?","volume":"25","author":"Fernandez-Monreal","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib32","first-page":"325","article-title":"Cytokine activation of human macro- and microvessel-derived endothelial cells","volume":"19","author":"Gerritsen","year":"1993","journal-title":"Blood Cells"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib33","series-title":"The tuberous sclerosis complex","author":"Gomez","year":"1999"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib34","doi-asserted-by":"crossref","first-page":"11083","DOI":"10.1523\/JNEUROSCI.2766-06.2006","article-title":"Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy","volume":"26","author":"Gorter","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib35","first-page":"1","article-title":"Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and temporal lobe during epileptogenesis in the rat","volume":"40","author":"Gorter","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/glia.20115","article-title":"Tissue plasminogen activator and glial function","volume":"49","author":"Gravanis","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib37","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1523\/JNEUROSCI.16-07-02220.1996","article-title":"Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator","volume":"16","author":"Gualandris","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib38","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/brain\/124.10.1978","article-title":"Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage","volume":"124","author":"Gveric","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/PL00000615","article-title":"The plasminogen activator system: biology and regulation","volume":"56","author":"Irigoyen","year":"1999","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/glia.440030513","article-title":"Developmental transition in plasticity properties of differentiating astrocytes: age-related biochemical profile of plasminogen activators in astroglial cultures","volume":"3","author":"Kalderon","year":"1990","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib41","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1111\/j.1460-9568.2006.05062.x","article-title":"Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis","volume":"24","author":"Lahtinen","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neuroscience.2009.06.019","article-title":"Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus","volume":"163","author":"Lahtinen","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib42a","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.nbd.2009.12.008","article-title":"Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus","volume":"37","author":"Lahtinen","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib43","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.thromres.2008.03.013","article-title":"Effects of IL-1beta and IL-6 on tissue-type plasminogen activator expression in vascular endothelial cells","volume":"123","author":"Larsson","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib44","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00701-003-0097-z","article-title":"Proteases in brain tumour progression","volume":"145","author":"Levicar","year":"2003","journal-title":"Acta Neurochirurgica"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib45","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1038\/onc.2009.245","article-title":"Downregulation of Mir-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer","volume":"28","author":"Li","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib46","doi-asserted-by":"crossref","first-page":"19083","DOI":"10.1016\/S0021-9258(18)37393-9","article-title":"Characterization of a chimeric plasminogen activator consisting of amino acids 1 to 274 of tissue-type plasminogen activator and amino acids 138 to 411 of single-chain urokinase-type plasminogen activator","volume":"263","author":"Lijnen","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.10270","article-title":"Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases","volume":"69","author":"Lo","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib48","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/0470846356.ch11","article-title":"Animal models of drug-resistant epilepsy","volume":"243","author":"Loscher","year":"2002","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib49","series-title":"WHO classification of tumours of the central nervous system","author":"Louis","year":"2007"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1460-9568.2003.02461.x","article-title":"cDNA profiling of epileptogenesis in the rat brain","volume":"17","author":"Lukasiuk","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib51","doi-asserted-by":"crossref","first-page":"9709","DOI":"10.1074\/jbc.270.17.9709","article-title":"Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells","volume":"270","author":"Mandriota","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0169-328X(95)00199-3","article-title":"Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain","volume":"35","author":"Masos","year":"1996","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib53","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1096\/fj.03-1123fje","article-title":"The sphingomyelin\/ceramide pathway is involved in ERK1\/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator","volume":"18","author":"Maupas-Schwalm","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2004.12.006","article-title":"Enhancement of urokinase-type plasminogen activator (uPA) secretion, but not that of substrate plasminogen (PGn), by rat microglia stimulated with neuronal conditioned medium","volume":"378","author":"Nakajima","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib55","first-page":"179","article-title":"Cytokine regulation of endothelial cell extracellular proteolysis","volume":"42","author":"Niedbala","year":"1993","journal-title":"Agents Actions Suppl"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib56","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/j.1528-1167.2006.00817.x","article-title":"The blood-brain barrier and epilepsy","volume":"47","author":"Oby","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib57","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/01.WNL.0000114507.30388.7E","article-title":"Terminology and classification of the cortical dysplasias","volume":"62","author":"Palmini","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib58","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI0215961","article-title":"Tissue plasminogen activator and seizures: a clot-buster's secret life","volume":"109","author":"Pawlak","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib59","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000468622","article-title":"Angiogenesis: a paradigm for balanced extracellular proteolysis during cell migration and morphogenesis","volume":"49","author":"Pepper","year":"1996","journal-title":"Enzyme Protein"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib60","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1523\/JNEUROSCI.09-12-04269.1989","article-title":"Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth","volume":"9","author":"Pittman","year":"1989","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib61","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1523\/JNEUROSCI.23-02-00622.2003","article-title":"Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction","volume":"23","author":"Powell","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib62","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s000180300039","article-title":"Role of plasminogen activator-plasmin system in tumor angiogenesis","volume":"60","author":"Rakic","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib63","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","article-title":"Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data","volume":"339","author":"Ramakers","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib64","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.nbd.2006.06.003","article-title":"The IL-1beta system in epilepsy-associated malformations of cortical development","volume":"24","author":"Ravizza","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib65","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.nbd.2007.08.012","article-title":"Innate and adaptive immune mechanisms during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy","volume":"29","author":"Ravizza","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib66","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.4049\/jimmunol.181.5.3567","article-title":"Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier","volume":"181","author":"Reijerkerk","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib67","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1093\/brain\/awm118","article-title":"Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy","volume":"130","author":"Rigau","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib68","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0304-3940(88)90700-8","article-title":"Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells","volume":"91","author":"Rogister","year":"1988","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib69","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1093\/hmg\/ddn256","article-title":"Epileptic and developmental disorders of the speech cortex: ligand\/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR","volume":"17","author":"Royer-Zemmour","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib70","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-2007-1002623","article-title":"Fluorescent probes as tools to assess the receptor for the urokinase-type plasminogen activator on tumor cells","volume":"17","author":"Schmitt","year":"1991","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib71","doi-asserted-by":"crossref","first-page":"14118","DOI":"10.1073\/pnas.96.24.14118","article-title":"Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene","volume":"96","author":"Seeds","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib72","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1523\/JNEUROSCI.23-08-03234.2003","article-title":"Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury","volume":"23","author":"Siao","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib73","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1523\/JNEUROSCI.22-09-03352.2002","article-title":"Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II","volume":"22","author":"Siao","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib74","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrm2821","article-title":"Regulation of cell signalling by uPAR","volume":"11","author":"Smith","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib75","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib76","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bst0300183","article-title":"Tissue plasminogen activator as a key effector in neurobiology and neuropathology","volume":"30","author":"Teesalu","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib77","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1160\/TH02-12-0310","article-title":"Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system","volume":"92","author":"Teesalu","year":"2004","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib78","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1586\/14737175.4.6.973","article-title":"Recent advances in the neuropathology of focal lesions in epilepsy","volume":"4","author":"Thom","year":"2004","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib79","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/glia.440060303","article-title":"Regulation of plasminogen activators and type-1 plasminogen activator inhibitor by cyclic AMP and phorbol ester in rat astrocytes","volume":"6","author":"Tranque","year":"1992","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib80","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1042\/bst0300222","article-title":"Tissue plasminogen activator as a modulator of neuronal survival and function","volume":"30","author":"Tsirka","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib81","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/377340a0","article-title":"Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator","volume":"377","author":"Tsirka","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib82","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jnr.10417","article-title":"Urokinase-type plasminogen activator inhibits amyloid-beta neurotoxicity and fibrillogenesis via plasminogen","volume":"70","author":"Tucker","year":"2002","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib83","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awl318","article-title":"Long-lasting increased permeability of the blood-brain barrier may contribute to seizure progression in temporal lobe epilepsy","volume":"130","author":"van Vliet","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib84","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/glia.10076","article-title":"Expression and distribution of id helix-loop-helix proteins in human astrocytic tumors","volume":"38","author":"Vandeputte","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib85","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1528-1167.2005.00298.x","article-title":"Brain inflammation in epilepsy: experimental and clinical evidence","volume":"46","author":"Vezzani","year":"2005","journal-title":"Epilepsia"},{"issue":"Suppl 2","key":"10.1016\/j.neuroscience.2010.02.047_bib86","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1528-1167.2008.01490.x","article-title":"Glia as a source of cytokines: implications for neuronal excitability and survival","volume":"49","author":"Vezzani","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib87","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01450878","article-title":"Sites of urokinase-type plasminogen activator expression and distribution of its receptor in the normal human kidney","volume":"105","author":"Wagner","year":"1996","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib88","first-page":"695","article-title":"ILAE Commission Report","volume":"45","author":"Wieser","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib89","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1528-1167.2007.01270.x","article-title":"Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation","volume":"49","author":"Wong","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib90","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1083\/jcb.148.6.1295","article-title":"The tissue plasminogen activator (tPA)\/ plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate","volume":"148","author":"Wu","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib91","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0896-6974(05)80120-3","article-title":"A grading system for mesial temporal pathology (hippocampal sclerosis) from anterior temporal lobectomy","volume":"5","author":"Wyler","year":"1992","journal-title":"J Epilepsy"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib92","first-page":"3656","article-title":"Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo","volume":"54","author":"Yamamoto","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib93","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1172\/JCI200319212","article-title":"Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein","volume":"112","author":"Yepes","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib94","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/exnr.1999.7188","article-title":"Selective coexpression of NMDAR2A\/B and NMDAR1 subunit proteins in dysplastic neurons of human epileptic cortex","volume":"159","author":"Ying","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.047_bib95","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0070-2153(05)66005-X","article-title":"Extracellular proteases: biological and behavioral roles in the mammalian central nervous system","volume":"66","author":"Zhang","year":"2005","journal-title":"Curr Top Dev Biol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210002757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210002757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T13:45:19Z","timestamp":1711287919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452210002757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":96,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0306452210002757"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.02.047","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}