{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:47:52Z","timestamp":1790884072353,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000070","name":"NIBIB","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.neuroscience.2010.02.057","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T17:45:29Z","timestamp":1269971129000},"page":"209-218","source":"Crossref","is-referenced-by-count":50,"title":["Selective potentiation of the metabotropic glutamate receptor subtype 2 blocks phencyclidine-induced hyperlocomotion and brain activation"],"prefix":"10.1016","volume":"168","author":[{"given":"E.A.","family":"Hackler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.E.","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.K.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Baheza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Grier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Avison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Conn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2010.02.057_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/hbm.10064","article-title":"Ketamine and fMRI BOLD signal: distinguishing between effects mediated by change in blood flow versus change in cognitive state","volume":"18","author":"Abel","year":"2003","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0006-3223(01)01195-7","article-title":"Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex","volume":"50","author":"Adams","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0730-725X(99)00028-4","article-title":"Principal component analysis of the dynamic response measured by fMRI: a generalized linear systems framework","volume":"17","author":"Andersen","year":"1999","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0165-0173(98)00050-2","article-title":"Metabotropic glutamate receptors: electrophysiological properties and role in plasticity","volume":"29","author":"Anwyl","year":"1999","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0022-3565(25)23831-9","article-title":"Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response","volume":"271","author":"Bakshi","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.107.035170","article-title":"A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis","volume":"72","author":"Benneyworth","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0022-3565(24)35084-0","article-title":"The metabotropic glutamate 2\/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats","volume":"291","author":"Cartmell","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1471-4159.2000.0750889.x","article-title":"Regulation of neurotransmitter release by metabotropic glutamate receptors","volume":"75","author":"Cartmell","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0304-3940(90)90498-X","article-title":"L-[3H]glutamate labels the metabotropic excitatory amino acid receptor in rodent brain","volume":"113","author":"Cha","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/mrm.1910380306","article-title":"Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data","volume":"38","author":"Chen","year":"1997","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.pharmtox.37.1.205","article-title":"Pharmacology and functions of metabotropic glutamate receptors","volume":"37","author":"Conn","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00213-008-1237-1","article-title":"Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis","volume":"200","author":"Daumann","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archgenpsychiatry.2007.37","article-title":"Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study","volume":"65","author":"Deakin","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1388-2457(02)00038-X","article-title":"Technical aspects and utility of fMRI using BOLD and ASL","volume":"113","author":"Detre","year":"2002","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0006-8993(82)90938-6","article-title":"Influence of chloralose on brain regional glucose utilization","volume":"233","author":"Dudley","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-8993(99)01776-X","article-title":"Comparison of brain metabolic activity patterns induced by ketamine, MK-801 and amphetamine in rats: support for NMDA receptor involvement in responses to subanesthetic dose of ketamine","volume":"843","author":"Duncan","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib17","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1523\/JNEUROSCI.3801-04.2005","article-title":"Estrogen influences cocaine-induced blood oxygen level-dependent signal changes in female rats","volume":"25","author":"Febo","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1124\/jpet.108.136861","article-title":"Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2\/3 receptor agonist (\u2212)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039)","volume":"326","author":"Fell","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib19","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1124\/jpet.105.091074","article-title":"A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2\/3 receptor agonist in mouse models predictive of antipsychotic activity","volume":"315","author":"Galici","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/jpet.106.102046","article-title":"Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice","volume":"318","author":"Galici","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature06612","article-title":"Identification of a serotonin\/glutamate receptor complex implicated in psychosis","volume":"452","author":"Gonzalez-Maeso","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1172\/JCI200319010","article-title":"Principles and practice of functional MRI of the human brain","volume":"112","author":"Gore","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib23","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/sj.npp.1301547","article-title":"Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine","volume":"33","author":"Gozzi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib24","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.mri.2008.01.012","article-title":"Drug-anaesthetic interaction in phMRI: the case of the psychotomimetic agent phencyclidine","volume":"26","author":"Gozzi","year":"2008","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib25","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/sj.npp.1300955","article-title":"Region-specific effects of nicotine on brain activity: a pharmacological MRI study in the drug-naive rat","volume":"31","author":"Gozzi","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2007.12.057","article-title":"Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: implication in emotional responses and central disinhibition","volume":"1197","author":"Gu","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib27","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1124\/jpet.106.113357","article-title":"5-Hydroxytryptamine 2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation","volume":"320","author":"Hackler","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/mrm.1910310307","article-title":"Artifacts due to stimulus correlated motion in functional imaging of the brain","volume":"31","author":"Hajnal","year":"1994","journal-title":"Magn Reson Med"},{"issue":"Suppl 12","key":"10.1016\/j.neuroscience.2010.02.057_bib29","first-page":"18","article-title":"Weight gain with atypical antipsychotics: evidence and insights","volume":"68","author":"Henderson","year":"2007","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib30","first-page":"182","article-title":"Molecular biology of glutamate receptors","volume":"17","author":"Hollmann","year":"1994","journal-title":"Ren Physiol Biochem"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib31","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1523\/JNEUROSCI.0910-08.2008","article-title":"Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo","volume":"28","author":"Honey","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib32","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1176\/ajp.148.10.1301","article-title":"Recent advances in the phencyclidine model of schizophrenia","volume":"148","author":"Javitt","year":"1991","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib33","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1021\/jm034015u","article-title":"Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine","volume":"46","author":"Johnson","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00213-004-2099-9","article-title":"Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)","volume":"179","author":"Johnson","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00213-004-1982-8","article-title":"Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects","volume":"179","author":"Krystal","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/hrp.7.3.125","article-title":"NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders","volume":"7","author":"Krystal","year":"1999","journal-title":"Harv Rev Psychiatry"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/archpsyc.1994.03950030035004","article-title":"Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans","volume":"51","author":"Krystal","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF02245249","article-title":"Extrapyramidal side effects of clozapine and haloperidol","volume":"118","author":"Kurz","year":"1995","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib39","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/00000542-200309000-00016","article-title":"Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans","volume":"99","author":"Langsjo","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00213-006-0344-0","article-title":"Mapping the central effects of ketamine in the rat using pharmacological MRI","volume":"186","author":"Littlewood","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/35084005","article-title":"Neurophysiological investigation of the basis of the fMRI signal","volume":"412","author":"Logothetis","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib42","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0079-6123(08)60655-X","article-title":"Animal models in psychiatric research","volume":"65","author":"Matthysse","year":"1986","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2003.09.010","article-title":"What's atypical about atypical antipsychotic drugs?","volume":"4","author":"Meltzer","year":"2004","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nrn1993","article-title":"Intermediate phenotypes and genetic mechanisms of psychiatrvic disorders","volume":"7","author":"Meyer-Lindenberg","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib45","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.281.5381.1349","article-title":"Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats","volume":"281","author":"Moghaddam","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.schres.2006.01.024","article-title":"Stereotypy in schizophrenia","volume":"84","author":"Morrens","year":"2006","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuint.2007.06.019","article-title":"Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment","volume":"51","author":"Mouri","year":"2007","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib48","first-page":"1145","article-title":"Glutamate receptors and brain function [in Japanese]","volume":"70","author":"Nakanishi","year":"1998","journal-title":"Seikagaku"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib49","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1098-2396(199604)22:4<304::AID-SYN2>3.0.CO;2-F","article-title":"Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis","volume":"22","author":"Nishijima","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib50","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.schres.2004.04.009","article-title":"NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI","volume":"72","author":"Northoff","year":"2005","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mrm.1910140108","article-title":"Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields","volume":"14","author":"Ogawa","year":"1990","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib52","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/cne.903350209","article-title":"Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study","volume":"335","author":"Ohishi","year":"1993","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00000542-198608000-00004","article-title":"Effects of isoflurane anesthesia on local cerebral glucose utilization in the rat","volume":"65","author":"Ori","year":"1986","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib54","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nm1632","article-title":"Activation of mGlu2\/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial","volume":"13","author":"Patil","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib54a","series-title":"The rat brain in stereotactic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib55","first-page":"5","article-title":"The synaptic basis of general anaesthesia","volume":"12","author":"Richards","year":"1995","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib56","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00213-005-2204-8","article-title":"Functional magnetic resonance imaging reveals similar brain activity changes in two different animal models of schizophrenia","volume":"180","author":"Risterucci","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00008877-199601000-00001","article-title":"Phencyclidine-induced stereotyped behaviour and social isolation in rats: a possible animal model of schizophrenia","volume":"7","author":"Sams-Dodd","year":"1996","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib58","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0028-3908(99)00092-1","article-title":"Pharmacological agents acting at subtypes of metabotropic glutamate receptors","volume":"38","author":"Schoepp","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib59","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/1568007024606177","article-title":"Preclinical pharmacology of mGlu2\/3 receptor agonists: novel agents for schizophrenia?","volume":"1","author":"Schoepp","year":"2002","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib60","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuroimage.2004.05.001","article-title":"Concurrent pharmacological MRI and in situ microdialysis of cocaine reveal a complex relationship between the central hemodynamic response and local dopamine concentration","volume":"23","author":"Schwarz","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-9964(01)00163-3","article-title":"A review of MRI findings in schizophrenia","volume":"49","author":"Shenton","year":"2001","journal-title":"Schizophr Res"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib62","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(00)00269-7","article-title":"Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice","volume":"397","author":"Spooren","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib63","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0014-2999(79)90279-6","article-title":"Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats","volume":"59","author":"Sturgeon","year":"1979","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib64","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0896-6273(89)90121-9","article-title":"Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA","volume":"3","author":"Sugiyama","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/sj.npp.1300127","article-title":"Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine","volume":"28","author":"Takahata","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1615\/CritRevNeurobiol.v12.i1-2.20","article-title":"Schizophrenia and glutamatergic transmission","volume":"12","author":"Tamminga","year":"1998","journal-title":"Crit Rev Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib67","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1006\/nimg.2002.1200","article-title":"Noise reduction in BOLD-based fMRI using component analysis","volume":"17","author":"Thomas","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib68","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1371\/journal.pbio.0050274","article-title":"Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine","volume":"5","author":"Williams","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1016\/j.neuroscience.2010.02.057_bib69","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00213-007-0974-x","article-title":"The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2\/3 agonist, LY379268, in mouse models predictive of antipsychotic activity","volume":"196","author":"Woolley","year":"2008","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221000285X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221000285X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:45:50Z","timestamp":1739994350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221000285X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S030645221000285X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.02.057","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}