{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:01:49Z","timestamp":1791183709459,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["NS26137"],"award-info":[{"award-number":["NS26137"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.neuroscience.2010.07.019","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T05:03:09Z","timestamp":1279602189000},"page":"678-685","source":"Crossref","is-referenced-by-count":9,"title":["Ultraviolet irradiation of the eye and Fos-positive neurons induced in trigeminal brainstem after intravitreal or ocular surface transient receptor potential vanilloid 1 activation"],"prefix":"10.1016","volume":"170","author":[{"given":"Z.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Bereiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2010.07.019_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pharmthera.2009.10.005","article-title":"The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation","volume":"125","author":"Alawi","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1113\/jphysiol.1991.sp018621","article-title":"Excitation by irritant chemical substances of sensory afferent units in the cat's cornea","volume":"437","author":"Belmonte","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0014-4835(71)90159-X","article-title":"Effects of intraocular pressure changes on the afferent activity of ciliary nerves","volume":"12","author":"Belmonte","year":"1971","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib4","series-title":"Science of pain","first-page":"435","article-title":"Trigeminal mechanisms of nociception: peripheral and brainstem organization","author":"Bereiter","year":"2009"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0304-3959(00)00434-6","article-title":"Trigeminal subnucleus caudalis: beyond homologies with the spinal dorsal horn","volume":"88","author":"Bereiter","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib6","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1152\/jn.00616.2005","article-title":"Endotoxin-induced uveitis causes long-term changes in trigeminal subnucleus caudalis neurons","volume":"94","author":"Bereiter","year":"2005","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0014-4835(03)00121-0","article-title":"Vasoactive intestinal and calcitonin gene-related peptides, tyrosine hydroxylase and nitrergic markers in the innervation of the rat central retinal artery","volume":"77","author":"Bergua","year":"2003","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cne.902960402","article-title":"Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat","volume":"296","author":"Bullitt","year":"1990","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/jn.1998.80.2.465","article-title":"Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa","volume":"80","author":"Carstens","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","article-title":"The vanilloid receptor: a molecular gateway to the pain pathway","volume":"24","author":"Caterina","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.emc.2007.10.001","article-title":"The painful eye","volume":"26","author":"Dargin","year":"2008","journal-title":"Emerg Med Clin North Am"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/jphysiol.1993.sp019791","article-title":"Response of sensory units with unmyelinated fibres to mechanical, thermal and chemical stimulation of the cat's cornea","volume":"468","author":"Gallar","year":"1993","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1017\/S0952523805226020","article-title":"Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide","volume":"22","author":"Glaser","year":"2005","journal-title":"Vis Neurosci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00429-003-0341-6","article-title":"Blink-related sensorimotor anatomy in the rat","volume":"207","author":"Gong","year":"2003","journal-title":"Anat Embryol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3109\/02713689508995800","article-title":"Localization of calcitonin gene-related peptide binding sites in the eye of different species","volume":"14","author":"Heino","year":"1995","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-1838(95)00126-3","article-title":"Sensory nerves play an efferent role in the function of the arterioles, but not the dilator muscle, of the rat iris","volume":"58","author":"Hill","year":"1996","journal-title":"J Auton Nerv Syst"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib17","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1523\/JNEUROSCI.0381-04.2004","article-title":"A novel class of neurons at the trigeminal subnucleus interpolaris\/caudalis transition region monitors ocular surface fluid status and modulates tear production","volume":"24","author":"Hirata","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0006-8993(00)03253-4","article-title":"VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion","volume":"890","author":"Ichikawa","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0163-7258(98)00040-0","article-title":"Nervous control of blood flow in the orofacial region","volume":"81","author":"Izumi","year":"1999","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/cne.902330302","article-title":"Rat medulla oblongata. I","volume":"233","author":"Kalia","year":"1985","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-0625.2008.00806.x","article-title":"Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo","volume":"18","author":"Lee","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1056\/NEJM200008033430507","article-title":"The red eye","volume":"343","author":"Leibowitz","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ijdevneu.2009.07.003","article-title":"Ontogenetic expression of the vanilloid receptors TRPV1 and TRPV2 in the rat retina","volume":"27","author":"Leonelli","year":"2009","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib24","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1152\/jn.00887.2006","article-title":"Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons","volume":"97","author":"Liu","year":"2007","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0306-4522(93)90250-J","article-title":"Adrenalectomy enhances Fos-like immunoreactivity within the spinal trigeminal nucleus induced by noxious thermal stimulation of the cornea","volume":"54","author":"Lu","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/cne.902610309","article-title":"Corneal sensory pathway in the rat: a horseradish peroxidase tracing study","volume":"261","author":"Marfurt","year":"1987","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cne.902850203","article-title":"Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation","volume":"285","author":"Menetrey","year":"1989","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0306-4522(95)00541-2","article-title":"Differential distribution of Fos-like immunoreactivity in the spinal trigeminal nucleus after noxious and innocuous thermal and chemical stimulation of rat cornea","volume":"72","author":"Meng","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib29","first-page":"1615","article-title":"Sensory receptors in the anterior uvea of the cat's eye","volume":"36","author":"Mintenig","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/cne.902890303","article-title":"Cytoarchitectonic organization of the spinal cord in the rat: II","volume":"289","author":"Molander","year":"1989","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2006.02.035","article-title":"Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons","volume":"1085","author":"Murata","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0079-6123(08)01131-X","article-title":"Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection","volume":"173","author":"Nucci","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pain.2010.02.004","article-title":"Bright light activates a trigeminal nociceptive pathway","volume":"149","author":"Okamoto","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib34","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neuroscience.2009.03.003","article-title":"Bright light produces Fos-positive neurons in caudal trigeminal brainstem","volume":"160","author":"Okamoto","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.exer.2009.11.018","article-title":"Distinct central representations for sensory fibers innervating either the conjunctiva or cornea of the rat","volume":"90","author":"Panneton","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/154405910808700306","article-title":"Trigeminal nociceptors express prostaglandin receptors","volume":"87","author":"Patwardhan","year":"2008","journal-title":"J Dent Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpain.2006.09.005","article-title":"Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B(4) binding in primary afferent neurons of the rat and mouse","volume":"8","author":"Price","year":"2007","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib38","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/sj.bjp.0705711","article-title":"Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide","volume":"141","author":"Price","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib39","first-page":"1159","article-title":"Characterization and localization of the rabbit ocular calcitonin gene-related peptide (CGRP)-receptor component protein (RCP)","volume":"41","author":"Rosenblatt","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3959(82)90092-6","article-title":"Density and organization of free nerve endings in the corneal epithelium of the rabbit","volume":"14","author":"Rozsa","year":"1982","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1167\/iovs.04-0608","article-title":"Neurokinin a is a main constituent of sensory neurons innervating the anterior segment of the eye","volume":"46","author":"Schmid","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib42","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/BF01945357","article-title":"Regulatory peptides in the eye","volume":"43","author":"Stone","year":"1987","journal-title":"Experientia"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib43","first-page":"2442","article-title":"Localization of cannabinoid CB1 receptors in the human anterior eye and retina","volume":"40","author":"Straiker","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/cne.903310406","article-title":"Somatotopic and laminar organization of Fos-like immunoreactivity in the medullary and cervical dorsal horn induced by noxious facial stimulation in the rat","volume":"331","author":"Strassman","year":"1993","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib45","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1152\/jn.1993.70.5.1811","article-title":"Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat","volume":"70","author":"Strassman","year":"1993","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/exnr.1994.1167","article-title":"c-Fos induction in the subnucleus caudalis following noxious mechanical stimulation of the oral mucous membrane","volume":"129","author":"Sugimoto","year":"1994","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib47","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0014-4886(91)90099-X","article-title":"Difference in central projection of primary afferents innervating facial and intraoral structures in the rat","volume":"111","author":"Takemura","year":"1991","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuroscience.2010.04.034","article-title":"Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis","volume":"169","author":"Tashiro","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-8993(89)90147-9","article-title":"The allocation of nerve fibres to the anterior eye segment and peripheral ganglia of rats. I","volume":"494","author":"ten Tusscher","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib50","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.902330410","article-title":"Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye","volume":"233","author":"Terenghi","year":"1985","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib51","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1167\/iovs.04-0425","article-title":"Secretoneurin in the peripheral ocular innervation","volume":"46","author":"Troger","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainresrev.2006.06.002","article-title":"Peptidergic nerves in the eye, their source and potential pathophysiological relevance","volume":"53","author":"Troger","year":"2007","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib53","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0014-4835(89)90030-4","article-title":"Calcitonin gene-related peptide (CGRP) immunoreactive sensory nerves in the human and guinea pig uvea and cornea","volume":"48","author":"Uusitalo","year":"1989","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0304-3959(03)00295-1","article-title":"Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in the rat","volume":"105","author":"Wenk","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib55","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cne.903070408","article-title":"Trigeminal projections to the nucleus submedius of the thalamus in the rat","volume":"307","author":"Yoshida","year":"1991","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.07.019_bib56","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0014-4835(86)80007-0","article-title":"Sensory nerve responses elicited by experimental ocular hypertension","volume":"43","author":"Zuazo","year":"1986","journal-title":"Exp Eye Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210009978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210009978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T05:15:35Z","timestamp":1559279735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452210009978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0306452210009978"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.07.019","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}