{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:11:44Z","timestamp":1790975504767,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.neuroscience.2010.08.035","type":"journal-article","created":{"date-parts":[[2010,8,23]],"date-time":"2010-08-23T04:22:11Z","timestamp":1282537331000},"page":"344-350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat"],"prefix":"10.1016","volume":"171","author":[{"given":"E.K.","family":"Joseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2010.08.035_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/379257a0","article-title":"A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons","volume":"379","author":"Akopian","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib2","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1523\/JNEUROSCI.15-12-08031.1995","article-title":"Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal","volume":"15","author":"Aley","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib3","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1523\/JNEUROSCI.17-20-08018.1997","article-title":"Different mechanisms mediate development and expression of tolerance and dependence for peripheral mu-opioid antinociception in rat","volume":"17","author":"Aley","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib4","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1523\/JNEUROSCI.17-10-03907.1997","article-title":"Dissociation of tolerance and dependence for opioid peripheral antinociception in rats","volume":"17","author":"Aley","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1523\/JNEUROSCI.17-02-00735.1997","article-title":"Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal","volume":"17","author":"Aley","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib6","unstructured":"Asante CO, Wallace VC, Dickenson AH (in press) Mammalian target of rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in the rat. J Pain."},{"key":"10.1016\/j.neuroscience.2010.08.035_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib8","doi-asserted-by":"crossref","first-page":"R429","DOI":"10.1016\/S0960-9822(99)80273-5","article-title":"Pain","volume":"9","author":"Basbaum","year":"1999","journal-title":"Curr Biol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib9","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1523\/JNEUROSCI.18-08-03059.1998","article-title":"A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury","volume":"18","author":"Bennett","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0006-8993(90)91519-M","article-title":"Pre- and postsynaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord","volume":"521","author":"Besse","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib11","first-page":"183","article-title":"Pre- and postsynaptic location of mu, delta and kappa opioid receptors in the superficial layers of the dorsal horn of the rat spinal cord","volume":"328","author":"Besse","year":"1990","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib12","doi-asserted-by":"crossref","first-page":"G130","DOI":"10.1152\/ajpgi.00388.2007","article-title":"Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice","volume":"294","author":"Bielefeldt","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib13","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.neuroscience.2008.12.049","article-title":"Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican","volume":"159","author":"Bogen","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1460-9568.2008.06308.x","article-title":"GDNF hyperalgesia is mediated by PLCgamma, MAPK\/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican","volume":"28","author":"Bogen","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib15","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.neuroscience.2009.07.051","article-title":"Triggering genetically-expressed transneuronal tracers by peripheral axotomy reveals convergent and segregated sensory neuron-spinal cord connectivity","volume":"163","author":"Br\u00e1z","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2005.08.015","article-title":"Parallel \u201cpain\u201d pathways arise from subpopulations of primary afferent nociceptor","volume":"47","author":"Braz","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib17","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/npp.2008.128","article-title":"Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice","volume":"34","author":"Chefer","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib18","doi-asserted-by":"crossref","first-page":"19208","DOI":"10.1073\/pnas.0506627102","article-title":"Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series","volume":"102","author":"Daniels","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12035-009-8085-9","article-title":"Presynaptic and postsynaptic cortical mechanisms of chronic pain","volume":"40","author":"Descalzi","year":"2009","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1567-424X(09)70337-X","article-title":"The neurobiology of persistent pain and its clinical implications","volume":"57","author":"Dubner","year":"2004","journal-title":"Suppl Clin Neurophysiol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib21","first-page":"146","article-title":"Treating and preventing chronic pain: a view from the spinal cord\u2014Bonica lecture, ASRA annual meeting, 2005","volume":"31","author":"Eisenach","year":"2006","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib22","doi-asserted-by":"crossref","first-page":"38478","DOI":"10.1074\/jbc.M505644200","article-title":"A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers","volume":"280","author":"Fan","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib23","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.1072-06.2006","article-title":"Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression","volume":"26","author":"Fang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1742-7843.2005.pto_97107.x","article-title":"A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80","volume":"97","author":"Gallantine","year":"2005","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2004.05.008","article-title":"Ultrastructural analysis of the central terminals of primary sensory neurones labelled by transganglionic transport of bandeiraea simplicifolia I-isolectin B4","volume":"127","author":"Gerke","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/nau.20343","article-title":"TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist","volume":"26","author":"Gevaert","year":"2007","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01244655","article-title":"Changes in cholinergic and opioid receptors in the rat spinal cord, dorsal root and sciatic nerve after ventral and dorsal root lesion","volume":"85","author":"Gillberg","year":"1991","journal-title":"J Neural Transm Gen Sect"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib28","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1073\/pnas.0307601101","article-title":"A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia","volume":"101","author":"Gomes","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib29","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuron.2007.07.008","article-title":"Signaling pathways in sensitization: toward a nociceptor cell biology","volume":"55","author":"Hucho","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib30","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1523\/JNEUROSCI.15-12-08156.1995","article-title":"Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation","volume":"15","author":"Ji","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib31","first-page":"343","article-title":"Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation","volume":"98","author":"Jordan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib32","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pain.2007.01.027","article-title":"PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia","volume":"132","author":"Joseph","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jpain.2008.01.335","article-title":"Oxaliplatin acts on IB4-positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy","volume":"9","author":"Joseph","year":"2008","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroscience.2010.04.082","article-title":"Hyperalgesic priming is restricted to isolectin B4-positive nociceptors","volume":"169","author":"Joseph","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cne.1380","article-title":"GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia","volume":"440","author":"Josephson","year":"2001","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(98)00558-8","article-title":"Glial cell line-derived neurotrophic factor and nerve growth factor receptor mRNAs are expressed in distinct subgroups of dorsal root ganglion neurons and are differentially regulated by peripheral axotomy in the rat","volume":"252","author":"Kashiba","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0169-328X(01)00224-8","article-title":"Difference in binding by isolectin B4 to trkA and c-ret mRNA-expressing neurons in rat sensory ganglia","volume":"95","author":"Kashiba","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-3940(93)90325-F","article-title":"Comparison of intradermal and subcutaneous hyperalgesic effects of inflammatory mediators in the rat","volume":"153","author":"Khasar","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0306-4522(93)90274-J","article-title":"Selective labelling of primary sensory afferent terminals in lamina II of the dorsal horn by injection of bandeiraea simplicifolia isolectin B4 into peripheral nerves","volume":"54","author":"Kitchener","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib40","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1523\/JNEUROSCI.4452-07.2008","article-title":"Spinal mu-opioid receptor-expressing dorsal horn neurons: role in nociception and morphine antinociception","volume":"28","author":"Kline","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib41","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(80)90319-2","article-title":"Opiate and peptide interaction: effect of enkephalins on morphine analgesia","volume":"68","author":"Lee","year":"1980","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/expphysiol.2006.035642","article-title":"Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals","volume":"92","author":"Liedtke","year":"2007","journal-title":"Exp Physiol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/978-3-540-34891-7_28","article-title":"TRPV channels' role in osmotransduction and mechanotransduction","volume":"179","author":"Liedtke","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib45","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1111\/j.1460-9568.2005.04173.x","article-title":"Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia","volume":"21","author":"Malik-Hall","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pain.2008.02.034","article-title":"Chronic pain may change the structure of the brain","volume":"137","author":"May","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib47","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/cne.903610305","article-title":"Presence or absence of TrkA protein distinguishes subsets of small sensory neurons with unique cytochemical characteristics and dorsal horn projections","volume":"361","author":"Molliver","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib48","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1523\/JNEUROSCI.2719-03.2004","article-title":"Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord","volume":"24","author":"Morinville","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib49","doi-asserted-by":"crossref","first-page":"10906","DOI":"10.1523\/JNEUROSCI.22-24-10906.2002","article-title":"Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice","volume":"22","author":"Nitsche","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0076-6879(07)28010-3","article-title":"Transient receptor potential channels in mechanosensing and cell volume regulation","volume":"428","author":"Pedersen","year":"2007","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib51","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpain.2006.09.005","article-title":"Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse","volume":"8","author":"Price","year":"2007","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib52","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jchemneu.2005.02.002","article-title":"Diverse immunocytochemical expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia","volume":"29","author":"Rau","year":"2005","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib53","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0006-8993(02)03750-2","article-title":"Expression of Nav1.8 sodium channels perturbs the firing patterns of cerebellar Purkinje cells","volume":"959","author":"Renganathan","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib54","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2174\/1568026054367638","article-title":"Cellular signalling pathways of spinal pain neuroplasticity as targets for analgesic development","volume":"5","author":"Salter","year":"2005","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib55","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1074\/jbc.271.11.5953","article-title":"Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons","volume":"271","author":"Sangameswaran","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib56","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.cell.2009.04.019","article-title":"Dissociation of the opioid receptor mechanisms that control mechanical and heat pain","volume":"137","author":"Scherrer","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib57","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1021\/jm980724+","article-title":"The opioid mu agonist\/delta antagonist DIPP-NH(2) [Psi]produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats","volume":"42","author":"Schiller","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib58","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00018-008-8428-0","article-title":"Central mechanisms of experimental and chronic neuropathic pain: findings from functional imaging studies","volume":"66","author":"Seifert","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib59","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1111\/j.1460-9568.2005.04382.x","article-title":"Remodelling of spinal nociceptive mechanisms in an animal model of monoarthritis","volume":"22","author":"Sharif Naeini","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib60","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(94)90333-6","article-title":"Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor","volume":"12","author":"Standifer","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/978-3-540-79090-7_14","article-title":"Opioids and sensory nerves","volume":"194","author":"Stein","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainres.2004.09.027","article-title":"The behavioral and neuroanatomical effects of IB4-saporin treatment in rat models of nociceptive and neuropathic pain","volume":"1029","author":"Tarpley","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1744-8069-5-46","article-title":"Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex","volume":"5","author":"Toyoda","year":"2009","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0306-4522(01)00377-3","article-title":"Cytotoxic targeting of isolectin IB4-binding sensory neurons","volume":"108","author":"Vulchanova","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib66","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1523\/JNEUROSCI.1157-07.2007","article-title":"Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons","volume":"27","author":"Walwyn","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib67","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1124\/mol.109.055913","article-title":"Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons","volume":"76","author":"Walwyn","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib68","doi-asserted-by":"crossref","first-page":"13117","DOI":"10.1073\/pnas.1008382107","article-title":"Coexpression of {delta}- and {micro}-opioid receptors in nociceptive sensory neurons","volume":"107","author":"Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib69","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/cne.903530113","article-title":"Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions","volume":"353","author":"Wetmore","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib70","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1523\/JNEUROSCI.0415-09.2009","article-title":"Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance","volume":"29","author":"Xie","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12013-009-9067-2","article-title":"Mechanotransduction by TRP channels: general concepts and specific role in the vasculature","volume":"56","author":"Yin","year":"2010","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0006-8993(89)91436-4","article-title":"Autoradiographic study of mu and delta opioid binding sites and neutral endopeptidase-24.11 in rat after dorsal root rhizotomy","volume":"477","author":"Zajac","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.08.035_bib73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(00)80836-3","article-title":"Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice","volume":"24","author":"Zhu","year":"1999","journal-title":"Neuron"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210011632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210011632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:34:55Z","timestamp":1759678495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452210011632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0306452210011632"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.08.035","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}