{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:54:31Z","timestamp":1792079671062,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.neuroscience.2010.08.067","type":"journal-article","created":{"date-parts":[[2010,9,7]],"date-time":"2010-09-07T04:20:58Z","timestamp":1283833258000},"page":"316-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models"],"prefix":"10.1016","volume":"171","author":[{"given":"S.","family":"Marinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Luvisetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cobianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Makuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Obara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mezzaroma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Straface","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Przewlocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2010.08.067_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(95)90168-X","article-title":"Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice","volume":"83","author":"Aigner","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00702-004-0265-1","article-title":"Botulinum toxin type A in experimental neuropathic pain","volume":"112","author":"Bach-Rojecky","year":"2005","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2010.01.020","article-title":"Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: bilateral effect after unilateral injection","volume":"633","author":"Bach-Rojecky","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jneumeth.2006.11.016","article-title":"A new approach to assess function after sciatic nerve lesion in the mouse-adaptation of the sciatic static index","volume":"161","author":"Baptista","year":"2007","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib5","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1016\/j.biocel.2006.05.007","article-title":"Schwann cells: origins and role in axonal maintenance and regeneration","volume":"38","author":"Bhatheja","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0165-6147(00)01536-4","article-title":"Keeping in touch: sensory neurone regeneration in the CNS","volume":"21","author":"Bradbury","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bbi.2006.12.008","article-title":"Schwann cells: activated peripheral glia and their role in neuropathic pain","volume":"21","author":"Campana","year":"2007","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib9","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1523\/JNEUROSCI.14-07-04375.1994","article-title":"GAP-43 expression in primary sensory neurons following central axotomy","volume":"14","author":"Chong","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuroscience.2010.03.035","article-title":"Short but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury","volume":"168","author":"Cobianchi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2003.10.008","article-title":"Subcutaneous administration of botulinum toxin A reduces formalin-induced pain","volume":"107","author":"Cui","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib12","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tins.2005.06.001","article-title":"Beyond BOTOX: advantages and limitations of individual botulinum neurotoxins","volume":"28","author":"Davletov","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1469-7580.2003.00248.x","article-title":"Wallerian degeneration in C57BL\/6J and A\/J mice: differences in time course of neurofilament and myelin breakdown, macrophage recruitment and iNOS expression","volume":"203","author":"de la Hoz","year":"2003","journal-title":"J Anat"},{"issue":"Suppl 4","key":"10.1016\/j.neuroscience.2010.08.067_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1468-1331.2006.01648.x","article-title":"The structure and mode of action of different botulinum toxins","volume":"13","author":"Dolly","year":"2006","journal-title":"Eur J Neurol"},{"issue":"12","key":"10.1016\/j.neuroscience.2010.08.067_bib15","doi-asserted-by":"crossref","first-page":"e8339","DOI":"10.1371\/journal.pone.0008339","article-title":"Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3\/Tis21 knockout mice","volume":"4","author":"Farioli-Vecchioli","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2009.06.047","article-title":"Different antinociceptive effects of botulinum toxin type A in inflammatory and peripheral polyneuropathic rat models","volume":"617","author":"Favre-Guilmard","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1385\/MN:26:1:057","article-title":"Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain","volume":"26","author":"Fukuoka","year":"2002","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.pain.2006.04.014","article-title":"The effects of Botulinum Toxin type A on capsaicin-evoked pain, \ufb02are, and secondary hyperalgesia in an experimental human model of trigeminal sensitization","volume":"122","author":"Gazerani","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.expneurol.2006.02.134","article-title":"Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury","volume":"200","author":"Gupta","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1242\/jcs.03322","article-title":"Cdc2-mediated Schwann cell migration during peripheral nerve regeneration","volume":"120","author":"Han","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.expneurol.2007.06.004","article-title":"A double-transgenic mouse used to track migrating Schwann cells and regenerating axons following engraftment of injured nerves","volume":"207","author":"Hayashi","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0021-5155(99)00197-5","article-title":"Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles","volume":"44","author":"Ishikawa","year":"2000","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ncpneuro0948","article-title":"Botulinum neurotoxins in the treatment of refractory pain","volume":"4","author":"Jabbari","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib24","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1212\/01.wnl.0000259085.61898.9e","article-title":"The impact of neuropathic pain on health-related quality of life: review and implications","volume":"68","author":"Jensen","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/WCO.0b013e3283311e13","article-title":"Pharmacology and treatment of neuropathic pains","volume":"22","author":"Jensen","year":"2009","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib26","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrn1746","article-title":"The origin and development of glial cells in peripheral nerves","volume":"6","author":"Jessen","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1242\/dev.109.1.91","article-title":"Three markers of adult non-myelin-forming Schwann cells, 217c(Ran-1), A5E3 and GFAP: development and regulation by neuron-Schwann cell interactions","volume":"109","author":"Jessen","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1533-2500.2008.00202.x","article-title":"Evidence for the use of botulinum toxin in the chronic pain setting\u2014a review of the literature","volume":"8","author":"Jeynes","year":"2008","journal-title":"Pain Pract"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib29","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.neuroscience.2009.01.066","article-title":"Botulinum toxin type a (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction","volume":"159","author":"Kitamura","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1526-4637.2006.00100.x","article-title":"Botulinum toxin A relieved neuropathic pain in a case of post-herpetic neuralgia","volume":"7","author":"Liu","year":"2006","journal-title":"Pain Med"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1464-410X.2007.07312.x","article-title":"Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation","volume":"101","author":"Lucioni","year":"2008","journal-title":"Br J Urol Int"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2006.12.004","article-title":"Anti-allodynic efficacy of botulinum neurotoxin A in a model of neuropathic pain","volume":"145","author":"Luvisetto","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2006.01.117","article-title":"Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice","volume":"1082","author":"Luvisetto","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuroscience.2006.06.049","article-title":"Pain sensitivity in mice lacking the Cav2.1\u03b11 subunit of P\/Q-type Ca2+ channels","volume":"142","author":"Luvisetto","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0041-0101(02)00370-7","article-title":"Toxicity of botulinum neurotoxins in central nervous system of mice","volume":"41","author":"Luvisetto","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.expneurol.2007.05.028","article-title":"Reinnervation of the tibialis anterior following sciatic nerve crush injury: a confocal microscopic study in transgenic mice","volume":"207","author":"Magill","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1083\/jcb.200212172","article-title":"Alpha(v)beta3 integrin expression up-regulates Cdc2, which modulates cell migration","volume":"161","author":"Manes","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib39","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.pain.2008.02.015","article-title":"Interleukin-1\u03b1 has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model","volume":"138","author":"Mika","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ejphar.2007.01.013","article-title":"Minocycline and pentoxyfilline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain","volume":"560","author":"Mika","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.coph.2004.12.006","article-title":"Botulinal neurotoxins: revival of an old killer","volume":"5","author":"Montecucco","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.mcn.2003.11.005","article-title":"Activation of cyclin-dependent kinase 5 is involved in axonal regeneration","volume":"25","author":"Namgung","year":"2004","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2007.06.005","article-title":"Neural plasticity after peripheral nerve injury and regeneration","volume":"82","author":"Navarro","year":"2007","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib44","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/sj.bjp.0705427","article-title":"Antagonists of the \u03ba-opioid receptor enhance allodynia in rats and mice after sciatic nerve ligation","volume":"140","author":"Obara","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pain.2008.03.017","article-title":"Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain","volume":"139","author":"Osikowicz","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib46","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF03022619","article-title":"The effects of botulinum toxin A on mechanical and cold allodynia in a rat model of neuropathic pain","volume":"53","author":"Park","year":"2006","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib47","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.1038\/11041","article-title":"Four-dimensional control of the cell cycle","volume":"1","author":"Pines","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib48","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.2174\/1381612054865055","article-title":"Opioids in neuropathic pain","volume":"11","author":"Przewlocki","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ana.21427","article-title":"Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain","volume":"64","author":"Ranoux","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00000542-200508000-00002","article-title":"Injured versus uninjured afferents: who is to blame for neuropathic pain?","volume":"103","author":"Ringkamp","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib51","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0076-6879(95)48041-2","article-title":"Tetanus and botulism neurotoxins: isolation and assay","volume":"248","author":"Schiavo","year":"1995","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib52","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1152\/physrev.2000.80.2.717","article-title":"Neurotoxins affecting neuroexocytosis","volume":"80","author":"Schiavo","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib53","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn1992","article-title":"The neuropathic pain triad: neurons, immune cells and glia","volume":"10","author":"Scholz","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib54","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1089\/neu.2008.0711","article-title":"ERK1\/2-mediated Schwann cell proliferation in the regenerating sciatic nerve by treadmill training","volume":"26","author":"Seo","year":"2009","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib55","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/01.ajp.0000210956.31997.89","article-title":"Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community","volume":"23","author":"Smith","year":"2007","journal-title":"Clin J Pain"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib56","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1242\/jcs.03168","article-title":"Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage","volume":"119","author":"Triolo","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.neuro.30.051606.094354","article-title":"Why is wallerian degeneration in the CNS so slow?","volume":"30","author":"Vargas","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib58","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0896-6273(04)00077-7","article-title":"SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization","volume":"41","author":"Verderio","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0854.2006.00520.x","article-title":"Traffic of botulinum toxins A and E in excitatory and inhibitory neurons","volume":"8","author":"Verderio","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib60","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib61","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1212\/01.wnl.0000345968.05959.cf","article-title":"Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial","volume":"72","author":"Yuan","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2010.08.067_bib62","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210012170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452210012170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:34:42Z","timestamp":1759678482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452210012170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0306452210012170"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.08.067","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2010.08.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}