{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:39:35Z","timestamp":1774118375183,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.neuroscience.2011.04.037","type":"journal-article","created":{"date-parts":[[2011,4,25]],"date-time":"2011-04-25T05:09:42Z","timestamp":1303708182000},"page":"106-115","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3\u03b2 phosphorylation"],"prefix":"10.1016","volume":"185","author":[{"given":"T.","family":"Nedachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Matsuwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yamanouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2011.04.037_bib1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2009.06133.x","article-title":"Neuroprotection by estrogen in the brain: the mitochondrial compartment as presumed therapeutic target","volume":"110","author":"Arnold","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib3","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib4","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1242\/dev.02429","article-title":"The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila","volume":"133","author":"Bello","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1262\/jrd.18108","article-title":"Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus","volume":"53","author":"Chiba","year":"2007","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib6","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nature05017","article-title":"Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21","volume":"442","author":"Cruts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1177\/002215540004800713","article-title":"Cellular localization of gene expression for progranulin","volume":"48","author":"Daniel","year":"2000","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1006\/dbio.1999.9564","article-title":"Modulation of mouse preimplantation embryo development by acrogranin (epithelin\/granulin precursor)","volume":"217","author":"D\u00edaz-Cueto","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1212\/01.wnl.0000325058.10218.fc","article-title":"Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration","volume":"71","author":"Ghidoni","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib10","first-page":"3222","article-title":"Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo","volume":"59","author":"He","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s00109-003-0474-3","article-title":"Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis","volume":"81","author":"He","year":"2003","journal-title":"J Mol Med"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/jcp.22031","article-title":"Progranulin (granulin\/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters","volume":"223","author":"Hoque","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/stem.246","article-title":"The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells","volume":"28","author":"Hu","year":"2010","journal-title":"Stem Cells"},{"issue":"2","key":"10.1016\/j.neuroscience.2011.04.037_bib14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbr.2007.07.020","article-title":"Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene","volume":"185","author":"Kayasuga","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib15","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nn.2408","article-title":"GSK-3 is a master regulator of neural progenitor homeostasis","volume":"12","author":"Kim","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2010.10.076","article-title":"Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells","volume":"488","author":"Lange","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib17","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1158\/0008-5472.CAN-06-0633","article-title":"Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1\/2 and the formation of a paxillin\/FAK\/ERK complex","volume":"66","author":"Monami","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib19","first-page":"1275","article-title":"Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis","volume":"18","author":"Ong","year":"2003","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib20","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1016\/S0021-9258(18)42382-4","article-title":"The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth","volume":"267","author":"Plowman","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-0185(19990815)257:4<137::AID-AR7>3.0.CO;2-Q","article-title":"Multipotent and restricted precursors in the central nervous system","volume":"257","author":"Rao","year":"1999","journal-title":"Anat Rec"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib22","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib23","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.1073\/pnas.89.18.8591","article-title":"De novo generation of neuronal cells from the adult mouse brain","volume":"89","author":"Richards","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1471-2202-10-130","article-title":"Progranulin is expressed within motor neurons and promotes neuronal cell survival","volume":"10","author":"Ryan","year":"2009","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib25","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1074\/jbc.M705115200","article-title":"Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion","volume":"283","author":"Shankaran","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/glia.20187","article-title":"Stem\/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes","volume":"51","author":"Shetty","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1212\/01.wnl.0000289191.54852.75","article-title":"Progranulin genetic variability contributes to amyotrophic lateral sclerosis","volume":"71","author":"Sleegers","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bj2960015","article-title":"Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling","volume":"296","author":"Sutherland","year":"1993","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1262\/jrd.20249","article-title":"Roles of progranulin in sexual differentiation of the developing brain and adult neurogenesis","volume":"55","author":"Suzuki","year":"2009","journal-title":"J Reprod Dev"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0304-3940(00)01699-2","article-title":"Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus","volume":"297","author":"Suzuki","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3940(98)00008-1","article-title":"Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus","volume":"242","author":"Suzuki","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1634\/stemcells.2006-0131","article-title":"Nitric oxide decreases subventicular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase\/Akt pathway","volume":"25","author":"Torroglosa","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.200712039","article-title":"Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival","volume":"181","author":"Van Damme","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib34","doi-asserted-by":"crossref","first-page":"20078","DOI":"10.1074\/jbc.273.32.20078","article-title":"The granulin\/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro","volume":"273","author":"Xu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1084\/jem.20091568","article-title":"Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice","volume":"207","author":"Yin","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib36","first-page":"5331","article-title":"Biological activities and signaling pathways of the granulin\/epithelin precursor","volume":"59","author":"Zanocco-Marani","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib37","doi-asserted-by":"crossref","first-page":"10530","DOI":"10.1523\/JNEUROSCI.3421-07.2007","article-title":"Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43","volume":"27","author":"Zhang","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.04.037_bib38","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(02)01141-8","article-title":"Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair","volume":"111","author":"Zhu","year":"2002","journal-title":"Cell"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211004556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211004556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T10:30:50Z","timestamp":1712399450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452211004556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":38,"alternative-id":["S0306452211004556"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2011.04.037","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}