{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:11:11Z","timestamp":1790737871697,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa Cient\u00edfica e Tecnol\u00f3gica do Estado de Santa Catarina"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.neuroscience.2011.05.075","type":"journal-article","created":{"date-parts":[[2011,6,25]],"date-time":"2011-06-25T23:28:05Z","timestamp":1309044485000},"page":"661-674","source":"Crossref","is-referenced-by-count":121,"special_numbering":"C","title":["Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression"],"prefix":"10.1016","volume":"192","author":[{"given":"A.R.","family":"Sigwalt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Budde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Helmich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ghisoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Cadore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.L.R.","family":"Lhullier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"de Bem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"de Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Prediger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.A.","family":"Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Latini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2011.05.075_bib1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fj.01-0876rev","article-title":"Muscle-derived interleukin-6: mechanisms for activation and possible biological roles","volume":"16","author":"Febbraio","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00702-008-0071-2","article-title":"Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels","volume":"115","author":"Aguiar","year":"2008","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neulet.2007.08.058","article-title":"Mitochondrial IV complex and brain neurothrophic derived factor responses of mice brain cortex after downhill training","volume":"426","author":"Aguiar","year":"2007","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib4","series-title":"Diagnostic and statistical manual of mental disorders","year":"2000"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/neu.1038","article-title":"Brain aromatase is neuroprotective","volume":"47","author":"Azcoitia","year":"2001","journal-title":"J Neurobiol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib6","first-page":"185","article-title":"Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression","volume":"29","author":"Barden","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00421-002-0783-1","article-title":"Methodological aspects of maximal lactate steady state-implications for performance testing","volume":"89","author":"Beneke","year":"2003","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib9","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1073\/pnas.97.7.3602","article-title":"The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus","volume":"97","author":"Bi","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib10","first-page":"509","article-title":"Neuroprotective role of testosterone in the nervous system","volume":"56","author":"Bia\u0142ek","year":"2004","journal-title":"Pol J Pharmacol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib11","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1001\/archinte.159.19.2349","article-title":"Effects of exercise training on older patients with major depression","volume":"159","author":"Blumenthal","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/ajp.157.1.115","article-title":"Hippocampal volume reduction in major depression","volume":"157","author":"Bremner","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2010.03.015","article-title":"Hormonal responses to physical and cognitive stress in a school setting","volume":"474","author":"Budde","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.psyneuen.2009.07.015","article-title":"Steroid hormones in the saliva of adolescents after different exercise intensities and their influence on working memory in a school setting","volume":"35","author":"Budde","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1055\/s-0030-1261895","article-title":"Physiological effects of concurrent training in elderly men","volume":"31","author":"Cadore","year":"2010","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.euroneuro.2007.03.001","article-title":"Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone","volume":"17","author":"Casarotto","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0022-3999(02)00304-5","article-title":"Depression and public health: an overview","volume":"53","author":"Cassano","year":"2002","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrn1629","article-title":"Is mood chemistry?","volume":"6","author":"Castr\u00e9n","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib19","first-page":"A22","article-title":"Depression as a major component of public health for older adults","volume":"5","author":"Chapman","year":"2008","journal-title":"Prev Chronic Dis"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib20","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/01.WNL.0000165995.98986.F1","article-title":"Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment","volume":"64","author":"Cherrier","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1123\/jsep.20.4.339","article-title":"The effect of exercise on clinical depression and depression resulting from mental illness: a meta-analysis","volume":"20","author":"Craft","year":"1998","journal-title":"J Sport Exerc Psychol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/exnr.1998.6801","article-title":"The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum","volume":"151","author":"Day","year":"1998","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib23","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nn1102-1131","article-title":"The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system","volume":"5","author":"Dechant","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1096-9861(19990428)407:1<77::AID-CNE6>3.0.CO;2-S","article-title":"p75NTR immunoreactivity in the rat dentate gyrus is mostly within presynaptic profiles but is also found in some astrocytic and postsynaptic profiles","volume":"407","author":"Dougherty","year":"1999","journal-title":"J Comp Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2011.05.075_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2005.08.018","article-title":"Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism","volume":"26","author":"Duman","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib26","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/cercor\/13.8.845","article-title":"Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex","volume":"13","author":"Ehninger","year":"2003","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib28","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1111\/j.1460-9568.2003.03041.x","article-title":"VEGF is necessary for exercise-induced adult hippocampal neurogenesis","volume":"18","author":"Fabel","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0193-953X(05)70283-5","article-title":"Definition and epidemiology of treatment-resistant depression","volume":"19","author":"Fava","year":"1996","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.neuroscience.2008.10.024","article-title":"Dexamethasone induces neurodegeneration but also up-regulates vascular endothelial growth factor A in neonatal rat brains","volume":"158","author":"Feng","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.5694\/j.1326-5377.2005.tb06849.x","article-title":"Effectiveness of treatments for depression in older people","volume":"182","author":"Frazer","year":"2005","journal-title":"Med J Aust"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0306-4530(98)00009-2","article-title":"Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy","volume":"23","author":"Frye","year":"1998","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biopsych.2009.02.027","article-title":"Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1","volume":"66","author":"Garcia-Garcia","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib34","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1111\/j.1743-6109.2010.01859.x","article-title":"Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome","volume":"7","author":"Giltay","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1095-6433(01)00362-2","article-title":"Maximal lactate steady state in rats submitted to swimming exercise","volume":"130","author":"Gobatto","year":"2001","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib36","first-page":"625","article-title":"Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders","volume":"7","author":"Gold","year":"2006","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib37","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/hipo.20636","article-title":"Effects of exercise training on hippocampus concentrations of insulin and IGF-1 in diabetic rats","volume":"19","author":"Gomes","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.biopsych.2007.07.016","article-title":"Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression","volume":"63","author":"Gourley","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib39","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1055\/s-0029-1202340","article-title":"Endurance training of moderate intensity increases testosterone concentration in young, healthy men","volume":"30","author":"Grandys","year":"2009","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib40","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1523\/JNEUROSCI.23-07-02889.2003","article-title":"Freewheel running prevents learned helplessness\/behavioral depression: role of dorsal raphe serotonergic neurons","volume":"23","author":"Greenwood","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib41","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1097\/HJH.0b013e3283379120","article-title":"Exercise training normalizes skeletal muscle vascular endothelial growth factor levels in patients with essential hypertension","volume":"28","author":"Hansen","year":"2010","journal-title":"J Hypertens"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-328X(96)00254-9","article-title":"Organization, sequence and functional analysis of a mouse BDNF promoter","volume":"45","author":"Hayes","year":"1997","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib43","first-page":"6","article-title":"Neurobiological alterations induced by exercise and their impact on depressive disorders","author":"Helmich","year":"2010","journal-title":"Clinical Practice & Epidemiology in mental health"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib44","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1111\/j.1743-6109.2009.01299.x","article-title":"Hypogonadism, decreased sexual desire, and long-term depression in middle-aged men","volume":"6","author":"Hintikka","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/PSY.0b013e31820433a5","article-title":"Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study","volume":"73","author":"Hoffman","year":"2011","journal-title":"Psychosom Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib46","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid receptor hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-2007-971084","article-title":"Serum testosterone responses to continuous and intermittent exercise training in male rats","volume":"20","author":"Hu","year":"1999","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib48","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000184631","article-title":"Kinetics of the pituitary-thyroid axis and the peripheral thyroid hormones in 2 children with thyroxine intoxication","volume":"44","author":"Kaiserman","year":"1995","journal-title":"Horm Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1471-4159.1997.69010034.x","article-title":"Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain","volume":"69","author":"Katoh-Semba","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib51","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/emboj\/19.6.1290","article-title":"BDNF regulates eating behavior and locomotor activity in mice","volume":"19","author":"Kernie","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1756-6606-2-27","article-title":"Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival","volume":"2","author":"Koshimizu","year":"2009","journal-title":"Mol Brain"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib53","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00406-009-0036-y","article-title":"Reduced hippocampal neurogenesis in the GR(+\/\u2212) genetic mouse model of depression","volume":"259","author":"Kronenberg","year":"2009","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib54","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.322.7289.763","article-title":"The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials","volume":"322","author":"Lawlor","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib55","first-page":"242","article-title":"Structure of the rat behaviour in the forced swimming test","volume":"158","author":"Lino-de-Oliveira","year":"2005","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib56","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s11011-009-9157-2","article-title":"Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats","volume":"24","author":"Marais","year":"2009","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib57","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1055\/s-2004-820945","article-title":"Effect of voluntary exercise on the expression of IGF-I and androgen receptor in three rat skeletal muscles and on serum IGF-I and testosterone levels","volume":"25","author":"Matsakas","year":"2004","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib58","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1037\/0022-3514.46.5.1142","article-title":"Influence of aerobic exercise on depression","volume":"46","author":"McCann","year":"1984","journal-title":"J Pers Soc Psychol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib59","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-510X(01)00688-8","article-title":"The serum level of free testosterone is reduced in amyotrophic lateral sclerosis","volume":"195","author":"Militello","year":"2002","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib61","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0140-6736(07)61415-9","article-title":"Depression, chronic diseases, and decrements in health: results from the World Health Surveys","volume":"370","author":"Moussavi","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib62","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1523\/JNEUROSCI.19-06-02069.1999","article-title":"Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons","volume":"19","author":"Mowla","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000097747","article-title":"Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory","volume":"84","author":"Mukai","year":"2006","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib65","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1365-2826.2010.02044.x","article-title":"Androgens selectively protect against apoptosis in hippocampal neurones","volume":"22","author":"Nguyen","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib66","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1249\/00003677-199001000-00016","article-title":"Effect of exercise on depression","volume":"18","author":"North","year":"1990","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib67","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0022-3956(90)90022-I","article-title":"Anhedonia, suicide ideation and dexamethasone nonsuppression in depressed patients","volume":"24","author":"Oei","year":"1990","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib68","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1006\/bbrc.1997.7220","article-title":"Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice","volume":"238","author":"Ono","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib69","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.1100135","article-title":"Cleavage of proBDNF by tPA\/plasmin is essential for long-term hippocampal plasticity","volume":"306","author":"Pang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib70","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0018-506X(02)00016-8","article-title":"Neuroendocrine aspects of hypercortisolism in major depression","volume":"43","author":"Parker","year":"2003","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib71","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1026070911202","article-title":"Searching for the exercise factor: is IL-6 a candidate?","volume":"24","author":"Pedersen","year":"2003","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib72","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1469-7793.2001.0329c.xd","article-title":"Muscle-derived interleukin-6: possible biological effects","volume":"536","author":"Pedersen","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib73","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/1076167502250792","article-title":"Physical activity as a nonpharmacological treatment for depression: a review","volume":"8","author":"Phillips","year":"2003","journal-title":"Complement Health Pract Rev"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib74","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1055\/s-2007-978915","article-title":"Direct effects of stress on adrenocortical function","volume":"30","author":"Pignatelli","year":"1998","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib75","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib76","first-page":"E564","article-title":"Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus","volume":"238","author":"Rannels","year":"1980","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib77","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/sj.npp.1301253","article-title":"Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomized rat","volume":"32","author":"Roche","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib78","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.brainresrev.2007.04.012","article-title":"Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease","volume":"57","author":"Rosario","year":"2008","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib79","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1086\/320716","article-title":"A human immunodeficiency virus-transgenic mouse model for assessing interventions that block microbial-induced proviral expression","volume":"183","author":"Schito","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib80","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0006-8993(99)01909-5","article-title":"Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides","volume":"848","author":"Seidah","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib81","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-0327(97)00168-7","article-title":"Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression","volume":"48","author":"Seidman","year":"1998","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib82","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1152\/physiolgenomics.00093.2007","article-title":"Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice","volume":"31","author":"Sha","year":"2007","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib83","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1001\/archpsyc.61.2.162","article-title":"Increased incidence of diagnosed depressive illness in hypogonadal older men","volume":"61","author":"Shores","year":"2004","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib84","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1399-6576.2008.01801.x","article-title":"The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality","volume":"53","author":"Stensballe","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib85","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12017-008-8027-0","article-title":"Central mechanisms of HPA axis regulation by voluntary exercise","volume":"10","author":"Stranahan","year":"2008","journal-title":"Neuromol Med"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib86","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1523\/JNEUROSCI.5123-04.2005","article-title":"ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin","volume":"25","author":"Teng","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib87","first-page":"365","article-title":"Quantitative immunohistochemical determination of 8-hydroxy-2\u2032-deoxyguanosine by a monoclonal antibody N451: its application to ferric nitrilotriacetate-induced renal carcinogenesis model","volume":"76","author":"Toyokuni","year":"1997","journal-title":"Lab Invest"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib88","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/cncr.23785","article-title":"The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes","volume":"113","author":"Tsimberidou","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib89","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbr.2005.08.012","article-title":"Hippocampal cell proliferation across the day: increase by running wheel activity, but no effect of sleep and wakefulness","volume":"167","author":"van der Borght","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib90","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tins.2008.12.007","article-title":"Exercise and the brain: something to chew on","volume":"32","author":"van Praag","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib91","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib92","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/6368","article-title":"Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus","volume":"2","author":"van Praag","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib93","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2008.09.001","article-title":"Frequency of climbing behavior as a predictor of altered motor activity in rat forced swimming test","volume":"445","author":"Vieira","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib94","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1210\/jc.2002-020878","article-title":"Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients","volume":"87","author":"Weill-Engerer","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib95","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1519\/JSC.0b013e3181bab493","article-title":"Effects of different intensities of resistance exercise on regulators of myogenesis","volume":"23","author":"Wilborn","year":"2009","journal-title":"J Strength Cond Res"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib96","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib97","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0031-9384(95)02256-2","article-title":"Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight","volume":"60","author":"Willner","year":"1996","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib98","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/00005768-199608000-00011","article-title":"Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans","volume":"28","author":"Wittert","year":"1996","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib99","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nn1510","article-title":"Activation of p75NTR by proBDNF facilitates hippocampal long-term depression","volume":"8","author":"Woo","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib100","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nn1073","article-title":"Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor","volume":"6","author":"Xu","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib101","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/1097-4695(20000905)44:3<308::AID-NEU2>3.0.CO;2-M","article-title":"Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons","volume":"44","author":"Yang","year":"2000","journal-title":"J Neurobiol"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib102","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neulet.2010.05.058","article-title":"Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF)","volume":"479","author":"Yarrow","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib103","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1253\/circj.71.1086","article-title":"Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention","volume":"71","author":"Yip","year":"2007","journal-title":"Circ J"},{"key":"10.1016\/j.neuroscience.2011.05.075_bib104","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/13685530601040679","article-title":"Testosterone and the brain","volume":"9","author":"Zitzmann","year":"2006","journal-title":"Aging Male"},{"issue":"Suppl 7","key":"10.1016\/j.neuroscience.2011.05.075_bib105","first-page":"119","article-title":"Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men","volume":"59","author":"Zoladz","year":"2008","journal-title":"J Physiol Pharmacol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211006725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211006725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T15:18:02Z","timestamp":1637939882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452211006725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":105,"alternative-id":["S0306452211006725"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2011.05.075","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}