{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:33:14Z","timestamp":1762101194277,"version":"3.38.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.neuroscience.2011.06.069","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T22:02:39Z","timestamp":1312236159000},"page":"452-465","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Potential mechanisms for hypoalgesia induced by anti-nerve growth factor immunoglobulin are identified using autoimmune nerve growth factor deprivation"],"prefix":"10.1016","volume":"193","author":[{"given":"E.M.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.B.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2011.06.069_bib1","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1110\/ps.035402.108","article-title":"Probing the binding mechanism and affinity of tanezumab, a recombinant humanized anti-NGF monoclonal antibody, using a repertoire of biosensors","volume":"17","author":"Abdiche","year":"2008","journal-title":"Protein Sci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1126\/science.1156916","article-title":"The cell and molecular basis of mechanical, cold, and inflammatory pain","volume":"321","author":"Abrahamsen","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/379257a0","article-title":"A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons","volume":"379","author":"Akopian","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/9195","article-title":"The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways","volume":"2","author":"Akopian","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib5","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1523\/JNEUROSCI.14-03-01422.1994","article-title":"Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system","volume":"14","author":"Albers","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0006-8993(88)91532-6","article-title":"Presence of calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity in intraepidermal free nerve endings of cat skin","volume":"442","author":"Alvarez","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib7","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1460-9568.1995.tb01143.x","article-title":"Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons","volume":"7","author":"Averill","year":"1995","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neulet.2008.06.079","article-title":"Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice","volume":"442","author":"Beiswenger","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib9","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1046\/j.1460-9568.1998.00139.x","article-title":"Endogenous nerve growth factor regulates the sensitivity of nociceptors in the adult rat","volume":"10","author":"Bennett","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/laban0906-24","article-title":"Blood collection from the tail of a rat","volume":"35","author":"Brown","year":"2006","journal-title":"Lab Anim (NY)"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.neuroscience.2007.02.068","article-title":"Expression of the vesicular glutamate transporters-1 and -2 in adult mouse dorsal root ganglia and spinal cord and their regulation by nerve injury","volume":"147","author":"Brumovsky","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib12","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1172\/JCI43195","article-title":"The discovery and development of analgesics: new mechanisms, new modalities","volume":"120","author":"Burgess","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1471-4892(01)00002-9","article-title":"Peripheral excitatory amino acids","volume":"1","author":"Carlton","year":"2001","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-8993(96)00619-1","article-title":"Localization and activation of substance P receptors in unmyelinated axons of rat glabrous skin","volume":"734","author":"Carlton","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib15","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pain.2010.11.012","article-title":"On the relationship between nociceptive evoked potentials and intraepidermal nerve fiber density in painful sensory polyneuropathies","volume":"152","author":"Casanova-Molla","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib16","first-page":"94","article-title":"Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain","volume":"12","author":"Cattaneo","year":"2010","journal-title":"Curr Opin Mol Ther"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib17","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/NEN.0b013e3181bef710","article-title":"Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes","volume":"68","author":"Cheng","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0006-8993(97)00681-1","article-title":"Nerve growth factor depletion by autoimmunization produces thermal hypoalgesia in adult rats","volume":"765","author":"Chudler","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/jpet.104.066225","article-title":"Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA","volume":"310","author":"Colquhoun","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/prot.20366","article-title":"Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight","volume":"58","author":"Covaceuszach","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/00001756-200002280-00014","article-title":"Peripheral glutamate release in the hind paw following low and high intensity sciatic stimulation","volume":"11","author":"deGroot","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","article-title":"Sodium channels in normal and pathological pain","volume":"33","author":"Dib-Hajj","year":"2010","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib23","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1523\/JNEUROSCI.21-22-08722.2001","article-title":"Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons","volume":"21","author":"Djouhri","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib24","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.1072-06.2006","article-title":"Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav19 expression","volume":"26","author":"Fang","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/jn.1999.81.2.803","article-title":"In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons","volume":"81","author":"Fjell","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib26","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00000658-199911000-00002","article-title":"Nerve growth factor and its high-affinity receptor in chronic pancreatitis","volume":"230","author":"Friess","year":"1999","journal-title":"Ann Surg"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jor.20986","article-title":"Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model","volume":"28","author":"Fukui","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/cne.21786","article-title":"Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons","volume":"510","author":"Fukuoka","year":"2008","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0006-8993(80)90341-8","article-title":"Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach","volume":"198","author":"Gorin","year":"1980","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib30","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1073\/pnas.76.10.5382","article-title":"Experimental autoimmune model of nerve growth factor deprivation: effects on developing peripheral sympathetic and sensory neurons","volume":"76","author":"Gorin","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0006-8993(99)02216-7","article-title":"A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain","volume":"854","author":"Gould","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib32","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1023\/A:1022475432077","article-title":"Elevated nerve growth factor levels in the synovial fluid of patients with inflammatory joint disease","volume":"23","author":"Halliday","year":"1998","journal-title":"Neurochem Res"},{"issue":"4","key":"10.1016\/j.neuroscience.2011.06.069_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.burns.2010.11.010","article-title":"Changes in cutaneous innervation in patients with chronic pain after burns","volume":"37","author":"Hamed","year":"2011","journal-title":"Burns"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2005.12.001","article-title":"Novel class of pain drugs based on antagonism of NGF","volume":"27","author":"Hefti","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neulet.2010.01.066","article-title":"Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat","volume":"472","author":"Hoffman","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1369\/jhc.2009.954008","article-title":"Fixative composition alters distributions of immunoreactivity for glutaminase and two markers of nociceptive neurons, Nav18 and TRPV1, in the rat dorsal root ganglion","volume":"58","author":"Hoffman","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib38","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.peptides.2004.02.004","article-title":"Just cool it! Cryoprotectant anti-freeze in immunocytochemistry and in situ hybridization","volume":"25","author":"Hoffman","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/humu.1224","article-title":"Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor","volume":"18","author":"Indo","year":"2001","journal-title":"Hum Mutat"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib40","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1586\/ern.10.154","article-title":"Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis","volume":"10","author":"Indo","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jhsa.2009.10.030","article-title":"Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related peptide expression in a rat model of wrist joint inflammatory pain","volume":"35","author":"Iwakura","year":"2010","journal-title":"J Hand Surg Am"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib42","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1073\/pnas.0611364104","article-title":"A-803467, a potent and selective Nav18 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat","volume":"104","author":"Jarvis","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib43","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.neuroscience.2005.12.049","article-title":"Effect of morphine on the release of excitatory amino acids in the rat hind instep: pain is modulated by the interaction between the peripheral opioid and glutamate systems","volume":"138","author":"Jin","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0006-8993(82)90650-3","article-title":"Effects of autoimmune NGF deprivation in the adult rabbit and offspring","volume":"240","author":"Johnson","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0169-328X(01)00224-8","article-title":"Difference in binding by isolectin B4 to trkA and c-ret mRNA-expressing neurons in rat sensory ganglia","volume":"95","author":"Kashiba","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0306-4522(96)00334-X","article-title":"Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons","volume":"76","author":"Kashiba","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0006-8993(89)90990-6","article-title":"Antinociceptive effect of intrathecally administered antiserum against calcitonin gene-related peptide on thermal and mechanical noxious stimuli in experimental hyperalgesic rats","volume":"497","author":"Kawamura","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib48","series-title":"Peripheral neuropathy","first-page":"869","article-title":"Pathology and quantification of cutaneous nerves","author":"Kennedy","year":"2005"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s004410000202","article-title":"Increase in NGF content and nerve fiber sprouting in human allergic contact eczema","volume":"302","author":"Kinkelin","year":"2000","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aanat.2006.07.006","article-title":"Effect of vinpocetine on retrograde axoplasmic transport","volume":"189","author":"Knyihar-Csillik","year":"2007","journal-title":"Ann Anat"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib51","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1046\/j.1460-9568.1999.00590.x","article-title":"Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin","volume":"11","author":"Koltzenburg","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib52","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0304-3940(88)90611-8","article-title":"Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide","volume":"92","author":"Kuraishi","year":"1988","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib53","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","article-title":"Tanezumab for the treatment of pain from osteoarthritis of the knee","volume":"363","author":"Lane","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1096-9861(19960212)365:3<355::AID-CNE2>3.0.CO;2-3","article-title":"Electrophysiological properties of neurones with CGRP-like immunoreactivity in rat dorsal root ganglia","volume":"365","author":"Lawson","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Animal models of nociception","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib56","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1073\/pnas.46.3.384","article-title":"Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein","volume":"46","author":"Levi-Montalcini","year":"1960","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-3940(95)12299-0","article-title":"Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons","volume":"204","author":"Li","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib58","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/sj.bjp.0701239","article-title":"Differential antinociceptive effects of spinal opioids on foot withdrawal responses evoked by C fibre or A delta nociceptor activation","volume":"121","author":"Lu","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib59","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/00001756-199703030-00001","article-title":"The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependent","volume":"8","author":"Ma","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib60","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1111\/j.1471-4159.1981.tb00439.x","article-title":"Transported enzymes in sciatic nerve and sensory ganglia of rats exposed to maternal antibodies against nerve growth factor","volume":"36","author":"McDougal","year":"1981","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib61","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1098\/rstb.1996.0039","article-title":"NGF as a mediator of inflammatory pain","volume":"351","author":"McMahon","year":"1996","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib62","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/0896-6273(94)90323-9","article-title":"Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets","volume":"12","author":"McMahon","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib63","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm0895-774","article-title":"The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule","volume":"1","author":"McMahon","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0306-4522(91)90175-N","article-title":"Ultrastructural visualization of glutamate and aspartate immunoreactivities in the rat dorsal horn, with special reference to the co-localization of glutamate, substance P and calcitonin-gene related peptide","volume":"40","author":"Merighi","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib65","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3940(93)90926-C","article-title":"Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)","volume":"160","author":"Miller","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib66","first-page":"249.10","article-title":"Intraplantar glutaminase inhibition: analgesic dose response of 6-diazo-5-oxo-l-norleucine during adjuvant induced arthritis in rats","author":"Miller","year":"2006","journal-title":"Proc Soc Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib67","unstructured":"Miller KE, Herzog BH, Sutharshan M (2010) 6-diazo-5-oxo-L-norleucine: a glutaminase inhibitor with local analgesic properties. 13th World Congress on Pain, PT 421."},{"issue":"3","key":"10.1016\/j.neuroscience.2011.06.069_bib68","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pharmthera.2011.01.005","article-title":"Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms","volume":"130","author":"Miller","year":"2011","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib69","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0090-4295(01)01597-7","article-title":"Nerve growth factor and chronic prostatitis\/chronic pelvic pain syndrome","volume":"59","author":"Miller","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-3940(91)90819-F","article-title":"Effect of neurokinin A, substance P and calcitonin gene related peptide in peripheral hyperalgesia in the rat paw","volume":"124","author":"Nakamura-Craig","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib71","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0006-8993(97)01568-0","article-title":"Formalin-induced release of excitatory amino acids in the skin of the rat hind paw","volume":"787","author":"Omote","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib72","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/jor.21170","article-title":"Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs","volume":"28","author":"Orita","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib73","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0006-8993(79)90871-0","article-title":"Immunization of adult rats against 2.5 S NGF: effects on the peripheral sympathetic nervous system","volume":"176","author":"Otten","year":"1979","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib74","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0022-3565(24)38269-2","article-title":"Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the rat","volume":"289","author":"Owolabi","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib75","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0196-9781(91)90022-H","article-title":"Calcitonin gene-related peptide, neurokinin A and substance P: effects on nociception and neurogenic inflammation in human skin and temporal muscle","volume":"12","author":"Pedersen-Bjergaard","year":"1991","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib76","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.neuro.29.051605.112929","article-title":"Neurotrophins: mediators and modulators of pain","volume":"29","author":"Pezet","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib77","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1098\/rstb.1996.0036","article-title":"Expression of the trk family of neurotrophin receptors in developing and adult dorsal root ganglion neurons","volume":"351","author":"Phillips","year":"1996","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib78","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.2337\/diacare.27.8.1974","article-title":"Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients","volume":"27","author":"Pittenger","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib79","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-3959(96)03048-5","article-title":"Individual differences in the hot plate test and effects of habituation on sensitivity to morphine","volume":"66","author":"Plone","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib80","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jpain.2006.09.005","article-title":"Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse","volume":"8","author":"Price","year":"2007","journal-title":"J Pain"},{"issue":"Suppl 2","key":"10.1016\/j.neuroscience.2011.06.069_bib81","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s003930050226","article-title":"Efferent functions of C-fiber nociceptors","volume":"57","author":"Sann","year":"1998","journal-title":"Z Rheumatol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib82","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0168-0102(99)00083-8","article-title":"Nerve growth factor stimulates synthesis of calcitonin gene-related peptide in dorsal root ganglion cells during sensory regeneration in capsaicin-treated rats","volume":"35","author":"Schicho","year":"1999","journal-title":"Neurosci Res"},{"issue":"6","key":"10.1016\/j.neuroscience.2011.06.069_bib83","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.joca.2011.01.009","article-title":"Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain","volume":"19","author":"Schnitzer","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib84","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.pain.2010.06.034","article-title":"Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurements","volume":"151","author":"Selim","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib85","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pain.2005.02.022","article-title":"Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization","volume":"115","author":"Sevcik","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib86","first-page":"1","article-title":"Skin homeostasis during inflammation: a role for nerve growth factor","volume":"23","author":"Sivilia","year":"2008","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib87","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.neurobiolaging.2005.04.009","article-title":"Reduced thermal sensitivity and Nav18 and TRPV1 channel expression in sensory neurons of aged mice","volume":"27","author":"Wang","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib88","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2165\/0063030-200822060-00002","article-title":"Targeting nerve growth factor in pain: what is the therapeutic potential?","volume":"22","author":"Watson","year":"2008","journal-title":"Biodrugs"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib89","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0006-8993(90)91233-7","article-title":"The specific antagonistic effect of intrathecal spantide II on substance P- and C-fiber conditioning stimulation-induced facilitation of the nociceptive flexor reflex in rat","volume":"526","author":"Wiesenfeld-Hallin","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib90","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMe1004416","article-title":"Nerve growth factor and pain","volume":"363","author":"Wood","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib91","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors\u2014noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib92","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0306-4522(94)90366-2","article-title":"Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity","volume":"62","author":"Woolf","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib93","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0304-3959(96)03177-6","article-title":"Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence","volume":"68","author":"Yeomans","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib94","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3959(02)00241-5","article-title":"Excitatory amino acid release in the spinal cord caused by plantar incision in the rat","volume":"100","author":"Zahn","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.06.069_bib95","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.neuroscience.2011.06.069_bib96","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.yrtph.2010.11.005","article-title":"A multiple-dose toxicity study of tanezumab in cynomolgus monkeys","volume":"59","author":"Zorbas","year":"2011","journal-title":"Regul Toxicol Pharmacol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211007792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211007792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:39:46Z","timestamp":1741394386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452211007792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":96,"alternative-id":["S0306452211007792"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2011.06.069","relation":{},"ISSN":["0306-4522"],"issn-type":[{"type":"print","value":"0306-4522"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}