{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:54:50Z","timestamp":1762808090467},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.neuroscience.2011.07.047","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T12:36:15Z","timestamp":1311942975000},"page":"283-290","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Early-life exposure to lipopolysaccharide reduces the severity of experimental autoimmune encephalomyelitis in adulthood and correlated with increased urine corticosterone and apoptotic CD4+ T cells"],"prefix":"10.1016","volume":"193","author":[{"given":"Z.-W.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.-H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-F.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Thomas","family":"O'Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-T.","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.-Y.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2011.07.047_bib1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0031-9384(00)00365-6","article-title":"Persistent stress-induced elevations of urinary corticosterone in rats","volume":"71","author":"Brennan","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbi.2007.12.004","article-title":"Reduced telomerase activity in human T lymphocytes exposed to cortisol","volume":"22","author":"Choi","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1055\/s-2008-1065330","article-title":"Effect of constant light on prolactin and corticosterone rhythms evaluated using a noninvasive urine sampling protocol in the rat","volume":"40","author":"Claustrat","year":"2008","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4049\/jimmunol.0803576","article-title":"Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells","volume":"183","author":"Ellestad","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/eph8702411","article-title":"Neuroendocrine function and chronic inflammatory stress","volume":"87","author":"Harbuz","year":"2002","journal-title":"Exp Physiol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00018-005-5390-y","article-title":"Glucocorticoids in T cell apoptosis and function","volume":"63","author":"Herold","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib7","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1523\/JNEUROSCI.4485-05.2006","article-title":"Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia","volume":"26","author":"Hou","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbrc.2007.12.103","article-title":"Sustained up-regulation of semaphorin 3A, Neuropilin1, and doublecortin expression in ischemic mouse brain during long-term recovery","volume":"367","author":"Hou","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 4","key":"10.1016\/j.neuroscience.2011.07.047_bib9","first-page":"87","article-title":"Effect of neonatal endotoxemia on the pancreas of adult rats","volume":"59","author":"Jaworek","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib10","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.4049\/jimmunol.180.8.5172","article-title":"Cutting edge: immunosuppressant as adjuvant for tolerogenic immunization","volume":"180","author":"Kang","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1084\/jem.168.1.213","article-title":"Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL\/J mice","volume":"168","author":"Kono","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib12","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/IAI.71.9.4996-5004.2003","article-title":"Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis","volume":"71","author":"La Flamme","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbrc.2010.06.086","article-title":"Neonatal endotoxin exposure suppresses experimental autoimmune encephalomyelitis through regulating the immune cells responsivity in the central nervous system of adult rats","volume":"398","author":"Li","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib14","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn.2436","article-title":"Dynamic DNA methylation programs persistent adverse effects of early-life stress","volume":"12","author":"Murgatroyd","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0165-5728(99)00139-3","article-title":"IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35\u201355 induced experimental autoimmune encephalomyelitis","volume":"101","author":"Okuda","year":"1999","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/archneur.63.4.611","article-title":"Not every patient with multiple sclerosis should be treated at time of diagnosis","volume":"63","author":"Pittock","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jns.2004.04.019","article-title":"Corticosteroids treatment","volume":"223","author":"Pozzilli","year":"2004","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00415-008-0878-7","article-title":"Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis","volume":"255","author":"Ramagopalan","year":"2008","journal-title":"J Neurol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib19","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1586\/14737175.6.11.1657","article-title":"Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"6","author":"Reichardt","year":"2006","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/intimm\/dxg012","article-title":"Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization","volume":"15","author":"Sewell","year":"2003","journal-title":"Int Immunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1523\/JNEUROSCI.15-01-00376.1995","article-title":"Neonatal endotoxin exposure alters the development of the hypothalamic-pituitary-adrenal axis: early illness and later responsivity to stress","volume":"15","author":"Shanks","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib22","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1073\/pnas.090571897","article-title":"Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation","volume":"97","author":"Shanks","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.nbd.2004.07.015","article-title":"Genes, environment, and susceptibility to multiple sclerosis","volume":"17","author":"Sotgiu","year":"2004","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib25","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S1474-4422(10)70249-0","article-title":"Pharmacological management of symptoms in multiple sclerosis: current approaches and future directions","volume":"9","author":"Thompson","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2007.03.007","article-title":"Glucocorticoids in the control of neuroinflammation","volume":"275","author":"Tischner","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib27","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/eji.200324735","article-title":"Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage","volume":"34","author":"van den Brandt","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainres.2008.11.059","article-title":"Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis","volume":"1253","author":"Wang","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jaci.2006.03.020","article-title":"Neonatal exposure with LPS and\/or allergen prevents experimental allergic airways disease: development of tolerance using environmental antigens","volume":"118","author":"Wang","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/labinvest.3780235","article-title":"Multiple sclerosis: current pathophysiological concepts","volume":"81","author":"Wingerchuk","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.neuroscience.2011.07.047_bib31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.autrev.2010.11.009","article-title":"The kaleidoscope of glucorticoid effects on immune system","volume":"10","author":"Zen","year":"2011","journal-title":"Autoimmun Rev"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211008724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211008724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T11:21:48Z","timestamp":1560424908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452211008724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":31,"alternative-id":["S0306452211008724"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2011.07.047","relation":{},"ISSN":["0306-4522"],"issn-type":[{"type":"print","value":"0306-4522"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}