{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:15:25Z","timestamp":1760984125157,"version":"build-2065373602"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.neuroscience.2011.10.019","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T11:05:24Z","timestamp":1319454324000},"page":"199-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism"],"prefix":"10.1016","volume":"200","author":[{"given":"C.A.","family":"Christianson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.L.","family":"Fitzsimmons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-Y.","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.L.","family":"Yaksh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2011.10.019_bib1","doi-asserted-by":"crossref","first-page":"28261","DOI":"10.1074\/jbc.M103608200","article-title":"Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)","volume":"276","author":"Agnihotri","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/cmdc.200700290","article-title":"Zinc-binding groups modulate selective inhibition of MMPs","volume":"3","author":"Agrawal","year":"2008","journal-title":"ChemMedChem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2007.06.003","article-title":"MMPs in the central nervous system: where the good guys go bad","volume":"19","author":"Agrawal","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib4","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1073\/pnas.0407106102","article-title":"Conformational variability of matrix metalloproteinases: beyond a single 3D structure","volume":"102","author":"Bertini","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jmb.2003.12.033","article-title":"Crystal structure of the catalytic domain of human matrix metalloproteinase 10","volume":"336","author":"Bertini","year":"2004","journal-title":"J Mol Biol"},{"issue":"Suppl 1","key":"10.1016\/j.neuroscience.2011.10.019_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-2006-939553","article-title":"Protease-activated receptors: how proteases signal to cells to cause inflammation and pain","volume":"32","author":"Bunnett","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10409230701340019","article-title":"The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases","volume":"42","author":"Cauwe","year":"2007","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1026028303196","article-title":"Regulation of matrix metalloproteinases: an overview","volume":"253","author":"Chakraborti","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/brbi.1995.1033","article-title":"Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-d-aspartate receptors","volume":"9","author":"Chao","year":"1995","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2010.02.008","article-title":"Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior","volume":"149","author":"Choi","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-5728(96)00210-X","article-title":"Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor","volume":"74","author":"Clements","year":"1997","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neulet.2008.01.070","article-title":"TNF-alpha differentially modulates ion channels of nociceptive neurons","volume":"434","author":"Czeschik","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0165-0270(97)00097-6","article-title":"Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli","volume":"76","author":"Dirig","year":"1997","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib15","first-page":"312","article-title":"Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells","volume":"17","author":"Duivenvoorden","year":"1997","journal-title":"Invasion Metastasis"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.plefa.2004.03.004","article-title":"Brain phospholipases A2: a perspective on the history","volume":"71","author":"Farooqui","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib17","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/BST0350689","article-title":"Matrix metalloproteinases: useful and deleterious","volume":"35","author":"Ganea","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroscience.2008.05.045","article-title":"High resolution in situ zymography reveals matrix metalloproteinase activity at glutamatergic synapses","volume":"158","author":"Gawlak","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/jnr.490360409","article-title":"Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein","volume":"36","author":"Gijbels","year":"1993","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib20","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.1021\/bi00146a017","article-title":"Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids","volume":"31","author":"Grobelny","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib21","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/j.1460-9568.2005.04451.x","article-title":"Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia","volume":"22","author":"Hua","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib22","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.exger.2006.11.012","article-title":"Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K\/Akt pathway","volume":"42","author":"Ito","year":"2007","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib23","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/cbic.200800148","article-title":"A macrophage cell model for selective metalloproteinase inhibitor design","volume":"9","author":"Jacobsen","year":"2008","journal-title":"Chembiochem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3959(99)00262-6","article-title":"Nociceptive and inflammatory effects of subcutaneous TNFalpha","volume":"85","author":"Junger","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm1723","article-title":"Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain","volume":"14","author":"Kawasaki","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib26","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1523\/JNEUROSCI.4346-04.2005","article-title":"Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia","volume":"25","author":"Kim","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0014-5793(92)80300-6","article-title":"A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases","volume":"296","author":"Knight","year":"1992","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/glia.20483","article-title":"Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury","volume":"55","author":"Kozai","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib29","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1126\/science.1065057","article-title":"Regulation of cell survival by secreted proneurotrophins","volume":"294","author":"Lee","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib30","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/jm960871c","article-title":"Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits","volume":"40","author":"MacPherson","year":"1997","journal-title":"J Med Chem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib31","first-page":"109","article-title":"Intrathecal catheterization and drug delivery in the rat","volume":"99","author":"Malkmus","year":"2004","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib32","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1700","article-title":"Role of the immune system in chronic pain","volume":"6","author":"Marchand","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib33","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.expneurol.2004.11.001","article-title":"Immune and glial cell factors as pain mediators and modulators","volume":"192","author":"McMahon","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrn2533","article-title":"Pathological and protective roles of glia in chronic pain","volume":"10","author":"Milligan","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib35","doi-asserted-by":"crossref","first-page":"9462","DOI":"10.1021\/bi0260132","article-title":"The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity","volume":"41","author":"Mohan","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib36","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1523\/JNEUROSCI.22-17-07526.2002","article-title":"Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events","volume":"22","author":"Noble","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib37","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/glia.20478","article-title":"Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia","volume":"55","author":"Nuttall","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib38","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1016\/S0021-9258(19)50563-4","article-title":"Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9","volume":"267","author":"Ogata","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib39","first-page":"729","article-title":"Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states","volume":"152","author":"Pagenstecher","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/path.2440","article-title":"The human protein atlas\u2014a tool for pathology","volume":"216","author":"Pont\u00e9n","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib41","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1210\/en.2007-1282","article-title":"Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling","volume":"149","author":"Prast","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib42","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1530\/rep.1.00234","article-title":"EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways","volume":"128","author":"Qiu","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/eujp.2000.0177","article-title":"Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat","volume":"4","author":"Reeve","year":"2000","journal-title":"Eur J Pain"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/FJC.0b013e3181a6aa83","article-title":"Effects of novel semiselective matrix metalloproteinase inhibitors on ex vivo cardiac structure-function","volume":"53","author":"Romero-Perez","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib45","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00004647-199605000-00002","article-title":"Proteolytic cascade enzymes increase in focal cerebral ischemia in rat","volume":"16","author":"Rosenberg","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-8993(89)90078-4","article-title":"Production of tumor necrosis factor-alpha by microglia and astrocytes in culture","volume":"491","author":"Sawada","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib47","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.expneurol.2003.09.015","article-title":"Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat","volume":"185","author":"Sch\u00e4fers","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib48","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.4049\/jimmunol.161.7.3340","article-title":"Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing","volume":"161","author":"Sch\u00f6nbeck","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(99)02321-5","article-title":"Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury","volume":"855","author":"Shubayev","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jnr.20160","article-title":"Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro","volume":"77","author":"Shubayev","year":"2004","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib51","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.4049\/jimmunol.0901925","article-title":"Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: evidence for the role of TNF-alpha and cyclooxygenase-2","volume":"183","author":"Steenport","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib52","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1523\/JNEUROSCI.4486-04.2005","article-title":"Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha","volume":"25","author":"Stellwagen","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib53","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1046\/j.1471-4159.2003.01969.x","article-title":"Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing","volume":"86","author":"Svensson","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neulet.2004.12.064","article-title":"Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38","volume":"379","author":"Svensson","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tins.2004.12.002","article-title":"Neuropathic pain and spinal microglia: a big problem from molecules in \u201csmall\u201d glia","volume":"28","author":"Tsuda","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib56","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/89945","article-title":"Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway","volume":"7","author":"Vergnolle","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib57","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.bmc.2007.01.026","article-title":"Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases","volume":"15","author":"Vidal","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib58","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nrd1251","article-title":"Glia: a novel drug discovery target for clinical pain","volume":"2","author":"Watkins","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib59","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","article-title":"Metalloproteinases in biology and pathology of the nervous system","volume":"2","author":"Yong","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib60","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/jnr.21726","article-title":"Exogenous tumor necrosis factor-alpha rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn","volume":"86","author":"Youn","year":"2008","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2011.10.019_bib61","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.1523\/JNEUROSCI.2437-10.2010","article-title":"A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha","volume":"30","author":"Zhang","year":"2010","journal-title":"J Neurosci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211011936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452211011936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:36:47Z","timestamp":1759678607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452211011936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":61,"alternative-id":["S0306452211011936"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2011.10.019","relation":{},"ISSN":["0306-4522"],"issn-type":[{"type":"print","value":"0306-4522"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2011.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}