{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:29:09Z","timestamp":1790702949449,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.neuroscience.2012.02.028","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T20:02:03Z","timestamp":1329940923000},"page":"47-53","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs"],"prefix":"10.1016","volume":"209","author":[{"given":"Y.","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.02.028_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2008.11.048","article-title":"Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model","volume":"1256","author":"Cai","year":"2009","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2008.05.077","article-title":"Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model","volume":"441","author":"Cai","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jss.2009.07.045","article-title":") The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats","volume":"167","author":"Chen","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbrc.2010.02.005","article-title":"Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats","volume":"393","author":"Chen","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.bbrc.2007.07.088","article-title":"Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia\/reperfusion through reducing oxidative stress","volume":"361","author":"Fukuda","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib6a","doi-asserted-by":"crossref","first-page":"H1062","DOI":"10.1152\/ajpheart.00150.2011","article-title":"Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice","volume":"301","author":"Hayashi","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5955(03)00067-4","article-title":"Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA","volume":"179","author":"Hight","year":"2003","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0378-5955(02)00286-1","article-title":"Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise","volume":"166","author":"Hu","year":"2002","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0378-5955(97)00143-3","article-title":"R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla","volume":"113","author":"Hu","year":"1997","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbrc.2011.04.008","article-title":"Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation","volume":"408","author":"Huang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2011.05.068","article-title":"Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus","volume":"1404","author":"Hugyecz","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/WNR.0b013e32832a5c68","article-title":"Hydrogen protects auditory hair cells from free radicals","volume":"20","author":"Kikkawa","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(00)02733-5","article-title":"Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea","volume":"878","author":"Ohinata","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000013846","article-title":"Early elevation of cochlear reactive oxygen species following noise exposure","volume":"4","author":"Ohlemiller","year":"1999","journal-title":"Audiol Neurootol"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib17","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1177\/019459989310900613","article-title":"The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage","volume":"109","author":"Seidman","year":"1993","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.heares.2006.08.010","article-title":"Therapeutic efficacy of intra-cochlear administration of methylprednisolone after acoustic trauma caused by gunshot noise in guinea pigs","volume":"221","author":"Sendowski","year":"2006","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib19","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.jss.2010.09.024","article-title":"Hydrogen-rich saline provides protection against hyperoxic lung injury","volume":"165","author":"Sun","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib20","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.3181\/0812-RM-349","article-title":"Hydrogen-rich saline protects myocardium against ischemia\/reperfusion injury in rats","volume":"234","author":"Sun","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0378-5955(96)00040-8","article-title":"Selective inner hair cell loss does not alter distortion product otoacoustic emissions","volume":"96","author":"Trautwein","year":"1996","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/00016489509121877","article-title":"The emergence of free radicals after acoustic trauma and strial blood flow","volume":"519","author":"Yamane","year":"1995","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/16513860903335795","article-title":"Functional and structural changes in the chinchilla cochlea and vestibular system following round window application of carboplatin","volume":"7","author":"Zhou","year":"2009","journal-title":"Audiol Med"},{"key":"10.1016\/j.neuroscience.2012.02.028_bib25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/00016480802342424","article-title":"Intratympanic administration of methylprednisolone reduces impact of experimental intensive impulse noise trauma on hearing","volume":"129","author":"Zhou","year":"2009","journal-title":"Acta Otolaryngol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212001716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212001716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T03:36:36Z","timestamp":1561347396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452212001716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":24,"alternative-id":["S0306452212001716"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.02.028","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}