{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:25:10Z","timestamp":1773674710177,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004888","name":"Illinois Department of Public Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004888","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.neuroscience.2012.04.043","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T17:07:26Z","timestamp":1335373646000},"page":"160-173","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation"],"prefix":"10.1016","volume":"215","author":[{"given":"Y.","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.-Q.","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-M.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.-B.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-G.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-X.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.04.043_b0005","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/brain\/awn312","article-title":"Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies","volume":"132","author":"Adalbert","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0010","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/337688a0","article-title":"A nose for Alzheimer\u2019s disease?","volume":"337","author":"Altman","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0015","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/ana.21910","article-title":"Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease","volume":"67","author":"Arnold","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/JAD-2005-7208","article-title":"Olfactory involvement in aging and Alzheimer\u2019s disease: an autopsy study","volume":"7","author":"Attems","year":"2005","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0025","first-page":"265","article-title":"Olfactory tau pathology in Alzheimer disease and mild cognitive impairment","volume":"25","author":"Attems","year":"2006","journal-title":"Clin Neuropathol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0030","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3233\/JAD-2010-100696","article-title":"Olfactory deficits and amyloid-\u03b2 burden in Alzheimer\u2019s disease, mild cognitive impairment, and healthy aging: a PiB PET study","volume":"22","author":"Bahar-Fuchs","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/85064","article-title":"BACE1 is the major beta-secretase for generation of Abeta peptides by neurons","volume":"4","author":"Cai","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12640-011-9256-9","article-title":"BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer\u2019s disease: differential A\u03b2 antibody labeling of early-onset axon terminal pathology","volume":"21","author":"Cai","year":"2012","journal-title":"Neurotox Res"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0045","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/srep00231","article-title":"The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease","volume":"2","author":"Cao","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0050","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbr.2011.06.029","article-title":"Olfactory memory is impaired in a triple transgenic model of Alzheimer disease","volume":"224","author":"Cassano","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0055","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.otohns.2005.12.035","article-title":"Nasal health in Down syndrome: a cross-sectional study","volume":"134","author":"Chen","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0060","doi-asserted-by":"crossref","first-page":"13699","DOI":"10.1523\/JNEUROSCI.1714-11.2011","article-title":"In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function","volume":"31","author":"Cheng","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1017\/S0317167100002389","article-title":"Early olfactory involvement in Alzheimer\u2019s disease","volume":"30","author":"Christen-Zaech","year":"2003","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-3806(95)00083-P","article-title":"Expression of the amyloid protein precursor of Alzheimer\u2019s disease in the developing rat olfactory system","volume":"88","author":"Clarris","year":"1995","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0075","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/000348949510400812","article-title":"Beta-amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer\u2019s disease, Parkinson\u2019s disease, and Down syndrome","volume":"104","author":"Crino","year":"1985","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0080","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-2011-110089","article-title":"Changing perspectives on Alzheimer\u2019s disease: thinking outside the amyloid box","volume":"25","author":"D\u2019Alton","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0085","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0197-4580(93)90121-Q","article-title":"Axonal loss from the olfactory tracts in Alzheimer\u2019s disease","volume":"14","author":"Davies","year":"1993","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0090","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1176\/appi.ajp.157.9.1399","article-title":"Olfactory deficits in patients with mild cognitive impairment predict Alzheimer\u2019s disease at follow-up","volume":"157","author":"Devanand","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0095","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.neurobiolaging.2006.11.014","article-title":"Olfaction in patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"29","author":"Djordjevic","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.47.1.56","article-title":"The olfactory bulbs in Alzheimer\u2019s disease","volume":"47","author":"Esiri","year":"1984","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0105","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1460-9568.2007.05400.x","article-title":"Synapse-specific localization of vesicular glutamate transporters in the rat olfactory bulb","volume":"25","author":"Gabellec","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0110","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1586\/ern.09.115","article-title":"Olfactory dysfunction as a diagnostic marker for Parkinson\u2019s disease","volume":"9","author":"Haehner","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1365-2990.2003.00459.x","article-title":"Misrouted olfactory fibres and ectopic olfactory glomeruli in normal humans and in Parkinson and Alzheimer patients","volume":"29","author":"Hoogland","year":"2003","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0120","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0896-6273(95)90302-X","article-title":"The precursor protein of non-A beta component of Alzheimer\u2019s disease amyloid is a presynaptic protein of the central nervous system","volume":"14","author":"Iwai","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cne.10583","article-title":"Odorant receptor expression as a function of neuronal maturity in the adult rodent olfactory system","volume":"459","author":"Iwema","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.21396","article-title":"Chemotopic odorant coding in a mammalian olfactory system","volume":"503","author":"Johnson","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0135","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.neurobiolaging.2005.09.017","article-title":"Activation of brain regions vulnerable to Alzheimer\u2019s disease: the effect of mild cognitive impairment","volume":"27","author":"Johnson","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1037\/0894-4105.15.1.18","article-title":"Olfactory-evoked regional cerebral blood flow in Alzheimer\u2019s disease","volume":"15","author":"Kareken","year":"2001","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0145","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/369365a0","article-title":"Early diagnosis of Alzheimer\u2019s?","volume":"369","author":"Kishikawa","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0150","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0197-4580(88)80087-3","article-title":"Olfactory tests as possible probes for detecting and monitoring Alzheimer\u2019s disease","volume":"9","author":"Kesslak","year":"1988","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0155","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2990.1999.00208.x","article-title":"Beta-amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer\u2019s disease","volume":"25","author":"Kovacs","year":"1999","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0160","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1523\/JNEUROSCI.2766-05.2005","article-title":"BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions","volume":"25","author":"Laird","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0165","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1093\/brain\/awq209","article-title":"Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer\u2019s disease","volume":"133","author":"Li","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0170","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2990.1986.tb00053.x","article-title":"The topography of plaques and tangles in Down\u2019s syndrome patients of different ages","volume":"12","author":"Mann","year":"1986","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0175","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-3083.1982.tb03764.x","article-title":"Olfactory marker protein (OMP)","volume":"9","author":"Margolis","year":"1982","journal-title":"Scand J Immunol Suppl"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0180","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1749-6632.1998.tb10649.x","article-title":"Human olfactory bulb: aging of glomeruli and mitral cells and a search for the accessory olfactory bulb","volume":"855","author":"Meisami","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0185","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/01688638708405208","article-title":"Olfactory recognition: differential impairments in early and late Huntington\u2019s and Alzheimer\u2019s diseases","volume":"9","author":"Moberg","year":"1987","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0190","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00401-011-0830-2","article-title":"Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders","volume":"122","author":"Mundi\u00f1ano","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0195","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0197-4580(96)00008-5","article-title":"Olfactory dysfunction in Down\u2019s Syndrome","volume":"17","author":"Murphy","year":"1996","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0197-4580(01)00263-9","article-title":"Olfactory impairment increases as a function of age in persons with Down syndrome","volume":"23","author":"Nijjar","year":"2002","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0205","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1749-6632.1998.tb10646.x","article-title":"Odor memory in normal aging and Alzheimer\u2019s disease","volume":"855","author":"Nordin","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0210","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal \u03b2-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0215","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00688261","article-title":"Olfactory bulb changes in Alzheimer\u2019s disease","volume":"73","author":"Ohm","year":"1987","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0220","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/cne.21356","article-title":"GABAergic phenotype of periglomerular cells in the rodent olfactory bulb","volume":"502","author":"Panzanelli","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0225","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1176\/ajp.142.4.524c","article-title":"Olfactory deficits and primary degenerative dementia","volume":"142","author":"Peabody","year":"1985","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0230","doi-asserted-by":"crossref","first-page":"e19567","DOI":"10.1371\/journal.pone.0019567","article-title":"Olfactory and visuospatial learning and memory performance in two strains of Alzheimer\u2019s disease model mice \u2013 a longitudinal study","volume":"6","author":"Phillips","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0235","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1750-1326-6-88","article-title":"The Alzheimer\u2019s beta-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb","volume":"6","author":"Rajapaksha","year":"2011","journal-title":"Mol Neurodegener"},{"issue":"426","key":"10.1016\/j.neuroscience.2012.04.043_b0330","first-page":"e1","article-title":"Locus coeruleus degeneration exacerbates olfactory deficits in APP\/PS1 transgenic mice","volume":"33","author":"Rey","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0245","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0197-4580(92)90074-8","article-title":"Olfactory bulb lesions in Alzheimer\u2019s disease","volume":"13","author":"Struble","year":"1992","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0250","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.expneurol.2009.06.010","article-title":"Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease","volume":"223","author":"Saiz-Sanchez","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0255","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00002093-199408010-00007","article-title":"The olfactory bulb in Alzheimer disease: a morphologic study of neuron loss, tangles, and senile plaques in relation to olfaction","volume":"8","author":"ter Laak","year":"1994","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0260","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.neurobiolaging.2007.08.001","article-title":"Reduced olfactory bulb and tract volume in early Alzheimer\u2019s disease \u2013 a MRI study","volume":"30","author":"Thomann","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0265","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1523\/JNEUROSCI.09-02-00683.1989","article-title":"The expression of the growth associated protein B50\/GAP43 in the olfactory system of neonatal and adult rats","volume":"9","author":"Verhaagen","year":"1989","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0270","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/0006-3223(88)90073-X","article-title":"Olfactory deficits and Down\u2019s syndrome","volume":"23","author":"Warner","year":"1988","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1523\/JNEUROSCI.4622-09.2010","article-title":"Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer\u2019s disease mouse model","volume":"30","author":"Wesson","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0280","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1586\/ern.10.33","article-title":"Should olfactory dysfunction be used as a biomarker of Alzheimer\u2019s disease?","volume":"10","author":"Wesson","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0285","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1523\/JNEUROSCI.6637-10.2011","article-title":"Intraneuronal APP, not free A\u03b2 peptides in 3xTg-AD mice: implications for tau versus A\u03b2-mediated Alzheimer neurodegeneration","volume":"31","author":"Winton","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0290","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2007.04.068","article-title":"[3H]-L-685,458 as a radiotracer that maps gamma-secretase complex in the rat brain: relevance to Abeta genesis and presence of active presenilin-1 components","volume":"9","author":"Xiong","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0295","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00221-007-0943-y","article-title":"Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina","volume":"181","author":"Xiong","year":"2007","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0300","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1523\/JNEUROSCI.0092-04.2004","article-title":"Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation","volume":"24","author":"Yan","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0305","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/cne.21239","article-title":"Beta-secretase expression in normal and functionally deprived rat olfactory bulbs: inverse correlation with oxidative metabolic activity","volume":"501","author":"Yan","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0310","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.neurobiolaging.2007.11.018","article-title":"Progressive impairment in olfactory working memory in a mouse model of Mild Cognitive Impairment","volume":"30","author":"Young","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0315","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1111\/j.1460-9568.2009.07017.x","article-title":"Beta-secretase-1 elevation in transgenic mouse models of Alzheimer\u2019s disease is associated with synaptic\/axonal pathology and amyloidogenesis: implications for neuritic plaque development","volume":"30","author":"Zhang","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0320","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1460-9568.2010.07103.x","article-title":"Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex","volume":"31","author":"Zhang","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.04.043_b0325","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2466\/pms.1994.78.2.627","article-title":"Olfactory deficits in Down subjects: a link with Alzheimer disease","volume":"78","author":"Zucco","year":"1994","journal-title":"Percept Mot Skills"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212004058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212004058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T19:13:37Z","timestamp":1561662817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452212004058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":65,"alternative-id":["S0306452212004058"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.04.043","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}