{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T16:19:08Z","timestamp":1757780348133,"version":"3.40.3"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.neuroscience.2012.06.028","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T15:19:36Z","timestamp":1340119176000},"page":"70-84","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro"],"prefix":"10.1016","volume":"220","author":[{"given":"H.","family":"Nashawi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Novotny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Oriowo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.B.","family":"Kombian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.06.028_b0005","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(00)81904-2","article-title":"Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory","volume":"88","author":"Abel","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0010","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/0024-3205(95)02362-3","article-title":"Glutamate-independent long term depression in rat hippocampus by activation GABAA receptors","volume":"58","author":"Akhondzadeh","year":"1996","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0015","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0022-3565(24)37139-3","article-title":"Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices","volume":"283","author":"Alkondon","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0020","doi-asserted-by":"crossref","first-page":"8142","DOI":"10.1016\/j.bmc.2008.07.045","article-title":"Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro","volume":"16","author":"Ananthalakshmi","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.eplepsyres.2007.07.001","article-title":"Anticonvulsant enaminone E139 suppresses epileptiform activity in rat hippocampal slices","volume":"76","author":"Ananthalakshmi","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0304-3940(90)90750-4","article-title":"The effects of adenosine on the development of long-term potentiation","volume":"119","author":"Arai","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molmed.2005.01.006","article-title":"Protein kinase A as a therapeutic target for memory disorders: rationale and challenges","volume":"11","author":"Arnsten","year":"2005","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(00)00916-2","article-title":"Cholinergic deafferentation of the rabbit cortex: a new animal model of Abeta deposition","volume":"283","author":"Beach","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0045","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0959-4388(94)90101-5","article-title":"Synaptic plasticity: LTP and LTD","volume":"4","author":"Bear","year":"1994","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0050","doi-asserted-by":"crossref","unstructured":"Birks J, Cholinesterase inhibitors for Alzheimer\u2019s disease. Cochrane Database Syst Rev:CD005593.2006.","DOI":"10.1002\/14651858.CD005593"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0055","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001190.pub2","article-title":"Donepezil for dementia due to Alzheimer\u2019s disease","author":"Birks","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0065","doi-asserted-by":"crossref","first-page":"8851","DOI":"10.1073\/pnas.92.19.8851","article-title":"Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase","volume":"92","author":"Brandon","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0026-895X(25)10259-9","article-title":"Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes","volume":"29","author":"Bruns","year":"1986","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0075","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0022-3565(25)09521-7","article-title":"Caffeine enhances acetylcholine release in the hippocampus in vivo by a selective interaction with adenosine A1 receptors","volume":"273","author":"Carter","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0080","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.4088\/JCP.v67n1118","article-title":"Alzheimer\u2019s disease a century later","volume":"67","author":"Caselli","year":"2006","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0006-8993(92)90803-H","article-title":"Modulation of synaptic efficacy in field CA1 of the rat hippocampus by forskolin","volume":"574","author":"Chavez-Noriega","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.1983.sp014478","article-title":"Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus","volume":"334","author":"Collingridge","year":"1983","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0095","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1517\/14656566.8.2.203","article-title":"Memantine in the treatment of mild-to-moderate Alzheimer\u2019s disease","volume":"8","author":"Cosman","year":"2007","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0490","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0896-6273(00)80102-6","article-title":"Ca2+ signaling requirements for long term depression in the hippocampus","volume":"16","author":"Cummings","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0100","first-page":"60","article-title":"Treatment of Alzheimer\u2019s disease: current and future therapeutic approaches","volume":"1","author":"Cummings","year":"2004","journal-title":"Rev Neurol Dis"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2006.08.008","article-title":"Caffeine and adenosine A2A receptor antagonists prevent beta-amyloid (25\u201335)-induced cognitive defects in mice","volume":"203","author":"Dall\u2019Igna","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0110","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/sj.bjp.0705185","article-title":"Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity","volume":"138","author":"Dall\u2019Igna","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0115","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0028-3908(93)90073-C","article-title":"CGP 55845A: a potent antagonist of GABAB receptors in the CA1 region of rat hippocampus","volume":"32","author":"Davies","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3940(81)90061-6","article-title":"2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation","volume":"21","author":"Davies","year":"1981","journal-title":"Neurosci Lett"},{"issue":"Suppl. 9","key":"10.1016\/j.neuroscience.2012.06.028_b0125","first-page":"11","article-title":"Current treatments for Alzheimer\u2019s disease: cholinesterase inhibitors","volume":"64","author":"Doody","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0130","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2165\/00023210-200216120-00003","article-title":"Non-cholinergic strategies for treating and preventing Alzheimer\u2019s disease","volume":"16","author":"Doraiswamy","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0135","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1073\/pnas.89.10.4363","article-title":"Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-d-aspartate receptor blockade","volume":"89","author":"Dudek","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF00501365","article-title":"Alkylxanthines elevate hippocampal excitability. Evidence for a role of endogenous adenosine","volume":"316","author":"Dunwiddie","year":"1981","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0145","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(05)67889-0","article-title":"Global prevalence of dementia: a Delphi consensus study","volume":"366","author":"Ferri","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0150","first-page":"83","article-title":"Actions of caffeine in the brain with special reference to factors that contribute to its widespread use","volume":"51","author":"Fredholm","year":"1999","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0155","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0074-7742(05)63007-3","article-title":"Adenosine and brain function","volume":"63","author":"Fredholm","year":"2005","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0160","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1126\/science.8389057","article-title":"Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons","volume":"260","author":"Frey","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2008.02.052","article-title":"Acute and chronic ethanol exposure differentially affect induction of hippocampal LTP","volume":"1211","author":"Fujii","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0170","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ddr.430280409","article-title":"Oxiracetam and aniracetam increase acetylcholine release from the rat hippocampus in vivo","volume":"28","author":"Giovannini","year":"1993","journal-title":"Drug Development Research"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0175","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0165-0173(94)90011-6","article-title":"Piracetam and other structurally related nootropics","volume":"19","author":"Gouliaev","year":"1994","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0180","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/383713a0","article-title":"Hippocampal synaptic transmission enhanced by low concentrations of nicotine","volume":"383","author":"Gray","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0306-4522(92)90072-A","article-title":"N-methyl-d-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway","volume":"49","author":"Grover","year":"1992","journal-title":"Neuroscience"},{"issue":"Pt 1","key":"10.1016\/j.neuroscience.2012.06.028_b0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1113\/jphysiol.1996.sp021296","article-title":"Endogenous and exogenous dopamine depress EPSCs in rat nucleus accumbens in vitro via D1 receptors activation","volume":"492","author":"Harvey","year":"1996","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3233\/JAD-2003-5106","article-title":"Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer\u2019s neuropathology","volume":"5","author":"Ikonomovic","year":"2003","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0200","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.neuroscience.2005.08.002","article-title":"Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms","volume":"136","author":"Izumi","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00506243","article-title":"Endogenous adenosine as a modulator of hippocampal acetylcholine release","volume":"327","author":"Jackisch","year":"1984","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0210","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1023\/A:1027376230898","article-title":"Cholinergic neurotransmission and synaptic plasticity concerning memory processing","volume":"22","author":"Jerusalinsky","year":"1997","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0215","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/aje\/kwf119","article-title":"Coffee consumption and cognitive function among older adults","volume":"156","author":"Johnson-Kozlow","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0220","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0896-6273(00)80633-9","article-title":"Involvement of a postsynaptic protein kinase A substrate in the expression of homosynaptic long-term depression","volume":"21","author":"Kameyama","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0225","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/334250a0","article-title":"NMDA application potentiates synaptic transmission in the hippocampus","volume":"334","author":"Kauer","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0230","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1152\/jn.1997.78.3.1651","article-title":"Suppresses epileptiform activity in rat hippocampus in vitro","volume":"78","author":"Klapstein","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0235","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1139\/y05-119","article-title":"Cholecystokinin-2 receptors couple to cAMP-protein kinase A to depress excitatory synaptic currents in rat nucleus accumbens in vitro","volume":"84","author":"Kombian","year":"2006","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0240","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neuropharm.2007.11.016","article-title":"The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3\u2013CA1 synapses in the adult mouse hippocampus","volume":"54","author":"Lagostena","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0245","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1525-1497.2001.10123.x","article-title":"National estimates of the quantity and cost of informal caregiving for the elderly with dementia","volume":"16","author":"Langa","year":"2001","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0250","doi-asserted-by":"crossref","first-page":"13541","DOI":"10.1073\/pnas.93.24.13541","article-title":"Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease","volume":"93","author":"Levey","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neures.2005.04.002","article-title":"Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors","volume":"52","author":"Li","year":"2005","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0260","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1615\/CritRevNeurobiol.v18.i1-2.80","article-title":"Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors","volume":"18","author":"MacDonald","year":"2006","journal-title":"Crit Rev Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0265","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1468-1331.2002.00421.x","article-title":"Does caffeine intake protect from Alzheimer\u2019s disease?","volume":"9","author":"Maia","year":"2002","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0270","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0166-2236(93)90197-T","article-title":"NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms","volume":"16","author":"Malenka","year":"1993","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nlme.1995.1001","article-title":"Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory","volume":"63","author":"Maren","year":"1995","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0280","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0447.1976.tb00107.x","article-title":"Piracetam-induced improvement of mental performance. A controlled study on normally aging individuals","volume":"54","author":"Mindus","year":"1976","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0495","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0896-6273(92)90248-C","article-title":"Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of hippocampus","volume":"9","author":"Mulkey","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0285","first-page":"250","article-title":"Heterogeneity of adenosine A1 receptor binding in brain tissue","volume":"22","author":"Murphy","year":"1982","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0290","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/00000542-200508000-00015","article-title":"Propofol inhibits long-term potentiation but not long-term depression in rat hippocampal slices","volume":"103","author":"Nagashima","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000017111","article-title":"The progression of Alzheimer\u2019s disease from limbic regions to the neocortex: clinical, radiological and pathological relationships","volume":"10","author":"Nagy","year":"1999","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0300","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.lfs.2003.09.015","article-title":"Unique mechanism of action of Alzheimer\u2019s drugs on brain nicotinic acetylcholine receptors and NMDA receptors","volume":"74","author":"Narahashi","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0305","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-0173(92)90012-B","article-title":"Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects","volume":"17","author":"Nehlig","year":"1992","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0310","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2303","article-title":"Synaptic plasticity, memory and the hippocampus: a neural network approach to causality","volume":"9","author":"Neves","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0315","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.pneurobio.2003.12.003","article-title":"Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases","volume":"71","author":"Nguyen","year":"2003","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0320","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1749-6632.1999.tb11320.x","article-title":"Expression mechanisms underlying NMDA receptor-dependent long-term potentiation","volume":"868","author":"Nicoll","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0325","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-8993(99)01312-8","article-title":"A \u2018long-term-potentiation-like\u2019 facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetam","volume":"826","author":"Nishizaki","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0330","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-8993(00)02417-3","article-title":"Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action","volume":"870","author":"Nomura","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0335","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/nlme.1998.3864","article-title":"MK-801 improves retention in aged rats: implications for altered neural plasticity in age-related memory deficits","volume":"71","author":"Norris","year":"1999","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0340","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12017-009-8091-0","article-title":"Alzheimer\u2019s disease amyloid beta-protein and synaptic function","volume":"12","author":"Ondrejcak","year":"2010","journal-title":"Neuromolecular Med"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0345","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0197-4580(03)00084-8","article-title":"Hippocampus and entorhinal cortex in mild cognitive impairment and early AD","volume":"25","author":"Pennanen","year":"2004","journal-title":"Neurobiol Aging"},{"issue":"l","key":"10.1016\/j.neuroscience.2012.06.028_b0350","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1016\/0278-5846(89)90112-7","article-title":"Nootropic drugs and brain cholinergic mechanisms","volume":"13","author":"Pepeu","year":"1989","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0355","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.neurobiolaging.2004.08.012","article-title":"Coffee reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors","volume":"26","author":"Prediger","year":"2005","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0360","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1046\/j.1365-3156.1997.d01-156.x","article-title":"The need for research on dementia in developing countries","volume":"2","author":"Prince","year":"1997","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0365","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-3940(98)00358-9","article-title":"Intraseptal infusions of a low dose of AP5, a NMDA receptor antagonist, improves memory in an object recognition task in rats","volume":"248","author":"Puma","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0370","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1073\/pnas.93.4.1571","article-title":"Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase","volume":"93","author":"Qi","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0375","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1006\/nlme.1998.3822","article-title":"L-type voltage-dependent calcium channel blocker nifedipine enhances memory retention when infused into the hippocampus","volume":"69","author":"Quevedo","year":"1998","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0380","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1523\/JNEUROSCI.18-18-07075.1998","article-title":"Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission","volume":"18","author":"Radcliffe","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0385","series-title":"Adenosine in the Nervous System","first-page":"77","article-title":"Adenosine receptor subtypes: classification and distribution","author":"Reddington","year":"1991"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0390","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0301-0082(02)00155-7","article-title":"Adenosine receptors in the nervous system: pathophysiological implications","volume":"68","author":"Ribeiro","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0395","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2006\/315386","article-title":"Current and emerging pharmacological treatment options for dementia","volume":"17","author":"Ringman","year":"2006","journal-title":"Behav Neurol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0400","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1523\/JNEUROSCI.20-21-08096.2000","article-title":"Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity","volume":"20","author":"Rotenberg","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0405","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0304-3940(86)90145-X","article-title":"Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea-pig hippocampal slices","volume":"68","author":"Satoh","year":"1986","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0410","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2006-9S312","article-title":"Alzheimer\u2019s disease-related alterations in synaptic density: neocortex and hippocampus","volume":"9","author":"Scheff","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0415","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0420","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","article-title":"Hippocampal synaptic loss in early Alzheimer\u2019s disease and mild cognitive impairment","volume":"27","author":"Scheff","year":"2006","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0425","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/01.wad.0000190808.97878.b8","article-title":"Drug development, clinical trials, cultural heterogeneity in Alzheimer disease: the need for pro-active recruitment","volume":"19","author":"Schneider","year":"2005","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0430","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archneurol.2011.69","article-title":"Lack of evidence for the efficacy of memantine in mild Alzheimer disease","volume":"68","author":"Schneider","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0435","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.molmed.2007.12.006","article-title":"Network dysfunction in Alzheimer\u2019s disease: does synaptic scaling drive disease progression?","volume":"14","author":"Small","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0440","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0197-4580(95)00093-T","article-title":"Nimodipine facilitates retention of the classically conditioned nictitating membrane response in aged rabbits over long retention intervals","volume":"16","author":"Solomon","year":"1995","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0445","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0091-3057(87)90353-4","article-title":"Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine","volume":"27","author":"Spignoli","year":"1987","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0450","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1523\/JNEUROSCI.17-12-04820.1997","article-title":"Studies on long-term depression in area CA1 of the anesthetized and freely moving rat","volume":"17","author":"Staubli","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0455","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0006-8993(90)91577-4","article-title":"Effect of xanthine derivatives on hippocampal long-term potentiation","volume":"522","author":"Tanaka","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0460","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-3940(89)90506-5","article-title":"Effect of scopolamine and HP 029, a cholinesterase inhibitor, on long-term potentiation in hippocampal slices of the guinea pig","volume":"98","author":"Tanaka","year":"1989","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0465","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0168-0102(93)90036-P","article-title":"Long-term depression in cerebral cortex: a possible substrate of \u201cforgetting\u201d that should not be forgotten","volume":"16","author":"Tsumoto","year":"1993","journal-title":"Neurosci Res"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0470","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1471-4159.1979.tb05236.x","article-title":"Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells","volume":"33","author":"van Calker","year":"1979","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0475","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3940(02)00183-0","article-title":"Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats","volume":"324","author":"Wei","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.06.028_b0480","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1185\/030079902125004349","article-title":"Impact of donepezil treatment for Alzheimer\u2019s disease on caregiver time","volume":"20","author":"Wimo","year":"2004","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"10.1016\/j.neuroscience.2012.06.028_b0485","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/01.wad.0000127495.10774.a4","article-title":"Long-term treatment of Alzheimer disease: efficacy and safety of acetylcholinesterase inhibitors","volume":"18","author":"Winblad","year":"2004","journal-title":"Alzheimer Dis Assoc Disord"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212006288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212006288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T23:09:11Z","timestamp":1743548951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452212006288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":99,"alternative-id":["S0306452212006288"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.06.028","relation":{},"ISSN":["0306-4522"],"issn-type":[{"type":"print","value":"0306-4522"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}