{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:18:40Z","timestamp":1773958720630,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.neuroscience.2012.08.048","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T04:31:55Z","timestamp":1347683515000},"page":"156-164","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Thermoregulatory responses elicited by microinjection of l-glutamate and its interaction with thermogenic effects of GABA and prostaglandin E2 in the preoptic area"],"prefix":"10.1016","volume":"226","author":[{"given":"T.","family":"Osaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.08.048_b0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1748-1716.1957.tb01512.x","article-title":"Cold defense reactions elicited by electrical stimulation within the septal area of the brain in goats","volume":"41","author":"Andersson","year":"1957","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0010","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0361-9230(82)90095-8","article-title":"Responses of preoptic thermosensitive neurons to mediobasal hypothalamic stimulation","volume":"8","author":"Hori","year":"1982","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2007.12.016","article-title":"The effects of Cirazoline, an alpha-1 adrenoreceptor agonist, on the firing rates of thermally classified anterior hypothalamic neurons in rat brain slices","volume":"1193","author":"Imbery","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0361-9230(95)00093-T","article-title":"Differences in Fos expression in the rat brains between cold and warm ambient exposures","volume":"38","author":"Kiyohara","year":"1995","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0025","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0361-9230(87)90210-3","article-title":"Responses of preoptic thermosensitive neurons to changes in blood pressure","volume":"18","author":"Koga","year":"1987","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0030","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nn1949","article-title":"EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses","volume":"10","author":"Lazarus","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0035","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/jn.1938.1.2.101","article-title":"Activation of heat loss mechanisms by local heating of the brain","volume":"1","author":"Magoun","year":"1938","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0040","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.2741\/1439","article-title":"Signaling the brain in inflammation: the role of endothelial cells","volume":"9","author":"Matsumura","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2741\/3677","article-title":"Central neural pathways for thermoregulation","volume":"16","author":"Morrison","year":"2011","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1566-0702(00)00216-2","article-title":"Neuronal circuitries involved in thermoregulation","volume":"85","author":"Nagashima","year":"2000","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0055","doi-asserted-by":"crossref","first-page":"R1207","DOI":"10.1152\/ajpregu.00109.2011","article-title":"Central circuitries for body temperature regulation and fever","volume":"301","author":"Nakamura","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0060","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1113\/jphysiol.2008.152686","article-title":"Preoptic mechanism for cold-defensive responses to skin cooling","volume":"586","author":"Nakamura","year":"2008","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0065","doi-asserted-by":"crossref","first-page":"8848","DOI":"10.1073\/pnas.0913358107","article-title":"A thermosensory pathway mediating heat-defense responses","volume":"107","author":"Nakamura","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0070","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.134.3478.560","article-title":"Single unit activity of anterior hypothalamus during local heating","volume":"134","author":"Nakayama","year":"1961","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0075","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.2741\/1458","article-title":"Prostaglandin E2 as a mediator of fever: the role of prostaglandin E (EP) receptors","volume":"9","author":"Oka","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0080","doi-asserted-by":"crossref","first-page":"R306","DOI":"10.1152\/ajpregu.00003.2004","article-title":"Cold-induced thermogenesis mediated by GABA in the preoptic area of anesthetized rats","volume":"287","author":"Osaka","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0085","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00424-007-0443-8","article-title":"Prostaglandin E2 fever mediated by inhibition of the GABAergic transmission in the region immediately adjacent to the organum vasculosum of the lamina terminalis","volume":"456","author":"Osaka","year":"2008","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2012.09.033","article-title":"Hypoxia-induced hypothermia mediated by the glutamatergic transmission in the lateral preoptic area","volume":"226","author":"Osaka","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0095","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0100","doi-asserted-by":"crossref","first-page":"6246","DOI":"10.1523\/JNEUROSCI.16-19-06246.1996","article-title":"Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways","volume":"16","author":"Scammell","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(93)91280-6","article-title":"Hyperthermia induces c-fos expression in the preoptic area","volume":"618","author":"Scammell","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0110","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.neuroscience.2006.01.003","article-title":"Differences in the effects of medial and lateral preoptic lesions on thermoregulation and sleep in rats","volume":"139","author":"Srividya","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0115","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1371\/journal.pbio.0040284","article-title":"Cellular and molecular bases of the initiation of fever","volume":"4","author":"Steiner","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/jphysiol.1991.sp018378","article-title":"Differential sensitivity in the sites of fever production by prostaglandin E1 within the hypothalamus of the rat","volume":"432","author":"Stitt","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0125","doi-asserted-by":"crossref","first-page":"R1248","DOI":"10.1152\/ajpregu.91010.2008","article-title":"Roles of two preoptic cell groups in tonic and febrile control of rat tail sympathetic fibers","volume":"296","author":"Tanaka","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0130","first-page":"R560","article-title":"In vitro diencephalic neuronal thermosensitivity in normotensive and hypertensive rats","volume":"256","author":"Travis","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0135","first-page":"R1200","article-title":"In vitro sensitivity of median preoptic neurons to angiotensin II, osmotic pressure, and temperature","volume":"264","author":"Travis","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0140","doi-asserted-by":"crossref","first-page":"11954","DOI":"10.1523\/JNEUROSCI.2643-09.2009","article-title":"Parallel preoptic pathways for thermoregulation","volume":"29","author":"Yoshida","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.08.048_b0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1113\/jphysiol.1995.sp020723","article-title":"Warm and cold signals from the preoptic area: which contribute more to the control of shivering in rats?","volume":"485","author":"Zhang","year":"1995","journal-title":"J Physiol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212008822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212008822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T19:38:39Z","timestamp":1562182719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452212008822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":29,"alternative-id":["S0306452212008822"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.08.048","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}