{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:17:38Z","timestamp":1792685858037,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.neuroscience.2012.11.033","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T23:45:39Z","timestamp":1354232739000},"page":"182-193","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Corneal afferents differentially target thalamic- and parabrachial-projecting neurons in spinal trigeminal nucleus caudalis"],"prefix":"10.1016","volume":"232","author":[{"given":"S.A.","family":"Aicher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Hermes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Hegarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.11.033_b0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0006-8993(03)02678-7","article-title":"Endomorphin-2 axon terminals contact mu-opioid receptor-containing dendrites in trigeminal dorsal horn","volume":"977","author":"Aicher","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0010","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/cne.903630405","article-title":"Monosynaptic projections from the medullary gigantocellular reticular formation to sympathetic preganglionic neurons in the thoracic spinal cord","volume":"363","author":"Aicher","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-8993(95)01580-9","article-title":"Trigeminal-parabrachial connections: possible pathway for nociception-induced cardiovascular reflex responses","volume":"715","author":"Allen","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0020","doi-asserted-by":"crossref","first-page":"11893","DOI":"10.1523\/JNEUROSCI.2044-06.2006","article-title":"Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns","volume":"26","author":"Bailey","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.exer.2003.09.023","article-title":"Neural basis of sensation in intact and injured corneas","volume":"78","author":"Belmonte","year":"2004","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0030","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0306-4522(96)00038-3","article-title":"N-methyl-d-aspartate and non-N-methyl-d-aspartate receptor antagonism reduces fos-like immunoreactivity in central trigeminal neurons after corneal stimulation in the rat","volume":"73","author":"Bereiter","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/cne.22524","article-title":"Distribution of Na\/K-ATPase alpha 3 isoform, a sodium-potassium P-type pump associated with rapid-onset of dystonia Parkinsonism (RDP) in the adult mouse brain","volume":"519","author":"Bottger","year":"2011","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/cne.902400205","article-title":"Spinal and trigeminal dorsal horn projections to the parabrachial nucleus in the rat","volume":"240","author":"Cechetto","year":"1985","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0045","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/cne.903530404","article-title":"Topographic organization of spinal and trigeminal somatosensory pathways to the rat parabrachial and K\u00f6lliker-Fuse nuclei","volume":"353","author":"Feil","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1090-3801(99)90186-6","article-title":"Quantification and immunocytochemical characteristics of trigeminal ganglion neurons projecting to the cornea: effect of corneal wounding","volume":"3","author":"Felipe","year":"1999","journal-title":"Eur J Pain"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/cne.901830112","article-title":"Organization of trigeminothalamic tracts and other thalamic afferent systems of the brainstem in the rat: presence of gelatinosa neurons with thalamic connections","volume":"183","author":"Fukushima","year":"1979","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0060","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1167\/iovs.07-0012","article-title":"Impulse activity in corneal sensory nerve fibers after photorefractive keratectomy","volume":"48","author":"Gallar","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0065","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1113\/eph8702357","article-title":"Pain pathways and parabrachial circuits in the rat","volume":"87","author":"Gauriau","year":"2002","journal-title":"Exp Physiol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0070","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1460-9568.2005.03918.x","article-title":"Both oral and caudal parts of the spinal trigeminal nucleus project to the somatosensory thalamus in the rat","volume":"21","author":"Guy","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0075","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1002\/cne.22414","article-title":"Differential localization of vesicular glutamate transporters and peptides in corneal afferents to trigeminal nucleus caudalis","volume":"518","author":"Hegarty","year":"2010","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0080","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1152\/jn.1999.82.5.2092","article-title":"Responses of medullary dorsal horn neurons to corneal stimulation by CO2 pulses in the rat","volume":"82","author":"Hirata","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0085","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1152\/jn.2000.84.2.1050","article-title":"Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projections to thalamus and brain stem","volume":"84","author":"Hirata","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0306-4522(89)90229-7","article-title":"Spinal lamina I projection neurons in the rat: collateral innervation of parabrachial area and thalamus","volume":"28","author":"Hylden","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0095","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/cne.903210308","article-title":"Diencephalic projections from the superficial and deep laminae of the medullary dorsal horn in the rat","volume":"321","author":"Iwata","year":"1992","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0100","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/cne.22012","article-title":"Collateral projection from the locus coeruleus to whisker-related sensory and motor brain regions of the rat","volume":"514","author":"Lee","year":"2009","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/cne.903540204","article-title":"Synapses on axons of sympathetic preganglionic neurons in rat and rabbit thoracic spinal cord","volume":"354","author":"Llewellyn-Smith","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0110","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/cne.902610309","article-title":"Corneal sensory pathway in the rat: a horseradish peroxidase tracing study","volume":"261","author":"Marfurt","year":"1987","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/jn.1997.77.1.43","volume":"77","author":"Meng","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0120","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1152\/jn.1998.79.5.2593","article-title":"Differential effects of morphine on corneal-responsive neurons in rostral versus caudal regions of spinal trigeminal nucleus in the rat","volume":"79","author":"Meng","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0304-3959(00)00289-X","article-title":"Parabrachial area and nucleus raphe magnus inhibition of corneal units in rostral and caudal portions of trigeminal subnucleus caudalis in the rat","volume":"87","author":"Meng","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00048-3","article-title":"The induction of pain: an integrative review","volume":"57","author":"Millan","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0135","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neuroscience.2004.07.026","article-title":"Rat trigeminal lamina I neurons that project to thalamic or parabrachial nuclei contain the mu-opioid receptor","volume":"128","author":"Mitchell","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"116","author":"Mullen","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0145","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/cne.903530402","article-title":"The spinoparabrachial pathway: shedding new light on an old path","volume":"353","author":"Saper","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0155","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1017\/S0317167100000135","article-title":"Neural mechanisms and pathways in craniofacial pain","volume":"26","author":"Sessle","year":"1999","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/cne.903390106","article-title":"Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin","volume":"339","author":"Slugg","year":"1994","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1460-9568.2003.02406.x","article-title":"The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn","volume":"17","author":"Todd","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0165-0270(94)90042-6","article-title":"Immunolabeling of retrogradely transported Fluoro-Gold: sensitivity and application to ultrastructural analysis of transmitter-specific mesolimbic circuitry","volume":"55","author":"Van Bockstaele","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.iio.0000155938.83083.94","article-title":"Epidemiology of uveitis","volume":"45","author":"Wakefield","year":"2005","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.neuroscience.2012.11.033_b0180","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1152\/jn.00676.2006","article-title":"Kappa opioid receptor (KOR) and GAD67 immunoreactivity are found in OFF and NEUTRAL cells in the rostral ventromedial medulla","volume":"96","author":"Winkler","year":"2006","journal-title":"J Neurophysiol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221201144X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221201144X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T18:20:47Z","timestamp":1643739647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221201144X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":36,"alternative-id":["S030645221201144X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.11.033","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}