{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:03:08Z","timestamp":1769324588390,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina (FAPESC)"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.neuroscience.2012.12.042","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T19:02:08Z","timestamp":1357239728000},"page":"69-76","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: Evidence for a role of the adenosinergic system"],"prefix":"10.1016","volume":"234","author":[{"given":"D.F.","family":"Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mazzardo-Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Soldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Stramosk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Piovezan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.12.042_b0005","first-page":"628","article-title":"Adenosine and coronary blood flow in conscious dogs during normal physiologic stimuli","volume":"243","author":"Bacchus","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0010","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.apmr.2005.03.029","article-title":"Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner","volume":"86","author":"Bement","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00583686","article-title":"Release of adenosine and lack of release of ATP from contracting skeletal muscle","volume":"355","author":"Bockman","year":"1975","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuroscience.2010.03.035","article-title":"Short- but not long-lasting treadmill running reduces allodynia and improves functional recovery after peripheral nerve injury","volume":"168","author":"Cobianchi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2165\/00023210-200013020-00001","article-title":"Adenosine as a potential analgesic target in inflammatory and neuropathic pains","volume":"13","author":"Dickenson","year":"2000","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0014-2999(95)00257-L","article-title":"Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat","volume":"281","author":"Doak","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.RES.29.4.375","article-title":"Role of adenine nucleotides, adenosine, and inorganic phosphate in the regulation of skeletal muscle blood flow","volume":"29","author":"Dobson","year":"1971","journal-title":"Circ Res"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0040","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuroscience.2007.09.062","article-title":"Intense exercise increases adenosine concentrations in rat brain: implications for a homeostatic sleep drive","volume":"150","author":"Dworak","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0045","first-page":"83","article-title":"Actions of caffeine in the brain with special reference to factors that contribute to its widespread use","volume":"51","author":"Fredholm","year":"1999","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0050","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nn.2562","article-title":"Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture","volume":"13","author":"Goldman","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0055","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1213\/ane.0b013e318173251f","article-title":"Expression of adenosine A2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents","volume":"106","author":"Guntz","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.280.2.147","article-title":"Persistent pain and well-being: a World Health Organization study in primary care","volume":"280","author":"Gureje","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2003.11.003","article-title":"Adenosine: an endogenous regulator of innate immunity","volume":"25","author":"Hask\u00f3","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0070","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pharmthera.2006.08.003","article-title":"Shaping of monocyte and macrophage function by adenosine receptors","volume":"113","author":"Hask\u00f3","year":"2007","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0075","first-page":"21","article-title":"Xanthinedehydrogenase and purine metabolism in man. With special reference to exercise","volume":"151","author":"Hellsten","year":"1994","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0080","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11916-003-0072-7","article-title":"Complex regional pain syndrome: a review of evidence-supported treatment options","volume":"7","author":"Hord","year":"2003","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0085","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrd1983","article-title":"Adenosine receptors as therapeutic targets","volume":"3","author":"Jacobson","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(83)90026-2","article-title":"Dipyridamole inhibition of adenosine metabolism in human blood","volume":"93","author":"Klabunde","year":"1983","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2165\/00007256-200029020-00002","article-title":"Analgesia following exercise: a review","volume":"29","author":"Koltyn","year":"2000","journal-title":"Sports Med"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0095","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/bjsm.32.1.20","article-title":"Perception of pain after resistance exercise","volume":"32","author":"Koltyn","year":"1998","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0105","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jpain.2007.08.001","article-title":"Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents","volume":"8","author":"Kuphal","year":"2007","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0110","first-page":"1642","article-title":"Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists","volume":"277","author":"Lee","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2007-1024853","article-title":"The purine nucleotide cycle revised","volume":"11","author":"Lowenstein","year":"1990","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0125","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1113\/jphysiol.2007.136416","article-title":"The roles of adenosine and related substances in exercise hyperaemia","volume":"583","author":"Marshall","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0120","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1526-4637.2012.01438.x","article-title":"Ankle joint mobilization decreases hypersensitivity by activation of peripheral opioid receptors in a mouse model of postoperative pain","volume":"13","author":"Martins","year":"2012","journal-title":"Pain Med"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0130","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jpain.2010.03.015","article-title":"High-intensity extended swimming exercise reduces pain-related behavior in mice: involvement of endogenous opioids and the serotonergic system","volume":"11","author":"Mazzardo-Martins","year":"2010","journal-title":"J Pain"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0235","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2165\/00007256-199520030-00004","article-title":"Exercise and brain neurotransmission","volume":"20","author":"Meeusen","year":"1995","journal-title":"Sports Med"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejphar.2008.01.006","article-title":"Rats with chronic post-ischemia pain exhibit an analgesic sensitivity profile similar to human patients with complex regional pain syndrome-type I","volume":"583","author":"Millecamps","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pain.2010.07.003","article-title":"Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)","volume":"151","author":"Millecamps","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0145","first-page":"1243","article-title":"Adenosine output from dog gracilis muscle during systemic hypercapnia and\/or amiloride\u2013SITS infusion","volume":"267","author":"Mo","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0150","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/jpet.110.166058","article-title":"Inosine reduces pain-related behavior in mice: involvement of adenosine A1 and A2A receptor subtypes and protein kinase C pathways","volume":"334","author":"Nascimento","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0155","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1113\/jphysiol.1991.sp018723","article-title":"The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat","volume":"440","author":"Neylon","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jep.2012.06.020","article-title":"Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain","volume":"143","author":"Nucci","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0165","first-page":"26","article-title":"Adenosine in the control of the cerebral circulation","volume":"1","author":"Phillis","year":"1989","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0170","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0304-3959(97)00186-3","article-title":"Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat","volume":"74","author":"Poon","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0175","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1590\/S1807-59322011001200017","article-title":"Moderate exercise training promotes adaptations in coronary blood flow and adenosine production in normotensive rats","volume":"66","author":"Roque","year":"2011","journal-title":"Clinics"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(97)01605-1","article-title":"Adenosine receptor activation and nociception","volume":"347","author":"Sawynok","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0190","first-page":"27","article-title":"Purines in pain management","volume":"1","author":"Sawynok","year":"1999","journal-title":"Curr Opin Cent Peripher Nerv Syst Investig Drugs"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0195","series-title":"Adenosine: a key link between metabolism and brain activity","first-page":"343","article-title":"Adenosine and pain","author":"Sawynok","year":"2013"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0200","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0301-0082(03)00050-9","article-title":"Adenosine in the spinal cord and periphery: release and regulation of pain","volume":"69","author":"Sawynok","year":"2003","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0205","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neulet.2010.02.028","article-title":"Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice","volume":"12","author":"Sawynok","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0240","unstructured":"Schappert SM, Burt CW (2006) Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States. 2001\u20132002."},{"key":"10.1016\/j.neuroscience.2012.12.042_b0215","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/bjsm.26.1.54","article-title":"Adenosine in exercise adaptation","volume":"26","author":"Simpson","year":"1992","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0220","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/ALN.0b013e318210f880","article-title":"Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids","volume":"114","author":"Stagg","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0225","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0143-4179(97)90069-X","article-title":"Differential effects of adenosine receptor antagonists injected intrathecally on antinociception induced by morphine and beta-endorphin administered intracerebroventricularly in the mouse","volume":"31","author":"Suh","year":"1997","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neuroscience.2012.12.042_b0230","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.pain.2004.11.020","article-title":"Increased nociceptive response in mice lacking the adenosine A1 receptor","volume":"113","author":"Wu","year":"2005","journal-title":"Pain"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212012377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452212012377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T19:07:00Z","timestamp":1539976020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452212012377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":46,"alternative-id":["S0306452212012377"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.12.042","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}