{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:44:47Z","timestamp":1777538687384,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2012M511032"],"award-info":[{"award-number":["2012M511032"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2012JC006"],"award-info":[{"award-number":["2012JC006"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2011HQ035"],"award-info":[{"award-number":["ZR2011HQ035"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2012HM021"],"award-info":[{"award-number":["ZR2012HM021"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010084","name":"Independent Innovation Foundation of Shandong University","doi-asserted-by":"publisher","award":["2012TS123"],"award-info":[{"award-number":["2012TS123"]}],"id":[{"id":"10.13039\/501100010084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010084","name":"Independent Innovation Foundation of Shandong University","doi-asserted-by":"publisher","award":["IIFSDU2012TS120"],"award-info":[{"award-number":["IIFSDU2012TS120"]}],"id":[{"id":"10.13039\/501100010084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20110131110036"],"award-info":[{"award-number":["20110131110036"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81071057"],"award-info":[{"award-number":["81071057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200879"],"award-info":[{"award-number":["81200879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.neuroscience.2012.12.057","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T03:03:56Z","timestamp":1359515036000},"page":"106-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["l-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS\/H2S pathway"],"prefix":"10.1016","volume":"237","author":[{"given":"Z.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.-X.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.-W.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.-X.","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-M.","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.-H.","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.-A.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-J.","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2012.12.057_b0005","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0010","doi-asserted-by":"crossref","first-page":"e24535","DOI":"10.1371\/journal.pone.0024535","article-title":"Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-kappaB signaling","volume":"6","author":"Ang","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0015","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1096\/fj.05-3724fje","article-title":"Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia\/astrocyte lineage of developing mouse CNS","volume":"19","author":"Enokido","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0020","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1523\/JNEUROSCI.22-09-03386.2002","article-title":"Hydrogen sulfide is produced in response to neuronal excitation","volume":"22","author":"Eto","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0025","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1042\/BST0341287","article-title":"Signalling molecules essential for neuronal survival and differentiation","volume":"34","author":"Frebel","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-079X.2011.00867.x","article-title":"Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro","volume":"51","author":"Fu","year":"2011","journal-title":"J Pineal Res"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1447-073x.2005.00097.x","article-title":"Cell fate determination regulated by a transcriptional signal network in the developing mouse brain","volume":"80","author":"Fukuda","year":"2005","journal-title":"Anat Sci Int"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0040","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1002\/jnr.22480","article-title":"Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms","volume":"88","author":"Fukushima","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.neuro.25.030702.130823","article-title":"Fishell G (The role of notch in promoting glial and neural stem cell fates","volume":"25","author":"Gaiano","year":"2002","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/mol.108.047985","article-title":"Hydrogen sulfide inhibits rotenone-induced apoptosis via preservation of mitochondrial function","volume":"75","author":"Hu","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0055","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yexcr.2005.03.015","article-title":"Roles of bHLH genes in neural stem cell differentiation","volume":"306","author":"Kageyama","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/ars.2010.3671","article-title":"Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson\u2019s disease","volume":"15","author":"Kida","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0070","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.1074\/jbc.M708373200","article-title":"Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus","volume":"283","author":"Kim","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0075","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1096\/fj.04-1815fje","article-title":"Hydrogen sulfide protects neurons from oxidative stress","volume":"18","author":"Kimura","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0080","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/10715760701263265","article-title":"Hydrogen sulphide: a novel physiological inhibitor of LDL atherogenic modification by HOCl","volume":"41","author":"Laggner","year":"2007","journal-title":"Free Radic Res"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0085","doi-asserted-by":"crossref","first-page":"e25921","DOI":"10.1371\/journal.pone.0025921","article-title":"Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1\/2 and p38MAPK signaling pathways in PC12 cells","volume":"6","author":"Lan","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0090","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/glia.20362","article-title":"Hydrogen sulphide regulates calcium homeostasis in microglial cells","volume":"54","author":"Lee","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0095","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1007\/s11064-011-0502-6","article-title":"Protective Effects of Exogenous Hydrogen Sulfide on Neurons of Hippocampus in a Rat Model of Brain Ischemia","volume":"36","author":"Li","year":"2011","journal-title":"Neurochem Res"},{"issue":"Suppl.","key":"10.1016\/j.neuroscience.2012.12.057_b0100","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1038\/nm1064","article-title":"Stem cell therapy for human neurodegenerative disorders-how to make it work","volume":"10","author":"Lindvall","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0105","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.neuroscience.2009.09.045","article-title":"Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells","volume":"164","author":"Liu","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0110","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.bbrc.2007.10.036","article-title":"Differential regulation of cell proliferation in neurogenic zones in mice lacking cystine transport by xCT","volume":"364","author":"Liu","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0115","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3233\/JAD-2010-101002","article-title":"Hydrogen sulfide protects amyloid-beta induced cell toxicity in microglia","volume":"22","author":"Liu","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0120","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.freeradbiomed.2008.09.014","article-title":"Hydrogen sulfide protects astrocytes against H(2)O(2)-induced neural injury via enhancing glutamate uptake","volume":"45","author":"Lu","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.276.5309.66","article-title":"Stem cells in the central nervous system","volume":"276","author":"McKay","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0130","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1096\/fj.03-1052fje","article-title":"Hydrogen sulfide induces calcium waves in astrocytes","volume":"18","author":"Nagai","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0135","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1471-4159.2008.05808.x","article-title":"Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels","volume":"108","author":"Nagasawa","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0140","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1365-2184.2002.00229.x","article-title":"Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells","volume":"35","author":"Noda","year":"2002","journal-title":"Cell Prolif"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/bbrc.1998.9079","article-title":"Spatial and temporal expression of the cystathionine beta-synthase gene during early human development","volume":"254","author":"Quere","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(03)00365-9","article-title":"Basic helix\u2013loop\u2013helix factors in cortical development","volume":"39","author":"Ross","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0155","doi-asserted-by":"crossref","first-page":"10514","DOI":"10.1523\/JNEUROSCI.3178-06.2006","article-title":"Cystine\/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation","volume":"26","author":"Shih","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12640-010-9180-4","article-title":"Inhibition of hydrogen sulfide generation contributes to 1-methy-4-phenylpyridinium ion-induced neurotoxicity","volume":"19","author":"Tang","year":"2011","journal-title":"Neurotox Res"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0165","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1007\/s11064-011-0542-y","article-title":"Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion","volume":"36","author":"Tang","year":"2011","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0170","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1681.2007.04799.x","article-title":"Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells","volume":"35","author":"Tang","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0175","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1471-4159.2010.06774.x","article-title":"Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide","volume":"114","author":"Tarui","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0180","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1089\/ars.2009.2938","article-title":"Hydrogen sulfide: the third gasotransmitter in biology and medicine","volume":"12","author":"Wang","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0185","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-4159.2004.02617.x","article-title":"The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite \u2018scavenger\u2019?","volume":"90","author":"Whiteman","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0190","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2004.11.110","article-title":"Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?","volume":"326","author":"Whiteman","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2012.12.057_b0195","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.cr.7310126","article-title":"Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation","volume":"17","author":"Xiao","year":"2007","journal-title":"Cell Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213000171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213000171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:38:28Z","timestamp":1759678708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452213000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":39,"alternative-id":["S0306452213000171"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.12.057","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"l-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS\/H2S pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2012.12.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}