{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:38:51Z","timestamp":1783489131512,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.neuroscience.2013.09.030","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T09:46:10Z","timestamp":1380102370000},"page":"292-299","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Hesperidin pretreatment protects hypoxia\u2013ischemic brain injury in neonatal rat"],"prefix":"10.1016","volume":"255","author":[{"given":"Z.","family":"Rong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2013.09.030_b0005","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/13880209.2010.509734","article-title":"Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines","volume":"49","author":"Al-Ashaal","year":"2011","journal-title":"Pharm Biol"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0010","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/CAD.0b013e32832d1149","article-title":"Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes beta-catenin cellular localization","volume":"20","author":"Amado","year":"2009","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0015","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0020","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/bjp.2008.345","article-title":"Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury","volume":"155","author":"Chen","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0025","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.siny.2010.02.002","article-title":"Synergistic neuroprotective therapies with hypothermia","volume":"15","author":"Cilio","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/fn.71.1.F1","article-title":"Perinatal asphyxia in less developed countries","volume":"71","author":"Costello","year":"1994","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0022-3476(81)80555-0","article-title":"Hypoxic ischemic encephalopathy in term neonates: perinatal factors and outcome","volume":"98","author":"Finer","year":"1981","journal-title":"J Pediatr"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1749-6632.2002.tb02099.x","article-title":"Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E","volume":"959","author":"Fukui","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0045","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1749-6632.2001.tb05646.x","article-title":"Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems","volume":"928","author":"Fukui","year":"2001","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.neuroscience.2013.09.030_b0050","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1734-1140(10)70321-2","article-title":"Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction","volume":"62","author":"Gaur","year":"2010","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0055","first-page":"3367","article-title":"Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression","volume":"25","author":"Hirata","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0060","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1021\/jf072826r","article-title":"Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells","volume":"56","author":"Hwang","year":"2008","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0180","doi-asserted-by":"crossref","DOI":"10.1177\/0748233713483192","article-title":"Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats","author":"Kamisli","year":"2013","journal-title":"Toxicol Ind Health"},{"issue":"3","key":"10.1016\/j.neuroscience.2013.09.030_b0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0959-4388(00)00092-1","article-title":"Neurotrophin signal transduction in the nervous system","volume":"10","author":"Kaplan","year":"2000","journal-title":"Curr Opin Neurobiol"},{"issue":"9","key":"10.1016\/j.neuroscience.2013.09.030_b0075","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbamcr.2006.06.006","article-title":"Interplay between PI3K\/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis","volume":"1763","author":"Lee","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2011.02.013","article-title":"Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia\u2013ischemia","volume":"1385","author":"Lin","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0085","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2007.11.011","article-title":"Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines","volume":"580","author":"Loscalzo","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0090","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.freeradbiomed.2012.06.012","article-title":"Increased NADPH oxidase derived superoxide is involved in the neuronal cell death induced by hypoxia ischemia in neonatal hippocampal slice cultures","volume":"53","author":"Lu","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.neuroscience.2013.09.030_b0095","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.pbb.2008.12.016","article-title":"Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1\/2 levels in mice","volume":"92","author":"Martinez","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0100","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s11064-011-0493-3","article-title":"Hesperidin, a flavone glycoside, as mediator of neuronal survival","volume":"36","author":"Nones","year":"2011","journal-title":"Neurochem Res"},{"issue":"4","key":"10.1016\/j.neuroscience.2013.09.030_b0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijdevneu.2012.01.008","article-title":"Effects of the flavonoid hesperidin in cerebral cortical progenitors in vitro: indirect action through astrocytes","volume":"30","author":"Nones","year":"2012","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/pr.2012.107","article-title":"Sodium pyruvate reduces hypoxic\u2013ischemic injury to neonatal rat brain","volume":"72","author":"Pan","year":"2012","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pediatrneurol.2010.05.009","article-title":"Whole body hypothermia and oxidative stress in babies with hypoxic\u2013ischemic brain injury","volume":"43","author":"Perrone","year":"2010","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2008.04.056","article-title":"Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation","volume":"438","author":"Rainey-Smith","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2011.08.047","article-title":"Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke","volume":"1420","author":"Raza","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0130","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1203\/PDR.0b013e31820efbcf","article-title":"Adverse and protective influences of adenosine on the newborn and embryo: implications for preterm white matter injury and embryo protection","volume":"69","author":"Rivkees","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/156720209789630302","article-title":"FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis","volume":"6","author":"Shang","year":"2009","journal-title":"Curr Neurovasc Res"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0140","doi-asserted-by":"crossref","first-page":"20814","DOI":"10.1074\/jbc.M500528200","article-title":"The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling","volume":"280","author":"Skurk","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0145","doi-asserted-by":"crossref","first-page":"20814","DOI":"10.1074\/jbc.M500528200","article-title":"The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling","volume":"280","author":"Skurk","year":"2005","journal-title":"J Biol Chem"},{"issue":"37","key":"10.1016\/j.neuroscience.2013.09.030_b0185","doi-asserted-by":"crossref","first-page":"34783","DOI":"10.1074\/jbc.M305063200","article-title":"Modulation of pro-survival Akt\/protein kinase B and ERK1\/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability","volume":"278","author":"Spencer","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0155","doi-asserted-by":"crossref","first-page":"542976","DOI":"10.1155\/2012\/542976","article-title":"Hypoxic\u2013ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria","volume":"2012","author":"Ten","year":"2012","journal-title":"Neurol Res Int"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.abb.2009.01.016","article-title":"The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury","volume":"484","author":"Vafeiadou","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0165","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1471-4159.2003.01652.x","article-title":"Interaction between flavonoids and the blood\u2013brain barrier: in vitro studies","volume":"85","author":"Youdim","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jep.2004.12.035","article-title":"Protective effect of Khamira Abreesham Uood Mastagiwala against free radical induced damage in focal ischemia","volume":"99","author":"Yousuf","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2013.09.030_b0175","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/jnr.20024","article-title":"High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways","volume":"75","author":"Zhong","year":"2004","journal-title":"J Neurosci Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213008026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213008026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T11:46:37Z","timestamp":1564055197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452213008026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":35,"alternative-id":["S0306452213008026"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2013.09.030","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}