{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:33:21Z","timestamp":1791192801451,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,27]],"date-time":"2013-09-27T00:00:00Z","timestamp":1380240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.neuroscience.2013.09.031","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T18:52:36Z","timestamp":1380135156000},"page":"324-334","source":"Crossref","is-referenced-by-count":117,"special_numbering":"C","title":["Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis"],"prefix":"10.1016","volume":"254","author":[{"given":"T.L.","family":"Briones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2013.09.031_b0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2010.02.066","article-title":"Longitudinal characterization of white matter maturation during adolescence","volume":"1327","author":"Bava","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0010","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1360-0443.2010.03351.x","article-title":"Alcohol and depression","volume":"106","author":"Boden","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0015","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1089\/neu.2008.0707","article-title":"Environmental experience modulates ischemia-induced amyloidogenesis and enhances functional recovery","volume":"24","author":"Briones","year":"2009","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/1099800404271328","article-title":"Dentate gyrus neurogenesis after cerebral ischemia and behavioral training","volume":"6","author":"Briones","year":"2005","journal-title":"Biol Res Nurs"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1471-2202-12-124","article-title":"Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications","volume":"9","author":"Briones","year":"2011","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbr.2005.11.015","article-title":"Amelioration of cognitive impairment and changes in microtubule-associated protein 2 after transient global cerebral ischemia are influenced by complex environment experience","volume":"168","author":"Briones","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0035","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.pbb.2008.05.004","article-title":"Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model","volume":"90","author":"Caldwell","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00213-013-2993-0","article-title":"Abstinence from repeated amphethamine treatment induces depressive-like behaviors and oxidative damage in rat brain","volume":"227","author":"Che","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0045","doi-asserted-by":"crossref","DOI":"10.1111\/j.1530-0277.2011.01548.x","article-title":"Brain-derived neurotrophic factor serum levels in alcohol-dependent subjects 6months after alcohol withdrawal","volume":"35","author":"Costa","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"Couillard-Despres","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0055","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1037\/a0014414","article-title":"Binge drinking in young adults: data, definitions, and determinants","volume":"135","author":"Courtney","year":"2009","journal-title":"Psychol Bull"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0060","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1530-0277.2000.tb01973.x","article-title":"Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats","volume":"24","author":"Crews","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0065","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/alcalc\/agn079","article-title":"Mechanisms of neurodegeneration and regeneration in alcoholism","volume":"44","author":"Crews","year":"2009","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0070","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1176\/appi.ajp.157.5.737","article-title":"Hippocampal volume in adolescent-onset alcohol use disorders","volume":"157","author":"De Bellis","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0075","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2105\/AJPH.77.2.178","article-title":"Adolescent depression, alcohol and drug use","volume":"77","author":"Deykin","year":"1987","journal-title":"Am J Public Health"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bandc.2009.08.008","article-title":"Motivational systems in adolescence: possible implications for age differences in substance abuse and risk-taking behaviors","volume":"72","author":"Doremus","year":"2010","journal-title":"Brain Cogn"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0085","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0090","doi-asserted-by":"crossref","first-page":"404","DOI":"10.15288\/jsa.2002.63.404","article-title":"Cognitive processes and motor skills differ in sensitivity to alcohol reinforcement","volume":"63","author":"Fogarty","year":"2002","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S1364-6613(99)01310-8","article-title":"Neurogenesis in adulthood: a possible role in learning","volume":"3","author":"Gould","year":"1999","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0899-3289(97)90009-2","article-title":"Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the national longitudinal alcohol epidemiologic survey","volume":"9","author":"Grant","year":"1997","journal-title":"J Subst Abuse"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0105","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2011.07.027","article-title":"Neonatal alcohol exposure disrupts hippocampal neurogenesis and contextual fear conditioning in adult rats","volume":"1412","author":"Hamilton","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pbb.2011.08.014","article-title":"Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF","volume":"100","author":"Hauser","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0115","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1111\/j.1460-9568.2005.04120.x","article-title":"Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth on newborn neurons","volume":"21","author":"He","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/alcalc\/agm172","article-title":"Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal","volume":"43","author":"Huang","year":"2008","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0125","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn.2185","article-title":"Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain","volume":"11","author":"Imayoshi","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0130","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0913572107","article-title":"A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone","volume":"107","author":"Jang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0135","unstructured":"Johnston LD, O\u2019Malley PM, Bachman JG, Schulenberg JE (2004) Monitoring the future, vol. 1. National Survey Results on Drug Use, 1975\u20132004. NIH Pub No. 05-5727."},{"key":"10.1016\/j.neuroscience.2013.09.031_b0140","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.conb.2004.03.001","article-title":"Functional significance of adult neurogenesis","volume":"14","author":"Kempermann","year":"2004","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0145","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/00000374-199904001-00010","article-title":"Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal","volume":"23","author":"Knapp","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0150","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.278.5335.52","article-title":"Drug abuse: hedonic homeostatic dysregulation","volume":"278","author":"Koob","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0155","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997","article-title":"Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation","volume":"17","author":"Kuhn","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5483\/BMBRep.2009.42.5.239","article-title":"Adult hippocampal neurogenesis and related neurotrophic factors","volume":"42","author":"Lee","year":"2009","journal-title":"BMB Rep"},{"issue":"Suppl. 4","key":"10.1016\/j.neuroscience.2013.09.031_b0165","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1542\/peds.2007-2243A","article-title":"Underage drinking: a developmental framework","volume":"121","author":"Masten","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0170","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1002\/cne.22647","article-title":"Adolescent binge alcohol exposure alters hippocampal progenitor cell proliferation in rats: effects on cell cycle kinetics","volume":"519","author":"McClain","year":"2011","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0175","article-title":"Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence","author":"McClain","year":"2013","journal-title":"Addict Biol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0180","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ntt.2006.10.010","article-title":"Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry","volume":"29","author":"Medina","year":"2007","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0185","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/hipo.20665","article-title":"Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model","volume":"20","author":"Morris","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0190","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pscychresns.2005.05.008","article-title":"Reduced hippocampal volume among adolescents wth alcohol use disorders without psychiatric comorbidity","volume":"139","author":"Nagel","year":"2005","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0195","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amepre.2009.09.039","article-title":"The intensity of binge alcohol consumption among U.S. adults","volume":"38","author":"Naimi","year":"2003","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0200","series-title":"Metacognition and cognition neuropsychology: monitoring and control processes","first-page":"161","article-title":"Effect of acute alcohol intoxication on recall and on judgments of learning during the acquisition of new information","author":"Nelson","year":"1999"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0205","doi-asserted-by":"crossref","first-page":"530","DOI":"10.2174\/157015911798376262","article-title":"Neurotrophins role in depression neurobiology: a review of basic and clinical evidence","volume":"9","author":"Neto","year":"2011","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0210","first-page":"3","article-title":"Binge drinking defined","volume":"3","author":"NIAAA","year":"2004","journal-title":"NIAAA Newslett"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0215","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1523\/JNEUROSCI.3063-04.2004","article-title":"Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol","volume":"24","author":"Nixon","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0220","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1523\/JNEUROSCI.5731-07.2008","article-title":"Brain chromatic remodeling: a novel mechanism of alcoholism","volume":"28","author":"Pandey","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0295","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1523\/JNEUROSCI.4988-05.2006","article-title":"Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors","volume":"26","author":"Pandey","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0230","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1016\/j.amepre.2006.07.002","article-title":"Links between depression and substance abuse in adolescents: neurobiological mechanism","volume":"31","author":"Rao","year":"2006","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0235","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1001\/jama.1990.03450190043026","article-title":"Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiological Catchment Area (ECA) Study","volume":"264","author":"Regier","year":"1990","journal-title":"JAMA"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0240","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1037\/0021-843X.100.2.214","article-title":"Comorbidity of unipolar depression. II. Comorbidity with other mental disorders in adolescents and adults","volume":"100","author":"Rohde","year":"1991","journal-title":"J Abnorm Psychol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0245","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.alcohol.2008.05.002","article-title":"Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young rats","volume":"42","author":"Schulteis","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0250","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.alcohol.2009.09.032","article-title":"A preliminary study of functional magnetic resonance imaging response during verbal encoding among adolescent binge drinkers","volume":"44","author":"Schweinsburg","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0255","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1176\/appi.ajp.160.8.1516","article-title":"Untreated depression and hippocampal volume loss","volume":"160","author":"Sheline","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0260","doi-asserted-by":"crossref","first-page":"a001842","DOI":"10.1101\/cshperspect.a001842","article-title":"Guidance molecules in synapse formation and plasticity","volume":"2","author":"Shen","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0265","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0270","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/npp.2008.90","article-title":"Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice","volume":"34","author":"Stevenson","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0275","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.amjmed.2005.01.007","article-title":"The prevalence and impact of alcohol problems in major depression: a systematic review","volume":"118","author":"Sullivan","year":"2005","journal-title":"Am J Med"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0280","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/1097-4547(20010115)63:2<200::AID-JNR1012>3.0.CO;2-Q","article-title":"Effects of alcohol on brain-derived neurotrophic factor mRNA expression in discrete regions of the rat hippocampus and hypothalamus","volume":"63","author":"Tapia-Arancibia","year":"2001","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0285","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.addbeh.2010.06.015","article-title":"Drinking at European universities? A review of students\u2019 alcohol use","volume":"35","author":"Vicki","year":"2010","journal-title":"Addict Behav"},{"key":"10.1016\/j.neuroscience.2013.09.031_b0290","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/0-306-48626-1_8","article-title":"Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults","volume":"17","author":"White","year":"2005","journal-title":"Recent Dev Alcohol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213008038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213008038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T04:34:59Z","timestamp":1716006899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452213008038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":58,"alternative-id":["S0306452213008038"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2013.09.031","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}