{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:42:59Z","timestamp":1781660579072,"version":"3.54.5"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.neuroscience.2013.10.064","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T14:01:22Z","timestamp":1384351282000},"page":"147-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Unpredictable neonatal stress enhances adult anxiety and alters amygdala gene expression related to serotonin and GABA"],"prefix":"10.1016","volume":"258","author":[{"given":"E.C.","family":"Sarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2013.10.064_b0005","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1046\/j.1460-9568.2003.02622.x","article-title":"Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro","volume":"17","author":"Alfarez","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"Anderson","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0015","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1176\/appi.ajp.2012.11091347","article-title":"Fragmentation and unpredictability of early-life experience in mental disorders","volume":"169","author":"Baram","year":"2012","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b9000","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nn.2403","article-title":"Transitions in infant learning are modulated by dopamine in the amygdala","volume":"12","author":"Barr","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0145-2134(92)90011-F","article-title":"A review of the long-term effects of child sexual abuse","volume":"16","author":"Beitchman","year":"1992","journal-title":"Child Abuse Negl"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0025","doi-asserted-by":"crossref","first-page":"9429","DOI":"10.1523\/JNEUROSCI.0394-12.2012","article-title":"Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex","volume":"32","author":"Beurdeley","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0030","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.npp.1301410","article-title":"Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment","volume":"33","author":"Bondi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mcn.2005.09.018","article-title":"Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice","volume":"31","author":"Borgkvist","year":"2006","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0040","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.febslet.2004.07.055","article-title":"Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments","volume":"573","author":"Breitling","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0045","doi-asserted-by":"crossref","first-page":"e64402","DOI":"10.1371\/journal.pone.0063302","article-title":"Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction","volume":"8","author":"Chakravarty","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0050","series-title":"Neuropsychopharmacology: the fifth generation of progress","first-page":"901","article-title":"Neurobiological basis of anxiety disorders","author":"Charney","year":"2002"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0055","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.60.8.837","article-title":"Prevalence and development of psychiatric disorders in childhood and adolescence","volume":"60","author":"Costello","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0065","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0031-9384(94)90316-6","article-title":"Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression","volume":"56","author":"D\u2019Aquila","year":"1994","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pbb.2012.05.010","article-title":"Subsequent anxiety-related behavior in rats exposed to low-dose methadone during gestation, lactation or both periods consecutively","volume":"102","author":"Daly","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0075","doi-asserted-by":"crossref","first-page":"828","DOI":"10.7326\/0003-4819-113-11-828","article-title":"Sexual and physical abuse in women with functional or organic gastrointestinal disorders","volume":"113","author":"Drossman","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0080","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00004583-199209000-00013","article-title":"Psychiatric diagnoses of maltreated children: preliminary findings","volume":"31","author":"Famularo","year":"1992","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0085","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1176\/appi.ajp.2010.10040484","article-title":"Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams\u2019 Syndrome","volume":"167","author":"Feyder","year":"2010","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0090","doi-asserted-by":"crossref","first-page":"e21842","DOI":"10.1371\/journal.pone.0021842","article-title":"Influence of early stress on social abilities and serotonergic functions across generations in mice","volume":"6","author":"Franklin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00004583-200404000-00004","article-title":"Childhood reactions to terrorism-induced trauma: a review of the past 10years","volume":"43","author":"Fremont","year":"2004","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0100","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/dev.420170607","article-title":"The effects of prenatal exposure to predictable or unpredictable stress on early development in the rat","volume":"17","author":"Fride","year":"1984","journal-title":"Dev Psychobiol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0105","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1037\/a0018898","article-title":"A latent growth examination of fear development in infancy: contributions of maternal depression and the risk for toddler anxiety","volume":"46","author":"Gartstein","year":"2010","journal-title":"Dev Psychol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0110","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.1174146","article-title":"Perineuronal nets protect fear memories from erasure","volume":"325","author":"Gogolla","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.psyneuen.2012.12.005","article-title":"Deconstructing sociality, social evolution and relevant nonapeptide functions","volume":"38","author":"Goodson","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yhbeh.2013.05.006","article-title":"What\u2019s in a name? Considerations of homologies and nomenclature for vertebrate social behavior networks","volume":"64","author":"Goodson","year":"2013","journal-title":"Horm Behav"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroscience.2012.08.014","article-title":"Differential distribution of serotonin receptor subtypes in BNST(ALG) neurons: modulation by unpredictable shock stress","volume":"225","author":"Hazra","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/neuro.08.041.2009","article-title":"Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene","volume":"3","author":"Heim","year":"2009","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0135","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0145","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2202-13-22","article-title":"Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat","volume":"13","author":"Huang","year":"2012","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0155","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s002130100701","article-title":"Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment","volume":"158","author":"Huot","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0160","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1128\/MCB.00083-12","article-title":"Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors","volume":"32","author":"Inoue","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0165","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1113\/jphysiol.2011.206169","article-title":"Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron","volume":"589","author":"Ishikawa","year":"2011","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0170","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/10253890500070005","article-title":"Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus","volume":"7","author":"Joels","year":"2004","journal-title":"Stress"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0175","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(02)00781-5","article-title":"Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long\u2013Evans rats","volume":"73","author":"Kalinichev","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/YCO.0b013e32816ebc8c","article-title":"Age of onset of mental disorders: a review of recent literature","volume":"20","author":"Kessler","year":"2007","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0185","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","article-title":"Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0190","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","article-title":"Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey","volume":"51","author":"Kessler","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0195","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.pbb.2012.12.004","article-title":"Increased anxiety-related behavior in male and female adult rats following early and late adolescent exposure to 3,4-methylenedioxymethamphetamine (MDMA)","volume":"103","author":"Kolyaduke","year":"2013","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0200","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainres.2006.03.009","article-title":"Early life stress impairs fear conditioning in adult male and female rats","volume":"1087","author":"Koston","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0205","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000336732","article-title":"The development and neurobiology of infant attachment and fear","volume":"34","author":"Landers","year":"2012","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0210","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1467-6494.1956.tb01283.x","article-title":"The effects of early shock and handling on later avoidance learning","volume":"24","author":"Levine","year":"1956","journal-title":"J Pers"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2007.07.039","article-title":"The expression of Troponin T1 gene is induced by ketamine in adult mouse brain","volume":"1174","author":"Lowe","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0220","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00004836-198706000-00017","article-title":"Recollection of childhood events in adults with irritable bowel syndrome","volume":"9","author":"Lowman","year":"1987","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0225","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1192\/bjp.184.6.482","article-title":"Age of traumatisation as a predictor of post-traumatic stress disorder or major depression in young women","volume":"184","author":"Maercker","year":"2004","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0230","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0306-4530(01)00092-0","article-title":"Chronic stress during prepubertal development: immediate and long-lasting effects on arterial blood pressure and anxiety-related behavior","volume":"27","author":"Maslova","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0235","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00213-003-1498-7","article-title":"Long-lasting effects of chronic stress on DOI-induced hyperthermia in male rats","volume":"169","author":"Matuszewich","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0240","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1146\/annurev.neuro.24.1.1161","article-title":"Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations","volume":"24","author":"Meaney","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0245","doi-asserted-by":"crossref","first-page":"D377","DOI":"10.1093\/nar\/gks1118","article-title":"PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees","volume":"41","author":"Mi","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.08.022.2009","article-title":"Enduring neurobehavioral effects of early life trauma mediated through learning and corticosterone suppression","volume":"3","author":"Moriceau","year":"2009","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0255","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1046\/j.1460-9568.2000.00203.x","article-title":"Close linkage between calcium\/calmodulin kinase II alpha\/beta and NMDA-2A receptors in the lateral amygdala and significance for retrieval of auditory fear conditioning","volume":"12","author":"Moriya","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0260","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tins.2012.08.004","article-title":"Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors","volume":"35","author":"Neumann","year":"2012","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0265","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1037\/0022-006X.64.3.552","article-title":"Psychiatric disorder in a birth cohort of young adults: prevalence, comorbidity, clinical significance, and new case incidence from ages 11 to 21","volume":"64","author":"Newman","year":"1996","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0270","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuroscience.2009.06.036","article-title":"Genetics of anxiety and trauma-related disorders","volume":"164","author":"Norrholm","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0275","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3109\/10253890903067418","article-title":"Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour","volume":"13","author":"O\u2019Malley","year":"2010","journal-title":"Stress"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0280","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0006-8993(99)01098-7","article-title":"Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor","volume":"821","author":"Okuyama","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0285","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.pnpbp.2010.12.018","article-title":"Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responses","volume":"35","author":"Piato","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/lm.027383.112","article-title":"The E3 ligase APC\/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice","volume":"20","author":"Pick","year":"2013","journal-title":"Learn Mem"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0295","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","article-title":"Stress, depression, and neuroplasticity: a convergence of mechanisms","volume":"33","author":"Pittenger","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0300","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1037\/0735-7044.121.3.462","article-title":"Repeated exposure to stress across the childhood-adolescent period alters rats\u2019 anxiety- and depression-like behaviors in adulthood: the importance of stressor type and gender","volume":"121","author":"Pohl","year":"2007","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0305","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0149-7634(03)00009-5","article-title":"Long-term neurobehavioral impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms","volume":"27","author":"Price","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0310","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1471-4159.2003.02332.x","article-title":"Chronic unpredictable stress alters gene expression in rat single dentate granule cells","volume":"89","author":"Qin","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0315","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.biopsych.2009.12.019","article-title":"Developing a neurobehavioral animal model of infant attachment to an abusive caregiver","volume":"67","author":"Raineki","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0320","doi-asserted-by":"crossref","first-page":"7758","DOI":"10.1523\/JNEUROSCI.5843-11.2012","article-title":"Effects of early-life abuse differ across development: infant social behavior deficits are followed by adolescent depressive-like behaviors mediated by the amygdala","volume":"32","author":"Raineki","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0325","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0447.1993.tb03411.x","article-title":"One-month prevalence of mental disorders in the United States and sociodemographic characteristics: The Epidemiologic Catchment Area study","volume":"88","author":"Regier","year":"1993","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0330","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1210\/en.2008-0633","article-title":"A novel mouse model for acute and long-lasting consequences of early life stress","volume":"149","author":"Rice","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055613","article-title":"Effects of AKAP5 Pro100Leu genotype on working memory for emotional stimuli","volume":"8","author":"Richter","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0340","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.neuro.051508.135620","article-title":"The influence of stress hormones on fear circuitry","volume":"32","author":"Rodrigues","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0345","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1469-7610.2010.02282.x","article-title":"Annual Research Review: epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development","volume":"52","author":"Roth","year":"2011","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0350","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1523\/JNEUROSCI.4765-06.2007","article-title":"Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation","volume":"27","author":"Sabatini","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/h0024514","article-title":"Failure to escape traumatic shock","volume":"74","author":"Seligman","year":"1967","journal-title":"J Exp Psychol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0360","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.biopsych.2007.04.025","article-title":"Enduring effects of infant memories: infant odor-shock conditioning attenuates amygdala activity and adult fear conditioning","volume":"62","author":"Sevelinges","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0365","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dcn.2010.07.005","article-title":"Adult depression-like behavior, amygdala and olfactory cortex functions are restored by odor previously paired with shock during infant\u2019s sensitive period attachment learning","volume":"1","author":"Sevelinges","year":"2011","journal-title":"Dev Cogn Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0370","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1101\/lm.998508","article-title":"Neonatal odor-shock conditioning alters the neural network involved in odor fear learning at adulthood","volume":"15","author":"Sevelinges","year":"2008","journal-title":"Learn Mem"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0375","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0028-3908(79)90087-X","article-title":"A neuropharmacologically relevant animal model of depression","volume":"18","author":"Sherman","year":"1979","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0380","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1037\/0022-006X.74.2.219","article-title":"Unresolved attachment, PTSD, and dissociation in women with childhood abuse histories","volume":"74","author":"Stovall-McClough","year":"2006","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0385","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1440-169X.2009.01093.x","article-title":"From brain formation to plasticity: insights on Otx2 homeoprotein","volume":"51","author":"Sugiyama","year":"2009","journal-title":"Dev Growth Differ"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0390","first-page":"366","article-title":"Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms","volume":"90","author":"Talley","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0395","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/0016-5085(94)90228-3","article-title":"Gastrointestinal tract symptoms and self-reported abuse: a population-based study","volume":"107","author":"Talley","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0400","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0149-7634(03)00007-1","article-title":"The neurobiological consequences of early stress and childhood maltreatment","volume":"27","author":"Teicher","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0435","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1365-2982.2007.00955.x","article-title":"Long-term colonic hypersensitivity in adult rats induced by neonatal unpredictable vs predictable shock","volume":"19","author":"Tyler","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0410","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1460-9568.2004.03568.x","article-title":"Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus","volume":"20","author":"Verkuyl","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0415","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2011.00003","article-title":"Inheritable effect of unpredictable maternal separation on behavioral responses in mice","volume":"5","author":"Weiss","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0420","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0031-9384(98)00300-X","article-title":"Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats","volume":"66","author":"Wigger","year":"1999","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0425","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1037\/a0027258","article-title":"Intermittent physical stress during early- and mid-adolescence differentially alters rats\u2019 anxiety- and depression-like behaviors in adulthood","volume":"126","author":"Wilkin","year":"2012","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2013.10.064_b9005","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nbt0604-656b","article-title":"Preprocessing of oligonucleotide array data","volume":"22","author":"Wu","year":"2004","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.neuroscience.2013.10.064_b0430","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0166-4328(00)00302-8","article-title":"Early exposure to chronic variable stress facilitates the occurrence of anhedonia and enhanced emotional reactions to novel stressors: reversal by naltrexone pretreatment","volume":"117","author":"Zurita","year":"2000","journal-title":"Behav Brain Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213009172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213009172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:40:13Z","timestamp":1759678813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452213009172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":88,"alternative-id":["S0306452213009172"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2013.10.064","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unpredictable neonatal stress enhances adult anxiety and alters amygdala gene expression related to serotonin and GABA","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2013.10.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}