{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:19:41Z","timestamp":1776176381968,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conacyt","award":["38648"],"award-info":[{"award-number":["38648"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.neuroscience.2013.12.035","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T11:15:34Z","timestamp":1387970134000},"page":"11-22","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Influence of the brain sexual differentiation process on despair and antidepressant-like effect of fluoxetine in the rat forced swim test"],"prefix":"10.1016","volume":"261","author":[{"given":"M.L.","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mart\u00ednez-Mota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Estrada-Camarena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez-Guasti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2013.12.035_b0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0031-9384(91)90232-D","article-title":"Sex differences in behavioral despair: relationships between behavioral despair and open field activity","volume":"49","author":"Alonso","year":"1991","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0010","series-title":"DSM-IV (diagnostic and statistical manual of mental disorders)","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0149-7634(98)00029-3","article-title":"Ethopharmacology of imipramine in the forced-swimming test: gender differences","volume":"23","author":"Barros","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jad.2006.04.029","article-title":"Different gender response to serotonergic and noradrenergic antidepressants. A comparative study of the efficacy of citalopram and reboxetine","volume":"95","author":"Berlanga","year":"2006","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0025","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0031-9384(89)90238-2","article-title":"Influence of ovariectormy, estradiol and progesterone on the behavior of mice in an experimental model of depression","volume":"45","author":"Bernardi","year":"1989","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0030","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0306-4530(91)90038-U","article-title":"Modification of gonadectomy-induced increases in brain monoamine metabolism by steroid hormones in male and female rats","volume":"16","author":"Bitar","year":"1991","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0035","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.physbeh.2010.07.011","article-title":"Orchidectomy modifies the antidepressant-like response of nicotine in the forced swimming test","volume":"101","author":"Bonilla-Jaime","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000006607","article-title":"The orthodox view of brain sexual differentiation","volume":"54","author":"Breedlove","year":"1999","journal-title":"Brain Behav Evol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0045","first-page":"87","article-title":"Sex differences in forced-swim and open-field test behaviours after chronic administration of melatonin Eur","volume":"402","author":"Brotto","year":"2000","journal-title":"J Pharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0050","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0278-5846(95)00266-9","article-title":"An early lesion of the lateral septal nuclei produced changes in the forced swim test depending on gender","volume":"19","author":"Contreras","year":"1995","journal-title":"Prog Neuropsychopharmacol Biol Psychiat"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0055","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0278-5846(98)00066-9","article-title":"Desipramine restricts estral cycle oscillations in swimming","volume":"22","author":"Contreras","year":"1998","journal-title":"Prog Neuropsychopharmacol Biol Psychiat"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0060","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/026988110101500401","article-title":"The lowest effective dose of fluoxetine in the forced swim test significantly affects the firing rate of lateral septal nucleus neurons in the rat","volume":"15","author":"Contreras","year":"2001","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0065","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/sj.npp.1301533","article-title":"Females do not express learned helplessness like males do","volume":"33","author":"Dalla","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1742-7843.2009.00516.x","article-title":"Sex differences in animal models of depression and antidepressant response","volume":"106","author":"Dalla","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0075","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-4328(00)00351-X","article-title":"Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?","volume":"119","author":"David","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-1781(86)90063-6","article-title":"Forms of atypical depression and their response to antidepressant drugs","volume":"17","author":"Davidson","year":"1985","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0085","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-4328(96)00067-8","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth","volume":"73","author":"Detke","year":"1996","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced test differentially produced by serotonergic and noradrenergic antidepressants","volume":"21","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1037\/1064-1297.5.2.107","article-title":"Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression","volume":"5","author":"Detke","year":"1997","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0100","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","article-title":"Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats","volume":"126","author":"Drossopoulou","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0105","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/sj.npp.1300097","article-title":"Antidepressant-like effect of different estrogenic compounds in the forced swimming test","volume":"28","author":"Estrada-Camarena","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00213-003-1707-4","article-title":"Interaction between estrogens and antidepressants in the forced swimming test in rats","volume":"173","author":"Estrada-Camarena","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00213-008-1291-8","article-title":"Reduction in the latency of action of antidepressants by 17\u03b2-estradiol in the forced swimming test","volume":"201","author":"Estrada-Camarena","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/FBP.0b013e32833db7e9","article-title":"Antidepressant effects of estrogens: a basic approximation","volume":"21","author":"Estrada-Camarena","year":"2010","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0125","series-title":"Psychoneuroendocrinology","first-page":"97","article-title":"Sex differences in depression and its treatment","author":"Estrada-Camarena","year":"2011"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0130","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1177\/0269881111408456","article-title":"Long-term ovariectomy modulates the antidepressant-like action of estrogens, but not of antidepressants","volume":"25","author":"Estrada-Camarena","year":"2011","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0135","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0306-4530(98)00048-1","article-title":"Sexual differentiation modifies the allopregnanolone anxiolytic actions in rats","volume":"24","author":"Fern\u00e1ndez-Guasti","year":"1999","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0140","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.1210\/en.2008-0433","article-title":"Organizational and activational effects of testosterone on masculinization of female physiological and behavioral stress responses","volume":"149","author":"Goel","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0145","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000123328","article-title":"Anesthetic pregnanes counteract androgen-induced defeminization","volume":"34","author":"Gonz\u00e1lez-Mariscal","year":"1982","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pbb.2012.03.012","article-title":"Alterations on the morphology, nitric oxide synthesis and activity of platelets reproduced in rats as possible biomarkers for depression are reversed by fluoxetine","volume":"102","author":"Gonz\u00e1lez-Trujano","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0155","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/201909","article-title":"Brain SERT expression of male rats is reduced by aging and increased by testosterone restitution","author":"Herrera-P\u00e9rez","year":"2013","journal-title":"Neurosci J"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0160","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1523\/JNEUROSCI.02-03-00354.1982","article-title":"The influence of sex hormones on antidepressant-induced alterations in neurotrasmitter receptor binding","volume":"2","author":"Kendall","year":"1982","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0165","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","article-title":"The epidemiology of major depressive disorder. Results from the National Comorbidity Survey Replication (NCS-R)","volume":"289","author":"Kessler","year":"2003","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.neuroscience.2013.12.035_b0170","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/0269881108095914","article-title":"Sex-related differential response to clomipramine treatment in a rat model of depression","volume":"2","author":"Kokras","year":"2009","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0175","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.neuropharm.2011.08.025","article-title":"Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity","volume":"62","author":"Kokras","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0180","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1176\/appi.ajp.157.9.1445","article-title":"Gender differences in treatment response to sertraline versus imipramine in chronic depression","volume":"157","author":"Kornstein","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2004.12.006","article-title":"The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats","volume":"114","author":"LaCroix-Fralish","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0190","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/jwh.1997.6.337","article-title":"Fluoxetine vs. tricyclic antidepressants in women with major depressive disorder","volume":"6","author":"Lewis-Hall","year":"1997","journal-title":"J Womens Health"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0195","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.euroneuro.2005.07.003","article-title":"Sex-dependent effects of fluoxetine and triiodothyronine in the forced swim test in rats","volume":"16","author":"Lifschytz","year":"2006","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0200","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0924-977X(01)00089-X","article-title":"Gender differences in the efficacy of fluoxetine and maprotiline in depressed patients","volume":"11","author":"Martenyi","year":"2001","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0205","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.pbb.2004.05.016","article-title":"Testosterone dependent antidepressant-like effect of noradrenergic but not of serotoninergic drugs","volume":"78","author":"Mart\u00ednez-Mota","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0210","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.pbb.2007.09.003","article-title":"Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats","volume":"88","author":"Mart\u00ednez-Mota","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0215","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0169-328X(98)00281-2","article-title":"Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids","volume":"63","author":"McQueen","year":"1999","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0220","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pbb.2005.07.021","article-title":"Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat","volume":"82","author":"Overstreet","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0225","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051156","article-title":"Serotonergic mediation of effects of fluoxetine, but not desipramine, in the rat forced swimming test","volume":"147","author":"Page","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0230","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbr.2012.05.034","article-title":"Synergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depression","volume":"233","author":"R\u00e9camier-Carballo","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0235","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s002130050555","article-title":"Antidepressant behavioral effects by dual inhibition of monoamine uptake in the rat forced swimming test","volume":"136","author":"R\u00e9n\u00e9ric","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0240","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-4328(02)00203-6","article-title":"In the rat forced swimming test, chronic but not subacute administration of dual 5-HT\/NA antidepressant treatments may produce greater effects than selective drugs","volume":"136","author":"R\u00e9n\u00e9ric","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(89)91049-4","article-title":"[3H]Imipramine binding in discrete brain areas is affected by castration in male rats","volume":"496","author":"Sandrini","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0250","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1176\/ajp.156.3.480","article-title":"Gender differences in the prevalence of clinical depression: the role played by depression associated with somatic symptoms","volume":"156","author":"Silverstein","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0255","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1124\/jpet.105.093948","article-title":"Differential gender-related vulnerability to depression induction and converging antidepressant responses in rats","volume":"316","author":"Sun","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0260","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archpsyc.1996.01830090023004","article-title":"A placebo-controlled randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia","volume":"53","author":"Thase","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0265","series-title":"Sex and internal secretions","first-page":"1173","article-title":"The hormones and mating behavior","author":"Young","year":"1961"},{"key":"10.1016\/j.neuroscience.2013.12.035_b0270","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00005053-199003000-00008","article-title":"Gender differences in the clinical features of unipolar major depressive disorder","volume":"178","author":"Young","year":"1990","journal-title":"J Nerv Ment Dis"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213010580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452213010580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T08:41:12Z","timestamp":1688892072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452213010580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":54,"alternative-id":["S0306452213010580"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2013.12.035","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}