{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:02:15Z","timestamp":1772798535570,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.neuroscience.2014.03.028","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T19:47:30Z","timestamp":1395517650000},"page":"297-308","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels"],"prefix":"10.1016","volume":"268","author":[{"given":"R.","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Satar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-6878","authenticated-orcid":false,"given":"M.","family":"Gurevitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Goldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2014.03.028_b0005","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.ejpain.2010.03.007","article-title":"A new Nav1.7 sodium channel mutation I234T in a child with severe pain","volume":"14","author":"Ahn","year":"2010","journal-title":"Eur J Pain"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0010","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1385\/CBB:44:3:424","article-title":"Effects of bound Ts3 on voltage dependence of sodium channel transitions to and from inactivation and energetics of its unbinding","volume":"44","author":"Campos","year":"2006","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","article-title":"From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels","volume":"26","author":"Catterall","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0020","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1113\/jphysiol.2011.224204","article-title":"Voltage-gated sodium channels at 60: structure, function and pathophysiology","volume":"590","author":"Catterall","year":"2012","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0025","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0896-6273(94)90271-2","article-title":"Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation","volume":"12","author":"Chahine","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1085\/jgp.20028679","article-title":"Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation","volume":"120","author":"Chanda","year":"2002","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00424-010-0801-9","article-title":"Biophysical characterisation of the persistent sodium current of the Nav1.6 neuronal sodium channel: a single-channel analysis","volume":"460","author":"Chatelier","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s003590050306","article-title":"Transient and persistent tetrodotoxin-sensitive sodium currents in squid olfactory receptor neurons","volume":"184","author":"Chen","year":"1999","journal-title":"J Comp Physiol [A]"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0045","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1085\/jgp.108.6.549","article-title":"A unique role for the S4 segment of domain 4 in the inactivation of sodium channels","volume":"108","author":"Chen","year":"1996","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0050","first-page":"423","article-title":"Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh\u03b1IT","volume":"439","author":"Chen","year":"2000","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0055","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1152\/jn.00652.2002","article-title":"On the persistent sodium current in squid giant axons","volume":"89","author":"Clay","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0060","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.ph.58.030196.002025","article-title":"Persistent sodium current in mammalian central neurons","volume":"58","author":"Crill","year":"1996","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0065","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0166-2236(02)02150-1","article-title":"NaN\/Nav1.9: a sodium channel with unique properties","volume":"25","author":"Dib-Hajj","year":"2002","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10158-006-0036-9","article-title":"Insect sodium channels and insecticide resistance","volume":"7","author":"Dong","year":"2007","journal-title":"Invert Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0075","series-title":"Insect pharmacology, channels, receptors, toxins and enzymes","first-page":"25","article-title":"Progress in insect sodium channel research","author":"Dong","year":"2010"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0080","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0092-8674(95)90279-1","article-title":"Cloning and functional analysis of tipE, a novel membrane protein that enhances drosophila para sodium channel function","volume":"82","author":"Feng","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/gb-2003-4-12-237","article-title":"Overview of the voltage-gated sodium channel family","volume":"4","author":"Frank","year":"2003","journal-title":"Genome Biol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0090","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0896-6273(00)00116-1","article-title":"Nomenclature of voltage-gated sodium channels","volume":"28","author":"Goldin","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0095","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/ncomms2356","article-title":"Multiple pore conformations driven by asynchronous movements of voltage sensors in a eukaryotic sodium channel","volume":"4","author":"Goldschen-Ohm","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0100","doi-asserted-by":"crossref","first-page":"35209","DOI":"10.1074\/jbc.M111.259507","article-title":"Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core-domain of scorpion alpha-toxins on sodium channels","volume":"286","author":"Gur","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuroscience.2014.03.028_b0105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.toxicon.2006.09.017","article-title":"Site-3 toxins and cardiac sodium channels","volume":"49","author":"Hanck","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0110","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1523\/JNEUROSCI.2146-04.2004","article-title":"Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons","volume":"24","author":"Jackson","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0115","doi-asserted-by":"crossref","first-page":"7401","DOI":"10.1523\/JNEUROSCI.0143-10.2010","article-title":"Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances","volume":"30","author":"Khaliq","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/ABiol.59.2008.Suppl.1","article-title":"Persistent Na-channels: origin and function","volume":"59","author":"Kiss","year":"2008","journal-title":"Acta Biol Hung"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0125","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.nlm.2009.03.001","article-title":"Food-aversive classical conditioning increases a persistent sodium current in molluscan withdrawal interneurons in a transcription dependent manner","volume":"92","author":"Kiss","year":"2009","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0130","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1085\/jgp.110.4.391","article-title":"Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains","volume":"110","author":"Kontis","year":"1997","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1085\/jgp.114.2.167","article-title":"Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization","volume":"114","author":"Kuhn","year":"1999","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0140","doi-asserted-by":"crossref","first-page":"36029","DOI":"10.1074\/jbc.M607637200","article-title":"Size matters: erythromelalgia mutation S241T in Nav1.7 alters channel gating","volume":"281","author":"Lampert","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0145","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00221-006-0511-x","article-title":"Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury","volume":"174","author":"Lampert","year":"2006","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-8993(90)91805-Q","article-title":"Sensitive nicotinic and mixed nicotinic-muscarinic receptors in insect neurosecretory cells","volume":"533","author":"Lapied","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0155","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1152\/jn.00613.2009","article-title":"Alternative splicing in the voltage-gated sodium channel DmNav regulates activation, inactivation, and persistent current","volume":"102","author":"Lin","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0160","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1523\/JNEUROSCI.6042-11.2012","article-title":"Activity-dependent alternative splicing increases persistent sodium current and promotes seizure","volume":"32","author":"Lin","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0165","doi-asserted-by":"crossref","first-page":"11862","DOI":"10.1073\/pnas.0307695101","article-title":"Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel","volume":"101","author":"Liu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0170","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1152\/jn.1992.68.4.1307","article-title":"Electrophysiology of the mammillary complex in vitro. I. Tuberomammillary and lateral mammillary neurons","volume":"68","author":"Llinas","year":"1992","journal-title":"Neurophysiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0175","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/0092-8674(89)90512-6","article-title":"Molecular analysis of the para locus, a sodium channel gene in Drosophila","volume":"58","author":"Loughney","year":"1989","journal-title":"Cell"},{"issue":"Pt 3","key":"10.1016\/j.neuroscience.2014.03.028_b0180","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1469-7793.1999.00629.x","article-title":"Direct demonstration of persistent Na+ channel activity in dendritic processes of mammalian cortical neurones","volume":"521","author":"Magistretti","year":"1999","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0185","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1523\/JNEUROSCI.19-17-07334.1999","article-title":"High conductance sustained single-channel activity responsible for the low-threshold persistent Na(+) current in entorhinal cortex neurons","volume":"19","author":"Magistretti","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0190","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1523\/JNEUROSCI.2282-04.2004","article-title":"Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene","volume":"24","author":"Mee","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1042\/BJ20070233","article-title":"Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels","volume":"406","author":"Moran","year":"2007","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0200","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ibmb.2008.01.003","article-title":"Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster","volume":"38","author":"Olson","year":"2008","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0205","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/BF00191850","article-title":"A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech","volume":"175","author":"Opdyke","year":"1994","journal-title":"J Comp Physiol [A]"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0210","doi-asserted-by":"crossref","first-page":"15974","DOI":"10.1073\/pnas.0407004101","article-title":"Identification of alternative splicing regulators by RNA interference in Drosophila","volume":"101","author":"Park","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0215","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1152\/jn.1997.78.4.1811","article-title":"Cellular mechanisms underlying spontaneous firing in rat suprachiasmatic nucleus: involvement of a slowly inactivating component of sodium current","volume":"78","author":"Pennartz","year":"1997","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0220","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1085\/jgp.20028500","article-title":"Single ion occupancy and steady-state gating of Na channels in squid giant axon","volume":"119","author":"Rakowski","year":"2002","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0225","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1523\/JNEUROSCI.20-24-09004.2000","article-title":"Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei","volume":"20","author":"Raman","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0230","doi-asserted-by":"crossref","first-page":"15950","DOI":"10.1074\/jbc.271.27.15950","article-title":"Molecular determinants of high affinity binding of \u03b2\u2013scorpion toxin and sea anemone toxin in the S3\u2013S4 extracellular loop in domain IV of the Na+ channel \u03b1- subunit","volume":"271","author":"Rogers","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0235","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1085\/jgp.106.4.617","article-title":"Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin","volume":"106","author":"Sheets","year":"1995","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0240","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1469-7793.1999.425ae.x","article-title":"Gating of skeletal and cardiac muscle sodium channels in mammalian cells","volume":"514","author":"Sheets","year":"1999","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0245","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1113\/jphysiol.2004.077644","article-title":"Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation","volume":"563","author":"Sheets","year":"2005","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0250","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1113\/jphysiol.2007.134262","article-title":"Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels","volume":"582","author":"Sheets","year":"2007","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0255","first-page":"747","article-title":"The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4","volume":"77","author":"Sheets","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0260","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1523\/JNEUROSCI.18-16-06093.1998","article-title":"Functional analysis of the mouse Scn8a sodium channel","volume":"18","author":"Smith","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1535-7511.2007.00156.x","article-title":"Persistent sodium current and its role in epilepsy","volume":"7","author":"Stafstrom","year":"2007","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0270","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1528-1167.2007.01001.x","article-title":"Carbamazepine and topiramate modulation of transient and persistent sodium currents studied in HEK293 cells expressing the Na(v)1.3 alpha-subunit","volume":"48","author":"Sun","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0275","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0896-6273(02)00574-3","article-title":"Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons","volume":"33","author":"Taddese","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0280","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1124\/mol.104.006205","article-title":"Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding","volume":"67","author":"Tan","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0285","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0166-2236(93)90077-Y","article-title":"Na+ currents that fail to inactivate","volume":"16","author":"Taylor","year":"1993","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0290","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1073\/pnas.85.22.8742","article-title":"Site of covalent attachment of alpha-scorpion toxin derivatives in domain I of the sodium channel alpha subunit","volume":"85","author":"Tejedor","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0295","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1073\/pnas.86.24.10161","article-title":"Localization of the receptor site for alpha-scorpion toxins by antibody mapping: implications for sodium channel topology","volume":"86","author":"Thomsen","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0306-4522(94)00593-T","article-title":"A persistent sodium current in acutely isolated histaminergic neurons from rat hypothalamus","volume":"66","author":"Uteshev","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0305","doi-asserted-by":"crossref","first-page":"15426","DOI":"10.1073\/pnas.1112320108","article-title":"Mapping the receptor site for \u03b1-scorpion toxins on a sodium channel voltage sensor","volume":"108","author":"Wang","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0310","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.110.2.119","article-title":"Functional expression of Drosophila para sodium channels \u2013 modulation by the membrane protein TipE and toxin pharmacology","volume":"110","author":"Warmke","year":"1997","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0315","doi-asserted-by":"crossref","first-page":"15011","DOI":"10.1523\/JNEUROSCI.0577-13.2013","article-title":"Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation","volume":"33","author":"Yamada-Hanff","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0320","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1523\/JNEUROSCI.23-12-04922.2003","article-title":"The position of the fourth segment of domain 4 determines status of the inactivation gate in Na+ channels","volume":"23","author":"Yang","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.028_b0325","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.1021\/bi9528309","article-title":"Functional expression and genetic alteration of an alpha scorpion neurotoxin","volume":"35","author":"Zilberberg","year":"1996","journal-title":"Biochemistry"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T16:37:51Z","timestamp":1565282271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452214002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":65,"alternative-id":["S0306452214002413"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2014.03.028","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}