{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:49:30Z","timestamp":1791179370220,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.neuroscience.2014.03.060","type":"journal-article","created":{"date-parts":[[2014,4,6]],"date-time":"2014-04-06T04:45:59Z","timestamp":1396759559000},"page":"76-87","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats"],"prefix":"10.1016","volume":"270","author":[{"given":"R.","family":"Ravenelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.B.","family":"Santolucito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Byrnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Byrnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.T.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2014.03.060_b0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0031-9384(00)00247-X","article-title":"Effects of baseline anxiety on response to kindling of the right medial amygdala","volume":"70","author":"Ademac","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00426903","article-title":"The effect of housing and gender on morphine self-administration in rats","volume":"58","author":"Alexander","year":"1978","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s002130100720","article-title":"Environmental enrichment decreases intravenous self-administration of amphetamine in female and male rats","volume":"155","author":"Bardo","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0020","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.pbb.2003.09.005","article-title":"Environmental enrichment lowers stress-responsive hormones in singly housed male and female rats","volume":"76","author":"Belz","year":"2003","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0025","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1460-9568.2004.03587.x","article-title":"Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity","volume":"20","author":"Benaroya-Milshtein","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2826.2005.01375.x","article-title":"Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats","volume":"18","author":"Bhatnagar","year":"2006","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0035","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2011.03.038","article-title":"Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression","volume":"495","author":"Branchi","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0040","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0031-9384(00)00365-6","article-title":"Persistent stress-induced elevations of urinary corticosterone in rats","volume":"71","author":"Brennan","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0045","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0031-9384(95)02043-8","article-title":"Effects of housing on male and female rats: crowding stresses males but calms females","volume":"58","author":"Brown","year":"1995","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0050","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1046\/j.1460-9568.2003.02647.x","article-title":"Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis","volume":"17","author":"Brown","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1037\/1064-1297.13.4.367","article-title":"Novelty seeking and drug use: contribution of an animal model","volume":"13","author":"Cain","year":"2005","journal-title":"Exp Clin Psychopharm"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0060","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0306-4522(94)00532-A","article-title":"Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: correlations with cardiovascular, hypothermic and endocrine responses","volume":"64","author":"Chen","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0065","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbr.2008.04.015","article-title":"Nature vs. nurture: can enrichment rescue the behavioral phenotype of BDNF heterozygous mice?","volume":"192","author":"Chourbaji","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0070","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0006-3223(03)00167-7","article-title":"Stress hormone responses to corticotropin-releasing hormone in substance abusers without severe comorbid psychiatric disease","volume":"54","author":"Contoreggi","year":"2003","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0075","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2006.05.048","article-title":"Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress","volume":"404","author":"Cui","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0080","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0001-37652001000200006","article-title":"Response of the brain to enrichment","volume":"73","author":"Diamond","year":"2001","journal-title":"An Acad Bras Ci\u00eanc"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2006.08.016","article-title":"Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress","volume":"175","author":"Fox","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0090","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1523\/JNEUROSCI.22-18-07840.2002","article-title":"Environmental enrichment reverses the effects of maternal separation on stress reactivity","volume":"22","author":"Francis","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0095","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0091-3057(96)00320-6","article-title":"No major differences in locomotor responses to dexamphetamine in high and low responders to novelty: a study of Wistar rats","volume":"57","author":"Gingras","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0100","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/archpsyc.61.8.807","article-title":"Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"61","author":"Grant","year":"2004","journal-title":"Arch Gen Psychiat"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0892-0362(93)90007-B","article-title":"Environmental enrichment and the behavioural effects of prenatal exposure to alcohol in rats","volume":"15","author":"Hannigan","year":"1993","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0110","first-page":"42","article-title":"Physiological and behavioral responses to stress: what does a rat find stressful?","volume":"31","author":"Harkin","year":"2002","journal-title":"Lab Anim"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0115","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1523\/JNEUROSCI.5369-06.2007","article-title":"Cerebral blood flow in immediate and sustained anxiety","volume":"27","author":"Hasler","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/exnr.2000.7415","article-title":"Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain","volume":"164","author":"Ickes","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0125","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004647-200201000-00011","article-title":"Neuronal plasticity in dendritic spines: effect of environmental enrichment on intact and postischemic rat brain","volume":"22","author":"Johansson","year":"2002","journal-title":"J Cereb Blood Flow"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1365-2826.1999.00342.x","article-title":"Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour","volume":"11","author":"Landgraf","year":"1999","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0135","first-page":"1655","volume":"20","author":"Laviola","year":"2004","journal-title":"Beneficial effects of enriched environment on adolescent rats from stressed pregnancies"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0140","first-page":"9","article-title":"The effects of housing enrichment on cardiovascular parameters in spontaneously hypertensive rats","volume":"39","author":"Lawson","year":"2000","journal-title":"Contemp Top Lab Anim Sci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0145","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0031-9384(90)90093-J","article-title":"Stress-induced rise of body temperature in rats is the same in warm and cool environments","volume":"47","author":"Long","year":"1990","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijpsycho.2005.10.007","article-title":"Cortisol secretion patterns in addiction and addiction risk","volume":"59","author":"Lovallo","year":"2006","journal-title":"Int J Psychophysiol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0155","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1196\/annals.1316.077","article-title":"Effects of postnatal cocaine exposure and environmental enrichment on rat behavior in a forced swim test","volume":"1025","author":"Magalhaes","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbr.2006.11.022","article-title":"Rats with persistently low or high exploratory activity: behaviour in tests of anxiety and depression, and extracellular levels of dopamine","volume":"177","author":"M\u00e4llo","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0165","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00041.2006","article-title":"Physiology and neurobiology of stress and adaptation: central role of the brain","volume":"87","author":"McEwen","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0170","first-page":"60","article-title":"The role of BDNF\/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum","volume":"5","author":"McGinity","year":"2011","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b9000","first-page":"188","article-title":"A comparison between Dark Agouti and Sprague-Dawley rats in their behavior on the elevated plus-maze, open-field apparatus (OFA) and activity meters, and their response to diazepam","volume":"150","author":"Merchen","year":"2002","journal-title":"Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0175","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1017\/S0021963098002522","article-title":"Psychopathology among offspring of parents with substance abuse and\/or anxiety disorders: a high-risk study","volume":"39","author":"Merikangas","year":"1998","journal-title":"J Child Psychol Psych"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0180","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00213-003-1411-4","article-title":"Strain differences in response to escapable and inescapable novel environments and their ability to predict amphetamine-induced locomotor activity","volume":"167","author":"Miserendino","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/archpsyc.59.1.77","article-title":"Perceived need and help-seeking in adults with mood, anxiety, or substance use disorders","volume":"59","author":"Mojtabai","year":"2002","journal-title":"Arch Gen Psychiat"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0190","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2826.2004.01173.x","article-title":"Effect of environmental enrichment on stress related systems in rats","volume":"16","author":"Moncek","year":"2004","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0195","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1111\/j.1460-9568.2003.03070.x","article-title":"Environmental enrichment during adolescence reverses the effects of prenatal stress on play behaviour and HPA axis reactivity in rats","volume":"18","author":"Morley-Fletcher","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.devbrainres.2004.09.001","article-title":"Environmental enrichment on behavior and dopamine transporter function in medial prefrontal cortex in adult rats prenatally treated with cocaine","volume":"153","author":"Neugebauer","year":"2004","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-2999(03)01326-8","article-title":"Stress-induced hyperthermia and anxiety: pharmacological validation","volume":"463","author":"Olivier","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0210","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0215","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.brainres.2008.04.010","article-title":"Early enriched housing results in partial recovery of memory deficits in female, but no in male, rats after neonatal hypoxia-ischemia","volume":"1218","author":"Pereira","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0220","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-4522(99)00316-4","article-title":"Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year","volume":"94","author":"Pham","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0225","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1126\/science.2781295","article-title":"Factors that predict individual vulnerability to amphetamine self-administration","volume":"245","author":"Piazza","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0230","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbr.2013.05.041","article-title":"Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats","volume":"252","author":"Ravenelle","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0235","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nn1944","article-title":"Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic","volume":"10","author":"Ressler","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0240","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/j.1460-9568.2006.05059.x","article-title":"Brain-derived neurotrophin factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment","volume":"24","author":"Rossi","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0245","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.biopsych.2003.10.021","article-title":"Neurobiological correlates of high (HAB) versus low anxiety-related behavior (LAB): differential Fos expression in HAB and LAB rats","volume":"55","author":"Salom\u00e9","year":"2004","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0250","first-page":"32","article-title":"Effects of cage enrichment program on heart rate, blood pressure, and activity of male Sprague-Dawley and spontaneously-hyperactive rats monitored by radiotelemetry","volume":"44","author":"Sharp","year":"2005","journal-title":"Contemp Top Lab Anim Sci"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0255","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0006-8993(96)01011-6","article-title":"Effect of microinjection of muscimol into the dorsomedial or paraventricular nucleus on air stress-induced neuroendocrine and cardiovascular changes in rats","volume":"742","author":"Stotz-Potter","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0260","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00702-008-0092-x","article-title":"Physical activity, exercise, depression and anxiety disorders","volume":"116","author":"Str\u00f6hle","year":"2009","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0265","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2003.10.015","article-title":"Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat","volume":"152","author":"Weiss","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0270","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/archpsyc.58.1.55","article-title":"The quality of care for depressive and anxiety disorders in the United States","volume":"58","author":"Young","year":"2001","journal-title":"Arch Gen Psychiat"},{"key":"10.1016\/j.neuroscience.2014.03.060_b0275","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbr.2008.09.032","article-title":"Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice","volume":"197","author":"Zhu","year":"2009","journal-title":"Behav Brain Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214002838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214002838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T04:36:40Z","timestamp":1565325400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452214002838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":56,"alternative-id":["S0306452214002838"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2014.03.060","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}