{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:29:09Z","timestamp":1773214149768,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100011698","name":"Junta de Comunidades de Castilla-La Mancha","doi-asserted-by":"crossref","award":["PAI-05-067"],"award-info":[{"award-number":["PAI-05-067"]}],"id":[{"id":"10.13039\/501100011698","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011698","name":"Junta de Comunidades de Castilla-La Mancha","doi-asserted-by":"crossref","award":["PI-2006\/14"],"award-info":[{"award-number":["PI-2006\/14"]}],"id":[{"id":"10.13039\/501100011698","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.neuroscience.2014.04.018","type":"journal-article","created":{"date-parts":[[2014,4,26]],"date-time":"2014-04-26T10:31:46Z","timestamp":1398508306000},"page":"77-98","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Developmental study of the distribution of hypoxia-induced factor-1 alpha and microtubule-associated protein 2 in children\u2019s brainstem: Comparison between controls and cases with signs of perinatal hypoxia"],"prefix":"10.1016","volume":"271","author":[{"given":"R.","family":"Cove\u00f1as","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gonz\u00e1lez-Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Rivas-Infante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Lagartos-Donate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cebada-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Arroyo-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Insausti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2014.04.018_b0005","doi-asserted-by":"crossref","first-page":"39728","DOI":"10.1074\/jbc.M204619200","article-title":"Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance","volume":"277","author":"Bernaudin","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1749-6632.1986.tb38392.x","article-title":"Differential localization of MAP-2 and tau in mammalian neurons in situ","volume":"466","author":"Binder","year":"1986","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0015","doi-asserted-by":"crossref","first-page":"e17375","DOI":"10.1371\/journal.pone.0017375","article-title":"Sumoylation of hypoxia-inducible factor-1\u03b1 ameliorates failure of brain stem cardiovascular regulation in experimental brain death","volume":"3","author":"Chan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0020","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/SHK.0b013e3181a71027","article-title":"Hypoxia-inducible factor 1\/heme oxygenase-1 cascade as upstream signals in the pro-life role of heat shock protein 70 at rostral ventrolateral medulla during experiment brain steam death","volume":"32","author":"Chang","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0025","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1152\/jappl.2000.89.5.1937","article-title":"Expression of hypoxia-inducible factor-1 alpha in the brain of rats during chronic hypoxia","volume":"89","author":"Chavez","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0030","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1203\/01.PDR.0000142732.09325.61","article-title":"Effects of hypoxia on stress proteins in the piglet brain at birth","volume":"56","author":"Chiral","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2009.06443.x","article-title":"Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?","volume":"112","author":"Correia","year":"2010","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s004290050217","article-title":"Anatomical distribution of beta-endorphin (1\u201327) in the cat brainstem: an immunocytochemical study","volume":"199","author":"Cove\u00f1as","year":"1999","journal-title":"Anat Embryol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0045","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuroscience.2004.07.009","article-title":"An immunocytochemical mapping of methionine-enkephalin-Arg6-Gly7-Leu8 in the human brainstem","volume":"128","author":"Cove\u00f1as","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0050","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbr.2011.08.002","article-title":"Roles for HIF-1alpha in neural stem cell function and the regenerative response to stroke","volume":"227","author":"Cunningham","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s004010050584","article-title":"Changes of cytoskeletal protein immunostaining in myelinated fibre tracts after focal cerebral ischaemia in the rat","volume":"93","author":"Dewar","year":"1997","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0060","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(91)90510-6","article-title":"Inhibition of MAP-2 expression affects both morphological and cell division phenotypes of neuronal differentiation","volume":"64","author":"Dinsmore","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0065","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/en.2007-1649","article-title":"Inhibition of vascular endothelial growth factor in the primate ovary up-regulates hypoxia-inducible factor-1alpha in the follicle and corpus luteum","volume":"149","author":"Duncan","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00429-012-0388-3","article-title":"Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem","volume":"218","author":"Duque","year":"2013","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0075","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jchemneu.2003.09.005","article-title":"Postnatal development of calcium-binding proteins (parvalbumin, calbindin, calretinin) immunoreactivity in the human entorhinal cortex","volume":"26","author":"Grater\u00f3n","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0080","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01954858","article-title":"An improved immunohistostaining procedure for peptides in human brain","volume":"45","author":"Guntern","year":"1989","journal-title":"Experientia"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0085","series-title":"Neuroanatomy: an atlas of structures, sections and systems","author":"Haines","year":"1987"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0090","first-page":"R15","article-title":"Abolition of hypoxic vagal bradycardia by lateral mesencephalic lesions in spinal cats","volume":"237","author":"Hall","year":"1979","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0006-8993(97)00168-6","article-title":"Hypoxia-induced ABR change and heat shock protein expression in the pontine auditory pathway of young rabbits","volume":"757","author":"Inagaki","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-03661-3_1","article-title":"Postnatal development of the human hippocampal formation","volume":"206","author":"Insausti","year":"2010","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","article-title":"Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1\u03b1","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0110","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1460-9568.2010.07400.x","article-title":"Morphology, molecular phenotypes and distribution of neurons in developing human corpus callosum","volume":"32","author":"Jovanov-Milosevic","year":"2010","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0115","doi-asserted-by":"crossref","first-page":"C167","DOI":"10.1152\/ajpcell.1998.274.1.C167","article-title":"Role of H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression","volume":"274","author":"Kroll","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1097-0177(20010201)220:2<175::AID-DVDY1101>3.0.CO;2-F","article-title":"Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development","volume":"220","author":"Lee","year":"2001","journal-title":"Dev Dyn"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0125","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/mgme.2001.3293","article-title":"Developmental stage-specific expression of the alpha and beta subunits of HIF-1 protein in the mouse and human fetus","volume":"75","author":"Madan","year":"2002","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0130","first-page":"95","article-title":"Modeling the neurovascular niche: implications for recovery from CNS injury","volume":"60","author":"Madri","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0135","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jchemneu.2010.10.002","article-title":"Mapping of tyrosine hydroxylase in the alpaca (Lama pacos) brainstem and colocalization with CGRP","volume":"41","author":"Marcos","year":"2011","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0145","first-page":"63","article-title":"Mapping of tyrosine hydroxylase in the diencephalon of the alpaca (Lama pacos) and co-distribution with somatostatin-28 (1\u201312)","volume":"50\u201351","author":"Marcos","year":"2013","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0150","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.neuropharm.2009.12.021","article-title":"De-routing neuronal precursors in the adult brain to sites of injury: role of the vasculature","volume":"58","author":"Massouh","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0155","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1523\/JNEUROSCI.2482-06.2007","article-title":"Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling","volume":"27","author":"Milosevic","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0160","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/jnr.21202","article-title":"Desferrioxamine enhances hypoxic ventilatory response and induces tyrosine hydroxylase gene expression in the rat brainstem in vivo","volume":"85","author":"Nguyen","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0165","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1046\/j.0953-816x.2001.01816.x","article-title":"Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor 1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem","volume":"14","author":"Pascual","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jnr.21837","article-title":"Glial vascular endothelial growth factor overexpression in rat brainstem under tolerable hypoxia: evidence for a central chemosensitivity","volume":"87","author":"Perrin","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0175","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1354\/vp.42-4-405","article-title":"Technical aspects of immunohistochemistry","volume":"42","author":"Ramos-Vara","year":"2005","journal-title":"Vet Pathol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0180","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10571-010-9561-5","article-title":"Continuous expression of HIF-1\u03b1 in neural stem\/progenitor cells","volume":"31","author":"Roitbak","year":"2011","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1203\/01.PDR.0000163390.78239.EA","article-title":"Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors","volume":"58","author":"Roux","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0190","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1471-4159.2003.01696.x","article-title":"Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors","volume":"85","author":"Schnell","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0195","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0006-2952(02)01168-1","article-title":"Signal transduction to hypoxia-inducible factor 1","volume":"64","author":"Semenza","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0200","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10571-012-9803-9","article-title":"Hypoxia inducible factor-1: its potential role in cerebral ischemia","volume":"32","author":"Singh","year":"2012","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0205","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1152\/jappl.1992.73.5.1810","article-title":"Differential effects of long-term hypoxia on norepinephrine turnover in brain stem cell groups","volume":"73","author":"Soulier","year":"1992","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0210","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0006-8993(92)90725-O","article-title":"The effect of axon injury on microtubule-associated protein MAP-2 mRNA in the hypoglossal nucleus of the adult rat","volume":"581","author":"Svensson","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0215","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1128\/MCB.23.19.6739-6749.2003","article-title":"Defective brain development in mice lacking the HIF-1\u03b1 gene in neural cells","volume":"23","author":"Tomita","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2014.04.018_b0220","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214003133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214003133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T18:34:25Z","timestamp":1589222065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452214003133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":44,"alternative-id":["S0306452214003133"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2014.04.018","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}