{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:16:45Z","timestamp":1784823405189,"version":"3.55.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01 HL080295"],"award-info":[{"award-number":["U01 HL080295"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCLA Older Americans Independence Center"},{"name":"UCLA Clinical and Translational Science Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.neuroscience.2014.05.005","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T15:04:12Z","timestamp":1400079852000},"page":"199-209","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Physical activity, inflammation, and volume of the aging brain"],"prefix":"10.1016","volume":"273","author":[{"given":"M.N.","family":"Braskie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.P.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rajagopalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.A.","family":"Gutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.W.","family":"Toga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Raji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.H.","family":"Kuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.T.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.L.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2014.05.005_b0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.biopsych.2009.08.003","article-title":"Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study","volume":"67","author":"Altena","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neurobiolaging.2012.04.013","article-title":"Association between physical activity and brain health in older adults","volume":"34","author":"Benedict","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5665\/sleep.3336","article-title":"Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men","volume":"37","author":"Benedict","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0025","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/01.wnl.0000219668.47116.e6","article-title":"Neuropathology of older persons without cognitive impairment from two community-based studies","volume":"66","author":"Bennett","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0030","first-page":"1","article-title":"The visual retention test as a constructional praxis task","volume":"29","author":"Benton","year":"1967","journal-title":"Confin Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0035","doi-asserted-by":"crossref","unstructured":"Boyle C, Raji CA, Erickson KI, Lopez O, Becker JT, Gach HM, Longstreth WT, Teverovskiy L, Kuller L, Carmichael OT, Thompson PM (in press) Physical activity, body mass index, and brain atrophy in Alzheimer\u2019s disease. Neurobiol Aging.","DOI":"10.1016\/j.neurobiolaging.2014.05.036"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0040","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/mp.2012.107","article-title":"Physical activity and amyloid-beta plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing","volume":"18","author":"Brown","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0045","first-page":"1625","article-title":"A method for using MR to evaluate the effects of cardiovascular disease on the brain: the cardiovascular health study","volume":"15","author":"Bryan","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0050","doi-asserted-by":"crossref","first-page":"756","DOI":"10.2337\/diab.34.8.756","article-title":"Acute reversal of the enhanced insulin action in trained athletes. Association with insulin receptor changes","volume":"34","author":"Burstein","year":"1985","journal-title":"Diabetes"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0055","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/gerona\/61.11.1166","article-title":"Aerobic exercise training increases brain volume in aging humans","volume":"61","author":"Colcombe","year":"2006","journal-title":"J Gerontol Ser A"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuroscience.2013.07.015","article-title":"Body mass index, but not FTO genotype or major depressive disorder, influences brain structure","volume":"252C","author":"Cole","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0065","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0070","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","article-title":"Exercise: a behavioral intervention to enhance brain health and plasticity","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0080","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","article-title":"Exercise builds brain health: key roles of growth factor cascades and inflammation","volume":"30","author":"Cotman","year":"2007","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0085","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJMoa1215740","article-title":"Glucose levels and risk of dementia","volume":"369","author":"Crane","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/ana.22062","article-title":"Visceral fat is associated with lower brain volume in healthy middle-aged adults","volume":"68","author":"Debette","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0095","doi-asserted-by":"crossref","first-page":"162","DOI":"10.7326\/0003-4819-158-3-201302050-00005","article-title":"The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study","volume":"158","author":"Defina","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jns.2009.02.318","article-title":"VEGF genetic variability is associated with increased risk of developing Alzheimer\u2019s disease","volume":"283","author":"Del Bo","year":"2009","journal-title":"J Neurol Sci"},{"issue":"8","key":"10.1016\/j.neuroscience.2014.05.005_b0105","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.neurobiolaging.2014.02.011","article-title":"Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer\u2019s disease with plaques and tangles","volume":"35","author":"Di Meco","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0110","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.2967\/jnumed.109.066647","article-title":"Neuroinflammation in schizophrenia-related psychosis: a PET study","volume":"50","author":"Doorduin","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jsr.12078","article-title":"Exercise and sleep in community-dwelling older adults: evidence for a reciprocal relationship","volume":"23","author":"Dzierzewski","year":"2014","journal-title":"J Sleep Res"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0120","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1212\/WNL.0b013e3181f88359","article-title":"Physical activity predicts gray matter volume in late adulthood: the cardiovascular health study","volume":"75","author":"Erickson","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0125","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1073\/pnas.1015950108","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"108","author":"Erickson","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0130","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.arcmed.2012.09.008","article-title":"Physical activity, brain plasticity, and Alzheimer\u2019s disease","volume":"43","author":"Erickson","year":"2012","journal-title":"Arch Med Res"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0135","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archneurol.2008.582","article-title":"Midlife and late-life obesity and the risk of dementia: cardiovascular health study","volume":"66","author":"Fitzpatrick","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0140","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1016\/j.neuroimage.2009.10.043","article-title":"Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link?","volume":"49","author":"Floel","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0150","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/1047-2797(91)90005-W","article-title":"The cardiovascular health study: design and rationale","volume":"1","author":"Fried","year":"1991","journal-title":"Ann Epidemiol"},{"issue":"6","key":"10.1016\/j.neuroscience.2014.05.005_b0155","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.bbi.2011.03.012","article-title":"Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity","volume":"25","author":"Funk","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0160","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/aje\/153.3.242","article-title":"Association between physical activity and markers of inflammation in a healthy elderly population","volume":"153","author":"Geffken","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0165","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archinte.163.13.1524","article-title":"An 18-year follow-up of overweight and risk of Alzheimer disease","volume":"163","author":"Gustafson","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0170","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuroimage.2012.12.052","article-title":"Maximizing power to track Alzheimer\u2019s disease and MCI progression by LDA-based weighting of longitudinal ventricular surface features","volume":"70","author":"Gutman","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0175","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0180","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnagi.2013.00031","article-title":"A review of cardiorespiratory fitness-related neuroplasticity in the aging brain","volume":"5","author":"Hayes","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0185","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/archneurol.2011.845","article-title":"Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition","volume":"69","author":"Head","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0190","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/jgs.12178","article-title":"High cortisol and low folate are the only routine blood tests predicting probable Alzheimer\u2019s disease after age 75-results of the Vienna Transdanube aging study","volume":"61","author":"Hinterberger","year":"2013","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0195","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.neurobiolaging.2010.04.006","article-title":"Obesity is linked with lower brain volume in 700 AD and MCI patients","volume":"31","author":"Ho","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0200","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.1073\/pnas.0910878107","article-title":"A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly","volume":"107","author":"Ho","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/WNR.0b013e3283412868","article-title":"Hippocampal volume is related to body mass index in Alzheimer\u2019s disease","volume":"22","author":"Ho","year":"2011","journal-title":"NeuroReport"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0210","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer\u2019s disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0215","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuroimage.2012.10.086","article-title":"Unbiased tensor-based morphometry: Improved robustness and sample size estimates for Alzheimer\u2019s disease clinical trials","volume":"66C","author":"Hua","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0220","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"issue":"Suppl.","key":"10.1016\/j.neuroscience.2014.05.005_b0225","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.bbi.2012.05.017","article-title":"Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors","volume":"30","author":"Kesler","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0230","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","article-title":"Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease","volume":"62","author":"Kivipelto","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0235","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1006\/nimg.2002.1084","article-title":"An optimized individual target brain in the Talairach coordinate system","volume":"17","author":"Kochunov","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0240","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/hbm.20090","article-title":"Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalization","volume":"24","author":"Kochunov","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0245","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1093\/brain\/awt145","article-title":"In vivo radioligand binding to translocator protein correlates with severity of Alzheimer\u2019s disease","volume":"136","author":"Kreisl","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2012.236","article-title":"Deciphering the mechanism underlying late-onset Alzheimer disease","volume":"9","author":"Krstic","year":"2013","journal-title":"Nat Revi Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0255","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0260","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/archneurol.2011.2748","article-title":"Association of lifetime cognitive engagement and low beta-amyloid deposition","volume":"69","author":"Landau","year":"2012","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0265","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0197-4580(00)00096-8","article-title":"Midlife blood pressure and dementia: the Honolulu-Asia aging study","volume":"21","author":"Launer","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0270","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s12272-010-1006-7","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"33","author":"Lee","year":"2010","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0275","series-title":"Principal ranking meta-algorithms Los Angeles","author":"Leung","year":"2011"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0280","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ana.22096","article-title":"Exercise and Alzheimer\u2019s disease biomarkers in cognitively normal older adults","volume":"68","author":"Liang","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0285","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1001\/archneur.60.10.1385","article-title":"Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1","volume":"60","author":"Lopez","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000067110","article-title":"Evaluation of dementia in the cardiovascular health cognition study","volume":"22","author":"Lopez","year":"2003","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0295","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/jnnp.2004.045567","article-title":"Neuropsychological characteristics of mild cognitive impairment subgroups","volume":"77","author":"Lopez","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0300","first-page":"1","article-title":"Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene-environment interaction for the risk of dementia and Alzheimer\u2019s disease dementia","author":"Luck","year":"2013","journal-title":"Psychol Med"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0305","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biopsych.2008.04.016","article-title":"Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults","volume":"64","author":"Marsland","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0310","first-page":"73","article-title":"Exercise and the stress system","volume":"4","author":"Mastorakos","year":"2005","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0315","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1212\/WNL.0b013e31822e145d","article-title":"Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama study","volume":"77","author":"Matsuzaki","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0320","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1098\/rstb.2001.0915","article-title":"A probabilistic atlas and reference system for the human brain: international consortium for brain mapping (ICBM)","volume":"356","author":"Mazziotta","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0325","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnint.2013.00059","article-title":"Inflammatory process in Alzheimer\u2019s disease","volume":"7","author":"Meraz-Rios","year":"2013","journal-title":"Front Integr Neurosci"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0330","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1532-5415.2010.02903.x","article-title":"Physical activity over the life course and its association with cognitive performance and impairment in old age","volume":"58","author":"Middleton","year":"2010","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0335","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1212\/WNL.0b013e31826e2696","article-title":"Indicators of amyloid burden in a population-based study of cognitively normal elderly","volume":"79","author":"Mielke","year":"2012","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.neuroscience.2014.05.005_b0340","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2990.2011.01181.x","article-title":"Commentary: the three new pathways leading to Alzheimer\u2019s disease","volume":"37","author":"Morgan","year":"2011","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0345","doi-asserted-by":"crossref","first-page":"e73697","DOI":"10.1371\/journal.pone.0073697","article-title":"High \u201cNormal\u201d blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through life study","volume":"8","author":"Mortby","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0350","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s11357-012-9414-x","article-title":"Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training","volume":"35","author":"Murrell","year":"2013","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0355","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat Genet"},{"issue":"Suppl. 3","key":"10.1016\/j.neuroscience.2014.05.005_b0360","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/dom.12156","article-title":"The effect of physical activity on mediators of inflammation","volume":"15","author":"Nimmo","year":"2013","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0365","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1001\/archgenpsychiatry.2009.193","article-title":"Hippocampal plasticity in response to exercise in schizophrenia","volume":"67","author":"Pajonk","year":"2010","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0370","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.exger.2010.08.022","article-title":"IGF-I and the aging mammalian brain","volume":"46","author":"Piriz","year":"2011","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0375","unstructured":"Rajagopalan P, Gutman B, Toga AW, Jack CR, Weiner MW, Thompson PM (2012) Plasma cortisol is associated with accelerated brain atrophy: an Alzheimer\u2019s disease neuroimaging initiative (ADNI) study. In: Society for neuroscience annual meeting New Orleans, LA, USA."},{"key":"10.1016\/j.neuroscience.2014.05.005_b0380","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/WNR.0b013e32835c5254","article-title":"Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly","volume":"24","author":"Rajagopalan","year":"2013","journal-title":"NeuroReport"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0385","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hbm.20870","article-title":"Brain structure and obesity","volume":"31","author":"Raji","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0390","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1748-1716.2010.02223.x","article-title":"In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice","volume":"201","author":"Rasmussen","year":"2011","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0395","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/bmj.331.7514.455","article-title":"Obesity in middle age and future risk of dementia: midlife obesity increases risk of future dementia","volume":"331","author":"Razay","year":"2005","journal-title":"Br Med J"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0400","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1249\/MSS.0b013e318295cdbb","article-title":"Modification of insulin sensitivity and glycemic control by activity and exercise","volume":"45","author":"Roberts","year":"2013","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0405","unstructured":"Ross J, Thompson PM, Tariot P, Reiman E, Schneider LS, Frigerio E, Fiorentini F, Giardino L, Calza L, Norris D, Cirirello H, Casula D, Imbimbo BP (2012) Primary and secondary prevention trials in subjects at risk of developing Alzheimer\u2019s disease: the GEPARD-AD (genetically enriched population at risk of developing Alzheimer\u2019s disease) studies. In: Clinical trials conference on Alzheimer\u2019s disease Monte Carlo, Monaco."},{"key":"10.1016\/j.neuroscience.2014.05.005_b0410","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood.V75.1.40.40","article-title":"Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF","volume":"75","author":"Schindler","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0415","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/oxfordjournals.aje.a009066","article-title":"Exercise intensity and subclinical cardiovascular disease in the elderly. The cardiovascular health study","volume":"145","author":"Siscovick","year":"1997","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0420","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000231980","article-title":"Midlife serum cholesterol and increased risk of Alzheimer\u2019s and vascular dementia three decades later","volume":"28","author":"Solomon","year":"2009","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0425","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive reserve in ageing and Alzheimer\u2019s disease","volume":"11","author":"Stern","year":"2012","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.neuroscience.2014.05.005_b0430","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/02640414.2013.812791","article-title":"Morphological and health-related changes associated with a 12-week self-guided exercise programme in overweight adults: a pilot study","volume":"32","author":"Stewart","year":"2014","journal-title":"J Sports Sci"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0435","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/156720512799015019","article-title":"Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer\u2019s disease","volume":"9","author":"Stranahan","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0440","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0021-9681(78)90058-9","article-title":"A questionnaire for the assessment of leisure time physical activities","volume":"31","author":"Taylor","year":"1978","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0445","first-page":"314","article-title":"The modified mini-mental state (3MS) examination","volume":"48","author":"Teng","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0450","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/japplphysiol.00822.2009","article-title":"Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled trial","volume":"108","author":"Thompson","year":"2010","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0455","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-130698","article-title":"Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort","author":"Tolppanen","year":"2013","journal-title":"J Alzheimer Dis"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0460","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/sj.ijo.0801373","article-title":"Moderate-intensity regular exercise decreases serum tumor necrosis factor-alpha and HbA1c levels in healthy women","volume":"24","author":"Tsukui","year":"2000","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0465","doi-asserted-by":"crossref","first-page":"e26558","DOI":"10.1371\/journal.pone.0026558","article-title":"NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging","volume":"6","author":"Vallejo","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0470","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neurobiolaging.2010.10.017","article-title":"IGF-I gene variability is associated with an increased risk for AD","volume":"32","author":"Vargas","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0475","first-page":"537","article-title":"Impact of a physical activity program on cerebral vasoreactivity in sedentary elderly people","volume":"52","author":"Vicente-Campos","year":"2012","journal-title":"J Sports Med Phys Fitness"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0480","series-title":"Wechsler adult intelligence scale \u2013 revised","author":"Wechsler","year":"1981"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0485","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1136\/bmj.38446.466238.E0","article-title":"Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study","volume":"330","author":"Whitmer","year":"2005","journal-title":"Br Med J"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0490","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182190d09","article-title":"Midlife overweight and obesity increase late-life dementia risk: a population-based twin study","volume":"76","author":"Xu","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0495","doi-asserted-by":"crossref","unstructured":"Yanovsky I, Thompson P, Osher S, Leow AD (2008) Asymmetric and symmetric unbiased image registration: statistical assessment of performance. In: IEEE computer society workshop on mathematical methods in biomedical image analysis, pp. 1\u20138.","DOI":"10.1109\/CVPRW.2008.4562988"},{"key":"10.1016\/j.neuroscience.2014.05.005_b0500","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.media.2009.06.002","article-title":"Comparing registration methods for mapping brain change using tensor-based morphometry","volume":"13","author":"Yanovsky","year":"2009","journal-title":"Med Image Anal"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221400387X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221400387X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T17:28:52Z","timestamp":1716744532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221400387X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":100,"alternative-id":["S030645221400387X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2014.05.005","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}