{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:41:47Z","timestamp":1780105307189,"version":"3.54.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31171072"],"award-info":[{"award-number":["31171072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Education Ministry of China","award":["20113503110001"],"award-info":[{"award-number":["20113503110001"]}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2014J05039"],"award-info":[{"award-number":["2014J05039"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.neuroscience.2014.08.048","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T19:39:42Z","timestamp":1410377982000},"page":"31-39","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Upregulation of pronociceptive mediators and downregulation of opioid peptide by adrenomedullin following chronic exposure to morphine in rats"],"prefix":"10.1016","volume":"280","author":[{"given":"D.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2014.08.048_b0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1399-6576.1988.tb02725.x","article-title":"Clinical experience of long-term treatment with epidural and intrathecal opioids\u2013a nationwide survey","volume":"32","author":"Arner","year":"1988","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0010","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0196-9781(97)00021-1","article-title":"Effect of 7-nitroindazole on tolerance to morphine, U-50,488H and [D-Pen2, D-Pen5] enkephalin in mice","volume":"18","author":"Bhargava","year":"1997","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0015","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ejpain.2006.12.008","article-title":"Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice","volume":"11","author":"Boettger","year":"2007","journal-title":"Eur J Pain"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0020","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/physrev.00037.2003","article-title":"Vascular actions of calcitonin gene-related peptide and adrenomedullin","volume":"84","author":"Brain","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0025","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1460-9568.2007.05755.x","article-title":"The involvement of spinal bovine adrenal medulla 22-like peptide, the proenkephalin derivative, in modulation of nociceptive processing","volume":"26","author":"Cai","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbr.2006.12.014","article-title":"Sensory neuron-specific receptor agonist BAM8-22 inhibits the development and expression of tolerance to morphine in rats","volume":"178","author":"Cai","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mcna.2006.10.003","article-title":"Opioid tolerance and hyperalgesia","volume":"91","author":"Chang","year":"2007","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2008.06.023","article-title":"Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats","volume":"589","author":"Chen","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0050","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.pain.2009.12.002","article-title":"The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation","volume":"148","author":"da Costa","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000115300","article-title":"The molecular evolution of neuropeptides: prospects for the \u201990s","volume":"36","author":"Dores","year":"1990","journal-title":"Brain Behav Evol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0060","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1471-4159.2004.02768.x","article-title":"Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves","volume":"91","author":"Fujita","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0065","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0006-8993(99)02448-8","article-title":"Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from the spinal cord is mediated by nitric oxide but not by cyclic GMP","volume":"861","author":"Garry","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1385\/JMN:22:1-2:105","article-title":"The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors","volume":"22","author":"Hay","year":"2004","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0075","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/sj.bjp.0705472","article-title":"CL\/RAMP2 and CL\/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS","volume":"140","author":"Hay","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0080","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.pain.2004.02.018","article-title":"HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)","volume":"110","author":"Holguin","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0085","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/sj.bjp.0705637","article-title":"Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor","volume":"141","author":"Hong","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pain.2009.07.015","article-title":"Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats","volume":"146","author":"Hong","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0095","doi-asserted-by":"crossref","first-page":"12508","DOI":"10.1523\/JNEUROSCI.0306-10.2010","article-title":"A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats","volume":"30","author":"Hong","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbr.2005.11.002","article-title":"Bovine adrenal medulla 22 reverses antinociceptive morphine tolerance in the rat","volume":"168","author":"Jiang","year":"2006","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0922-4106(95)90117-5","article-title":"Receptors for adrenomedullin in human vascular endothelial cells","volume":"289","author":"Kato","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0110","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(83)90212-3","article-title":"Colocalization of proenkephalin peptides in rat brain neurons","volume":"279","author":"Khachaturian","year":"1983","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0115","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000087658","article-title":"Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?","volume":"14","author":"King","year":"2005","journal-title":"Neurosignals"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0120","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","article-title":"Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma","volume":"192","author":"Kitamura","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0125","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1073\/pnas.94.15.8220","article-title":"Functionally differentiating two neuronal nitric oxide synthase isoforms through antisense mapping: evidence for opposing NO actions on morphine analgesia and tolerance","volume":"94","author":"Kolesnikov","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0130","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1210\/en.2004-1424","article-title":"Autocrine\/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue","volume":"146","author":"Linscheid","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0135","doi-asserted-by":"crossref","first-page":"16027","DOI":"10.1073\/pnas.0602488103","article-title":"A role for adrenomedullin as a pain-related peptide in the rat","volume":"103","author":"Ma","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0140","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1097\/00001756-199708180-00020","article-title":"Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord","volume":"8","author":"Machelska","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(86)91187-X","article-title":"Distribution and development of proenkephalin-like immunoreactivity in the lumbar spinal cord of the chicken","volume":"377","author":"Maderdrut","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0150","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1523\/JNEUROSCI.14-04-02301.1994","article-title":"Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C","volume":"14","author":"Mao","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0155","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1523\/JNEUROSCI.16-07-02342.1996","article-title":"A calcitonin gene-related peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia","volume":"16","author":"Menard","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0160","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1172\/JCI43766","article-title":"Central modulation of pain","volume":"120","author":"Ossipov","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-8993(84)90868-0","article-title":"Distribution and characterization of opioid peptides derived from proenkephalin A in human and rat central nervous system","volume":"304","author":"Pittius","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0170","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1046\/j.1460-9568.2003.02887.x","article-title":"Inhibition of neurokinin-1-substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons","volume":"18","author":"Powell","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1124\/pr.54.2.233","article-title":"International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors","volume":"54","author":"Poyner","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0180","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1016\/0024-3205(93)90615-A","article-title":"Inhibition of nitric oxide synthase enhances morphine antinociception in the rat spinal cord","volume":"53","author":"Przewlocki","year":"1993","journal-title":"Life Sci"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/cne.1090","article-title":"Distribution of preproadrenomedullin mRNA in the rat central nervous system and its modulation by physiological stressors","volume":"432","author":"Shan","year":"2001","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0190","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbr.2011.02.046","article-title":"Blockade of adrenomedullin receptors reverses morphine tolerance and its neurochemical mechanisms","volume":"221","author":"Wang","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.peptides.2014.01.009","article-title":"Involvement of adrenomedullin in the attenuation of acute morphine-induced analgesia in rats","volume":"54C","author":"Wang","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0200","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.expneurol.2012.10.006","article-title":"Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats","volume":"239","author":"Wang","year":"2013","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0205","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1744-8069-7-68","article-title":"On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats","volume":"7","author":"Wang","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0210","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1152\/jn.1993.70.6.2350","article-title":"Nitric oxide mediates ongoing discharges in dorsal root ganglion cells after peripheral nerve injury","volume":"70","author":"Wiesenfeld-Hallin","year":"1993","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0215","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0022-3565(24)37187-3","article-title":"The nitric oxide\/cyclic GMP system at the supraspinal site is involved in the development of acute morphine antinociceptive tolerance","volume":"284","author":"Xu","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0220","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuroscience.2014.08.048_b0225","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.brainres.2004.09.020","article-title":"Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn","volume":"1028","author":"Zeng","year":"2004","journal-title":"Brain Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214007350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214007350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T15:37:56Z","timestamp":1746373076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452214007350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":45,"alternative-id":["S0306452214007350"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2014.08.048","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}