{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:07:06Z","timestamp":1779386826655,"version":"3.53.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.neuroscience.2014.11.039","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T01:18:53Z","timestamp":1416964733000},"page":"324-332","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["The involvement of P2Y12 receptors, NADPH oxidase, and lipid rafts in the action of extracellular ATP on synaptic transmission at the frog neuromuscular junction"],"prefix":"10.1016","volume":"285","author":[{"given":"A.","family":"Giniatullin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Petrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Giniatullin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neuroscience.2014.11.039_b0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.neuroscience.2014.11.039_b0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0024-3205(00)00923-1","article-title":"ATP as a presynaptic modulator","volume":"68","author":"Cunha","year":"2000","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.neuroscience.2014.11.039_b0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1042\/BST20120295","article-title":"Molecular mechanisms of platelet P2Y(12) receptor regulation","volume":"41","author":"Cunningham","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0030","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00018-005-5177-1","article-title":"Regulation and termination of NADPH oxidase activity","volume":"62","author":"DeCoursey","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0005","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1242\/jcs.091736","article-title":"Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation","volume":"125","author":"del Puerto","year":"2011","journal-title":"J Cell Sci"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0035","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature05185","article-title":"Phosphoinositides in cell regulation and membrane dynamics","volume":"443","author":"Di Paolo","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/1568006053004967","article-title":"Leukocyte P2 receptors: a novel target for anti-inflammatory and antitumor therapy","volume":"5","author":"Di Virgilio","year":"2005","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"issue":"2","key":"10.1016\/j.neuroscience.2014.11.039_b0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1113\/jphysiol.1969.sp008917","article-title":"Identification of adenosine triphosphate in human plasma and the concentration in the venous effluent of forearm muscles before, during and after sustained contractions","volume":"204","author":"Forrester","year":"1969","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0050","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11302-012-9303-x","article-title":"P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells","volume":"8","author":"Gachet","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0055","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1113\/jphysiol.2003.050690","article-title":"Dual action of hydrogen peroxide on synaptic transmission at the frog neuromuscular junction","volume":"552","author":"Giniatullin","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0060","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1113\/jphysiol.2005.084186","article-title":"Reactive oxygen species contribute to the presynaptic action of extracellular ATP at the frog neuromuscular junction","volume":"565","author":"Giniatullin","year":"2005","journal-title":"J Physiol"},{"issue":"4","key":"10.1016\/j.neuroscience.2014.11.039_b0065","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/sj.bjp.0701881","article-title":"ATP and adenosine inhibit transmitter release at the frog neuromuscular junction through distinct presynaptic receptors","volume":"124","author":"Giniatullin","year":"1998","journal-title":"Brit J Pharmacol"},{"issue":"2","key":"10.1016\/j.neuroscience.2014.11.039_b0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1113\/jphysiol.1979.sp012784","article-title":"Voltage clamping of unparalysed cut rat diaphragm for study of transmitter release","volume":"290","author":"Glavinovic","year":"1979","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0075","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/j.1460-9568.2005.03976.x","article-title":"Mechanisms of ATP action on motor nerve terminals at the frog neuromuscular junction","volume":"21","author":"Grishin","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/BJ20041835","article-title":"Activation and assembly of the NADPH oxidase: a structural perspective","volume":"386","author":"Groemping","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0085","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2006.8.1583","article-title":"NADPH oxidases of the brain: distribution, regulation, and function","volume":"8","author":"Infanger","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0090","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1089\/ars.2009.2585","article-title":"Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets","volume":"11","author":"Jaquet","year":"2009","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"10.1016\/j.neuroscience.2014.11.039_b0095","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1089\/ars.2010.3619","article-title":"Lipid raft redox signalling: molecular mechanisms in health and disease","volume":"15","author":"Jin","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1016\/j.neuroscience.2014.11.039_b0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.bjp.0705037","article-title":"Attenuation of the P2Y receptor-mediated control of neuronal Ca2+ channels in PC12 cells by antithrombotic drugs","volume":"138","author":"Kubista","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0105","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0022-3565(25)32376-1","article-title":"Characterization of and-plate conductance in transected frog muscle: modification by drugs","volume":"216","author":"Lambert","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0110","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1152\/ajpregu.00124.2004","article-title":"Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology","volume":"287","author":"Li","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"29","key":"10.1016\/j.neuroscience.2014.11.039_b0115","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1073\/pnas.0804374105","article-title":"Plasma membranes are poised for activation of raft phase coalescence at physiological temperature","volume":"105","author":"Lingwood","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1460-9568.2004.03831.x","article-title":"Secretion of ATP from Schwann cells in response to uridine triphosphate","volume":"21","author":"Liu","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1039\/b919728a","article-title":"P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions","volume":"2","author":"Maloney","year":"2010","journal-title":"Integr Biol (Camb)"},{"issue":"17","key":"10.1016\/j.neuroscience.2014.11.039_b0130","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1089\/ars.2013.5703","article-title":"New insights on NOX enzymes in the central nervous system","volume":"20","author":"Nayernia","year":"2014","journal-title":"Antioxid Redox Signal"},{"issue":"23","key":"10.1016\/j.neuroscience.2014.11.039_b0135","doi-asserted-by":"crossref","first-page":"20139","DOI":"10.1074\/jbc.M200594200","article-title":"Manipulation of cholesterol levels in rod disk membranes by methyl-beta-cyclodextrin: effects on receptor activation","volume":"277","author":"Niu","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0140","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1021\/bi9528816","article-title":"Cyclodextrin-mediated removal of sterols from monolayers: effects of sterol structure and phospholipids on desorption rate","volume":"35","author":"Ohvo","year":"1996","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.neuroscience.2014.11.039_b0145","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s11055-010-9338-9","article-title":"The role of cholesterol in the exo- and endocytosis of synaptic vesicles in frog motor nerve endings","volume":"40","author":"Petrov","year":"2010","journal-title":"Neurosci Behav Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.04.051","article-title":"Increased non-quantal release of acetylcholine after inhibition of endocytosis by methyl-\u042f-cyclodextrin: the role of vesicular acetylcholine transporter","volume":"186","author":"Petrov","year":"2011","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neuroscience.2014.11.039_b0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1134\/S1819712411010089","article-title":"Cholesterol and lipid rafts in the plasma membrane of nerve terminal and membrane of synaptic vesicles","volume":"5","author":"Petrov","year":"2011","journal-title":"Neurochem J"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0160","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1189\/jlb.0404216","article-title":"Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases","volume":"76","author":"Quinn","year":"2004","journal-title":"J Leukoc Biol"},{"issue":"3","key":"10.1016\/j.neuroscience.2014.11.039_b0165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1113\/jphysiol.1987.sp016470","article-title":"On the role, inactivation and origin of endogenous adenosine at the frog neuromuscular junction","volume":"384","author":"Ribeiro","year":"1987","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0175","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.1975.tb06931.x","article-title":"The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions","volume":"54","author":"Ribeiro","year":"1975","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrn1608","article-title":"Lipid regulation of the synaptic vesicle cycle","volume":"6","author":"Rohrbough","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0185","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cellsig.2005.03.024","article-title":"Revaluation of the role of cholesterol in stabilizing rafts implicated in T cell receptor signaling","volume":"18","author":"Rouquette-Jazdanian","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0304-3940(02)01419-2","article-title":"ATP is released from nerve terminals and from activated muscle fibres on stimulation of the rat phrenic nerve","volume":"338","author":"Santos","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0195","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1189\/jlb.0804442","article-title":"Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation","volume":"78","author":"Sheppard","year":"2005","journal-title":"J Leukoc Biol"},{"issue":"1\u20133","key":"10.1016\/j.neuroscience.2014.11.039_b0200","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2012.04.008","article-title":"Evidence for constitutively-active adenosine receptors at mammalian motor nerve endings","volume":"685","author":"Searl","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0079-6123(08)63552-9","article-title":"Quantal ATP release from motor nerve endings and its role in neurally mediated depression","volume":"120","author":"Silinsky","year":"1999","journal-title":"Prog Brain Res"},{"issue":"1","key":"10.1016\/j.neuroscience.2014.11.039_b0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1113\/jphysiol.1975.sp010925","article-title":"On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals","volume":"247","author":"Silinsky","year":"1975","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0215","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1113\/jphysiol.1991.sp018388","article-title":"Sources of adenosine released during neuromuscular transmission in the rat","volume":"432","author":"Smith","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0220","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1046\/j.1460-9568.2003.02835.x","article-title":"Distinct receptors and different transduction mechanisms for ATP and adenosine at the frog motor nerve endings","volume":"18","author":"Sokolova","year":"2003","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.neuroscience.2014.11.039_b0225","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.neuroscience.2008.04.056","article-title":"Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction","volume":"154","author":"Veggetti","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0230","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s00018-002-8520-9","article-title":"The superoxide-generating NADPH oxidase: structural aspects and activation mechanism","volume":"59","author":"Vignais","year":"2002","journal-title":"Cell Mol Life Sci"},{"issue":"23","key":"10.1016\/j.neuroscience.2014.11.039_b0235","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1113\/jphysiol.2009.179275","article-title":"Extracellular ATP inhibits chloride channels in mature mammalian skeletal muscle by activating P2Y1 receptors","volume":"587","author":"Voss","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0240","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/sj.bjp.0705588","article-title":"Adenine nucleotides inhibit recombinant N-type calcium channels via G protein-coupled mechanisms in HEK293 cells; involvement of the P2Y13 receptor-type","volume":"141","author":"Wirkner","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0245","doi-asserted-by":"crossref","DOI":"10.1096\/fj.14-255885","article-title":"ADP-induced bladder contractility is mediated by P2Y12 receptor and temporally regulated by ectonucleotidases and adenosine signaling","author":"Yu","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0250","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/jpet.301.2.705","article-title":"P2Y13: identification and characterization of a novel G\u03b1i-coupled ADP receptor from human and mouse","volume":"30","author":"Zhang","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2014.11.039_b0255","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bbamem.2007.03.026","article-title":"Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies","volume":"1768","author":"Zidovetzki","year":"2007","journal-title":"Biochim Biophys Acta"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214010057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452214010057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:02:34Z","timestamp":1747170154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452214010057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":50,"alternative-id":["S0306452214010057"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2014.11.039","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}