{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:27:43Z","timestamp":1778056063873,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions of China"},{"name":"Jiangsu Province\u2019s Key Provincial Talents Program"},{"name":"Suzhou Key Laboratory of Neuro-Psychiatric Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.neuroscience.2015.01.054","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T17:04:46Z","timestamp":1423328686000},"page":"552-560","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["The inhibition of Cdk5 activity after hypoxia\/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats"],"prefix":"10.1016","volume":"290","author":[{"given":"X.","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.01.054_b0005","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bbadis.2013.02.002","article-title":"Inhibition of calpain-regulated p35\/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate","volume":"1832","author":"Barros-Minones","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0531-5565(98)00019-9","article-title":"Effects of glucocorticoids on oxidative stress-induced hippocampal cell death: implications for the pathogenesis of Alzheimer\u2019s disease","volume":"33","author":"Behl","year":"1998","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0015","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1203\/00006450-199711000-00021","article-title":"Sensorimotor function and neuropathology five to six weeks after hypoxia\u2013ischemia in seven-day-old rats","volume":"42","author":"Bona","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuron.2006.02.024","article-title":"Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases","volume":"50","author":"Cheung","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neulet.2003.12.117","article-title":"Cdk5: mediator of neuronal death and survival","volume":"361","author":"Cheung","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10571-007-9242-1","article-title":"An unusual member of the Cdk family: Cdk5","volume":"28","author":"Dhariwala","year":"2008","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0035","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.neuint.2013.09.017","article-title":"Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K\/Akt pathway","volume":"63","author":"Gu","year":"2013","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0304-3940(99)00201-3","article-title":"Expression of cyclin-dependent kinase 5 and its activator p35 in rat brain after middle cerebral artery occlusion","volume":"265","author":"Hayashi","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0045","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.6026\/97320630091023","article-title":"The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer\u2019s disease","volume":"9","author":"Jayapalan","year":"2013","journal-title":"Bioinformation"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(08)60823-5","article-title":"Neurofilaments in health and disease","volume":"61","author":"Julien","year":"1998","journal-title":"Prog Nucl Acid Res Mol Biol"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0055","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1210\/me.2006-0345","article-title":"Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress","volume":"21","author":"Kino","year":"2007","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2003.09.004","article-title":"Neuronal expression of cell cycle-related proteins after brain ischaemia in man","volume":"353","author":"Love","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0065","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1523\/JNEUROSCI.2899-05.2005","article-title":"Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death","volume":"25","author":"O\u2019Hare","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0070","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/45159","article-title":"Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration","volume":"402","author":"Patrick","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.nlm.2006.07.003","article-title":"Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia\u2013ischemia in the rat","volume":"87","author":"Pereira","year":"2007","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0080","doi-asserted-by":"crossref","first-page":"14080","DOI":"10.1073\/pnas.0500099102","article-title":"Multiple cyclin-dependent kinases signals are critical mediators of ischemia\/hypoxic neuronal death in vitro and in vivo","volume":"102","author":"Rashidian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0085","doi-asserted-by":"crossref","first-page":"12497","DOI":"10.1523\/JNEUROSCI.3892-09.2009","article-title":"Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo","volume":"29","author":"Rashidian","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0090","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.coph.2008.10.003","article-title":"Cyclin-dependent kinase-5 targeting for ischaemic stroke","volume":"9","author":"Slevin","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-4615-5873-6_20","article-title":"Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators","volume":"2","author":"Tang","year":"1996","journal-title":"Prog Cell Cycle Res"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/371419a0","article-title":"P35 is a neural-specific regulatory subunit of cyclin-dependent kinase-5","volume":"371","author":"Tsai","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0105","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nn1119","article-title":"Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors","volume":"6","author":"Wang","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0110","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bbadis.2006.10.011","article-title":"Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats","volume":"1772","author":"Wen","year":"2007","journal-title":"Bba-Mol Basis Dis"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2008.06.018","article-title":"Neuroprotective effect of humanin on cerebral ischemia\/reperfusion injury is mediated by a PI3K\/Akt pathway","volume":"1227","author":"Xu","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0120","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/01.WCB.0000073946.29308.55","article-title":"Inhibition of apoptosis by hyperbaric oxygen in a rat focal cerebral ischemic model","volume":"23","author":"Yin","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0125","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jcb.22408","article-title":"Tau as a potential novel therapeutic target in ischemic stroke","volume":"109","author":"Zheng","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0130","doi-asserted-by":"crossref","first-page":"34202","DOI":"10.1074\/jbc.M110.134643","article-title":"A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation","volume":"285","author":"Zheng","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0135","doi-asserted-by":"crossref","first-page":"34202","DOI":"10.1074\/jbc.M110.134643","article-title":"A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation","volume":"285","author":"Zheng","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2015.01.054_b0140","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1021\/pr800108k","article-title":"Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins","volume":"7","author":"Zhou","year":"2008","journal-title":"J Proteome Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215001116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215001116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T02:24:33Z","timestamp":1717727073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215001116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":28,"alternative-id":["S0306452215001116"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.01.054","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}