{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:57:27Z","timestamp":1761400647805},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R01NS045207","R01NS058802"],"award-info":[{"award-number":["R01NS045207","R01NS058802"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.neuroscience.2015.02.017","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T01:46:06Z","timestamp":1424310366000},"page":"148-158","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Coalescence of deep and superficial epileptic foci into larger discharge units in adult rat neocortex"],"prefix":"10.1016","volume":"292","author":[{"given":"Ruggero","family":"Serafini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Loeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.02.017_b0005","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1460-9568.1995.tb01117.x","article-title":"Epileptiform activity in the guinea-pig neocortical slice spreads preferentially along supragranular layers\u2013recordings with voltage-sensitive dyes","volume":"7","author":"Albowitz","year":"1995","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0010","series-title":"Brain slices","first-page":"381","article-title":"Brain slice methods","author":"Alger","year":"1985"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0015","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/155005940904000405","article-title":"An animal model to study the clinical significance of interictal spiking","volume":"40","author":"Barkmeier","year":"2009","journal-title":"Clin EEG Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nbd.2012.03.026","article-title":"Electrical, molecular and behavioral effects of interictal spiking in the rat","volume":"47","author":"Barkmeier","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0025","doi-asserted-by":"crossref","first-page":"14389","DOI":"10.1523\/JNEUROSCI.3408-12.2012","article-title":"Layer-specific CREB target gene induction in human neocortical epilepsy","volume":"32","author":"Beaumont","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0030","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainresbull.2005.11.018","article-title":"Laminar analysis and spread of epileptiform discharges in three in vitro models","volume":"69","author":"Borbely","year":"2006","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0035","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1523\/JNEUROSCI.15-07-05324.1995","article-title":"Different forms of synaptic plasticity in the somatosensory and motor areas of the neocortex","volume":"15","author":"Castro-Alamancos","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0040","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1152\/jn.1989.62.5.1149","article-title":"Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex","volume":"62","author":"Chagnac-Amitai","year":"1989","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0045","series-title":"Niedermeyer\u2019s electroencephalography. Basic principles, clinical applications and related fields","first-page":"1018","article-title":"Epilepsy in the adults and elderly","author":"Chang","year":"1991"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0050","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1111\/j.1528-1167.2011.03312.x","article-title":"Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice","volume":"52","author":"Chang","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0055","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/brain\/awu350","article-title":"Predicting novel histopathological microlesions in human epileptic brain through transcriptional clustering","volume":"138","author":"Dachet","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0060","series-title":"Jasper\u2019s basic mechanisms of the epilepsies","first-page":"213","article-title":"Interictal epileptiform discharges in partial epilepsy: complex neurobiological mechanisms based on experimental and clinical evidence","author":"De Curtis","year":"2012"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0065","series-title":"Current practice of clinical electroencephalography","first-page":"12","article-title":"Cortical generators and EEG voltage fields","author":"Ebersole","year":"2003"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0070","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuropharm.2010.10.007","article-title":"The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array","volume":"60","author":"Gonzalez-Sulser","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0075","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1152\/jn.00363.2012","article-title":"Hippocampal neuron firing and local field potentials in the in vitro 4-aminopyridine epilepsy model","volume":"108","author":"Gonzalez-Sulser","year":"2012","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0006-8993(91)91392-E","article-title":"O2 tension in adult and neonatal brain slices under several experimental conditions","volume":"568","author":"Jiang","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0090","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0302-4598(99)00083-5","article-title":"Propagation of spontaneous synchronized activity in cortical slice cultures recorded by planar electrode arrays","volume":"51","author":"Jimbo","year":"2000","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0080","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1152\/jn.2000.84.4.2161","article-title":"Optical monitoring of neuronal activity during spontaneous sharp waves in chronically epileptic human neocortical tissue","volume":"84","author":"Kohling","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0100","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0105","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/ana.20633","article-title":"A common pattern of persistent gene activation in human neocortical epileptic foci","volume":"58","author":"Rakhade","year":"2005","journal-title":"Ann Neurol"},{"issue":"Suppl. 5","key":"10.1016\/j.neuroscience.2015.02.017_b0110","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1528-1167.2007.01294.x","article-title":"Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy","volume":"48","author":"Rakhade","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0115","series-title":"Epilepsy a comprehensive textbook. Neocortical anatomy and physiology","first-page":"323","author":"Richardson","year":"2007"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0120","series-title":"Cerebral cortex, Vol. 11. The barrel cortex of rodents","first-page":"1","article-title":"Comparative aspects of barrel structure and development","author":"Rice","year":"1995"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0125","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/WNP.0b013e31818e8010","article-title":"Micro physiology of epileptiform activity in human neocortex","volume":"25","author":"Schevon","year":"2008","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0130","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/WNP.0b013e3181fdf8a1","article-title":"Propagation of epileptiform activity on a submillimeter scale","volume":"27","author":"Schevon","year":"2010","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0135","unstructured":"Serafini R, Dettloff S, Loeb JL (2013) Altered neocortical network revealed by multielectrode recordings in a model of cortical epilepsy. American Epilepsy Society. Abstract 3.001."},{"key":"10.1016\/j.neuroscience.2015.02.017_b0140","series-title":"Wyllie\u2019s treatment of epilepsy, neurophysiological basis of the electroencephalogram","first-page":"132","author":"Speckmann","year":"2011"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0145","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neulet.2011.03.070","article-title":"Interictal spikes. Harbingers or causes of epilepsy?","volume":"497","author":"Staley","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0150","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/brain\/awq190","article-title":"Microseizures and the spatiotemporal scales of human partial epilepsy","volume":"133","author":"Stead","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0155","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2006.04.034","article-title":"The adult hippocampal slice revisited with multielectrode arrays","volume":"1096","author":"Steidl","year":"2006","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0160","series-title":"Atlas of EEG patterns","first-page":"148","article-title":"Interictal epileptiform patterns","author":"Stern","year":"2013"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0165","series-title":"Atlas of EEG patterns","first-page":"208","article-title":"Periodic epileptiform patterns","author":"Stern","year":"2013"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0170","series-title":"Atlas of EEG patterns","first-page":"134","article-title":"Ictal epileptiform patterns","author":"Stern","year":"2013"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0175","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1528-1157.1998.tb01154.x","article-title":"Layer-specific pathways for the horizontal propagation of epileptiform discharges in neocortex","volume":"39","author":"Telfeian","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0180","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrn1346","article-title":"MAPK cascade signaling and synaptic plasticity","volume":"5","author":"Thomas","year":"2004","journal-title":"Nature Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0185","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1523\/JNEUROSCI.3005-07.2007","article-title":"The source of after discharge activity in neocortical tonic-clonic epilepsy","volume":"27","author":"Trevelyan","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0190","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1152\/jn.1998.80.2.978","article-title":"Initiation of spontaneous epileptiform activity in the neocortical slice","volume":"80","author":"Tsau","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0195","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1152\/jn.1999.82.4.1965","article-title":"Epileptiform activity can be initiated in various neocortical layers: an optical imaging study","volume":"82","author":"Tsau","year":"1999","journal-title":"J Neurophysiol"},{"issue":"Suppl. 4","key":"10.1016\/j.neuroscience.2015.02.017_b0200","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.0013-9580.2004.04011.x","article-title":"Laminar analysis of human neocortical interictal spike generation and propagation: current source density and multiunit analysis in vivo","volume":"45","author":"Ulbert","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0205","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/WNP.0b013e318039b4de","article-title":"Propagation of seizure-like activity in a model of neocortex","volume":"24","author":"Van Drongelen","year":"2007","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0210","doi-asserted-by":"crossref","first-page":"18303","DOI":"10.1523\/JNEUROSCI.3203-11.2011","article-title":"Essential role for phosphatidylinositol 4-5 biphoshonate in the expression, regulation and gating of the slow afterhyperpolarization current in the cerebral cortex","volume":"31","author":"Villalobos","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.017_b0215","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0306-4522(01)00622-4","article-title":"Laminar properties of 4-aminopyridine-induced synchronous network activities in rat neocortex","volume":"111","author":"Yang","year":"2011","journal-title":"Neuroscience"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215001694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215001694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T02:28:17Z","timestamp":1566354497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215001694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":42,"alternative-id":["S0306452215001694"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.02.017","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}