{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:42:56Z","timestamp":1793148176510,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102562"],"award-info":[{"award-number":["81102562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Ministry of Education Fund for Doctor Discipline Scientific Research","award":["20110071120072"],"award-info":[{"award-number":["20110071120072"]}]},{"name":"Zhejiang Province Natural Science Fund","award":["Y2111111"],"award-info":[{"award-number":["Y2111111"]}]},{"name":"Zhejiang Province Traditional Chinese medicine health science and technology project","award":["2012ZA105"],"award-info":[{"award-number":["2012ZA105"]}]},{"name":"Hangzhou Medical research and Key Special disease project","award":["20110833B32"],"award-info":[{"award-number":["20110833B32"]}]},{"name":"Zhejiang Province Medical and health science and technology project","award":["2014KYB196"],"award-info":[{"award-number":["2014KYB196"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ibroneuroscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.neuroscience.2015.02.053","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T14:08:47Z","timestamp":1426774127000},"page":"193-205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":186,"special_numbering":"C","title":["Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation"],"prefix":"10.1016","volume":"294","author":[{"given":"B.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.02.053_b0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-Gomez","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"278\u2013286","key":"10.1016\/j.neuroscience.2015.02.053_b0010","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.mp.4001484","article-title":"Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression","volume":"9","author":"Alonso","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0015","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1741-7015-11-200","article-title":"So depression is an inflammatory disease, but where does the inflammation come from?","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pbb.2014.03.029","article-title":"Protective effects of a novel 5-HT3 receptor antagonist, N-n-butyl-3-methoxy quinoxaline-2-carboxamide (6o) against chronic unpredictable mild stress-induced behavioral changes and biochemical alterations","volume":"122","author":"Bhatt","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0030","first-page":"4447","article-title":"Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice","volume":"12","author":"Bluthe","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0035","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0306-4530(01)00030-0","article-title":"Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy","volume":"26","author":"Capuron","year":"2001","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0045","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0050","first-page":"3442","article-title":"Phase II trial of interleukin 2, interferon alpha, and 5-fluorouracil in metastatic renal cell cancer: a cytokine working group study","volume":"6","author":"Dutcher","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneumeth.2011.01.019","article-title":"Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: relevance to emotionality and sex","volume":"197","author":"Guilloux","year":"2011","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0060","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.phymed.2010.03.007","article-title":"Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats","volume":"17","author":"Guo","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0065","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.neubiorev.2012.07.001","article-title":"Neurobiology of chronic mild stress: parallels to major depression","volume":"36","author":"Hill","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0070","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuropharm.2008.06.045","article-title":"Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants","volume":"55","author":"Hwang","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2012.12.008","article-title":"The inflammasome: pathways linking psychological stress, depression, and systemic illnesses","volume":"31","author":"Iwata","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0080","first-page":"2727","article-title":"Progress of pharmacological research on icariin","volume":"33","author":"Li","year":"2008","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0085","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.intimp.2014.01.009","article-title":"Icariin attenuates glucocorticoid insensitivity mediated by repeated psychosocial stress on an ovalbumin-induced murine model of asthma","volume":"19","author":"Li","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0090","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.euroneuro.2009.06.010","article-title":"Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression","volume":"19","author":"Liu","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2010.12.053","article-title":"Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons","volume":"1375","author":"Liu","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0100","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1177\/0269881112458732","article-title":"Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects","volume":"26","author":"Lopresti","year":"2012","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0105","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1017\/S1461145714000285","article-title":"Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis","volume":"17","author":"Lu","year":"2014","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0110","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/j.1440-1681.2007.04647.x","article-title":"Protective effects of icariin against learning and memory deficits induced by aluminium in rats","volume":"34","author":"Luo","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0893-133X(01)00292-5","article-title":"The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress","volume":"26","author":"Madrigal","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0120","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0125","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jad.2011.08.023","article-title":"IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology","volume":"135","author":"Maes","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2012.10.014","article-title":"The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure","volume":"28","author":"Maslanik","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0135","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archneur.57.3.418","article-title":"The global burden of disease study: implications for neurology","volume":"57","author":"Menken","year":"2000","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0145","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1017\/S1461145707008401","article-title":"Oxidative stress in psychiatric disorders: evidence base and therapeutic implications","volume":"11","author":"Ng","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0150","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/sbu048","article-title":"Oxidative\/nitrosative stress in psychiatric disorders: are we there yet?","author":"O\u2019Donnell","year":"2014","journal-title":"Schizophrenia Bull"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0155","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1248\/bpb.29.2399","article-title":"Effects of icariin on hypothalamic\u2013pituitary\u2013adrenal axis action and cytokine levels in stressed Sprague\u2013Dawley rats","volume":"29","author":"Pan","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0160","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pbb.2007.04.009","article-title":"Icariin from Epimedium brevicornum attenuates chronic mild stress-induced behavioral and neuroendocrinological alterations in male Wistar rats","volume":"87","author":"Pan","year":"2007","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0165","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.psyneuen.2009.06.020","article-title":"Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats","volume":"35","author":"Pan","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0170","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.psyneuen.2012.05.007","article-title":"Impaired hypothalamic insulin signaling in CUMS rats: restored by icariin and fluoxetine through inhibiting CRF system","volume":"38","author":"Pan","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2014.04.007","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats","author":"Pan","year":"2014","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0180","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pnpbp.2012.10.017","article-title":"Antioxidants as potential therapeutics for neuropsychiatric disorders","volume":"46","author":"Pandya","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0185","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1017\/S1121189X00001974","article-title":"Depression: major problem for public health","volume":"15","author":"Paykel","year":"2006","journal-title":"Epidemiol Psichiatr Soc"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbi.2012.11.011","article-title":"Dysregulated relationship of inflammation and oxidative stress in major depression","volume":"31","author":"Rawdin","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0195","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuroscience.2013.09.044","article-title":"Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats","volume":"255","author":"Rinwa","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbr.2004.04.022","article-title":"Alterations in brain antioxidant status, protein oxidation and lipid peroxidation in response to different stress models","volume":"155","author":"Sahin","year":"2004","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0205","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/11633190-000000000-00000","article-title":"Antioxidants as antidepressants: fact or fiction?","volume":"26","author":"Scapagnini","year":"2012","journal-title":"CNS Drugs"},{"issue":"Suppl. 2","key":"10.1016\/j.neuroscience.2015.02.053_b0210","first-page":"19","article-title":"Beyond monoamine-based therapies: clues to new approaches","volume":"63","author":"Skolnick","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0215","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0220","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.338.6103.67","article-title":"Depression. Defeating the dementors. Introduction","volume":"338","author":"Stern","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0225","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1038\/sj.npp.1300532","article-title":"Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration","volume":"29","author":"Strekalova","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0230","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1038\/tp.2012.120","article-title":"Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes","volume":"2","author":"Sukoff","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0235","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0240","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0245","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pbb.2011.01.008","article-title":"Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice","volume":"98","author":"Wu","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0250","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejphar.2010.05.012","article-title":"Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K\/Akt and NF-kappaB signaling pathway","volume":"642","author":"Xu","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0255","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/1570159X11666131120231448","article-title":"Novel therapeutic targets in depression and anxiety: antioxidants as a candidate treatment","volume":"12","author":"Xu","year":"2014","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0260","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pnpbp.2013.03.003","article-title":"Oxidative stress and therapeutic implications in psychiatric disorders","volume":"46","author":"Zhang","year":"2013","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0265","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/cns.12170","article-title":"Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors","volume":"20","author":"Zhang","year":"2014","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.neuroscience.2015.02.053_b0270","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2014.06.013","article-title":"Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease","volume":"74C","author":"Zhou","year":"2014","journal-title":"Free Radical Biol Med"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215002419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215002419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T15:41:48Z","timestamp":1759678908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215002419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":54,"alternative-id":["S0306452215002419"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.02.053","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.02.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 IBRO. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}