{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:57:43Z","timestamp":1780358263144,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070933"],"award-info":[{"award-number":["81070933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.neuroscience.2015.03.033","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T13:31:02Z","timestamp":1429104662000},"page":"118-126","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Ecto-5\u2032-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines"],"prefix":"10.1016","volume":"297","author":[{"given":"X.","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-F.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.03.033_b0005","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1086\/596205","article-title":"CD73 Is expressed by human regulatory T Helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice","volume":"199","author":"Alam","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0010","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molmed.2013.03.005","article-title":"CD39 and CD73 in immunity and inflammation","volume":"19","author":"Antonioli","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0015","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.1523\/JNEUROSCI.5817-12.2013","article-title":"Ecto-5\u2032-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A(2A) receptor functions","volume":"33","author":"Augusto","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0020","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/jnr.22599","article-title":"Dynamic changes in the expression pattern of ecto-5\u2032-nucleotidase in the rat model of cortical stab injury","volume":"89","author":"Bjelobaba","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0006-8993(97)00559-3","article-title":"Focal cerebral ischemia enhances glial expression of ecto-5\u2032-nucleotidase","volume":"766","author":"Braun","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0030","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuint.2012.06.017","article-title":"Regulation of ecto-5\u2032-nucleotidase (CD73) in cultured cortical astrocytes by different inflammatory factors","volume":"61","author":"Brisevac","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0035","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cortex.2009.07.005","article-title":"White matter pathways associated with working memory in normal aging","volume":"46","author":"Charlton","year":"2010","journal-title":"Cortex"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-801022-8.00001-5","article-title":"Adenosine receptor neurobiology: overview","volume":"119","author":"Chen","year":"2014","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0045","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4049\/jimmunol.0901295","article-title":"A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation","volume":"185","author":"Csoka","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2174\/157015909789152146","article-title":"Release of adenosine and ATP during ischemia and epilepsy","volume":"7","author":"Dale","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0055","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jns.2009.05.010","article-title":"Adenosine A2A receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice","volume":"285","author":"Duan","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0060","first-page":"285245","article-title":"The contribution of immune and glial cell types in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"2014","author":"Duffy","year":"2014","journal-title":"Mult Scler Int"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0065","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.7150\/ijbs.4679","article-title":"Interleukin-6, a major cytokine in the central nervous system","volume":"8","author":"Erta","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0070","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0075","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0140-6736(00)02604-0","article-title":"Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study","volume":"356","author":"Garde","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0080","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1212\/WNL.43.10.2159-a","article-title":"Vascular dementia","volume":"43","author":"Hachinski","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2003.11.003","article-title":"Adenosine: an endogenous regulator of innate immunity","volume":"25","author":"Hasko","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0090","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.tips.2005.08.004","article-title":"Adenosine receptor signaling in the brain immune system","volume":"26","author":"Hasko","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.it.2009.04.001","article-title":"A(2B) adenosine receptors in immunity and inflammation","volume":"30","author":"Hasko","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0100","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0105","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/00005072-195312040-00008","article-title":"A method for the combined staining of cells and fibers in the nervous system","volume":"12","author":"Kluver","year":"1953","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0110","first-page":"H1703","article-title":"Role of adenosine in regulation of regional cerebral blood flow in sensory cortex","volume":"259","author":"Ko","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0115","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1124\/jpet.109.157651","article-title":"Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway","volume":"331","author":"Kreckler","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0120","doi-asserted-by":"crossref","first-page":"e66896","DOI":"10.1371\/journal.pone.0066896","article-title":"CD73 is a major regulator of adenosinergic signalling in mouse brain","volume":"8","author":"Kulesskaya","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0125","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/jcbfm.1991.83","article-title":"The role of adenosine in the vascular adaptation of neonatal cerebral blood flow during hypotension","volume":"11","author":"Laudignon","year":"1991","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0130","doi-asserted-by":"crossref","first-page":"e84802","DOI":"10.1371\/journal.pone.0084802","article-title":"White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/jnnp.69.1.48","article-title":"Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI","volume":"69","author":"Markus","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0140","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/jnr.21925","article-title":"Intensity of chronic cerebral hypoperfusion determines white\/gray matter injury and cognitive\/motor dysfunction in mice","volume":"87","author":"Miki","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0145","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1073\/pnas.0711175105","article-title":"CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis","volume":"105","author":"Mills","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0150","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cellbi.2006.03.001","article-title":"Up-regulation of ectonucleotidase activity after cortical stab injury in rats","volume":"30","author":"Nedeljkovic","year":"2006","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0155","series-title":"The mouse brain in stereotaxic coordinates","author":"Paxinos","year":"2004"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0160","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0197-4580(01)00291-3","article-title":"The role of TNF and its receptors in Alzheimer\u2019s disease","volume":"22","author":"Perry","year":"2001","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0165","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.4049\/jimmunol.1003671","article-title":"Tissue-resident Ecto-5\u2032 nucleotidase (CD73) regulates leukocyte trafficking in the ischemic brain","volume":"188","author":"Petrovic-Djergovic","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0170","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/NEN.0000000000000174","article-title":"Critical contribution of adenosine A2A receptors in bone marrow-derived cells to white matter lesions induced by chronic cerebral hypoperfusion","volume":"74","author":"Ran","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arcmed.2007.10.001","article-title":"Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer\u2019s disease","volume":"39","author":"Rojo","year":"2008","journal-title":"Arch Med Res"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0180","doi-asserted-by":"crossref","first-page":"C530","DOI":"10.1152\/ajpcell.00385.2010","article-title":"Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells","volume":"301","author":"Romio","year":"2011","journal-title":"Am J Physiol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-2094-5-7","article-title":"The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective","volume":"5","author":"Shaftel","year":"2008","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0190","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1161\/STROKEAHA.107.490151","article-title":"Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion","volume":"38","author":"Shibata","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0195","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.20040915","article-title":"Crucial role for ecto-5\u2032-nucleotidase (CD73) in vascular leakage during hypoxia","volume":"200","author":"Thompson","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0200","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/ATVBAHA.113.302440","article-title":"Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion","volume":"34","author":"Toyama","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0205","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-0404.2004.00286.x","article-title":"Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients","volume":"110","author":"Wada-Isoe","year":"2004","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0210","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF00294175","article-title":"Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study","volume":"87","author":"Wakita","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0215","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.bbamem.2010.12.018","article-title":"Normal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies","volume":"1808","author":"Wei","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0220","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.08.009","article-title":"Interleukin-6 is associated with cognitive function: the Northern Manhattan Study","volume":"15","author":"Wright","year":"2006","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0225","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s11064-013-1158-1","article-title":"Changes in levels of hypoxia-induced mediators in rat hippocampus during chronic cerebral hypoperfusion","volume":"38","author":"Yang","year":"2013","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0230","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.expneurol.2007.12.005","article-title":"Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice","volume":"210","author":"Yoshizaki","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0235","article-title":"Inhibition of hippocampal synaptic activity by ATP, hypoxia or oxygen-glucose deprivation does not require CD73","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0240","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1007\/s00018-007-7218-4","article-title":"Causes of oxidative stress in Alzheimer disease","volume":"64","author":"Zhu","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.neuroscience.2015.03.033_b0245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2004.11.014","article-title":"TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition","volume":"1034","author":"Zou","year":"2005","journal-title":"Brain Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215002602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215002602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T09:57:28Z","timestamp":1537696648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215002602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":49,"alternative-id":["S0306452215002602"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.03.033","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}