{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:29:47Z","timestamp":1777498187306,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["H1818"],"award-info":[{"award-number":["H1818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.neuroscience.2015.06.030","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:38:14Z","timestamp":1435106294000},"page":"489-502","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153\/NF-E2-related factor 2\/antioxidant response element signaling pathway"],"prefix":"10.1016","volume":"303","author":[{"given":"X.S.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.L.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.L.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.A.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.06.030_b0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1001\/archneur.1975.00490440064010","article-title":"Brain peroxidase and catalase in Parkinson disease","volume":"32","author":"Ambani","year":"1975","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0010","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/BF00978370","article-title":"The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls","volume":"18","author":"Andrew","year":"1993","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0015","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1128\/MCB.22.15.5492-5505.2002","article-title":"Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound","volume":"22","author":"Braun","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pep.2010.06.017","article-title":"Expression, purification, and refolding of active Nrf2 transcription factor fused to protein transduction TAT tag","volume":"74","author":"Chumanov","year":"2010","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0025","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/oxfordjournals.bmb.a011637","article-title":"The importance of oxidative stress in apoptosis","volume":"53","author":"Clutton","year":"1997","journal-title":"Br Med Bull"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0030","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/S0021-9258(19)42751-8","article-title":"The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents","volume":"249","author":"Cohen","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2015.04.029","article-title":"Structural and functional characterization of NRF2 degradation by glycogen synthase kinase 3\/beta-TrCP","author":"Cuadrado","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-1759(02)00070-4","article-title":"Regulation and measurement of oxidative stress in apoptosis","volume":"265","author":"Curtin","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0021-9673(00)90882-3","article-title":"Mass fragmentography of dopamine and 6-hydroxydopamine. Application to the determination of dopamine in human brain biopsies from the caudate nucleus","volume":"99","author":"Curtius","year":"1974","journal-title":"J Chromatogr"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/exnr.2002.7891","article-title":"Modeling Parkinson\u2019s disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway","volume":"175","author":"Deumens","year":"2002","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0055","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1471-4159.1989.tb09133.x","article-title":"Basal lipid peroxidation in substantia nigra is increased in Parkinson\u2019s disease","volume":"52","author":"Dexter","year":"1989","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0060","doi-asserted-by":"crossref","first-page":"12726","DOI":"10.1074\/jbc.M109.086827","article-title":"Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153","volume":"285","author":"Doxakis","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0065","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/aps.2010.176","article-title":"Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes","volume":"31","author":"Hong","year":"2010","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0070","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1002\/ana.410440712","article-title":"Understanding cell death in Parkinson\u2019s disease","volume":"44","author":"Jenner","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0075","first-page":"202","article-title":"The inhibiting effect and its molecular mechanism of Tanshinone on human lung cancer cell line in vitro","volume":"11","author":"Ji","year":"2008","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2014.11.047","article-title":"Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson\u2019s disease by enhancing Nrf2 activity","volume":"286","author":"Jing","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0085","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1124\/mol.62.5.1001","article-title":"Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress","volume":"62","author":"Kang","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0304-3940(85)90078-3","article-title":"Glutathione peroxidase activity in Parkinson\u2019s disease brain","volume":"58","author":"Kish","year":"1985","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0095","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0100","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2174\/1871527311211080012","article-title":"Nuclear factor erythroid 2-related factor 2 signaling in Parkinson disease: a promising multi therapeutic target against oxidative stress, neuroinflammation and cell death","volume":"11","author":"Kumar","year":"2012","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/toxsci\/kfi027","article-title":"Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells","volume":"83","author":"Li","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2164-8-166","article-title":"Characterization of microRNA expression profiles in normal human tissues","volume":"8","author":"Liang","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neuroscience.2015.06.030_b1500","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jep.2006.05.004","article-title":"Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism","volume":"108","author":"Lin","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0115","doi-asserted-by":"crossref","first-page":"e103948","DOI":"10.1371\/journal.pone.0103948","article-title":"Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0120","doi-asserted-by":"crossref","first-page":"31298","DOI":"10.1074\/jbc.M112.366336","article-title":"MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients","volume":"287","author":"Long","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0125","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuropharm.2013.11.026","article-title":"Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2\/ARE signaling pathway","volume":"79","author":"Lou","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0130","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","article-title":"Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region","volume":"91","author":"Moi","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0135","doi-asserted-by":"crossref","first-page":"e51111","DOI":"10.1371\/journal.pone.0051111","article-title":"Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells","volume":"7","author":"Narasimhan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.toxlet.2014.05.020","article-title":"Hydrogen peroxide responsive miR153 targets Nrf2\/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity","volume":"228","author":"Narasimhan","year":"2014","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/08923970903120997","article-title":"Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines","volume":"32","author":"Qin","year":"2010","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","article-title":"Expression of Nrf2 in neurodegenerative diseases","volume":"66","author":"Ramsey","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0155","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jns.2014.11.026","article-title":"Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson\u2019s disease","volume":"348","author":"Ren","year":"2015","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0160","doi-asserted-by":"crossref","first-page":"e113663","DOI":"10.1371\/journal.pone.0113663","article-title":"Bacterial fucose-rich polysaccharide stabilizes MAPK-mediated Nrf2\/Keap1 signaling by directly scavenging reactive oxygen species during hydrogen peroxide-induced apoptosis of human lung fibroblast cells","volume":"9","author":"Roy Chowdhury","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0165","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1471-4159.2005.03587.x","article-title":"Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death","volume":"96","author":"Signore","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/emm.1999.28","article-title":"Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3","volume":"31","author":"Sung","year":"1999","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1358\/dnp.2007.20.2.1083437","article-title":"Chemopreventive promise of targeting the Nrf2 pathway","volume":"20","author":"Yates","year":"2007","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.neuroscience.2015.06.030_b0180","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jchromb.2011.02.011","article-title":"The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry","volume":"879","author":"Zhu","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215005710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215005710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T01:09:36Z","timestamp":1652576976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215005710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":37,"alternative-id":["S0306452215005710"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.06.030","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}