{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:21:28Z","timestamp":1790749288401,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.neuroscience.2015.07.025","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:22:46Z","timestamp":1436919766000},"page":"515-523","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6\/1 model of Huntington\u2019s disease"],"prefix":"10.1016","volume":"303","author":[{"given":"E.A.F.","family":"Herbst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.P.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.07.025_b0005","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington\u2019s disease","volume":"4","author":"Andrew","year":"1993","journal-title":"Nat Genet"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0010","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1091\/mbc.e05-07-0607","article-title":"Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin","volume":"17","author":"Benchoua","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0015","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1074\/jbc.M704332200","article-title":"Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria","volume":"283","author":"Benton","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0020","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1073\/pnas.92.15.7105","article-title":"Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates","volume":"92","author":"Brouillet","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0025","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/ana.410410514","article-title":"Oxidative damage and metabolic dysfunction in Huntington\u2019s disease: selective vulnerability of the basal ganglia","volume":"41","author":"Browne","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington\u2019s disease","volume":"9","author":"Browne","year":"1999","journal-title":"Brain Pathol"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0035","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1093\/hmg\/ddt242","article-title":"A role of mitochondrial complex II defects in genetic models of Huntington\u2019s disease expressing N-terminal fragments of mutant huntingtin","volume":"22","author":"Damiano","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbadis.2009.07.012","article-title":"Mitochondria in Huntington\u2019s disease","volume":"1802","author":"Damiano","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410390317","article-title":"Mitochondrial defect in Huntington\u2019s disease caudate nucleus","volume":"39","author":"Gu","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0050","doi-asserted-by":"crossref","DOI":"10.3791\/1787","article-title":"A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia","author":"Guyenet","year":"2010","journal-title":"J Vis Exp"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0055","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1113\/jphysiol.2014.285379","article-title":"Permeabilization of brain tissue in situ enables multiregion analysis of mitochondrial function in a single mouse brain","volume":"593","author":"Herbst","year":"2015","journal-title":"J Physiol"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0060","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1212\/WNL.45.10.1879","article-title":"Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington\u2019s disease patients","volume":"45","author":"Horton","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0065","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1602\/neurorx.2.3.447","article-title":"The use of the R6 transgenic mouse models of Huntington\u2019s disease in attempts to develop novel therapeutic strategies","volume":"2","author":"Li","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0075","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0140-6736(90)92242-A","article-title":"Mitochondrial function and parental sex effect in Huntington\u2019s disease","volume":"336","author":"Mann","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0165-6147(00)01884-8","article-title":"Mouse models of Huntington\u2019s disease","volume":"23","author":"Menalled","year":"2002","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0085","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington\u2019s disease transgenic mice","volume":"141","author":"Pang","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0090","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(00)02082-5","article-title":"Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington\u2019s disease","volume":"862","author":"Perez-Severiano","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0095","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1523\/JNEUROSCI.6223-10.2011","article-title":"The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions","volume":"31","author":"Pickrell","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0100","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1073\/pnas.1019581108","article-title":"Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice","volume":"108","author":"Safdar","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0105","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0197-0186(95)00122-0","article-title":"Involvement of oxidative stress in 3-nitropropionic acid neurotoxicity","volume":"29","author":"Schulz","year":"1996","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0110","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/hmg\/ddm054","article-title":"Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain","volume":"16","author":"Shelbourne","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0115","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.freeradbiomed.2012.06.008","article-title":"Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington\u2019s disease","volume":"53","author":"Siddiqui","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0120","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/cne.20680","article-title":"Chronology of behavioral symptoms and neuropathological sequela in R6\/2 Huntington\u2019s disease transgenic mice","volume":"490","author":"Stack","year":"2005","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0125","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington\u2019s in mice","volume":"404","author":"van Dellen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2202-9-34","article-title":"Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington\u2019s disease","volume":"9","author":"van Dellen","year":"2008","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0135","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1523\/JNEUROSCI.23-06-02193.2003","article-title":"Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington\u2019s disease","volume":"23","author":"Yu","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.07.025_b0140","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1074\/mcp.M800277-MCP200","article-title":"A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease","volume":"8","author":"Zabel","year":"2009","journal-title":"Mol Cell Proteomics"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215006399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215006399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T16:44:47Z","timestamp":1556556287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215006399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":28,"alternative-id":["S0306452215006399"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.07.025","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}