{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:54:10Z","timestamp":1791338050528,"version":"4.3.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Pharmacology Departments of Shiraz University of Medical Sciences"},{"name":"Tehran University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.neuroscience.2015.08.018","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T13:01:52Z","timestamp":1439211712000},"page":"1-9","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats"],"prefix":"10.1016","volume":"306","author":[{"given":"M.","family":"Dastgheib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Moezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.08.018_b0005","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.neuint.2006.02.002","article-title":"Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma","volume":"49","author":"Ahboucha","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0010","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1073\/pnas.241503698","article-title":"The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?","volume":"98","author":"Akwa","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0015","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s007020050217","article-title":"Ventral hippocampal glutamate receptors in the rat: possible involvement in learning mechanisms of an active avoidance response","volume":"106","author":"Alvarez","year":"1999","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/363347a0","article-title":"Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors","volume":"363","author":"Bashir","year":"1993","journal-title":"Nature"},{"issue":"Spec No","key":"10.1016\/j.neuroscience.2015.08.018_b0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/hipo.1993.4500030727","article-title":"Entorhinal-hippocampal interaction in amnestic disorders","volume":"3","author":"Braak","year":"1993","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-2007-1007236","article-title":"The neurobiology of hepatic encephalopathy","volume":"16","author":"Butterworth","year":"1996","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11011-008-9115-4","article-title":"Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy","volume":"24","author":"Cauli","year":"2009","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0040","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1037\/0735-7044.110.6.1321","article-title":"Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment","volume":"110","author":"Conrad","year":"1996","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0006-8993(99)01964-2","article-title":"Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition","volume":"852","author":"Darnaudery","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0050","doi-asserted-by":"crossref","first-page":"C757","DOI":"10.1152\/ajpcell.00252.2002","article-title":"Activation of NMDA receptors linked to modulation of voltage-gated ion channels and functional implications","volume":"284","author":"Davis","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1523\/JNEUROSCI.12-01-00021.1992","article-title":"The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro","volume":"12","author":"Davis","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/nlme.1999.3919","article-title":"Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice","volume":"73","author":"Dellu","year":"2000","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0065","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pnpbp.2004.11.001","article-title":"Steroids, neuroactive steroids and neurosteroids in psychopathology","volume":"29","author":"Dubrovsky","year":"2005","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0070","first-page":"617","article-title":"The effect of cholestasis on rewarding and exploratory behaviors induced by opioidergic and dopaminergic agents in mice","volume":"15","author":"Ebrahimi-ghiri","year":"2012","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0075","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.3748\/wjg.v12.i48.7737","article-title":"Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy","volume":"12","author":"Felipo","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0080","doi-asserted-by":"crossref","first-page":"10806","DOI":"10.1073\/pnas.92.23.10806","article-title":"Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive","volume":"92","author":"Flood","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1590\/S0100-879X2005000100019","article-title":"Evaluation of two experimental models of hepatic encephalopathy in rats","volume":"38","author":"Garcia-Moreno","year":"2005","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0090","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/ajg.2009.191","article-title":"Management and treatment of patients with cirrhosis and portal hypertension: recommendations from the Department of Veterans Affairs Hepatitis C Resource Center Program and the National Hepatitis C Program","volume":"104","author":"Garcia-Tsao","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0095","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1053\/gast.1996.v110.pm8536857","article-title":"Down-regulation of expression and function of the rat liver Na+\/bile acid cotransporter in extrahepatic cholestasis","volume":"110","author":"Gartung","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/cn400168y","article-title":"Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats","volume":"5","author":"Gonzalez-Usano","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0006-8993(84)90275-0","article-title":"Long-term potentiation in the hippocampus involves activation of N-methyl-d-aspartate receptors","volume":"323","author":"Harris","year":"1984","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0110","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bbr.2013.08.018","article-title":"Effects of CA1 glutamatergic systems upon memory impairments in cholestatic rats","volume":"256","author":"Hosseini","year":"2013","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(97)00252-8","article-title":"Long-term potentiation and long-term depression are induced through pharmacologically distinct NMDA receptors","volume":"226","author":"Hrabetova","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0120","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1203\/PDR.0b013e31818d5bc7","article-title":"Melatonin ameliorates bile duct ligation-induced systemic oxidative stress and spatial memory deficits in developing rats","volume":"65","author":"Huang","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0125","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijdevneu.2009.11.006","article-title":"The interaction between high ammonia diet and bile duct ligation in developing rats: assessment by spatial memory and asymmetric dimethylarginine","volume":"28","author":"Huang","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/FBP.0b013e32834aff1f","article-title":"Influence of N-methyl-d-aspartate receptor mechanism on WIN55,212-2-induced amnesia in rat dorsal hippocampus","volume":"22","author":"Jamali-Raeufy","year":"2011","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/FBP.0b013e3283618a8c","article-title":"Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats","volume":"24","author":"Javadi-Paydar","year":"2013","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0140","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0006-8993(92)90624-I","article-title":"The learning capacity of high or low performance rats is related to the hippocampus NMDA receptors","volume":"576","author":"Keller","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2012.02.049","article-title":"Scopolamine induced memory impairment; possible involvement of NMDA receptor mechanisms of dorsal hippocampus and\/or septum","volume":"231","author":"Khakpai","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0150","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/npp.2011.189","article-title":"GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels","volume":"37","author":"Kim","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0155","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat","volume":"65","author":"Kountouras","year":"1984","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0160","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0006-8993(00)01953-3","article-title":"Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse","volume":"858","author":"Ladurelle","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0165","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11011-007-9067-0","article-title":"NMDA receptors in hyperammonemia and hepatic encephalopathy","volume":"22","author":"Llansola","year":"2007","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0170","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1476-5381.2009.00589.x","article-title":"Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation","volume":"159","author":"Magen","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0304-3940(88)90202-9","article-title":"Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons","volume":"90","author":"Majewska","year":"1988","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1051\/jbio\/1999193030299","article-title":"Models for the study of memory and neurosteroids","volume":"193","author":"Mathis","year":"1999","journal-title":"J Soc Biol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1254\/jjp.81.125","article-title":"Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: pharmacological evidence and therapeutic opportunities","volume":"81","author":"Maurice","year":"1999","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0190","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0006-8993(93)91524-V","article-title":"Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat","volume":"607","author":"Mayo","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF02247383","article-title":"The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task","volume":"126","author":"Meziane","year":"1996","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0200","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1460-9568.2007.05444.x","article-title":"Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability","volume":"25","author":"Monfort","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0205","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1523\/JNEUROSCI.09-09-03040.1989","article-title":"Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-d-aspartate receptor antagonist AP5","volume":"9","author":"Morris","year":"1989","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0210","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/ejn.12086","article-title":"N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning","volume":"37","author":"Morris","year":"2013","journal-title":"The European journal of neuroscience"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0215","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.psyneuen.2007.09.002","article-title":"Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats","volume":"32","author":"Naert","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0220","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/FBP.0b013e3283618aab","article-title":"Involvement of opioidergic and nitrergic systems in memory acquisition and exploratory behaviors in cholestatic mice","volume":"24","author":"Nasehi","year":"2013","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2009.06.090","article-title":"Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes","volume":"462","author":"Ohara","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0230","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1124\/mol.52.6.1113","article-title":"Distinct sites for inverse modulation of N-methyl-d-aspartate receptors by sulfated steroids","volume":"52","author":"Park-Chung","year":"1997","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0235","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0006-8993(99)01381-5","article-title":"Sulfated and unsulfated steroids modulate gamma-aminobutyric acid A receptor function through distinct sites","volume":"830","author":"Park-Chung","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0240","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0245","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.euroneuro.2010.09.010","article-title":"Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice","volume":"21","author":"Petit","year":"2011","journal-title":"Eur Nneuropsychopharmacol"},{"issue":"9","key":"10.1016\/j.neuroscience.2015.08.018_b9000","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0250","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0006-8993(98)00676-3","article-title":"Involvement of NMDA receptors and voltage-dependent calcium channels on augmentation of long-term potentiation in hippocampal CA1 area of morphine dependent rats","volume":"804","author":"Pourmotabbed","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0255","first-page":"834","article-title":"Differential expression of human homeodomain TGIFLX in brain tumor cell lines","volume":"51","author":"Raoofian","year":"2013","journal-title":"Acta Med Iran"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0260","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0028-3908(94)90181-3","article-title":"Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning","volume":"33","author":"Richter-Levin","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0265","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jhep.2007.04.005","article-title":"Critical flicker frequency: it is time to break down barriers surrounding minimal hepatic encephalopathy","volume":"47","author":"Romero-Gomez","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0270","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0306-4530(02)00064-1","article-title":"Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties","volume":"28","author":"Rupprecht","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0275","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00221-013-3818-4","article-title":"The role of serotonin in memory: interactions with neurotransmitters and downstream signaling","volume":"232","author":"Seyedabadi","year":"2014","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0280","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","article-title":"Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans","volume":"99","author":"Squire","year":"1992","journal-title":"Psychol Rev"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0285","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yfrne.2004.04.001","article-title":"Physiology of BDNF: focus on hypothalamic function","volume":"25","author":"Tapia-Arancibia","year":"2004","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0290","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.21268","article-title":"Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis","volume":"44","author":"Uchinami","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0295","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejphar.2003.12.018","article-title":"Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1\u201340) protein","volume":"486","author":"Urani","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0300","doi-asserted-by":"crossref","first-page":"14865","DOI":"10.1073\/pnas.94.26.14865","article-title":"Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus","volume":"94","author":"Vallee","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0305","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0026-895X(25)12923-4","article-title":"Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-d-aspartate receptor","volume":"40","author":"Wu","year":"1991","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0310","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1037\/0735-7044.112.4.892","article-title":"Comparison of the amnestic effects of NMDA receptor antagonist MK-801 and nitric oxide synthase inhibitors: L-NAME and L-NOARG in goldfish","volume":"112","author":"Xu","year":"1998","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0315","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejphar.2015.03.080","article-title":"Hippocampal AP5 treatment impairs both spatial working and reference memory in radial maze performance in rats","volume":"758","author":"Yamada","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0320","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2011.11.039","article-title":"Possible interaction between opioidergic and cholinergic systems of CA1 in cholestasis-induced amnesia in mice","volume":"228","author":"Zarrindast","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2015.08.018_b0325","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.pneurobio.2009.07.001","article-title":"Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance","volume":"89","author":"Zheng","year":"2009","journal-title":"Prog Neurobiol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215007411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215007411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T19:17:06Z","timestamp":1748546226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215007411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":66,"alternative-id":["S0306452215007411"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.08.018","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}