{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:39:59Z","timestamp":1782837599444,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.neuroscience.2015.11.035","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T17:57:04Z","timestamp":1448301424000},"page":"110-121","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Analysis of the protective effects of a neuronal Cav2.1 calcium channel in brain injury"],"prefix":"10.1016","volume":"313","author":[{"given":"T.Y.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2015.11.035_b0005","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neuron.2008.09.005","article-title":"Calcium channel regulation and presynaptic plasticity","volume":"59","author":"Catterall","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0010","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","article-title":"International Union of Pharmacology. XLVIII. Nomenclature and structure\u2013function relationships of voltage-gated calcium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(01)01683-4","article-title":"Enhanced expression of L-type Ca2+ channels in reactive astrocytes after ischemic injury in rats","volume":"302","author":"Chung","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0020","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.tins.2006.08.006","article-title":"Presynaptic Ca2+ channels \u2013 integration centers for neuronal signaling pathways","volume":"29","author":"Evans","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0025","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/jnc.13123","article-title":"Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury","volume":"134","author":"Gao","year":"2015","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0030","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/ph6070788","article-title":"Voltage-gated calcium channel antagonists and traumatic brain injury","volume":"6","author":"Gurkoff","year":"2013","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0035","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ceb.2007.04.020","article-title":"Trafficking and regulation of neuronal voltage-gated calcium channels","volume":"19","author":"Jarvis","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0040","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/2070","article-title":"Impaired blood\u2013brain barrier function in angiotensinogen-deficient mice","volume":"4","author":"Kakinuma","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0045","first-page":"1015","article-title":"Expression and potential role of phospholipase D1 in cryoinjured cerebral cortex of rats","volume":"19","author":"Kim","year":"2004","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0050","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pbb.2014.06.022","article-title":"Age-dependent kainate sensitivity in heterozygous rolling Nagoya Cav2.1 channel mutant mice","volume":"124","author":"Kim","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1538\/expanim.62.173","article-title":"Anesthetic effect of a mixture of medetomidine, midazolam and butorphanol in two strains of mice","volume":"62","author":"Kirihara","year":"2013","journal-title":"Exp Anim"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0060","first-page":"97","article-title":"Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities","volume":"11","author":"Lozano","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/355827a0","article-title":"P-type calcium channels blocked by the spider toxin omega-Aga-IVA","volume":"355","author":"Mintz","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0070","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1523\/JNEUROSCI.20-15-05654.2000","article-title":"Reduced voltage sensitivity of activation of P\/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol))","volume":"20","author":"Mori","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0075","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0306-4522(97)00197-8","article-title":"Occurrence of apoptosis following cold injury-induced brain edema in mice","volume":"81","author":"Murakami","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0080","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0301-0082(98)00047-1","article-title":"Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis","volume":"57","author":"Murakami","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1471-4914(01)02221-3","article-title":"The blood\u2013brain barrier and cerebral angiogenesis: lessons from the cold-injury model","volume":"8","author":"Nag","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0090","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.exger.2008.06.010","article-title":"Improved short-term memory and increased expression of NR2B observed in senescence-accelerated mouse (SAM) P6","volume":"43","author":"Niimi","year":"2008","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1538\/expanim1957.22.4_281","article-title":"The observation of rolling mouse Nagoya (rol), a new neurological mutant, and its maintenance","volume":"22","author":"Oda","year":"1973","journal-title":"Exp Anim"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0100","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0196-9781(98)00058-8","article-title":"Peptide N- and P\/Q-type Ca2+ blockers inhibit stimulant-induced hyperactivity in mice","volume":"19","author":"Ogura","year":"1998","journal-title":"Peptides"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0105","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.conb.2005.05.010","article-title":"Function and dysfunction of synaptic calcium channels: insights from mouse models","volume":"15","author":"Pietrobon","year":"2005","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/toxins3010017","article-title":"Peptide neurotoxins that affect voltage-gated calcium channels: A close-up on \u03c9-agatoxins","volume":"3","author":"Pringos","year":"2011","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079837","article-title":"Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-\u03b1","volume":"8","author":"Rachmany","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0125","article-title":"Modulation of spike-evoked synaptic transmission: the role of presynaptic calcium and potassium channels","author":"Rama","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0130","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/jcbfm.2010.28","article-title":"Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood\u2013brain barrier leakage and inflammation","volume":"30","author":"Raslan","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0135","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s12031-014-0398-0","article-title":"P38 MAPK inhibition protects against glutamate neurotoxicity and modifies NMDA and AMPA receptor subunit expression","volume":"55","author":"Rivera-Cervantes","year":"2015","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0140","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1590\/1414-431X20143601","article-title":"Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice","volume":"47","author":"Shang","year":"2014","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0145","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12264-012-1063-7","article-title":"Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain","volume":"28","author":"Shi","year":"2012","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0150","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2174\/18715273113126660196","article-title":"Novel approach to the role of NMDA receptors in traumatic brain injury","volume":"13","author":"Shohami","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0155","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","article-title":"Neuronal voltage-gated calcium channels: structure, function, and dysfunction","volume":"82","author":"Simms","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0160","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.exger.2008.11.006","article-title":"Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya","volume":"44","author":"Takahashi","year":"2009","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbr.2009.05.020","article-title":"Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya","volume":"204","author":"Takahashi","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0170","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbr.2010.04.030","article-title":"Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the Ca V 2.1 alpha1 mutation","volume":"213","author":"Takahashi","year":"2010","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0175","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neurobiolaging.2009.03.001","article-title":"Emotional behavior in heterozygous rolling mouse Nagoya Cav2.1 channel mutant mice","volume":"32","author":"Takahashi","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2013.03.066","article-title":"Analysis of ischemic neuronal injury in CaV2.1 channel \u03b11 subunit mutant mice","volume":"434","author":"Tian","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0185","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1126\/science.1357749","article-title":"Calcium channels coupled to glutamate release identified by omega-Aga-IVA","volume":"258","author":"Turner","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0190","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2004.06.046","article-title":"Edema and brain trauma","volume":"129","author":"Unterberg","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0195","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1212\/WNL.0b013e3181fd62d2","article-title":"GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study","volume":"75","author":"Vos","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0200","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","article-title":"Hydrogen sulfide protects blood\u2013brain barrier integrity following cerebral ischemia","volume":"129","author":"Wang","year":"2014","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0205","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-6606-5-18","article-title":"Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats","volume":"5","author":"Yang","year":"2012","journal-title":"Mol Brain"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0210","first-page":"609","article-title":"Involvement of MAPK pathways in NMDA-induced apoptosis of rat cortical neurons","volume":"64","author":"Yang","year":"2012","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.neuroscience.2015.11.035_b0215","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/cne.22431","article-title":"Suppression of fibrotic scar formation promotes axonal regeneration without disturbing blood\u2013brain barrier repair and withdrawal of leukocytes after traumatic brain injury","volume":"518","author":"Yoshioka","year":"2010","journal-title":"J Comp Neurol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215010246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452215010246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T16:55:11Z","timestamp":1567356911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452215010246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":43,"alternative-id":["S0306452215010246"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2015.11.035","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}