{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:56:12Z","timestamp":1791600972568,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neuroscience.2016.03.031","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T20:00:42Z","timestamp":1458763242000},"page":"74-88","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin"],"prefix":"10.1016","volume":"325","author":[{"given":"C.","family":"Connolly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Magnusson-Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.K.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Southwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Leavitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"205(8)","key":"10.1016\/j.neuroscience.2016.03.031_b0005","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington\u2019s disease","volume":"4","author":"Bjorkqvist","year":"2008","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.neuroscience.2016.03.031_b0010","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.molimm.2006.03.007","article-title":"Role of complement in neurodegeneration and neuroinflammation","volume":"44","author":"Bonifati","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0015","doi-asserted-by":"crossref","first-page":"18259","DOI":"10.1523\/JNEUROSCI.4008-12.2012","article-title":"Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington\u2019s disease","volume":"32","author":"Bouchard","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0020","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/mt.2011.201","article-title":"Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene\/allele-specific silencing of mutant huntingtin","volume":"12","author":"Carroll","year":"2011","journal-title":"Mol Ther"},{"issue":"4","key":"10.1016\/j.neuroscience.2016.03.031_b9005","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbi.2011.01.020","article-title":"The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: Evidence for a cross-talk between IL-i 2p70\/IL-23 axis and IL- 10 in microglial cells","volume":"25","author":"Correa","year":"2011","journal-title":"Brain Behav Immun"},{"issue":"4","key":"10.1016\/j.neuroscience.2016.03.031_b0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nn.3668","article-title":"Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors","volume":"17","author":"Crotti","year":"2014","journal-title":"Nat Neurosci"},{"issue":"7","key":"10.1016\/j.neuroscience.2016.03.031_b0030","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/pr0700753","article-title":"Proteomic profiling of plasma in Huntington\u2019s disease reveals neuroinflammatory activation and biomarker candidates","volume":"6","author":"Dalrymple","year":"2007","journal-title":"J Proteome Res"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0035","first-page":"430","article-title":"Cerebrovascular and blood\u2013brain barrier impairments in Huntington\u2019s disease: potential implications for its pathophysiology","volume":"82","author":"Drouin-Ouellet","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0040","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/541259","article-title":"The role of the immune system in Huntington\u2019s disease","volume":"2013","author":"Ellrichmann","year":"2013","journal-title":"Clin Dev Immunol"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.03.031_b0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.nbd.2011.09.003","article-title":"Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease","volume":"45","author":"Franciosi","year":"2012","journal-title":"Neurobiol Dis"},{"issue":"22(9)","key":"10.1016\/j.neuroscience.2016.03.031_b0050","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/hmg\/ddt036","article-title":"A critical role of astrocyte-mediated nuclear factor-\u03baB-dependent inflammation in Huntington\u2019s disease","volume":"1","author":"Hsiao","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.031_b0055","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington\u2019s Disease Rating Scale: reliability and consistency","volume":"11","author":"Huntington Study Group","year":"1996","journal-title":"Mov Disord"},{"issue":"14","key":"10.1016\/j.neuroscience.2016.03.031_b0060","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1523\/JNEUROSCI.4346-04.2005","article-title":"Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia","volume":"25","author":"Kim","year":"2005","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.03.031_b0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1096\/fj.06-5865com","article-title":"A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation","volume":"21","author":"Kim","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0070","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1172\/JCI64484","article-title":"Mutant huntingtin impairs immune cell migration in Huntington disease","volume":"122","author":"Kwan","year":"2012","journal-title":"J Clin Invest"},{"issue":"67(2)","key":"10.1016\/j.neuroscience.2016.03.031_b0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuron.2010.06.021","article-title":"Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington\u2019s disease","volume":"29","author":"Miller","year":"2010","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.neuroscience.2016.03.031_b0080","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00702-010-0430-7","article-title":"Neuroinflammation in Huntington\u2019s disease","volume":"117","author":"Moller","year":"2010","journal-title":"J. Neural Transm."},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.031_b0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.031_b9010","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hbm.21008","article-title":"Microglial activation in regions related to cognitive function predicts disease onset in Huntington\u2019s disease: a multimodal imaging study","volume":"32","author":"Politis","year":"2011","journal-title":"Hum Brain Mapp"},{"issue":"5","key":"10.1016\/j.neuroscience.2016.03.031_b0090","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Formation of polyglutamine inclusions in non-CNS tissue","volume":"8","author":"Sathasivam","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.031_b0095","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/glia.10274","article-title":"High-yield isolation of murine microglia by mild trypsinization","volume":"44","author":"Saura","year":"2003","journal-title":"Glia"},{"issue":"12","key":"10.1016\/j.neuroscience.2016.03.031_b9015","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/WNR.0b013e32832e34ee","article-title":"Distinct neuroinflammatory profile in post-mortem human Huntington\u2019s disease","volume":"20","author":"Silvestroni","year":"2009","journal-title":"Neuroreport"},{"issue":"13","key":"10.1016\/j.neuroscience.2016.03.031_b9020","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0100","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/path.1400","article-title":"Extracellular matrix remodelling: the role of matrix metalloproteinases","volume":"200","author":"Stamenkovic","year":"2003","journal-title":"J Pathol"},{"issue":"19","key":"10.1016\/j.neuroscience.2016.03.031_b0105","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/WNL.0b013e3181fc27e4","article-title":"Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease","volume":"75","author":"Sturrock","year":"2010","journal-title":"Neurology"},{"issue":"Pt 7","key":"10.1016\/j.neuroscience.2016.03.031_b0110","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1093\/brain\/awm044","article-title":"Microglial activation in presymptomatic Huntington\u2019s disease gene carriers","volume":"130","author":"Tai","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1524-475X.1996.40307.x","article-title":"Biochemical analysis of acute and chronic wound environments","volume":"4","author":"Tarnuzzer","year":"1996","journal-title":"Wound Rep. Reg."},{"key":"10.1016\/j.neuroscience.2016.03.031_b0120","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/brain\/awt355","article-title":"HTT-lowering reverses Huntington\u2019s disease immune dysfunction caused by NFkappaB pathway dysregulation","volume":"137","author":"Tr\u00e4ger","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1999.79.1.1","article-title":"Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action","volume":"79","author":"Turnbull","year":"1999","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.neuroscience.2016.03.031_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0135","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"6","author":"Vonsattel","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.neuroscience.2016.03.031_b0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/gut.47.1.63","article-title":"Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease","volume":"1","author":"Von Lampe","year":"2000","journal-title":"Gut"},{"issue":"18","key":"10.1016\/j.neuroscience.2016.03.031_b9025","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","article-title":"Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington\u2019s disease","volume":"22","author":"Wellington","year":"2002","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.neuroscience.2016.03.031_b0145","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(02)00615-3","article-title":"Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington\u2019s disease","volume":"33","author":"Zeron","year":"2002","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.neuroscience.2016.03.031_b9030","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cell.2011.05.020","article-title":"Muchowski PJ Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration","volume":"145","author":"Zwilling","year":"2011","journal-title":"Cell"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221630001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030645221630001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T18:56:07Z","timestamp":1567709767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030645221630001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":35,"alternative-id":["S030645221630001X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.03.031","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}