{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:40:12Z","timestamp":1791297612374,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neuroscience.2016.03.051","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T08:59:36Z","timestamp":1459069176000},"page":"124-131","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Analysis of genetics and risk factors of Alzheimer\u2019s Disease"],"prefix":"10.1016","volume":"325","author":[{"given":"M.","family":"Panpalli Ates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Karaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Guntekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0005","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000091654","article-title":"The relation of cigarette smoking to incident Alzheimer\u2019s disease in a biracial urban community population","volume":"26","author":"Aggarwal","year":"2006","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0010","first-page":"13","article-title":"Alzheimer hastal\u0131\u011f\u0131n\u0131 de\u011ferlendirme skalas\u0131 kognitif alt skorunun (ADAS-Cog) betimsel istatistiksel de\u011ferlerinin bir normal Turk ornekleminde saptanmas\u0131","volume":"40","author":"Akca Kalem","year":"2003","journal-title":"N\u00f6ropsikiyatri Ar\u015fivi"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0015","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.03.051_b0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","article-title":"Risk of dementia in diabetes mellitus: a systematic review","volume":"5","author":"Biessels","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0025","doi-asserted-by":"crossref","first-page":"927","DOI":"10.7326\/0003-4819-138-11-200306030-00015","article-title":"U.S. Preventive Services Task Force. Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force","volume":"138","author":"Boustania","year":"2003","journal-title":"Ann Int Med"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.051_b0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0197-4580(99)00110-4","article-title":"Vascular risk factors for Alzheimer\u2019s disease: an epidemiologic perspective","volume":"21","author":"Breteler","year":"2000","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"9","key":"10.1016\/j.neuroscience.2016.03.051_b0040","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archneur.1975.00490510088009","article-title":"Cerebral blood flow in dementia","volume":"32","author":"Hachinski","year":"1975","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0050","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0055","series-title":"Demanslar. 1.bask\u0131","first-page":"113","author":"Karaman","year":"2010"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0060","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1001\/jama.1995.03530230032026","article-title":"The association between midlife blood pressure levels and late-life cognitive function: the Honolulu-Asia Aging Study","volume":"274","author":"Launer","year":"1995","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.neuroscience.2016.03.051_b0065","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1471-4159.2003.01615.x","article-title":"Expanding the association between the APOE gene and the risk of Alzheimer\u2019s disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription","volume":"84","author":"Laws","year":"2003","journal-title":"J Neurochem"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0070","first-page":"176","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.051_b0075","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000051248","article-title":"Elevated serum total and LDL cholesterol in very old patients with Alzheimer\u2019s disease","volume":"12","author":"Lesser","year":"2001","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"10","key":"10.1016\/j.neuroscience.2016.03.051_b0080","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.neurobiolaging.2008.09.015","article-title":"The apolipoprotein E gene and its age-specific effects on cognitive function","volume":"31","author":"Liu","year":"2010","journal-title":"Neurobiol Aging"},{"issue":"9","key":"10.1016\/j.neuroscience.2016.03.051_b0085","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1212\/WNL.58.9.1395","article-title":"Functional vitamin B(12) deficiency and Alzheimer disease","volume":"58","author":"McCaddon","year":"2002","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.03.051_b0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2010.07.063","article-title":"Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer\u2019s disease and vascular dementia","volume":"483","author":"McGuinness","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0095","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neuroscience.2016.03.051_b0100","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1212\/WNL.52.7.1408","article-title":"The influence of smoking on the risk of Alzheimer\u2019s disease","volume":"52","author":"Merchant","year":"1999","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neuroscience.2016.03.051_b0105","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1532-5415.2005.53360.x","article-title":"Dementia and Alzheimer\u2018s disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort","volume":"53","author":"Newman","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0110","series-title":"Genetik Kavramlar","first-page":"515","author":"Oner","year":"2000"},{"issue":"6","key":"10.1016\/j.neuroscience.2016.03.051_b0115","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/01.WNL.0000115110.35610.80","article-title":"Effect of smoking on global cognitive function in nondemented elderly","volume":"62","author":"Ott","year":"2004","journal-title":"Neurology"},{"issue":"15","key":"10.1016\/j.neuroscience.2016.03.051_b0120","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1055\/s-0032-1315377","article-title":"Novel role of red wine-derived polyphenols in the prevention of Alzheimer\u2019s disease dementia and brain pathology: experimental approaches and clinical implications","volume":"78","author":"Pasinetti","year":"2012","journal-title":"Planta Med"},{"issue":"9","key":"10.1016\/j.neuroscience.2016.03.051_b0125","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.56.9.1133","article-title":"Practice parameter: early detection of dementia: mild cognitive impairment (an evidence- based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"56","author":"Petersen","year":"2001","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.051_b0130","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5507\/bp.2012.055","article-title":"Epidemiological of and risk factors for Alzheimer\u2018s disease: a review","volume":"156","author":"Povova","year":"2012","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"issue":"9","key":"10.1016\/j.neuroscience.2016.03.051_b0135","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1212\/01.WNL.0000032494.05619.93","article-title":"Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study","volume":"59","author":"Prins","year":"2002","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.neuroscience.2016.03.051_b0140","first-page":"661","article-title":"Global deterioration scale (GDS)","volume":"24","author":"Reisberg","year":"1988","journal-title":"Psychopharmacol Bull"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1212\/01.wnl.0000251303.50459.8a","article-title":"Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis","volume":"68","author":"Roe","year":"2007","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.051_b0150","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia. Diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"Rom\u00e1n","year":"1993","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.03.051_b0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000264630","article-title":"Volume loss of the medial temporal lobe structures in subjective memory impairment","volume":"29","author":"Striepens","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"5","key":"10.1016\/j.neuroscience.2016.03.051_b0160","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/1533317512452037","article-title":"APOE genotype in the diagnosis of Alzheimer\u2019s disease in patients with cognitive impairment","volume":"27","author":"Sun","year":"2012","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0165","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.archger.2008.03.009","article-title":"Hyperhomocysteinemia and Alzheimer\u2019s disease: a systematic review","volume":"48","author":"Van Dam","year":"2009","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.neuroscience.2016.03.051_b0170","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1136\/bmj.302.6791.1491","article-title":"Relation between nicotine intake and Alzheimer\u2019s disease","volume":"302","author":"Van Duijn","year":"1991","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.neuroscience.2016.03.051_b0175","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1212\/01.WNL.0000098934.18300.BE","article-title":"Low blood pressure and the risk of dementia in very old individuals","volume":"61","author":"Verghese","year":"2003","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.03.051_b0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/JAD-2008-15307","article-title":"Apolipoprotein E highly correlates with AbetaPP- and tau- related markers in human cerebrospinal fluid","volume":"15","author":"Vuletic","year":"2008","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.03.051_b0185","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1212\/01.WNL.0000149519.47454.F2","article-title":"Midlife cardiovascular risk factors and risk of dementia in late life","volume":"64","author":"Whitmer","year":"2005","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.neuroscience.2016.03.051_b0190","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ana.20289","article-title":"Serum lipids and hippocampal volume: the link to Alzheimer\u2019s disease?","volume":"56","author":"Wolf","year":"2004","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.03.051_b0195","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2337\/db06-0879","article-title":"The effect of borderline diabetes on the risk of dementia and Alzheimer\u2019s disease","volume":"56","author":"Xu","year":"2007","journal-title":"Diabetes"},{"issue":"18","key":"10.1016\/j.neuroscience.2016.03.051_b0200","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e3182190d09","article-title":"Midlife overweight and obesity increase late-life dementia risk: a population-based twin study","volume":"76","author":"Xu","year":"2011","journal-title":"Neurology"},{"issue":"18","key":"10.1016\/j.neuroscience.2016.03.051_b0205","first-page":"3211","article-title":"A pilot study on the relationship between thyroid status and neuropsychiatric symptoms in patients with Alzheimer disease","volume":"125","author":"Zhang","year":"2012","journal-title":"Chin Med J (Engl)"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216300306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216300306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T01:56:40Z","timestamp":1536890200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216300306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":41,"alternative-id":["S0306452216300306"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.03.051","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}