{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:55:39Z","timestamp":1778885739144,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.neuroscience.2016.04.023","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T19:05:31Z","timestamp":1461956731000},"page":"1-8","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Neuronatin is a stress-responsive protein of rod photoreceptors"],"prefix":"10.1016","volume":"328","author":[{"given":"Vishal","family":"Shinde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyamvada M.","family":"Pitale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Howse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Gorbatyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Gorbatyuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2016.04.023_b0005","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2337\/diabetes.48.3.552","article-title":"Specific gene expression in pancreatic beta-cells: cloning and characterization of differentially expressed genes","volume":"48","author":"Arava","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0010","first-page":"242","article-title":"Processing of visual signals in vertebrate photoreceptors","volume":"120","author":"Cervetto","year":"1982","journal-title":"Arch Ital Biol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tibs.2013.06.012","article-title":"UPR-inducible miRNAs contribute to stressful situations","volume":"38","author":"Chitnis","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0020","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2337\/diabetes.54.4.1064","article-title":"Neuronatin, a downstream target of BETA2\/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion","volume":"54","author":"Chu","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0025","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1167\/iovs.03-0806","article-title":"Global gene expression analysis of the developing postnatal mouse retina","volume":"45","author":"Dorrell","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(96)00167-9","article-title":"Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel \u2018proteolipid\u2019","volume":"723","author":"Dou","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0035","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1346-8138.2010.00873.x","article-title":"Abundant expression of neuronatin in normal eccrine, apocrine and sebaceous glands and their neoplasms","volume":"37","author":"Dugu","year":"2010","journal-title":"J Dermatol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0040","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cellsig.2008.01.005","article-title":"Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells","volume":"20","author":"Joe","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/dbio.2001.0327","article-title":"Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers","volume":"236","author":"John","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ygeno.2013.12.001","article-title":"Neuronatin gene: imprinted and misfolded: studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss","volume":"103","author":"Joseph","year":"2014","journal-title":"Genomics"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0055","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1006\/bbrc.1994.1836","article-title":"Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in neonatal mammalian brain","volume":"201","author":"Joseph","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0006-8993(95)00621-V","article-title":"Neuronatin mRNA: alternatively spliced forms of a novel brain-specific mammalian developmental gene","volume":"690","author":"Joseph","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0065","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1167\/iovs.11-9235","article-title":"ER stress is involved in T17M rhodopsin-induced retinal degeneration","volume":"53","author":"Kunte","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/cell.2012.0076","article-title":"Human induced pluripotent stem cells as a tool to model a form of Leber congenital amaurosis","volume":"15","author":"Lustremant","year":"2013","journal-title":"Cell Reprogram"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0075","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/0959-4388(94)90048-5","article-title":"Differences in transduction between rod and cone photoreceptors: an exploration of the role of calcium homeostasis","volume":"4","author":"Miller","year":"1994","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0080","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/cne.902820409","article-title":"Topography of cones and rods in the tree shrew retina","volume":"282","author":"Muller","year":"1989","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0085","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.2337\/db07-1746","article-title":"Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice","volume":"57","author":"Mzhavia","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0090","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1210\/endo.138.4.5066","article-title":"Identification of pancreatic beta cell-related genes by representational difference analysis","volume":"138","author":"Niwa","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0095","doi-asserted-by":"crossref","first-page":"e24879","DOI":"10.1371\/journal.pone.0024879","article-title":"Functional characterization of the dendritically localized mRNA neuronatin in hippocampal neurons","volume":"6","author":"Oyang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0100","doi-asserted-by":"crossref","first-page":"13390","DOI":"10.1523\/JNEUROSCI.3432-06.2006","article-title":"Identification of process-localized mRNAs from cultured rodent hippocampal neurons","volume":"26","author":"Poon","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0105","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1074\/jbc.M112.416180","article-title":"Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease","volume":"288","author":"Sharma","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0110","doi-asserted-by":"crossref","first-page":"e33266","DOI":"10.1371\/journal.pone.0033266","article-title":"ER stress in retinal degeneration in S334ter Rho rats","volume":"7","author":"Shinde","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0115","doi-asserted-by":"crossref","first-page":"e2085","DOI":"10.1038\/cddis.2015.325","article-title":"Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa","volume":"7","author":"Shinde","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0120","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1215\/15228517-2008-038","article-title":"Coexpression of neuronatin splice forms promotes medulloblastoma growth","volume":"10","author":"Siu","year":"2008","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0125","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cellsig.2013.12.008","article-title":"Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors","volume":"26","author":"Sizova","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bbrc.2005.09.078","article-title":"Ectopic expression of Neuronatin potentiates adipogenesis through enhanced phosphorylation of cAMP-response element-binding protein in 3T3-L1 cells","volume":"337","author":"Suh","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-3806(96)00152-6","article-title":"Isolation of cDNA clones of the rat mRNAs expressed preferentially in the prenatal stages of brain development","volume":"97","author":"Usui","year":"1996","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0140","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/oby.2009.361","article-title":"The imprinted gene neuronatin is regulated by metabolic status and associated with obesity","volume":"18","author":"Vrang","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/dbio.1995.1261","article-title":"Segment-specific expression of the neuronatin gene during early hindbrain development","volume":"171","author":"Wijnholds","year":"1995","journal-title":"Dev Biol"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0150","doi-asserted-by":"crossref","first-page":"e37811","DOI":"10.1371\/journal.pone.0037811","article-title":"Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0155","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1038\/oncsis.2015.18","article-title":"Metformin induces ER stress-dependent apoptosis through miR-708-5p\/NNAT pathway in prostate cancer","volume":"4","author":"Yang","year":"2015","journal-title":"Oncogenesis"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0160","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1167\/iovs.12-9851","article-title":"Chemical chaperone TUDCA preserves cone photoreceptors in a mouse model of Leber congenital amaurosis","volume":"53","author":"Zhang","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.neuroscience.2016.04.023_b0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0165-3806(02)00348-6","article-title":"The fetal and neonatal brain protein neuronatin protects PC12 cells against certain types of toxic insult","volume":"136","author":"Zheng","year":"2002","journal-title":"Brain Res Dev Brain Res"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216300884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216300884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T04:51:28Z","timestamp":1567831888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216300884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":33,"alternative-id":["S0306452216300884"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.04.023","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}