{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:09:44Z","timestamp":1791306584769,"version":"4.3.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.neuroscience.2016.08.054","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T16:50:44Z","timestamp":1473785444000},"page":"9-16","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome"],"prefix":"10.1016","volume":"337","author":[{"given":"Sanja","family":"Ramirez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Villagracia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yooree","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Rubens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2016.08.054_b0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.neuroscience.2010.11.034","article-title":"Inner ear insult suppresses the respiratory response to carbon dioxide","volume":"175","author":"Allen","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuroscience.2013.08.059","article-title":"Inner ear insult ablates the arousal response to hypoxia and hypercarbia","volume":"253","author":"Allen","year":"2013","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.neuroscience.2016.08.054_b0015","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1097\/00005537-200209000-00015","article-title":"Round window gentamicin absorption: an in vivo human model","volume":"112","author":"Becvaroski","year":"2002","journal-title":"Laryngoscope"},{"issue":"37","key":"10.1016\/j.neuroscience.2016.08.054_b0020","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1073\/pnas.1004587107","article-title":"Central serotonin neurons are required for arousal to CO2","volume":"107","author":"Buchanan","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.08.054_b0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1152\/jn.00213.2015","article-title":"5-HT2A receptor activation is necessary for CO2-induced arousal","volume":"114","author":"Buchanan","year":"2015","journal-title":"J Neurophysiol"},{"issue":"12","key":"10.1016\/j.neuroscience.2016.08.054_b0030","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1152\/japplphysiol.00164.2015","article-title":"Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs","volume":"118","author":"Burke","year":"2015","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0035","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/japplphysiol.00336.2011","article-title":"Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS","volume":"111","author":"Cummings","year":"2011","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.08.054_b0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.resp.2012.06.005","article-title":"The carotid body and arousal in the fetus and neonate","volume":"185","author":"Darnall","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0045","doi-asserted-by":"crossref","DOI":"10.1542\/peds.114.2.e192","article-title":"Decreased arousals among healthy infants after short-term sleep deprivation","volume":"114","author":"Franco","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0050","series-title":"Section II, Central and Peripheral Neurophysiology, Chapter 10, Hearing and Equilibrium","first-page":"201","article-title":"Review of medical physiology","author":"Ganong","year":"2016"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0055","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.resp.2013.05.032","article-title":"The physiological determinants of sudden infant death syndrome","volume":"189","author":"Garcia","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"issue":"2 Pt 1","key":"10.1016\/j.neuroscience.2016.08.054_b0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1164\/ajrccm\/145.2_Pt_1.453","article-title":"Adenosine stimulation, ventilation, and arousal from sleep","volume":"145","author":"Gleeson","year":"1992","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0070","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.resp.2013.04.011","article-title":"Chemoreception and asphyxia-induced arousal","volume":"188","author":"Guyenet","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.08.054_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2869.2004.00388.x","article-title":"The nature of arousal in sleep","volume":"13","author":"Hal\u00e1sz","year":"2004","journal-title":"J Sleep Res"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0080","first-page":"185","article-title":"Autonomic control during sleep and risk for sudden death in infancy","volume":"139","author":"Harper","year":"2001","journal-title":"Arch Ital Biol"},{"issue":"1\u20132","key":"10.1016\/j.neuroscience.2016.08.054_b0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.heares.2004.01.006","article-title":"Round window gentamicin application: an inner ear hair cell damage protocol for the mouse","volume":"192","author":"Heydt","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0090","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1152\/jn.00160.2004","article-title":"Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla","volume":"93","author":"Hirvonen","year":"2005","journal-title":"J Neurophysiol"},{"issue":"8","key":"10.1016\/j.neuroscience.2016.08.054_b0095","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00005537-200108000-00007","article-title":"Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function","volume":"111","author":"Hoffer","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroscience.2010.12.011","article-title":"Direct projections from the caudal vestibular nuclei to the ventrolateral medulla in the rat","volume":"175","author":"Holstein","year":"2011","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"10.1016\/j.neuroscience.2016.08.054_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5955(98)00137-3","article-title":"Round window administration of gentamicin: a new method for the study of ototoxicity of cochlear hair cells","volume":"125","author":"Husmann","year":"1998","journal-title":"Hear Res"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.brainres.2005.03.010","article-title":"Afferent pathways to the region of the vestibular nuclei that participates in cardiovascular and respiratory control","volume":"1044","author":"Jian","year":"2005","journal-title":"Brain Res"},{"issue":"6","key":"10.1016\/j.neuroscience.2016.08.054_b0115","first-page":"425","article-title":"Anatomo-pathologic study of the temporal bone in our 4 cases of sudden infant death","volume":"102","author":"Josset","year":"1985","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/dev.20367","article-title":"Brainstem mechanisms underlying the sudden infant death syndrome: evidence from human pathologic studies","volume":"51","author":"Kinney","year":"2009","journal-title":"Dev Psychobiol"},{"issue":"8","key":"10.1016\/j.neuroscience.2016.08.054_b0125","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMra0803836","article-title":"The sudden infant death syndrome","volume":"361","author":"Kinney","year":"2009","journal-title":"N Engl J Med"},{"issue":"1\u20132","key":"10.1016\/j.neuroscience.2016.08.054_b0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jns.2015.07.050","article-title":"Developmental alterations of the auditory brainstem centers\u2013pathogenetic implications in Sudden Infant Death Syndrome","volume":"357","author":"Lavezzi","year":"2015","journal-title":"J Neurol Sci"},{"issue":"7124","key":"10.1016\/j.neuroscience.2016.08.054_b0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.neuroscience.2016.08.054_b0140","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1152\/jn.01073.2014","article-title":"Isoflurane abolishes spontaneous firing of serotonin neurons and masks their pH\/CO2 chemosensitivity","volume":"113","author":"Massey","year":"2015","journal-title":"J Neurophysiol"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0145","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5665\/sleep.1712","article-title":"Assessing REM sleep in mice using video data","volume":"35","author":"McShane","year":"2012","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0150","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1152\/jn.00378.2006","article-title":"Acid-sensing ionic channels in the rat vestibular endorgans and ganglia","volume":"96","author":"Mercado","year":"2006","journal-title":"J Neurophysiol"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0155","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00221-008-1359-z","article-title":"Responses of caudal vestibular nucleus neurons of conscious cats to rotations in vertical planes, before and after a bilateral vestibular neurectomy","volume":"188","author":"Miller","year":"2008","journal-title":"Exp Brain Res"},{"issue":"5","key":"10.1016\/j.neuroscience.2016.08.054_b0160","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1542\/peds.2011-2284","article-title":"SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment","volume":"128","author":"Moon","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0165","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1523\/JNEUROSCI.5685-07.2008","article-title":"Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling","volume":"28","author":"Naidoo","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0170","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1152\/physiolgenomics.00139.2006","article-title":"Novel method for high-throughput phenotyping of sleep in mice","volume":"28","author":"Pack","year":"2007","journal-title":"Physiol Genomics"},{"issue":"33","key":"10.1016\/j.neuroscience.2016.08.054_b0175","doi-asserted-by":"crossref","first-page":"11259","DOI":"10.1523\/JNEUROSCI.0948-12.2012","article-title":"State-dependent modulation of breathing in urethane-anesthetized rats","volume":"32","author":"Pagliardini","year":"2012","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.08.054_b0180","first-page":"3","article-title":"Prevention and modulation of aminoglycoside ototoxicity (Review)","volume":"1","author":"Perletti","year":"2008","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0185","first-page":"251","article-title":"Ventilatory and waking responses to CO2 in sleeping dogs","volume":"115","author":"Phillipson","year":"1977","journal-title":"Am Rev Respir Dis"},{"issue":"1","key":"10.1016\/j.neuroscience.2016.08.054_b0190","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.resp.2012.05.013","article-title":"The carotid body in Sudden Infant Death Syndrome","volume":"185","author":"Porzionato","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.neuroscience.2016.08.054_b0195","series-title":"Unit II Sensation and Sensory Processing, Chapter 14. The Vestibular system. Neuroscience","author":"Purves","year":"2012"},{"issue":"7","key":"10.1016\/j.neuroscience.2016.08.054_b0200","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1172\/JCI62923","article-title":"Fatal breathing dysfunction in a mouse model of Leigh syndrome","volume":"122","author":"Quintana","year":"2012","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0205","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3171\/jns.2006.105.2.242","article-title":"Surgical shunt infection: significant reduction when using intraventricular and systemic antibiotic agents","volume":"105","author":"Ragel","year":"2006","journal-title":"J Neurosurg"},{"issue":"4","key":"10.1016\/j.neuroscience.2016.08.054_b0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.earlhumdev.2007.06.001","article-title":"Newborn oto-acoustic emission hearing screening tests: preliminary evidence for a marker of susceptibility to SIDS","volume":"84","author":"Rubens","year":"2008","journal-title":"Early Hum Dev"},{"issue":"4","key":"10.1016\/j.neuroscience.2016.08.054_b0215","first-page":"457","article-title":"Comparison of vestibular and cochlear ototoxicity from transtympanic streptomycin administration","volume":"20","author":"Wanamaker","year":"1999","journal-title":"Am J Otol"},{"issue":"3","key":"10.1016\/j.neuroscience.2016.08.054_b0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/VES-2005-15301","article-title":"The effects of vestibular system lesions on autonomic regulation: observations, mechanisms, and clinical implications","volume":"15","author":"Yates","year":"2005","journal-title":"J Vestib Res"},{"issue":"2","key":"10.1016\/j.neuroscience.2016.08.054_b0225","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuroscience.2008.03.040","article-title":"Functional characterization of acid-sensing ion channels in cultured neurons of rat inferior colliculus","volume":"154","author":"Zhang","year":"2008","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neuroscience.2016.08.054_b0230","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1601-183X.2007.00361.x","article-title":"Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness","volume":"7","author":"Zhang","year":"2008","journal-title":"Genes Brain Behav"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216304365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216304365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T09:49:52Z","timestamp":1657273792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216304365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":45,"alternative-id":["S0306452216304365"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.08.054","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]}}}