{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:48:09Z","timestamp":1789987689734,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.neuroscience.2016.09.037","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T13:53:13Z","timestamp":1475243593000},"page":"22-31","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Deletion of autophagy-related gene 7 in dopaminergic neurons prevents their loss induced by MPTP"],"prefix":"10.1016","volume":"339","author":[{"given":"Xue-Yuan","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-Ju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Bao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-You","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuroscience.2016.09.037_b0005","doi-asserted-by":"crossref","first-page":"16503","DOI":"10.1523\/JNEUROSCI.0209-12.2012","article-title":"Development and characterization of a new Parkinson\u2019s disease model resulting from impaired autophagy","volume":"32","author":"Ahmed","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.tins.2010.09.001","article-title":"Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications","volume":"33","author":"Banerjee","year":"2010","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0304-3940(97)00663-0","article-title":"Kinetics of nigral degeneration in a chronic model of MPTP-treated mice","volume":"234","author":"Bezard","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2217\/14796708.3.3.309","article-title":"Autophagy in neuroprotection and neurodegeneration: a question of balance","volume":"3","author":"Cherra","year":"2008","journal-title":"Future Neurol"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0025","doi-asserted-by":"crossref","first-page":"11981","DOI":"10.1073\/pnas.0801329105","article-title":"Enhanced contextual fear memory in central serotonin-deficient mice","volume":"105","author":"Dai","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0030","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3892\/etm.2014.1745","article-title":"Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson\u2019s disease","volume":"8","author":"Dai","year":"2014","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0035","doi-asserted-by":"crossref","first-page":"12535","DOI":"10.1523\/JNEUROSCI.1920-10.2010","article-title":"Pathogenic lysosomal depletion in Parkinson\u2019s disease","volume":"30","author":"Dehay","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0040","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1096\/fj.11-181958","article-title":"Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson\u2019s disease models","volume":"25","author":"Domanskyi","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0045","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.1523\/JNEUROSCI.5809-11.2012","article-title":"Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain","volume":"32","author":"Friedman","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0050","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/gene.10217","article-title":"Transgenic mice engineered to target Cre\/loxP-mediated DNA recombination into catecholaminergic neurons","volume":"36","author":"Gelman","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0055","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/15548627.2015.1058683","article-title":"Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2\/quinone oxidoreductase 2: Implications for neuroprotection","volume":"11","author":"Janda","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0060","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4161\/auto.20792","article-title":"ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage","volume":"8","author":"Kessel","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0065","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0070","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.phrs.2012.07.004","article-title":"P62\/SQSTM1\/A170: physiology and pathology","volume":"66","author":"Komatsu","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0075","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1523\/JNEUROSCI.3809-03.2004","article-title":"Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway","volume":"24","author":"Lee","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0085","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI26390","article-title":"Autophagy in cell death: an innocent convict?","volume":"115","author":"Levine","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1750-1326-9-47","article-title":"The role of the LRRK2 gene in Parkinsonism","volume":"9","author":"Li","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0095","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/cn300145z","article-title":"Rotenone inhibits autophagic flux prior to inducing cell death","volume":"3","author":"Mader","year":"2012","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0105","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tins.2006.07.003","article-title":"Autophagy in neurodegenerative disease: friend, foe or turncoat?","volume":"29","author":"Nixon","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-59745-157-4_13","article-title":"Clearance of mutant aggregate-prone proteins by autophagy","volume":"445","author":"Ravikumar","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4161\/auto.1.1.1513","article-title":"Autophagy and its possible roles in nervous system diseases, damage and repair","volume":"1","author":"Rubinsztein","year":"2004","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0120","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0125","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1080\/15548627.2015.1082020","article-title":"Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA\/alpha-synuclein aggregation","volume":"11","author":"Su","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0130","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1074\/jbc.C000752200","article-title":"The human homolog of Saccharomyces cerevisiae Apg7p is a protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3","volume":"276","author":"Tanida","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0135","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0014-5793(93)80398-E","article-title":"Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae","volume":"333","author":"Tsukada","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0140","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molmed.2010.11.002","article-title":"Mitophagy: the latest problem for Parkinson\u2019s disease","volume":"17","author":"Vives-Bauza","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0145","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/j.1474-9726.2011.00721.x","article-title":"DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson\u2019s disease","volume":"10","author":"Wang","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0150","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn.2575","article-title":"Autophagy gone awry in neurodegenerative diseases","volume":"13","author":"Wong","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0155","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/15548627.2015.1132134","article-title":"Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury","volume":"12","author":"Xie","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.neuroscience.2016.09.037_b0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2353\/ajpath.2007.060524","article-title":"Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death","volume":"170","author":"Zhu","year":"2007","journal-title":"Am J Pathol"}],"container-title":["Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216304845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306452216304845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T13:32:54Z","timestamp":1657373574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306452216304845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":32,"alternative-id":["S0306452216304845"],"URL":"https:\/\/doi.org\/10.1016\/j.neuroscience.2016.09.037","relation":{},"ISSN":["0306-4522"],"issn-type":[{"value":"0306-4522","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}